-
1
-
-
84960994832
-
Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices
-
Hokin MR, Hokin LE: Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices. J Biol Chem 1953;203:967-977.
-
(1953)
J Biol Chem
, vol.203
, pp. 967-977
-
-
Hokin, M.R.1
Hokin, L.E.2
-
2
-
-
34548601740
-
The physiology of phosphoinositides
-
Sasaki T, Sasaki J, Sakai T, Takasuga S, Suzuki A: The physiology of phosphoinositides. Biol Pharm Bull 2007;30:1599-1604.
-
(2007)
Biol Pharm Bull
, vol.30
, pp. 1599-1604
-
-
Sasaki, T.1
Sasaki, J.2
Sakai, T.3
Takasuga, S.4
Suzuki, A.5
-
3
-
-
0034988333
-
Phosphoinositides: Key players in cell signalling, in time and space
-
Payrastre B, Missy K, Giuriato S, Bodin S, Plantavid M, Gratacap M: Phosphoinositides: key players in cell signalling, in time and space. Cell Signal 2001;13:377-387.
-
(2001)
Cell Signal
, vol.13
, pp. 377-387
-
-
Payrastre, B.1
Missy, K.2
Giuriato, S.3
Bodin, S.4
Plantavid, M.5
Gratacap, M.6
-
4
-
-
0036280038
-
Phosphoinositides and signal transduction
-
Toker A: Phosphoinositides and signal transduction. Cell Mol Life Sci 2002;59:761-779.
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 761-779
-
-
Toker, A.1
-
5
-
-
84908065769
-
The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1
-
Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA: The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc Natl Acad Sci USA 2014;111:15054-15059.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 15054-15059
-
-
Blind, R.D.1
Sablin, E.P.2
Kuchenbecker, K.M.3
Chiu, H.J.4
Deacon, A.M.5
Das, D.6
Fletterick, R.J.7
Ingraham, H.A.8
-
7
-
-
0033605718
-
The role of phosphoinositide 3-kinase lipid products in cell function
-
Rameh LE, Cantley LC: The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999;274:8347-8350.
-
(1999)
J Biol Chem
, vol.274
, pp. 8347-8350
-
-
Rameh, L.E.1
Cantley, L.C.2
-
8
-
-
0030790548
-
Using structure to define the function of phosphoinositide 3-kinase family members
-
Domin J, Waterfield MD: Using structure to define the function of phosphoinositide 3-kinase family members. FEBS Lett 1997;410:91-95.
-
(1997)
FEBS Lett
, vol.410
, pp. 91-95
-
-
Domin, J.1
Waterfield, M.D.2
-
9
-
-
84884994299
-
Role of phosphatidylinositol 3, 4, 5-trisphosphate in cell signaling
-
Riehle RD, Cornea S, Degterev A: Role of phosphatidylinositol 3, 4, 5-trisphosphate in cell signaling. Adv Exp Med Biol 2013;991:105-139.
-
(2013)
Adv Exp Med Biol
, vol.991
, pp. 105-139
-
-
Riehle, R.D.1
Cornea, S.2
Degterev, A.3
-
10
-
-
0026654026
-
Platelet-derived growth factor stimulates synthesis of PtdIns(3, 4, 5) P3 by activating a PtdIns(4, 5)P2 3-OH kinase
-
Hawkins PT, Jackson TR, Stephens LR: Platelet-derived growth factor stimulates synthesis of PtdIns(3, 4, 5) P3 by activating a PtdIns(4, 5)P2 3-OH kinase. Nature 1992;358:157-159.
-
(1992)
Nature
, vol.358
, pp. 157-159
-
-
Hawkins, P.T.1
Jackson, T.R.2
Stephens, L.R.3
-
11
-
-
0026069474
-
Oncogenes and signal transduction
-
Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S: Oncogenes and signal transduction. Cell 1991;64:281-302.
-
(1991)
Cell
, vol.64
, pp. 281-302
-
-
Cantley, L.C.1
Auger, K.R.2
Carpenter, C.3
Duckworth, B.4
Graziani, A.5
Kapeller, R.6
Soltoff, S.7
-
12
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J: Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 1994;370:527-532.
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
Waterfield, M.D.7
Downward, J.8
-
14
-
-
15444351150
-
Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules
-
Zhang X, Loijens JC, Boronenkov IV, Parker GJ, Norris FA, Chen J, Thum O, Prestwich GD, Majerus PW, Anderson RA: Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem 1997;272:17756-17761.
-
(1997)
J Biol Chem
, vol.272
, pp. 17756-17761
-
-
Zhang, X.1
Loijens, J.C.2
Boronenkov, I.V.3
Parker, G.J.4
Norris, F.A.5
Chen, J.6
Thum, O.7
Prestwich, G.D.8
Majerus, P.W.9
Anderson, R.A.10
-
15
-
-
0032541172
-
Type i phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3, 5-bisphosphate and phosphatidylinositol 5-phosphate
-
Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter CL: Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3, 5-bisphosphate and phosphatidylinositol 5-phosphate. J Biol Chem 1998;273:18040-18046.
-
(1998)
J Biol Chem
, vol.273
, pp. 18040-18046
-
-
Tolias, K.F.1
Rameh, L.E.2
Ishihara, H.3
Shibasaki, Y.4
Chen, J.5
Prestwich, G.D.6
Cantley, L.C.7
Carpenter, C.L.8
-
16
-
-
83455203533
-
Understanding the relative affinity and specificity of the pleckstrin homology domain of protein kinase B for inositol phosphates
-
Rosen SA, Gaffney PR, Spiess B, Gould IR: Understanding the relative affinity and specificity of the pleckstrin homology domain of protein kinase B for inositol phosphates. Phys Chem Chem Phys 2012;14:929-936.
-
(2012)
Phys Chem Chem Phys
, vol.14
, pp. 929-936
-
-
Rosen, S.A.1
Gaffney, P.R.2
Spiess, B.3
Gould, I.R.4
-
17
-
-
34548643512
-
Phosphoinositide phosphatases in a network of signalling reactions
-
Blero D, Payrastre B, Schurmans S, Erneux C: Phosphoinositide phosphatases in a network of signalling reactions. Pflugers Arch 2007;455:31-44.
-
(2007)
Pflugers Arch
, vol.455
, pp. 31-44
-
-
Blero, D.1
Payrastre, B.2
Schurmans, S.3
Erneux, C.4
-
18
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
-
Maehama T, Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 1998;273:13375-13378.
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
19
-
-
0029978202
-
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3, 4, 5-triphosphate 5-phosphatase
-
Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G: The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3, 4, 5-triphosphate 5-phosphatase. Proc Natl Acad Sci USA 1996;93:1689-1693.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 1689-1693
-
-
Damen, J.E.1
Liu, L.2
Rosten, P.3
Humphries, R.K.4
Jefferson, A.B.5
Majerus, P.W.6
Krystal, G.7
-
20
-
-
51449111718
-
Molecular mechanism of membrane targeting by the GRP1 PH domain
-
He J, Haney RM, Vora M, Verkhusha VV, Stahelin RV, Kutateladze TG: Molecular mechanism of membrane targeting by the GRP1 PH domain. J Lipid Res 2008;49:1807-1815.
-
(2008)
J Lipid Res
, vol.49
, pp. 1807-1815
-
-
He, J.1
Haney, R.M.2
Vora, M.3
Verkhusha, V.V.4
Stahelin, R.V.5
Kutateladze, T.G.6
-
21
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA: Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996;15:6541-6551.
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
22
-
-
43249093752
-
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
-
Bayascas JR, Wullschleger S, Sakamoto K, Garcia-Martinez JM, Clacher C, Komander D, van Aalten DM, Boini KM, Lang F, Lipina C, Logie L, Sutherland C, Chudek JA, van Diepen JA, Voshol PJ, Lucocq JM, Alessi DR: Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance. Mol Cell Biol 2008;28:3258-3272.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3258-3272
-
-
Bayascas, J.R.1
Wullschleger, S.2
Sakamoto, K.3
Garcia-Martinez, J.M.4
Clacher, C.5
Komander, D.6
Van Aalten, D.M.7
Boini, K.M.8
Lang, F.9
Lipina, C.10
Logie, L.11
Sutherland, C.12
Chudek, J.A.13
Van Diepen, J.A.14
Voshol, P.J.15
Lucocq, J.M.16
Alessi, D.R.17
-
23
-
-
0032578998
-
Phosphorylation and activation of p70s6k by PDK1
-
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G: Phosphorylation and activation of p70s6k by PDK1. Science 1998;279:707-710.
-
(1998)
Science
, vol.279
, pp. 707-710
-
-
Pullen, N.1
Dennis, P.B.2
Andjelkovic, M.3
Dufner, A.4
Kozma, S.C.5
Hemmings, B.A.6
Thomas, G.7
-
24
-
-
0032566691
-
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
-
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ: Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 1998;281:2042-2045.
-
(1998)
Science
, vol.281
, pp. 2042-2045
-
-
Le Good, J.A.1
Ziegler, W.H.2
Parekh, D.B.3
Alessi, D.R.4
Cohen, P.5
Parker, P.J.6
-
25
-
-
0027535742
-
Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3, 4, 5-trisphosphate
-
Nakanishi H, Brewer KA, Exton JH: Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 1993;268:13-16.
-
(1993)
J Biol Chem
, vol.268
, pp. 13-16
-
-
Nakanishi, H.1
Brewer, K.A.2
Exton, J.H.3
-
26
-
-
0027183541
-
The PH domain: A common piece in the structural patchwork of signalling proteins
-
Musacchio A, Gibson T, Rice P, Thompson J, Saraste M: The PH domain: a common piece in the structural patchwork of signalling proteins. Trends Biochem Sci 1993;18:343-348.
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 343-348
-
-
Musacchio, A.1
Gibson, T.2
Rice, P.3
Thompson, J.4
Saraste, M.5
-
27
-
-
36249015526
-
Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors
-
DiNitto JP, Delprato A, Gabe Lee MT, Cronin TC, Huang S, Guilherme A, Czech MP, Lambright DG: Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. Mol Cell 2007;28:569-583.
-
(2007)
Mol Cell
, vol.28
, pp. 569-583
-
-
Dinitto, J.P.1
Delprato, A.2
Gabe Lee, M.T.3
Cronin, T.C.4
Huang, S.5
Guilherme, A.6
Czech, M.P.7
Lambright, D.G.8
-
28
-
-
15144353776
-
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
-
Han J, Luby-Phelps K, Das B, Shu X, Xia Y, Mosteller RD, Krishna UM, Falck JR, White MA, Broek D: Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 1998;279:558-560.
-
(1998)
Science
, vol.279
, pp. 558-560
-
-
Han, J.1
Luby-Phelps, K.2
Das, B.3
Shu, X.4
Xia, Y.5
Mosteller, R.D.6
Krishna, U.M.7
Falck, J.R.8
White, M.A.9
Broek, D.10
-
29
-
-
0029278739
-
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase
-
Hawkins PT, Eguinoa A, Qiu RG, Stokoe D, Cooke FT, Walters R, Wennstrom S, Claesson-Welsh L, Evans T, Symons M, et al.: PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase. Curr Biol 1995;5:393-403.
