T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 12, 2014, Pages 2632-2636

  McLaughlin, Tracey ^a   Liu, Li Fen ^a   Lamendola, Cindy ^a   Shen, Lei ^b   Morton, John ^b   Rivas, Homero ^a   Winer, Daniel ^b   Tolentino, Lorna ^b   Choi, Okmi ^b   Zhang, Hong ^b   Chng, Melissa Hui Yen ^b   Engleman, Edgar ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Adaptive immunity; C reactive protein; Human adipose tissue specific secretory factor; inflammation; insulin resistance; interleukin 10; interleukin 6; obesity; T helper lymphocytes; T lymphocytes; visceral fat

Indexed keywords

C REACTIVE PROTEIN; GAMMA INTERFERON; GLUCOSE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 6; AUTACOID; CYTOKINE;

ADAPTIVE IMMUNITY; ADIPOSE TISSUE; ADULT; ARTICLE; BIOPSY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; FUNCTION TEST; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INSULIN RESISTANCE; INSULIN SUPPRESSION TEST; INTRAABDOMINAL FAT; OBESITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; SUBCUTANEOUS FAT; T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; AGED; ANIMAL; BLOOD; CLINICAL TRIAL; GENETICS; IMMUNOLOGY; MALE; MIDDLE AGED; MOUSE; PATHOLOGY; T LYMPHOCYTE SUBPOPULATION;

ADIPOSE TISSUE; ADULT; AGED; ANIMALS; CYTOKINES; FEMALE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MALE; MICE; MIDDLE AGED; OBESITY; OVERWEIGHT; SUBCUTANEOUS FAT; T-LYMPHOCYTE SUBSETS;

EID: 84918593760     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.304636     Document Type: Article

References (15)

1. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405:458-462.
2. de Jonge WJ, Van Der Zanden EP, The FO, Bijlsma MF, Van Westerloo DJ, Bennink RJ, Berthoud HR, Uematsu S, Akira S, Van den Wijngaard RM, Boeckxstaens GE. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol. 2005;6:844-851.
3. Wang H, Liao H, Ochani M, Justiniani M, Lin X, Yang L, Al-Abed Y, Wang H, Metz C, Miller EJ, Tracey KJ, Ulloa L. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med. 2004;10:1216-1221.
4. Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 2007;117:289-296.
5. Wang H, Yu M, Ochani M, Amella C.A., Tanovic M, Susarla S, Li JH, Wang H, Yang H, Ulloa L, Al-Abed Y, Czura CJ, Tracey KJ. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003;421:384-388.
6. Rosas-Ballina M, Olofsson PS, Ochani M, Valdés-Ferrer SI, Levine YA, Reardon C, Tusche MW, Pavlov VA, Andersson U, Chavan S, Mak TW, Tracey KJ. Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 2011;334:98-101.
7. Moser N, Mechawar N, Jones I, et al. Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures. J Neurochem. 2007;102:479-492.
8. Wilund KR, Rosenblat M, Chung HR, Volkova N, Kaplan M, Woods JA, Aviram M. Macrophages from alpha 7 nicotinic acetylcholine receptor knockout mice demonstrate increased cholesterol accumulation and decreased cellular paraoxonase expression: a possible link between the nervous system and atherosclerosis development. Biochem Biophys Res Commun. 2009;390:148-154.
9. Fujii YX, Fujigaya H, Moriwaki Y, Misawa H, Kasahara T, Grando SA, Kawashima K. Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice. J Neuroimmunol. 2007;189:69-74.
10. Karimi K, Bienenstock J, Wang L, Forsythe P. The vagus nerve modulates CD4+ T cell activity. Brain Behav Immun. 2010;24:316-323.
11. Inanaga K, Ichiki T, Miyazaki R, Takeda K, Hashimoto T, Matsuura H, Sunagawa K. Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice. Atherosclerosis. 2010;213:52-58.
12. Erhardt S, Olsson SK, Engberg G. Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders. CNS Drugs. 2009;23:91-101.
13. Zhang L, Ovchinnikova O, Jönsson A, Lundberg AM, Berg M, Hansson GK, Ketelhuth DF. The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice. Eur Heart J. 2012;33:2025-2034.
14. Lau PP, Li L, Merched AJ, Zhang AL, Ko KW, Chan L. Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice. Arterioscler Thromb Vasc Biol. 2006;26:143-149.
15. Zhou MS, Chadipiralla K, Mendez AJ, Jaimes EA, Silverstein RL, Webster K, Raij L. Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling. Am J Physiol Heart Circ Physiol. 2013;305:H563-H574.