-
(1995)
Curr Biol
, vol.5
, pp. 393-403
-
-
Hawkins, P.T.1
Eguinoa, A.2
Qiu, R.G.3
Stokoe, D.4
Cooke, F.T.5
Walters, R.6
Wennstrom, S.7
Claesson-Welsh, L.8
Evans, T.9
Symons, M.10
-
30
-
-
10544219605
-
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
-
Salim K, Bottomley MJ, Querfurth E, Zvelebil MJ, Gout I, Scaife R, Margolis RL, Gigg R, Smith CI, Driscoll PC, Waterfield MD, Panayotou G: Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase. EMBO J 1996;15:6241-6250.
-
(1996)
EMBO J
, vol.15
, pp. 6241-6250
-
-
Salim, K.1
Bottomley, M.J.2
Querfurth, E.3
Zvelebil, M.J.4
Gout, I.5
Scaife, R.6
Margolis, R.L.7
Gigg, R.8
Smith, C.I.9
Driscoll, P.C.10
Waterfield, M.D.11
Panayotou, G.12
-
31
-
-
0031471231
-
Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases
-
Li Z, Wahl MI, Eguinoa A, Stephens LR, Hawkins PT, Witte ON: Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases. Proc Natl Acad Sci USA 1997;94:13820-13825.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13820-13825
-
-
Li, Z.1
Wahl, M.I.2
Eguinoa, A.3
Stephens, L.R.4
Hawkins, P.T.5
Witte, O.N.6
-
32
-
-
0032055484
-
Phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns-3, 4, 5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
-
Scharenberg AM, El-Hillal O, Fruman DA, Beitz LO, Li Z, Lin S, Gout I, Cantley LC, Rawlings DJ, Kinet JP: Phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns-3, 4, 5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. EMBO J 1998;17:1961-1972.
-
(1998)
EMBO J
, vol.17
, pp. 1961-1972
-
-
Scharenberg, A.M.1
El-Hillal, O.2
Fruman, D.A.3
Beitz, L.O.4
Li, Z.5
Lin, S.6
Gout, I.7
Cantley, L.C.8
Rawlings, D.J.9
Kinet, J.P.10
-
33
-
-
0029824848
-
Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1, 3, 4, 5-tetrakisphosphate binding capacity
-
Fukuda M, Kojima T, Kabayama H, Mikoshiba K: Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1, 3, 4, 5-tetrakisphosphate binding capacity. J Biol Chem 1996;271:30303-30306.
-
(1996)
J Biol Chem
, vol.271
, pp. 30303-30306
-
-
Fukuda, M.1
Kojima, T.2
Kabayama, H.3
Mikoshiba, K.4
-
34
-
-
0028892253
-
Phosphatidylinositol (3, 4, 5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins
-
Rameh LE, Chen CS, Cantley LC: Phosphatidylinositol (3, 4, 5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins. Cell 1995;83:821-830.
-
(1995)
Cell
, vol.83
, pp. 821-830
-
-
Rameh, L.E.1
Chen, C.S.2
Cantley, L.C.3
-
35
-
-
0344653108
-
Activation of phospholipase C-gamma by phosphatidylinositol 3, 4, 5-trisphosphate
-
Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG: Activation of phospholipase C-gamma by phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 1998;273:4465-4469.
-
(1998)
J Biol Chem
, vol.273
, pp. 4465-4469
-
-
Bae, Y.S.1
Cantley, L.G.2
Chen, C.S.3
Kim, S.R.4
Kwon, K.S.5
Rhee, S.G.6
-
36
-
-
14444287277
-
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling
-
Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantley LG: Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. J Biol Chem 1998;273:23750-23757.
-
(1998)
J Biol Chem
, vol.273
, pp. 23750-23757
-
-
Rameh, L.E.1
Rhee, S.G.2
Spokes, K.3
Kazlauskas, A.4
Cantley, L.C.5
Cantley, L.G.6
-
37
-
-
0032518666
-
Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting
-
Falasca M, Logan SK, Lehto VP, Baccante G, Lemmon MA, Schlessinger J: Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J 1998;17:414-422.
-
(1998)
EMBO J
, vol.17
, pp. 414-422
-
-
Falasca, M.1
Logan, S.K.2
Lehto, V.P.3
Baccante, G.4
Lemmon, M.A.5
Schlessinger, J.6
-
38
-
-
79251541212
-
The extending network of FOXO transcriptional target genes
-
van der Vos KE, Coffer PJ: The extending network of FOXO transcriptional target genes. Antioxid Redox Signal 2011;14:579-592.
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 579-592
-
-
Van Der Vos, K.E.1
Coffer, P.J.2
-
39
-
-
2342618936
-
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
-
Liang J, Slingerland JM: Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2003;2:339-345.
-
(2003)
Cell Cycle
, vol.2
, pp. 339-345
-
-
Liang, J.1
Slingerland, J.M.2
-
40
-
-
17644379936
-
FOXO transcription factors in cell-cycle regulation and the response to oxidative stress
-
Furukawa-Hibi Y, Kobayashi Y, Chen C, Motoyama N: FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid Redox Signal 2005;7:752-760.
-
(2005)
Antioxid Redox Signal
, vol.7
, pp. 752-760
-
-
Furukawa-Hibi, Y.1
Kobayashi, Y.2
Chen, C.3
Motoyama, N.4
-
42
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997;278:687-689.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
43
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
44
-
-
0036781052
-
NF-kappaB regulation in the immune system
-
Li Q, Verma IM: NF-kappaB regulation in the immune system. Nat Rev Immunol 2002;2:725-734.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 725-734
-
-
Li, Q.1
Verma, I.M.2
-
45
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB: NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999;401:82-85.
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
46
-
-
0442323560
-
Tuberous sclerosis complex: From Drosophila to human disease
-
Pan D, Dong J, Zhang Y, Gao X: Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol 2004;14:78-85.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 78-85
-
-
Pan, D.1
Dong, J.2
Zhang, Y.3
Gao, X.4
-
47
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell 2006;124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
48
-
-
78650239404
-
Functions and regulation of the 70kDa ribosomal S6 kinases
-
Fenton TR, Gout IT: Functions and regulation of the 70kDa ribosomal S6 kinases. Int J Biochem Cell Biol 2011;43:47-59.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 47-59
-
-
Fenton, T.R.1
Gout, I.T.2
-
49
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
-
Ward PS, Thompson CB: Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012;21:297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
50
-
-
0028308412
-
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
-
Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 1994;14:4902-4911.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4902-4911
-
-
Cheatham, B.1
Vlahos, C.J.2
Cheatham, L.3
Wang, L.4
Blenis, J.5
Kahn, C.R.6
-
51
-
-
0028875678
-
Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway
-
Haruta T, Morris AJ, Rose DW, Nelson JG, Mueckler M, Olefsky JM: Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway. J Biol Chem 1995;270:27991-27994.
-
(1995)
J Biol Chem
, vol.270
, pp. 27991-27994
-
-
Haruta, T.1
Morris, A.J.2
Rose, D.W.3
Nelson, J.G.4
Mueckler, M.5
Olefsky, J.M.6
-
52
-
-
33947596679
-
The GLUT4 glucose transporter
-
Huang S, Czech MP: The GLUT4 glucose transporter. Cell Metab 2007;5:237-252.
-
(2007)
Cell Metab
, vol.5
, pp. 237-252
-
-
Huang, S.1
Czech, M.P.2
-
53
-
-
26844573782
-
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain
-
Miinea CP, Sano H, Kane S, Sano E, Fukuda M, Peranen J, Lane WS, Lienhard GE: AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J 2005;391:87-93.
-
(2005)
Biochem J
, vol.391
, pp. 87-93
-
-
Miinea, C.P.1
Sano, H.2
Kane, S.3
Sano, E.4
Fukuda, M.5
Peranen, J.6
Lane, W.S.7
Lienhard, G.E.8
-
55
-
-
0037677096
-
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation
-
Sano H, Kane S, Sano E, Miinea CP, Asara JM, Lane WS, Garner CW, Lienhard GE: Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem 2003;278:14599-14602.
-
(2003)
J Biol Chem
, vol.278
, pp. 14599-14602
-
-
Sano, H.1
Kane, S.2
Sano, E.3
Miinea, C.P.4
Asara, J.M.5
Lane, W.S.6
Garner, C.W.7
Lienhard, G.E.8
-
56
-
-
70149109353
-
GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation
-
Chen Y, Deng Y, Zhang J, Yang L, Xie X, Xu T: GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation. Biochem J 2009;422:229-235.
-
(2009)
Biochem J
, vol.422
, pp. 229-235
-
-
Chen, Y.1
Deng, Y.2
Zhang, J.3
Yang, L.4
Xie, X.5
Xu, T.6
-
57
-
-
41649109193
-
Rab10 in insulin-stimulated GLUT4 translocation
-
Sano H, Roach WG, Peck GR, Fukuda M, Lienhard GE: Rab10 in insulin-stimulated GLUT4 translocation. Biochem J 2008;411:89-95.
-
(2008)
Biochem J
, vol.411
, pp. 89-95
-
-
Sano, H.1
Roach, W.G.2
Peck, G.R.3
Fukuda, M.4
Lienhard, G.E.5
-
58
-
-
33947578085
-
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane
-
Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE: Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metab 2007;5:293-303.
-
(2007)
Cell Metab
, vol.5
, pp. 293-303
-
-
Sano, H.1
Eguez, L.2
Teruel, M.N.3
Fukuda, M.4
Chuang, T.D.5
Chavez, J.A.6
Lienhard, G.E.7
McGraw, T.E.8
-
59
-
-
84866347107
-
Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes
-
Chen Y, Wang Y, Zhang J, Deng Y, Jiang L, Song E, Wu XS, Hammer JA, Xu T, Lippincott-Schwartz J: Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol 2012;198:545-560.
-
(2012)
J Cell Biol
, vol.198
, pp. 545-560
-
-
Chen, Y.1
Wang, Y.2
Zhang, J.3
Deng, Y.4
Jiang, L.5
Song, E.6
Wu, X.S.7
Hammer, J.A.8
Xu, T.9
Lippincott-Schwartz, J.10
-
60
-
-
33846178185
-
Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells
-
Ishikura S, Bilan PJ, Klip A: Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells. Biochem Biophys Res Commun 2007;353:1074-1079.
-
(2007)
Biochem Biophys Res Commun
, vol.353
, pp. 1074-1079
-
-
Ishikura, S.1
Bilan, P.J.2
Klip, A.3
-
61
-
-
0030975196
-
Signaling by phosphoinositide-3, 4, 5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains
-
Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP: Signaling by phosphoinositide-3, 4, 5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 1997;275:1927-1930.
-
(1997)
Science
, vol.275
, pp. 1927-1930
-
-
Klarlund, J.K.1
Guilherme, A.2
Holik, J.J.3
Virbasius, J.V.4
Chawla, A.5
Czech, M.P.6
-
62
-
-
0031939743
-
Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3, 4, 5-trisphosphate
-
Klarlund JK, Rameh LE, Cantley LC, Buxton JM, Holik JJ, Sakelis C, Patki V, Corvera S, Czech MP: Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 1998;273:1859-1862.
-
(1998)
J Biol Chem
, vol.273
, pp. 1859-1862
-
-
Klarlund, J.K.1
Rameh, L.E.2
Cantley, L.C.3
Buxton, J.M.4
Holik, J.J.5
Sakelis, C.6
Patki, V.7
Corvera, S.8
Czech, M.P.9
-
63
-
-
84555191987
-
Akt isoform-specific signaling in breast cancer: Uncovering an anti-migratory role for palladin
-
Chin YR, Toker A: Akt isoform-specific signaling in breast cancer: uncovering an anti-migratory role for palladin. Cell Adh Migr 2011;5:211-214.
-
(2011)
Cell Adh Migr
, vol.5
, pp. 211-214
-
-
Chin, Y.R.1
Toker, A.2
-
64
-
-
33947728156
-
Essential role of PDK1 in regulating endothelial cell migration
-
Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F: Essential role of PDK1 in regulating endothelial cell migration. J Cell Biol 2007;176:1035-1047.
-
(2007)
J Cell Biol
, vol.176
, pp. 1035-1047
-
-
Primo, L.1
Di Blasio, L.2
Roca, C.3
Droetto, S.4
Piva, R.5
Schaffhausen, B.6
Bussolino, F.7
-
65
-
-
33645274673
-
Analyzing phosphoinositides and their interacting proteins
-
Rusten TE, Stenmark H: Analyzing phosphoinositides and their interacting proteins. Nat Methods 2006;3:251-258.
-
(2006)
Nat Methods
, vol.3
, pp. 251-258
-
-
Rusten, T.E.1
Stenmark, H.2
-
66
-
-
0343168409
-
Phosphoinositides and protein secretion in pancreas slices
-
Hokin LE, Hokin MR: Phosphoinositides and protein secretion in pancreas slices. J Biol Chem 1958;233:805-810.
-
(1958)
J Biol Chem
, vol.233
, pp. 805-810
-
-
Hokin, L.E.1
Hokin, M.R.2
-
67
-
-
0030669546
-
Osmotic stress activates phosphatidylinositol-3, 5-bisphosphate synthesis
-
Dove SK, Cooke FT, Douglas MR, Sayers LG, Parker PJ, Michell RH: Osmotic stress activates phosphatidylinositol-3, 5-bisphosphate synthesis. Nature 1997;390:187-192.
-
(1997)
Nature
, vol.390
, pp. 187-192
-
-
Dove, S.K.1
Cooke, F.T.2
Douglas, M.R.3
Sayers, L.G.4
Parker, P.J.5
Michell, R.H.6
-
68
-
-
38449088077
-
Quantitative measurement of phosphatidylinositol 3, 4, 5-trisphosphate
-
Guillou H, Stephens LR, Hawkins PT: Quantitative measurement of phosphatidylinositol 3, 4, 5-trisphosphate. Methods Enzymol 2007;434:117-130.
-
(2007)
Methods Enzymol
, vol.434
, pp. 117-130
-
-
Guillou, H.1
Stephens, L.R.2
Hawkins, P.T.3
-
69
-
-
0037083398
-
Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection
-
Nasuhoglu C, Feng S, Mao J, Yamamoto M, Yin HL, Earnest S, Barylko B, Albanesi JP, Hilgemann DW: Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection. Anal Biochem 2002;301:243-254.
-
(2002)
Anal Biochem
, vol.301
, pp. 243-254
-
-
Nasuhoglu, C.1
Feng, S.2
Mao, J.3
Yamamoto, M.4
Yin, H.L.5
Earnest, S.6
Barylko, B.7
Albanesi, J.P.8
Hilgemann, D.W.9
-
70
-
-
0141653274
-
Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: A bridge to lipidomics
-
Han X, Gross RW: Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res 2003;44:1071-1079.
-
(2003)
J Lipid Res
, vol.44
, pp. 1071-1079
-
-
Han, X.1
Gross, R.W.2
-
71
-
-
0037435030
-
Mass spectrometry-based proteomics
-
Aebersold R, Mann M: Mass spectrometry-based proteomics. Nature 2003;422:198-207.
-
(2003)
Nature
, vol.422
, pp. 198-207
-
-
Aebersold, R.1
Mann, M.2
-
72
-
-
0034487745
-
Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4, 5-bisphosphate by electrospray ionization tandem mass spectrometry: A mechanistic study
-
Hsu FF, Turk J: Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4, 5-bisphosphate by electrospray ionization tandem mass spectrometry: a mechanistic study. J Am Soc Mass Spectrom 2000;11:986-999.
-
(2000)
J Am Soc Mass Spectrom
, vol.11
, pp. 986-999
-
-
Hsu, F.F.1
Turk, J.2
-
76
-
-
84875504205
-
Diabesity
-
Kalra S: Diabesity. J Pak Med Assoc 2013;63:532-534.
-
(2013)
J Pak Med Assoc
, vol.63
, pp. 532-534
-
-
Kalra, S.1
-
77
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel AR, Kahn CR: Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799-806.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
78
-
-
0035914361
-
Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver
-
Tobe K, Suzuki R, Aoyama M, Yamauchi T, Kamon J, Kubota N, Terauchi Y, Matsui J, Akanuma Y, Kimura S, Tanaka J, Abe M, Ohsumi J, Nagai R, Kadowaki T: Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver. J Biol Chem 2001;276:38337-38340.
-
(2001)
J Biol Chem
, vol.276
, pp. 38337-38340
-
-
Tobe, K.1
Suzuki, R.2
Aoyama, M.3
Yamauchi, T.4
Kamon, J.5
Kubota, N.6
Terauchi, Y.7
Matsui, J.8
Akanuma, Y.9
Kimura, S.10
Tanaka, J.11
Abe, M.12
Ohsumi, J.13
Nagai, R.14
Kadowaki, T.15
-
79
-
-
4644227974
-
Obesity in insulin receptor substrate-2-deficient mice: Disrupted control of arcuate nucleus neuropeptides
-
Masaki T, Chiba S, Noguchi H, Yasuda T, Tobe K, Suzuki R, Kadowaki T, Yoshimatsu H: Obesity in insulin receptor substrate-2-deficient mice: disrupted control of arcuate nucleus neuropeptides. Obes Res 2004;12:878-885.
-
(2004)
Obes Res
, vol.12
, pp. 878-885
-
-
Masaki, T.1
Chiba, S.2
Noguchi, H.3
Yasuda, T.4
Tobe, K.5
Suzuki, R.6
Kadowaki, T.7
Yoshimatsu, H.8
-
80
-
-
33744990592
-
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
-
Foukas LC, Claret M, Pearce W, Okkenhaug K, Meek S, Peskett E, Sancho S, Smith AJ, Withers DJ, Vanhaesebroeck B: Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 2006;441:366-370.
-
(2006)
Nature
, vol.441
, pp. 366-370
-
-
Foukas, L.C.1
Claret, M.2
Pearce, W.3
Okkenhaug, K.4
Meek, S.5
Peskett, E.6
Sancho, S.7
Smith, A.J.8
Withers, D.J.9
Vanhaesebroeck, B.10
-
81
-
-
14144250240
-
Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
-
Brachmann SM, Ueki K, Engelman JA, Kahn RC, Cantley LC: Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol Cell Biol 2005;25:1596-1607.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 1596-1607
-
-
Brachmann, S.M.1
Ueki, K.2
Engelman, J.A.3
Kahn, R.C.4
Cantley, L.C.5
-
82
-
-
4544386330
-
Unraveling the cellular mechanism of insulin resistance in humans: New insights from magnetic resonance spectroscopy
-
Shulman GI: Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy. Physiology (Bethesda) 2004;19:183-190.
-
(2004)
Physiology (Bethesda)
, vol.19
, pp. 183-190
-
-
Shulman, G.I.1
-
83
-
-
0036231778
-
Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice
-
Butler M, McKay RA, Popoff IJ, Gaarde WA, Witchell D, Murray SF, Dean NM, Bhanot S, Monia BP: Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes 2002;51:1028-1034.
-
(2002)
Diabetes
, vol.51
, pp. 1028-1034
-
-
Butler, M.1
McKay, R.A.2
Popoff, I.J.3
Gaarde, W.A.4
Witchell, D.5
Murray, S.F.6
Dean, N.M.7
Bhanot, S.8
Monia, B.P.9
-
84
-
-
17844371042
-
Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes
-
Ono H, Katagiri H, Funaki M, Anai M, Inukai K, Fukushima Y, Sakoda H, Ogihara T, Onishi Y, Fujishiro M, Kikuchi M, Oka Y, Asano T: Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes. Mol Endocrinol 2001;15:1411-1422.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 1411-1422
-
-
Ono, H.1
Katagiri, H.2
Funaki, M.3
Anai, M.4
Inukai, K.5
Fukushima, Y.6
Sakoda, H.7
Ogihara, T.8
Onishi, Y.9
Fujishiro, M.10
Kikuchi, M.11
Oka, Y.12
Asano, T.13
-
85
-
-
14844340146
-
Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue
-
Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H: Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol 2005;25:2498-2510.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2498-2510
-
-
Kurlawalla-Martinez, C.1
Stiles, B.2
Wang, Y.3
Devaskar, S.U.4
Kahn, B.B.5
Wu, H.6
-
86
-
-
10744222107
-
Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]
-
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H: Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci USA 2004;101:2082-2087.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2082-2087
-
-
Stiles, B.1
Wang, Y.2
Stahl, A.3
Bassilian, S.4
Lee, W.P.5
Kim, Y.J.6
Sherwin, R.7
Devaskar, S.8
Lesche, R.9
Magnuson, M.A.10
Wu, H.11
-
88
-
-
33748657133
-
PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling
-
Vinciguerra M, Foti M: PTEN and SHIP2 phosphoinositide phosphatases as negative regulators of insulin signalling. Arch Physiol Biochem 2006;112:89-104.
-
(2006)
Arch Physiol Biochem
, vol.112
, pp. 89-104
-
-
Vinciguerra, M.1
Foti, M.2
-
89
-
-
24044468429
-
Turning signals on and off: GLUT4 traffic in the insulin-signaling highway
-
Thong FS, Dugani CB, Klip A: Turning signals on and off: GLUT4 traffic in the insulin-signaling highway. Physiology (Bethesda) 2005;20:271-284.
-
(2005)
Physiology (Bethesda)
, vol.20
, pp. 271-284
-
-
Thong, F.S.1
Dugani, C.B.2
Klip, A.3
-
90
-
-
27844528870
-
Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
-
Larance M, Ramm G, Stockli J, van Dam EM, Winata S, Wasinger V, Simpson F, Graham M, Junutula JR, Guilhaus M, James DE: Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. J Biol Chem 2005;280:37803-37813.
-
(2005)
J Biol Chem
, vol.280
, pp. 37803-37813
-
-
Larance, M.1
Ramm, G.2
Stockli, J.3
Van Dam, E.M.4
Winata, S.5
Wasinger, V.6
Simpson, F.7
Graham, M.8
Junutula, J.R.9
Guilhaus, M.10
De, J.11
-
91
-
-
28544435205
-
Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein
-
Eguez L, Lee A, Chavez JA, Miinea CP, Kane S, Lienhard GE, McGraw TE: Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein. Cell Metab 2005;2:263-272.
-
(2005)
Cell Metab
, vol.2
, pp. 263-272
-
-
Eguez, L.1
Lee, A.2
Chavez, J.A.3
Miinea, C.P.4
Kane, S.5
Lienhard, G.E.6
McGraw, T.E.7
-
92
-
-
33845666593
-
Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action
-
Bai L, Wang Y, Fan J, Chen Y, Ji W, Qu A, Xu P, James DE, Xu T: Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action. Cell Metab 2007;5:47-57.
-
(2007)
Cell Metab
, vol.5
, pp. 47-57
-
-
Bai, L.1
Wang, Y.2
Fan, J.3
Chen, Y.4
Ji, W.5
Qu, A.6
Xu, P.7
James, D.E.8
Xu, T.9
-
93
-
-
33749489511
-
Insulin signaling diverges into Akt-dependent and-independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane
-
Gonzalez E, McGraw TE: Insulin signaling diverges into Akt-dependent and-independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane. Mol Biol Cell 2006;17:4484-4493.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 4484-4493
-
-
Gonzalez, E.1
McGraw, T.E.2
-
96
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB, 3rd, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001;292:1728-1731.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
97
-
-
84867898269
-
Decreased hepatic phosphatidylinositol-3, 4, 5-triphosphate (PIP3) levels and impaired glucose homeostasis in type 1 and type 2 diabetic rats
-
Manna P, Jain SK: Decreased hepatic phosphatidylinositol-3, 4, 5-triphosphate (PIP3) levels and impaired glucose homeostasis in type 1 and type 2 diabetic rats. Cell Physiol Biochem 2012;30:1363-1370.
-
(2012)
Cell Physiol Biochem
, vol.30
, pp. 1363-1370
-
-
Manna, P.1
Jain, S.K.2
-
98
-
-
84882603424
-
PIP3 but not PIP2 increases GLUT4 surface expression and glucose metabolism mediated by AKT/PKCzeta/lambda phosphorylation in 3T3L1 adipocytes
-
Manna P, Jain SK: PIP3 but not PIP2 increases GLUT4 surface expression and glucose metabolism mediated by AKT/PKCzeta/lambda phosphorylation in 3T3L1 adipocytes. Mol Cell Biochem 2013;
-
(2013)
Mol Cell Biochem
-
-
Manna, P.1
Jain, S.K.2
-
99
-
-
0032080120
-
Membrane-permeant esters of phosphatidylinositol 3, 4, 5-trisphosphate
-
Jiang T, Sweeney G, Rudolf MT, Klip A, Traynor-Kaplan A, Tsien RY: Membrane-permeant esters of phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 1998;273:11017-11024.
-
(1998)
J Biol Chem
, vol.273
, pp. 11017-11024
-
-
Jiang, T.1
Sweeney, G.2
Rudolf, M.T.3
Klip, A.4
Traynor-Kaplan, A.5
Tsien, R.Y.6
-
100
-
-
74049097246
-
Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy
-
Rane MJ, Song Y, Jin S, Barati MT, Wu R, Kausar H, Tan Y, Wang Y, Zhou G, Klein JB, Li X, Cai L: Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy. Am J Physiol Renal Physiol 2010;298:F49-61.
-
(2010)
Am J Physiol Renal Physiol
, vol.298
, pp. F49-61
-
-
Rane, M.J.1
Song, Y.2
Jin, S.3
Barati, M.T.4
Wu, R.5
Kausar, H.6
Tan, Y.7
Wang, Y.8
Zhou, G.9
Klein, J.B.10
Li, X.11
Cai, L.12
-
101
-
-
48149101434
-
The endocannabinoid system in obesity and type 2 diabetes
-
Di Marzo V: The endocannabinoid system in obesity and type 2 diabetes. Diabetologia 2008;51:1356-1367.
-
(2008)
Diabetologia
, vol.51
, pp. 1356-1367
-
-
Di Marzo, V.1
-
102
-
-
84890679220
-
Cannabinoid receptor 2 expression in human proximal tubule cells is regulated by albumin independent of ERK1/2 signaling
-
Jenkin KA, McAinch AJ, Briffa JF, Zhang Y, Kelly DJ, Pollock CA, Poronnik P, Hryciw DH: Cannabinoid receptor 2 expression in human proximal tubule cells is regulated by albumin independent of ERK1/2 signaling. Cell Physiol Biochem 2013;32:1309-1319.
-
(2013)
Cell Physiol Biochem
, vol.32
, pp. 1309-1319
-
-
Jenkin, K.A.1
McAinch, A.J.2
Briffa, J.F.3
Zhang, Y.4
Kelly, D.J.5
Pollock, C.A.6
Poronnik, P.7
Hryciw, D.H.8
-
103
-
-
67650249730
-
Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation
-
Romero-Sandoval EA, Horvath R, Landry RP, DeLeo JA: Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain 2009;5:25.
-
(2009)
Mol Pain
, vol.5
, pp. 25
-
-
Romero-Sandoval, E.A.1
Horvath, R.2
Landry, R.P.3
Deleo, J.A.4
-
104
-
-
0042093782
-
Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3, 4, 5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: Amelioration by rosiglitazone and exercise
-
Beeson M, Sajan MP, Dizon M, Grebenev D, Gomez-Daspet J, Miura A, Kanoh Y, Powe J, Bandyopadhyay G, Standaert ML, Farese RV: Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3, 4, 5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise. Diabetes 2003;52:1926-1934.
-
(2003)
Diabetes
, vol.52
, pp. 1926-1934
-
-
Beeson, M.1
Sajan, M.P.2
Dizon, M.3
Grebenev, D.4
Gomez-Daspet, J.5
Miura, A.6
Kanoh, Y.7
Powe, J.8
Bandyopadhyay, G.9
Standaert, M.L.10
Farese, R.V.11
-
105
-
-
0042093781
-
Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: Reversal with weight reduction
-
Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB: Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction. Diabetes 2003;52:1935-1942.
-
(2003)
Diabetes
, vol.52
, pp. 1935-1942
-
-
Kim, Y.B.1
Kotani, K.2
Ciaraldi, T.P.3
Henry, R.R.4
Kahn, B.B.5
-
106
-
-
84882454959
-
Atypical protein kinase C in cell motility
-
Xiao H, Liu M: Atypical protein kinase C in cell motility. Cell Mol Life Sci 2013;70:3057-3066.
-
(2013)
Cell Mol Life Sci
, vol.70
, pp. 3057-3066
-
-
Xiao, H.1
Liu, M.2
-
107
-
-
0642376906
-
Protein kinase Czeta (PKCzeta): Activation mechanisms and cellular functions
-
Hirai T, Chida K: Protein kinase Czeta (PKCzeta): activation mechanisms and cellular functions. J Biochem 2003;133:1-7.
-
(2003)
J Biochem
, vol.133
, pp. 1-7
-
-
Hirai, T.1
Chida, K.2
-
108
-
-
5044250556
-
Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3, 4, 5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome
-
Beeson M, Sajan MP, Daspet JG, Luna V, Dizon M, Grebenev D, Powe JL, Lucidi S, Miura A, Kanoh Y, Bandyopadhyay G, Standaert ML, Yeko TR, Farese RV: Defective Activation of Protein Kinase C-z in Muscle by Insulin and Phosphatidylinositol-3, 4, 5,-(PO(4))(3) in Obesity and Polycystic Ovary Syndrome. Metab Syndr Relat Disord 2004;2:49-56.
-
(2004)
Metab Syndr Relat Disord
, vol.2
, pp. 49-56
-
-
Beeson, M.1
Sajan, M.P.2
Daspet, J.G.3
Luna, V.4
Dizon, M.5
Grebenev, D.6
Powe, J.L.7
Lucidi, S.8
Miura, A.9
Kanoh, Y.10
Bandyopadhyay, G.11
Standaert, M.L.12
Yeko, T.R.13
Farese, R.V.14
-
109
-
-
0036227755
-
Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance
-
Vollenweider P, Menard B, Nicod P: Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3' kinase activation, and impaired atypical protein kinase C (zeta/lambda) activation in myotubes from obese patients with impaired glucose tolerance. Diabetes 2002;51:1052-1059.
-
(2002)
Diabetes
, vol.51
, pp. 1052-1059
-
-
Vollenweider, P.1
Menard, B.2
Nicod, P.3
-
110
-
-
31844437335
-
Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3, 4, 5-(PO4)3 in muscle of diabetic subjects
-
Luna V, Casauban L, Sajan MP, Gomez-Daspet J, Powe JL, Miura A, Rivas J, Standaert ML, Farese RV: Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3, 4, 5-(PO4)3 in muscle of diabetic subjects. Diabetologia 2006;49:375-382.
-
(2006)
Diabetologia
, vol.49
, pp. 375-382
-
-
Luna, V.1
Casauban, L.2
Sajan, M.P.3
Gomez-Daspet, J.4
Powe, J.L.5
Miura, A.6
Rivas, J.7
Standaert, M.L.8
Farese, R.V.9
-
111
-
-
67949102053
-
Recent progress in the biology and physiology of sirtuins
-
Finkel T, Deng CX, Mostoslavsky R: Recent progress in the biology and physiology of sirtuins. Nature 2009;460:587-591.
-
(2009)
Nature
, vol.460
, pp. 587-591
-
-
Finkel, T.1
Deng, C.X.2
Mostoslavsky, R.3
-
112
-
-
33751113602
-
Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
-
Haigis MC, Guarente LP: Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006;20:2913-2921.
-
(2006)
Genes Dev
, vol.20
, pp. 2913-2921
-
-
Haigis, M.C.1
Guarente, L.P.2
-
113
-
-
54849425547
-
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
-
Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J: Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 2008;8:347-358.
-
(2008)
Cell Metab
, vol.8
, pp. 347-358
-
-
Feige, J.N.1
Lagouge, M.2
Canto, C.3
Strehle, A.4
Houten, S.M.5
Milne, J.C.6
Lambert, P.D.7
Mataki, C.8
Elliott, P.J.9
Auwerx, J.10
-
115
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH: Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007;450:712-716.
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
Gagne, D.J.6
Jin, L.7
Boss, O.8
Perni, R.B.9
Vu, C.B.10
Bemis, J.E.11
Xie, R.12
Disch, J.S.13
Ng, P.Y.14
Nunes, J.J.15
Lynch, A.V.16
Yang, H.17
Galonek, H.18
Israelian, K.19
Choy, W.20
Iffland, A.21
Lavu, S.22
Medvedik, O.23
Sinclair, D.A.24
Olefsky, J.M.25
Jirousek, M.R.26
Elliott, P.J.27
Westphal, C.H.28
more..
-
116
-
-
36348974168
-
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
-
Zhang J: The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation. J Biol Chem 2007;282:34356-34364.
-
(2007)
J Biol Chem
, vol.282
, pp. 34356-34364
-
-
Zhang, J.1
-
117
-
-
61749095297
-
SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
-
Yoshizaki T, Milne JC, Imamura T, Schenk S, Sonoda N, Babendure JL, Lu JC, Smith JJ, Jirousek MR, Olefsky JM: SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol Cell Biol 2009;29:1363-1374.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1363-1374
-
-
Yoshizaki, T.1
Milne, J.C.2
Imamura, T.3
Schenk, S.4
Sonoda, N.5
Babendure, J.L.6
Lu, J.C.7
Smith, J.J.8
Jirousek, M.R.9
Olefsky, J.M.10
-
118
-
-
34548857700
-
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
-
Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, Zhai Q: SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab 2007;6:307-319.
-
(2007)
Cell Metab
, vol.6
, pp. 307-319
-
-
Sun, C.1
Zhang, F.2
Ge, X.3
Yan, T.4
Chen, X.5
Shi, X.6
Zhai, Q.7
-
119
-
-
67650914230
-
AMPK in Health and Disease
-
Steinberg GR, Kemp BE: AMPK in Health and Disease. Physiol Rev 2009;89:1025-1078.
-
(2009)
Physiol Rev
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
120
-
-
61449106744
-
AMPK and the biochemistry of exercise: Implications for human health and disease
-
Richter EA, Ruderman NB: AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J 2009;418:261-275.
-
(2009)
Biochem J
, vol.418
, pp. 261-275
-
-
Richter, E.A.1
Ruderman, N.B.2
-
121
-
-
33847399214
-
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: A time-course and dose-response study
-
Sriwijitkamol A, Coletta DK, Wajcberg E, Balbontin GB, Reyna SM, Barrientes J, Eagan PA, Jenkinson CP, Cersosimo E, DeFronzo RA, Sakamoto K, Musi N: Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study. Diabetes 2007;56:836-848.
-
(2007)
Diabetes
, vol.56
, pp. 836-848
-
-
Sriwijitkamol, A.1
Coletta, D.K.2
Wajcberg, E.3
Balbontin, G.B.4
Reyna, S.M.5
Barrientes, J.6
Eagan, P.A.7
Jenkinson, C.P.8
Cersosimo, E.9
Defronzo, R.A.10
Sakamoto, K.11
Musi, N.12
-
122
-
-
40449094269
-
Insulin-resistant muscle is exercise resistant: Evidence for reduced response of nuclear-encoded mitochondrial genes to exercise
-
De Filippis E, Alvarez G, Berria R, Cusi K, Everman S, Meyer C, Mandarino LJ: Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise. Am J Physiol Endocrinol Metab 2008;294:E607-614.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
, pp. E607-614
-
-
De Filippis, E.1
Alvarez, G.2
Berria, R.3
Cusi, K.4
Everman, S.5
Meyer, C.6
Mandarino, L.J.7
-
123
-
-
78650964142
-
Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
-
Gauthier MS, O'Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N: Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun 2011;404:382-387.
-
(2011)
Biochem Biophys Res Commun
, vol.404
, pp. 382-387
-
-
Gauthier, M.S.1
O'Brien, E.L.2
Bigornia, S.3
Mott, M.4
Cacicedo, J.M.5
Xu, X.J.6
Gokce, N.7
Apovian, C.8
Ruderman, N.9
-
124
-
-
12144271041
-
Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition
-
Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB: Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia 2004;47:2012-2021.
-
(2004)
Diabetologia
, vol.47
, pp. 2012-2021
-
-
Yu, X.1
McCorkle, S.2
Wang, M.3
Lee, Y.4
Li, J.5
Saha, A.K.6
Unger, R.H.7
Ruderman, N.B.8
-
125
-
-
0346374720
-
Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
-
Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB: Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun 2004;314:580-585.
-
(2004)
Biochem Biophys Res Commun
, vol.314
, pp. 580-585
-
-
Saha, A.K.1
Avilucea, P.R.2
Ye, J.M.3
Assifi, M.M.4
Kraegen, E.W.5
Ruderman, N.B.6
-
126
-
-
84856755004
-
Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle
-
Chopra I, Li HF, Wang H, Webster KA: Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle. Diabetologia 2012;55:783-794.
-
(2012)
Diabetologia
, vol.55
, pp. 783-794
-
-
Chopra, I.1
Li, H.F.2
Wang, H.3
Webster, K.A.4
-
127
-
-
34547482573
-
Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
-
Okada T, Liew CW, Hu J, Hinault C, Michael MD, Krtzfeldt J, Yin C, Holzenberger M, Stoffel M, Kulkarni RN: Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci USA 2007;104:8977-8982.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8977-8982
-
-
Okada, T.1
Liew, C.W.2
Hu, J.3
Hinault, C.4
Michael, M.D.5
Krtzfeldt, J.6
Yin, C.7
Holzenberger, M.8
Stoffel, M.9
Kulkarni, R.N.10
-
128
-
-
0033604585
-
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
-
Kandel ES, Hay N: The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp Cell Res 1999;253:210-229.
-
(1999)
Exp Cell Res
, vol.253
, pp. 210-229
-
-
Kandel, E.S.1
Hay, N.2
-
129
-
-
33644754585
-
Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity
-
Fatrai S, Elghazi L, Balcazar N, Cras-Meneur C, Krits I, Kiyokawa H, Bernal-Mizrachi E: Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. Diabetes 2006;55:318-325.
-
(2006)
Diabetes
, vol.55
, pp. 318-325
-
-
Fatrai, S.1
Elghazi, L.2
Balcazar, N.3
Cras-Meneur, C.4
Krits, I.5
Kiyokawa, H.6
Bernal-Mizrachi, E.7
-
130
-
-
0037147215
-
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1)
-
Wrede CE, Dickson LM, Lingohr MK, Briaud I, Rhodes CJ: Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J Biol Chem 2002;277:49676-49684.
-
(2002)
J Biol Chem
, vol.277
, pp. 49676-49684
-
-
Wrede, C.E.1
Dickson, L.M.2
Lingohr, M.K.3
Briaud, I.4
Rhodes, C.J.5
-
131
-
-
0027288587
-
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signalling
-
Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, Jr., Backer JM, Ullrich A, White MF, et al.: The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J 1993;12:1929-1936.
-
(1993)
EMBO J
, vol.12
, pp. 1929-1936
-
-
Skolnik, E.Y.1
Lee, C.H.2
Batzer, A.3
Vicentini, L.M.4
Zhou, M.5
Daly, R.6
Myers, M.J.7
Backer, J.M.8
Ullrich, A.9
White, M.F.10
-
132
-
-
66449093171
-
Minireview: Meeting the demand for insulin: Molecular mechanisms of adaptive postnatal beta-cell mass expansion
-
Sachdeva MM, Stoffers DA: Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion. Mol Endocrinol 2009;23:747-758.
-
(2009)
Mol Endocrinol
, vol.23
, pp. 747-758
-
-
Sachdeva, M.M.1
Stoffers, D.A.2
-
133
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
134
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
-
Paradis S, Ruvkun G: Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 1998;12:2488-2498.
-
(1998)
Genes Dev
, vol.12
, pp. 2488-2498
-
-
Paradis, S.1
Ruvkun, G.2
-
135
-
-
0035185021
-
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
Nakae J, Kitamura T, Silver DL, Accili D: The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 2001;108:1359-1367.
-
(2001)
J Clin Invest
, vol.108
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
-
136
-
-
0141727772
-
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice
-
Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung SN, Meseck M, Accili D, Dong H: Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am J Physiol Endocrinol Metab 2003;285:E718-728.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
, pp. E718-728
-
-
Altomonte, J.1
Richter, A.2
Harbaran, S.3
Suriawinata, J.4
Nakae, J.5
Thung, S.N.6
Meseck, M.7
Accili, D.8
Dong, H.9
-
137
-
-
84867099976
-
Expanding roles for SREBP in metabolism
-
Shao W, Espenshade PJ: Expanding roles for SREBP in metabolism. Cell Metab 2012;16:414-419.
-
(2012)
Cell Metab
, vol.16
, pp. 414-419
-
-
Shao, W.1
Espenshade, P.J.2
-
138
-
-
33744732467
-
Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: A link between a key cell proliferative pathway and membrane synthesis
-
Du X, Kristiana I, Wong J, Brown AJ: Involvement of Akt in ER-to-Golgi transport of SCAP/SREBP: a link between a key cell proliferative pathway and membrane synthesis. Mol Biol Cell 2006;17:2735-2745.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 2735-2745
-
-
Du, X.1
Kristiana, I.2
Wong, J.3
Brown, A.J.4
-
139
-
-
65549171104
-
Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles
-
Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Mansbach CM, 2nd, Siddiqi SA, Park EA, Raghow R, Elam MB: Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. J Biol Chem 2009;284:7518-7532.
-
(2009)
J Biol Chem
, vol.284
, pp. 7518-7532
-
-
Yellaturu, C.R.1
Deng, X.2
Cagen, L.M.3
Wilcox, H.G.4
Mansbach, C.M.5
Siddiqi, S.A.6
Park, E.A.7
Raghow, R.8
Elam, M.B.9
-
140
-
-
0142217895
-
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity
-
Matsumoto M, Ogawa W, Akimoto K, Inoue H, Miyake K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, Shimano H, Yamada N, Ohno S, Kasuga M, Noda T: PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest 2003;112:935-944.
-
(2003)
J Clin Invest
, vol.112
, pp. 935-944
-
-
Matsumoto, M.1
Ogawa, W.2
Akimoto, K.3
Inoue, H.4
Miyake, K.5
Furukawa, K.6
Hayashi, Y.7
Iguchi, H.8
Matsuki, Y.9
Hiramatsu, R.10
Shimano, H.11
Yamada, N.12
Ohno, S.13
Kasuga, M.14
Noda, T.15
-
141
-
-
67349090336
-
Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance
-
Sajan MP, Standaert ML, Rivas J, Miura A, Kanoh Y, Soto J, Taniguchi CM, Kahn CR, Farese RV: Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance. Diabetologia 2009;52:1197-1207.
-
(2009)
Diabetologia
, vol.52
, pp. 1197-1207
-
-
Sajan, M.P.1
Standaert, M.L.2
Rivas, J.3
Miura, A.4
Kanoh, Y.5
Soto, J.6
Taniguchi, C.M.7
Kahn, C.R.8
Farese, R.V.9
-
142
-
-
79551470306
-
Oxidative stress, insulin signaling, and diabetes
-
Rains JL, Jain SK: Oxidative stress, insulin signaling, and diabetes. Free Radic Biol Med 2011;50:567-575.
-
(2011)
Free Radic Biol Med
, vol.50
, pp. 567-575
-
-
Rains, J.L.1
Jain, S.K.2
-
143
-
-
0024408737
-
Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes
-
Jain SK, McVie R, Duett J, Herbst JJ: Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes 1989;38:1539-1543.
-
(1989)
Diabetes
, vol.38
, pp. 1539-1543
-
-
Jain, S.K.1
McVie, R.2
Duett, J.3
Herbst, J.J.4
-
144
-
-
0024803840
-
Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells
-
Jain SK: Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells. J Biol Chem 1989;264:21340-21345.
-
(1989)
J Biol Chem
, vol.264
, pp. 21340-21345
-
-
Jain, S.K.1
-
145
-
-
0025026316
-
Elevated lipid peroxidation levels in red blood cells of streptozotocin-treated diabetic rats
-
Jain SK, Levine SN, Duett J, Hollier B: Elevated lipid peroxidation levels in red blood cells of streptozotocin-treated diabetic rats. Metabolism 1990;39:971-975.
-
(1990)
Metabolism
, vol.39
, pp. 971-975
-
-
Jain, S.K.1
Levine, S.N.2
Duett, J.3
Hollier, B.4
-
146
-
-
0019450954
-
Calcium potentiates the peroxidation of erythrocyte membrane lipids
-
Jain SK, Shohet SB: Calcium potentiates the peroxidation of erythrocyte membrane lipids. Biochim Biophys Acta 1981;642:46-54.
-
(1981)
Biochim Biophys Acta
, vol.642
, pp. 46-54
-
-
Jain, S.K.1
Shohet, S.B.2
-
147
-
-
84864417986
-
Activation level of JNK and Akt/ERK signaling pathways determinates extent of DNA damage in the liver of diabetic rats
-
Martinovic V, Grigorov I, Bogojevic D, Petrovic A, Jovanovic S, Ilic M, Ivanovic Matic S: Activation level of JNK and Akt/ERK signaling pathways determinates extent of DNA damage in the liver of diabetic rats. Cell Physiol Biochem 2012;30:723-734.
-
(2012)
Cell Physiol Biochem
, vol.30
, pp. 723-734
-
-
Martinovic, V.1
Grigorov, I.2
Bogojevic, D.3
Petrovic, A.4
Jovanovic, S.5
Ilic, M.6
Ivanovic Matic, S.7
-
148
-
-
0035432971
-
Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities
-
Tremblay F, Lavigne C, Jacques H, Marette A: Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities. Diabetes 2001;50:1901-1910.
-
(2001)
Diabetes
, vol.50
, pp. 1901-1910
-
-
Tremblay, F.1
Lavigne, C.2
Jacques, H.3
Marette, A.4
-
149
-
-
46349103337
-
Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Balpha
-
Yun SJ, Kim EK, Tucker DF, Kim CD, Birnbaum MJ, Bae SS: Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Balpha. Biochem Biophys Res Commun 2008;371:138-143.
-
(2008)
Biochem Biophys Res Commun
, vol.371
, pp. 138-143
-
-
Yun, S.J.1
Kim, E.K.2
Tucker, D.F.3
Kim, C.D.4
Birnbaum, M.J.5
Bae, S.S.6
-
150
-
-
4143153021
-
Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation
-
Xu J, Liao K: Protein kinase B/AKT 1 plays a pivotal role in insulin-like growth factor-1 receptor signaling induced 3T3-L1 adipocyte differentiation. J Biol Chem 2004;279:35914-35922.
-
(2004)
J Biol Chem
, vol.279
, pp. 35914-35922
-
-
Xu, J.1
Liao, K.2
-
151
-
-
0029908016
-
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
-
Kohn AD, Summers SA, Birnbaum MJ, Roth RA: Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 1996;271:31372-31378.
-
(1996)
J Biol Chem
, vol.271
, pp. 31372-31378
-
-
Kohn, A.D.1
Summers, S.A.2
Birnbaum, M.J.3
Roth, R.A.4
-
152
-
-
33645214765
-
PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts
-
Baudry A, Yang ZZ, Hemmings BA: PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts. J Cell Sci 2006;119:889-897.
-
(2006)
J Cell Sci
, vol.119
, pp. 889-897
-
-
Baudry, A.1
Yang, Z.Z.2
Hemmings, B.A.3
-
154
-
-
26244464326
-
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
-
Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, Schulze A: PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 2005;24:6465-6481.
-
(2005)
Oncogene
, vol.24
, pp. 6465-6481
-
-
Porstmann, T.1
Griffiths, B.2
Chung, Y.L.3
Delpuech, O.4
Griffiths, J.R.5
Downward, J.6
Schulze, A.7
-
156
-
-
17644404111
-
Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: A novel pathway linking obesity to atherosclerosis
-
Menghini R, Marchetti V, Cardellini M, Hribal ML, Mauriello A, Lauro D, Sbraccia P, Lauro R, Federici M: Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. Circulation 2005;111:1946-1953.
-
(2005)
Circulation
, vol.111
, pp. 1946-1953
-
-
Menghini, R.1
Marchetti, V.2
Cardellini, M.3
Hribal, M.L.4
Mauriello, A.5
Lauro, D.6
Sbraccia, P.7
Lauro, R.8
Federici, M.9
-
157
-
-
50049116472
-
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
-
Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A: SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 2008;8:224-236.
-
(2008)
Cell Metab
, vol.8
, pp. 224-236
-
-
Porstmann, T.1
Santos, C.R.2
Griffiths, B.3
Cully, M.4
Wu, M.5
Leevers, S.6
Griffiths, J.R.7
Chung, Y.L.8
Schulze, A.9
-
158
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR: Role of brain insulin receptor in control of body weight and reproduction. Science 2000;289:2122-2125.
-
(2000)
Science
, vol.289
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillette, J.4
Schubert, M.5
Orban, P.C.6
Klein, R.7
Krone, W.8
Muller-Wieland, D.9
Kahn, C.R.10
-
159
-
-
34547097247
-
Brain IRS2 signaling coordinates life span and nutrient homeostasis
-
Taguchi A, Wartschow LM, White MF: Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 2007;317:369-372.
-
(2007)
Science
, vol.317
, pp. 369-372
-
-
Taguchi, A.1
Wartschow, L.M.2
White, M.F.3
-
160
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
-
Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF: Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 2004;114:908-916.
-
(2004)
J Clin Invest
, vol.114
, pp. 908-916
-
-
Lin, X.1
Taguchi, A.2
Park, S.3
Kushner, J.A.4
Li, F.5
Li, Y.6
White, M.F.7
-
161
-
-
0030594830
-
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
-
Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang PL, Sinha MK, Considine RV: Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996;348:159-161.
-
(1996)
Lancet
, vol.348
, pp. 159-161
-
-
Caro, J.F.1
Kolaczynski, J.W.2
Nyce, M.R.3
Ohannesian, J.P.4
Opentanova, I.5
Goldman, W.H.6
Lynn, R.B.7
Zhang, P.L.8
Sinha, M.K.9
Considine, R.V.10
-
162
-
-
84863477910
-
Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity
-
Sartorius T, Heni M, Tschritter O, Preissl H, Hopp S, Fritsche A, Lievertz PS, Gertler A, Berthou F, Taouis M, Staiger H, Haring HU, Hennige AM: Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity. Cell Physiol Biochem 2012;30:238-246.
-
(2012)
Cell Physiol Biochem
, vol.30
, pp. 238-246
-
-
Sartorius, T.1
Heni, M.2
Tschritter, O.3
Preissl, H.4
Hopp, S.5
Fritsche, A.6
Lievertz, P.S.7
Gertler, A.8
Berthou, F.9
Taouis, M.10
Staiger, H.11
Haring, H.U.12
Hennige, A.M.13
-
163
-
-
39749104251
-
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
-
Yang X, Ongusaha PP, Miles PD, Havstad JC, Zhang F, So WV, Kudlow JE, Michell RH, Olefsky JM, Field SJ, Evans RM: Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance. Nature 2008;451:964-969.
-
(2008)
Nature
, vol.451
, pp. 964-969
-
-
Yang, X.1
Ongusaha, P.P.2
Miles, P.D.3
Havstad, J.C.4
Zhang, F.5
So, W.V.6
Kudlow, J.E.7
Michell, R.H.8
Olefsky, J.M.9
Field, S.J.10
Evans, R.M.11
-
164
-
-
70449705816
-
Prohibitin interacts with phosphatidylinositol 3, 4, 5-triphosphate (PIP3) and modulates insulin signaling
-
Ande SR, Mishra S: Prohibitin interacts with phosphatidylinositol 3, 4, 5-triphosphate (PIP3) and modulates insulin signaling. Biochem Biophys Res Commun 2009;390:1023-1028.
-
(2009)
Biochem Biophys Res Commun
, vol.390
, pp. 1023-1028
-
-
Ande, S.R.1
Mishra, S.2
-
165
-
-
77955597981
-
Central nervous system nutrient signaling: The regulation of energy balance and the future of dietary therapies
-
Stefater MA, Seeley RJ: Central nervous system nutrient signaling: the regulation of energy balance and the future of dietary therapies. Annu Rev Nutr 2010;30:219-235.
-
(2010)
Annu Rev Nutr
, vol.30
, pp. 219-235
-
-
Stefater, M.A.1
Seeley, R.J.2
-
166
-
-
0037288941
-
Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signaling capabilities
-
Niswender KD, Schwartz MW: Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol 2003;24:1-10.
-
(2003)
Front Neuroendocrinol
, vol.24
, pp. 1-10
-
-
Niswender, K.D.1
Schwartz, M.W.2
-
167
-
-
33745819212
-
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
-
Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Munzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Bruning JC: Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest 2006;116:1886-1901.
-
(2006)
J Clin Invest
, vol.116
, pp. 1886-1901
-
-
Plum, L.1
Ma, X.2
Hampel, B.3
Balthasar, N.4
Coppari, R.5
Munzberg, H.6
Shanabrough, M.7
Burdakov, D.8
Rother, E.9
Janoschek, R.10
Alber, J.11
Belgardt, B.F.12
Koch, L.13
Seibler, J.14
Schwenk, F.15
Fekete, C.16
Suzuki, A.17
Mak, T.W.18
Krone, W.19
Horvath, T.L.20
Ashcroft, F.M.21
Bruning, J.C.22
more..
-
170
-
-
65549109680
-
Obesity and cardiovascular disease: Risk factor, paradox, and impact of weight loss
-
Lavie CJ, Milani RV, Ventura HO: Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol 2009;53:1925-1932.
-
(2009)
J Am Coll Cardiol
, vol.53
, pp. 1925-1932
-
-
Lavie, C.J.1
Milani, R.V.2
Ventura, H.O.3
-
171
-
-
0034837376
-
Cardiovascular morbidity and mortality associated with the metabolic syndrome
-
Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, Groop L: Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001;24:683-689.
-
(2001)
Diabetes Care
, vol.24
, pp. 683-689
-
-
Isomaa, B.1
Almgren, P.2
Tuomi, T.3
Forsen, B.4
Lahti, K.5
Nissen, M.6
Taskinen, M.R.7
Groop, L.8
-
172
-
-
62349105876
-
Cardiac regulation by phosphoinositide 3-kinases and PTEN
-
Oudit GY, Penninger JM: Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res 2009;82:250-260.
-
(2009)
Cardiovasc Res
, vol.82
, pp. 250-260
-
-
Oudit, G.Y.1
Penninger, J.M.2
-
173
-
-
3242698804
-
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
-
Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH: The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 2004;37:449-471.
-
(2004)
J Mol Cell Cardiol
, vol.37
, pp. 449-471
-
-
Oudit, G.Y.1
Sun, H.2
Kerfant, B.G.3
Crackower, M.A.4
Penninger, J.M.5
Backx, P.H.6
-
174
-
-
18644372367
-
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
-
Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM: Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002;110:737-749.
-
(2002)
Cell
, vol.110
, pp. 737-749
-
-
Crackower, M.A.1
Oudit, G.Y.2
Kozieradzki, I.3
Sarao, R.4
Sun, H.5
Sasaki, T.6
Hirsch, E.7
Suzuki, A.8
Shioi, T.9
Irie-Sasaki, J.10
Sah, R.11
Cheng, H.Y.12
Rybin, V.O.13
Lembo, G.14
Fratta, L.15
Oliveira-Dos-Santos, A.J.16
Benovic, J.L.17
Kahn, C.R.18
Izumo, S.19
Steinberg, S.F.20
Wymann, M.P.21
Backx, P.H.22
Penninger, J.M.23
more..
-
175
-
-
0042330513
-
Preconditioning: Is the Akt-ion in the PI3K pathway?
-
Murphy E, Tong H, Steenbergen C: Preconditioning: is the Akt-ion in the PI3K pathway? J Mol Cell Cardiol 2003;35:1021-1025.
-
(2003)
J Mol Cell Cardiol
, vol.35
, pp. 1021-1025
-
-
Murphy, E.1
Tong, H.2
Steenbergen, C.3
-
176
-
-
53949106975
-
Ischemia-reperfusion injury and cardioprotection: Investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency
-
Siddall HK, Warrell CE, Yellon DM, Mocanu MM: Ischemia-reperfusion injury and cardioprotection: investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency. Basic Res Cardiol 2008;103:560-568.
-
(2008)
Basic Res Cardiol
, vol.103
, pp. 560-568
-
-
Siddall, H.K.1
Warrell, C.E.2
Yellon, D.M.3
Mocanu, M.M.4
-
177
-
-
33846318098
-
Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy
-
McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL: Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA 2007;104:612-617.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 612-617
-
-
McMullen, J.R.1
Amirahmadi, F.2
Woodcock, E.A.3
Schinke-Braun, M.4
Bouwman, R.D.5
Hewitt, K.A.6
Mollica, J.P.7
Zhang, L.8
Zhang, Y.9
Shioi, T.10
Buerger, A.11
Izumo, S.12
Jay, P.Y.13
Jennings, G.L.14
-
179
-
-
40349098058
-
Glycogen synthase kinase 3 (GSK3) in the heart: A point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
-
Sugden PH, Fuller SJ, Weiss SC, Clerk A: Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis. Br J Pharmacol 2008;153 Suppl 1:S137-153.
-
(2008)
Br J Pharmacol
, vol.153
, pp. S137-153
-
-
Sugden, P.H.1
Fuller, S.J.2
Weiss, S.C.3
Clerk, A.4
-
180
-
-
33646449520
-
Akt1 is required for physiological cardiac growth
-
DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ: Akt1 is required for physiological cardiac growth. Circulation 2006;113:2097-2104.
-
(2006)
Circulation
, vol.113
, pp. 2097-2104
-
-
Debosch, B.1
Treskov, I.2
Lupu, T.S.3
Weinheimer, C.4
Kovacs, A.5
Courtois, M.6
Muslin, A.J.7
-
181
-
-
33845703636
-
Akt2 regulates cardiac metabolism and cardiomyocyte survival
-
DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ: Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem 2006;281:32841-32851.
-
(2006)
J Biol Chem
, vol.281
, pp. 32841-32851
-
-
Debosch, B.1
Sambandam, N.2
Weinheimer, C.3
Courtois, M.4
Muslin, A.J.5
-
183
-
-
0036200937
-
Akt/protein kinase B promotes organ growth in transgenic mice
-
Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S: Akt/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol 2002;22:2799-2809.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 2799-2809
-
-
Shioi, T.1
McMullen, J.R.2
Kang, P.M.3
Douglas, P.S.4
Obata, T.5
Franke, T.F.6
Cantley, L.C.7
Izumo, S.8
-
184
-
-
0037125980
-
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
-
Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J, Jr.: Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci USA 2002;99:12333-12338.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12333-12338
-
-
Condorelli, G.1
Drusco, A.2
Stassi, G.3
Bellacosa, A.4
Roncarati, R.5
Iaccarino, G.6
Russo, M.A.7
Gu, Y.8
Dalton, N.9
Chung, C.10
Latronico, M.V.11
Napoli, C.12
Sadoshima, J.13
Croce, C.M.14
Ross, J.15
-
185
-
-
0037151101
-
Transcriptional effects of chronic Akt activation in the heart
-
Cook SA, Matsui T, Li L, Rosenzweig A: Transcriptional effects of chronic Akt activation in the heart. J Biol Chem 2002;277:22528-22533.
-
(2002)
J Biol Chem
, vol.277
, pp. 22528-22533
-
-
Cook, S.A.1
Matsui, T.2
Li, L.3
Rosenzweig, A.4
-
186
-
-
0037154168
-
Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo
-
Antos CL, McKinsey TA, Frey N, Kutschke W, McAnally J, Shelton JM, Richardson JA, Hill JA, Olson EN: Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci USA 2002;99:907-912.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 907-912
-
-
Antos, C.L.1
McKinsey, T.A.2
Frey, N.3
Kutschke, W.4
McAnally, J.5
Shelton, J.M.6
Richardson, J.A.7
Hill, J.A.8
Olson, E.N.9
-
187
-
-
33645280925
-
Diabetic cardiomyopathy: The search for a unifying hypothesis
-
Poornima IG, Parikh P, Shannon RP: Diabetic cardiomyopathy: the search for a unifying hypothesis. Circ Res 2006;98:596-605.
-
(2006)
Circ Res
, vol.98
, pp. 596-605
-
-
Poornima, I.G.1
Parikh, P.2
Shannon, R.P.3
-
188
-
-
37349123107
-
Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway
-
Kim KH, Oudit GY, Backx PH: Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway. J Pharmacol Exp Ther 2008;324:160-169.
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 160-169
-
-
Kim, K.H.1
Oudit, G.Y.2
Backx, P.H.3
-
189
-
-
0242381308
-
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure
-
Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki I, Sasaki T, Irie-Sasaki J, Gidrewicz D, Rybin VO, Wada T, Steinberg SF, Backx PH, Penninger JM: Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation 2003;108:2147-2152.
-
(2003)
Circulation
, vol.108
, pp. 2147-2152
-
-
Oudit, G.Y.1
Crackower, M.A.2
Eriksson, U.3
Sarao, R.4
Kozieradzki, I.5
Sasaki, T.6
Irie-Sasaki, J.7
Gidrewicz, D.8
Rybin, V.O.9
Wada, T.10
Steinberg, S.F.11
Backx, P.H.12
Penninger, J.M.13
-
190
-
-
84865275725
-
PI3Kgamma in hypertension: A novel therapeutic target controlling vascular myogenic tone and target organ damage
-
Carnevale D, Lembo G: PI3Kgamma in hypertension: a novel therapeutic target controlling vascular myogenic tone and target organ damage. Cardiovasc Res 2012;95:403-408.
-
(2012)
Cardiovasc Res
, vol.95
, pp. 403-408
-
-
Carnevale, D.1
Lembo, G.2
-
191
-
-
3543039430
-
AlphaB-crystallin inhibits glucose-induced apoptosis in vascular endothelial cells
-
Liu B, Bhat M, Nagaraj RH: AlphaB-crystallin inhibits glucose-induced apoptosis in vascular endothelial cells. Biochem Biophys Res Commun 2004;321:254-258.
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 254-258
-
-
Liu, B.1
Bhat, M.2
Nagaraj, R.H.3
-
192
-
-
1042298771
-
Reduction of high glucose and phorbol-myristate-acetate-induced endothelial cell permeability by protein kinase C inhibitors LY379196 and hypocrellin A
-
Dang L, Seale JP, Qu X: Reduction of high glucose and phorbol-myristate-acetate-induced endothelial cell permeability by protein kinase C inhibitors LY379196 and hypocrellin A. Biochem Pharmacol 2004;67:855-864.
-
(2004)
Biochem Pharmacol
, vol.67
, pp. 855-864
-
-
Dang, L.1
Seale, J.P.2
Qu, X.3
-
193
-
-
0027935267
-
Evidence that glucose increases monocyte binding to human aortic endothelial cells
-
Kim JA, Berliner JA, Natarajan RD, Nadler JL: Evidence that glucose increases monocyte binding to human aortic endothelial cells. Diabetes 1994;43:1103-1107.
-
(1994)
Diabetes
, vol.43
, pp. 1103-1107
-
-
Kim, J.A.1
Berliner, J.A.2
Natarajan, R.D.3
Nadler, J.L.4
-
195
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3, 4-bisphosphate
-
Franke TF, Kaplan DR, Cantley LC, Toker A: Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3, 4-bisphosphate. Science 1997;275:665-668.
-
(1997)
Science
, vol.275
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
196
-
-
0034652392
-
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
-
Jiang BH, Zheng JZ, Aoki M, Vogt PK: Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA 2000;97:1749-1753.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1749-1753
-
-
Jiang, B.H.1
Zheng, J.Z.2
Aoki, M.3
Vogt, P.K.4
-
197
-
-
0141727773
-
High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase
-
McGinn S, Saad S, Poronnik P, Pollock CA: High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase. Am J Physiol Endocrinol Metab 2003;285:E708-717.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
, pp. E708-717
-
-
McGinn, S.1
Saad, S.2
Poronnik, P.3
Pollock, C.A.4
-
198
-
-
25444432767
-
Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction
-
Varma S, Lal BK, Zheng R, Breslin JW, Saito S, Pappas PJ, Hobson RW, 2nd, Duran WN: Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction. Am J Physiol Heart Circ Physiol 2005;289:H1744-1751.
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.289
, pp. H1744-1751
-
-
Varma, S.1
Lal, B.K.2
Zheng, R.3
Breslin, J.W.4
Saito, S.5
Pappas, P.J.6
Hobson, R.W.7
Duran, W.N.8
-
199
-
-
84898673512
-
Effect of PIP3 on adhesion molecules and adhesion of THP-1 monocytes to HUVEC treated with high glucose
-
Manna P, Jain SK: Effect of PIP3 on adhesion molecules and adhesion of THP-1 monocytes to HUVEC treated with high glucose. Cell Physiol Biochem 2014;33:1197-1204.
-
(2014)
Cell Physiol Biochem
, vol.33
, pp. 1197-1204
-
-
Manna, P.1
Jain, S.K.2
-
200
-
-
0038549067
-
PI3K in lymphocyte development, differentiation and activation
-
Okkenhaug K, Vanhaesebroeck B: PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 2003;3:317-330.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 317-330
-
-
Okkenhaug, K.1
Vanhaesebroeck, B.2
-
201
-
-
84874219783
-
Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: Success, disappointment, and new opportunities
-
Blunt MD, Ward SG: Pharmacological targeting of phosphoinositide lipid kinases and phosphatases in the immune system: success, disappointment, and new opportunities. Front Immunol 2012;3:226.
-
(2012)
Front Immunol
, vol.3
, pp. 226
-
-
Blunt, M.D.1
Ward, S.G.2
-
202
-
-
84865012034
-
Targeting PI3K isoforms and SHIP in the immune system: New therapeutics for inflammation and leukemia
-
Blunt MD, Ward SG: Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia. Curr Opin Pharmacol 2012;12:444-451.
-
(2012)
Curr Opin Pharmacol
, vol.12
, pp. 444-451
-
-
Blunt, M.D.1
Ward, S.G.2
-
203
-
-
35348821220
-
PIP3 pathway in regulatory T cells and autoimmunity
-
Kashiwada M, Lu P, Rothman PB: PIP3 pathway in regulatory T cells and autoimmunity. Immunol Res 2007;39:194-224.
-
(2007)
Immunol Res
, vol.39
, pp. 194-224
-
-
Kashiwada, M.1
Lu, P.2
Rothman, P.B.3
-
205
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP: Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 2000;287:1049-1053.
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
Azzolino, O.4
Pirola, L.5
Silengo, L.6
Sozzani, S.7
Mantovani, A.8
Altruda, F.9
Wymann, M.P.10
-
206
-
-
0034635264
-
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
-
Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM: Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 2000;287:1040-1046.
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-Dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
Wakeham, A.7
Itie, A.8
Bouchard, D.9
Kozieradzki, I.10
Joza, N.11
Mak, T.W.12
Ohashi, P.S.13
Suzuki, A.14
Penninger, J.M.15
-
207
-
-
0037369696
-
Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement
-
Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE: Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol 2003;170:2647-2654.
-
(2003)
J Immunol
, vol.170
, pp. 2647-2654
-
-
Sadhu, C.1
Masinovsky, B.2
Dick, K.3
Sowell, C.G.4
De, S.5
-
208
-
-
77950365395
-
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability
-
Vemula S, Shi J, Hanneman P, Wei L, Kapur R: ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Blood 2010;115:1785-1796.
-
(2010)
Blood
, vol.115
, pp. 1785-1796
-
-
Vemula, S.1
Shi, J.2
Hanneman, P.3
Wei, L.4
Kapur, R.5
-
209
-
-
23744492188
-
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
-
Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb L, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT: Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood 2005;106:1432-1440.
-
(2005)
Blood
, vol.106
, pp. 1432-1440
-
-
Condliffe, A.M.1
Davidson, K.2
Anderson, K.E.3
Ellson, C.D.4
Crabbe, T.5
Okkenhaug, K.6
Vanhaesebroeck, B.7
Turner, M.8
Webb, L.9
Wymann, M.P.10
Hirsch, E.11
Ruckle, T.12
Camps, M.13
Rommel, C.14
Jackson, S.P.15
Chilvers, E.R.16
Stephens, L.R.17
Hawkins, P.T.18
-
210
-
-
9644259382
-
The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase
-
Perisic O, Wilson MI, Karathanassis D, Bravo J, Pacold ME, Ellson CD, Hawkins PT, Stephens L, Williams RL: The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase. Adv Enzyme Regul 2004;44:279-298.
-
(2004)
Adv Enzyme Regul
, vol.44
, pp. 279-298
-
-
Perisic, O.1
Wilson, M.I.2
Karathanassis, D.3
Bravo, J.4
Pacold, M.E.5
Ellson, C.D.6
Hawkins, P.T.7
Stephens, L.8
Williams, R.L.9
-
211
-
-
79151475516
-
Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function
-
Fung-Leung WP: Phosphoinositide 3-kinase delta (PI3Kdelta) in leukocyte signaling and function. Cell Signal 2011;23:603-608.
-
(2011)
Cell Signal
, vol.23
, pp. 603-608
-
-
Fung-Leung, W.P.1
-
212
-
-
81255188900
-
Atherosclerosis: Current pathogenesis and therapeutic options
-
Weber C, Noels H: Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011;17:1410-1422.
-
(2011)
Nat Med
, vol.17
, pp. 1410-1422
-
-
Weber, C.1
Noels, H.2
-
213
-
-
0034069624
-
The diverse potential effector and immunoregulatory roles of mast cells in allergic disease
-
Williams CM, Galli SJ: The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol 2000;105:847-859.
-
(2000)
J Allergy Clin Immunol
, vol.105
, pp. 847-859
-
-
Williams, C.M.1
Galli, S.J.2
-
214
-
-
33847239467
-
PI3K delta and PI3K gamma: Partners in crime in inflammation in rheumatoid arthritis and beyond?
-
Rommel C, Camps M, Ji H: PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? Nat Rev Immunol 2007;7:191-201.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 191-201
-
-
Rommel, C.1
Camps, M.2
Ji, H.3
-
215
-
-
7244232917
-
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response
-
Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, Kuehn N, Gray A, Giddings J, Peskett E, Fox R, Bruce I, Walker C, Sawyer C, Okkenhaug K, Finan P, Vanhaesebroeck B: Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature 2004;431:1007-1011.
-
(2004)
Nature
, vol.431
, pp. 1007-1011
-
-
Ali, K.1
Bilancio, A.2
Thomas, M.3
Pearce, W.4
Gilfillan, A.M.5
Tkaczyk, C.6
Kuehn, N.7
Gray, A.8
Giddings, J.9
Peskett, E.10
Fox, R.11
Bruce, I.12
Walker, C.13
Sawyer, C.14
Okkenhaug, K.15
Finan, P.16
Vanhaesebroeck, B.17
-
216
-
-
0036200415
-
Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function
-
Laffargue M, Calvez R, Finan P, Trifilieff A, Barbier M, Altruda F, Hirsch E, Wymann MP: Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function. Immunity 2002;16:441-451.
-
(2002)
Immunity
, vol.16
, pp. 441-451
-
-
Laffargue, M.1
Calvez, R.2
Finan, P.3
Trifilieff, A.4
Barbier, M.5
Altruda, F.6
Hirsch, E.7
Wymann, M.P.8
-
217
-
-
81555208939
-
PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability
-
Furumoto Y, Charles N, Olivera A, Leung WH, Dillahunt S, Sargent JL, Tinsley K, Odom S, Scott E, Wilson TM, Ghoreschi K, Kneilling M, Chen M, Lee DM, Bolland S, Rivera J: PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability. Blood 2011;118:5466-5475.
-
(2011)
Blood
, vol.118
, pp. 5466-5475
-
-
Furumoto, Y.1
Charles, N.2
Olivera, A.3
Leung, W.H.4
Dillahunt, S.5
Sargent, J.L.6
Tinsley, K.7
Odom, S.8
Scott, E.9
Wilson, T.M.10
Ghoreschi, K.11
Kneilling, M.12
Chen, M.13
Lee, D.M.14
Bolland, S.15
Rivera, J.16
-
218
-
-
33646007018
-
Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival
-
Furumoto Y, Brooks S, Olivera A, Takagi Y, Miyagishi M, Taira K, Casellas R, Beaven MA, Gilfillan AM, Rivera J: Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival. J Immunol 2006;176:5167-5171.
-
(2006)
J Immunol
, vol.176
, pp. 5167-5171
-
-
Furumoto, Y.1
Brooks, S.2
Olivera, A.3
Takagi, Y.4
Miyagishi, M.5
Taira, K.6
Casellas, R.7
Beaven, M.A.8
Gilfillan, A.M.9
Rivera, J.10
-
219
-
-
83455238361
-
PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases
-
Shenker BJ, Ali H, Boesze-Battaglia K: PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases. Curr Pharm Des 2011;17:3815-3822.
-
(2011)
Curr Pharm des
, vol.17
, pp. 3815-3822
-
-
Shenker, B.J.1
Ali, H.2
Boesze-Battaglia, K.3
-
221
-
-
4043082729
-
Cutting edge: Differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing
-
Reif K, Okkenhaug K, Sasaki T, Penninger JM, Vanhaesebroeck B, Cyster JG: Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol 2004;173:2236-2240.
-
(2004)
J Immunol
, vol.173
, pp. 2236-2240
-
-
Reif, K.1
Okkenhaug, K.2
Sasaki, T.3
Penninger, J.M.4
Vanhaesebroeck, B.5
Cyster, J.G.6
-
222
-
-
0036595050
-
T-cell signalling and autoimmunity: Molecular mechanisms of disease
-
Ohashi PS: T-cell signalling and autoimmunity: molecular mechanisms of disease. Nat Rev Immunol 2002;2:427-438.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 427-438
-
-
Ohashi, P.S.1
-
223
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
-
Okkenhaug K, Bilancio A, Farjot G, Priddle H, Sancho S, Peskett E, Pearce W, Meek SE, Salpekar A, Waterfield MD, Smith AJ, Vanhaesebroeck B: Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 2002;297:1031-1034.
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
Bilancio, A.2
Farjot, G.3
Priddle, H.4
Sancho, S.5
Peskett, E.6
Pearce, W.7
Meek, S.E.8
Salpekar, A.9
Waterfield, M.D.10
Smith, A.J.11
Vanhaesebroeck, B.12
-
224
-
-
0031598288
-
Diabetes and wound healing
-
Silhi N: Diabetes and wound healing. J Wound Care 1998;7:47-51.
-
(1998)
J Wound Care
, vol.7
, pp. 47-51
-
-
Silhi, N.1
-
225
-
-
2542478053
-
Wound healing: An overview of acute, fibrotic and delayed healing
-
Diegelmann RF, Evans MC: Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci 2004;9:283-289.
-
(2004)
Front Biosci
, vol.9
, pp. 283-289
-
-
Diegelmann, R.F.1
Evans, M.C.2
-
226
-
-
0038676258
-
Regulation of wound healing by growth factors and cytokines
-
Werner S, Grose R: Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003;83:835-870.
-
(2003)
Physiol Rev
, vol.83
, pp. 835-870
-
-
Werner, S.1
Grose, R.2
-
227
-
-
77949310647
-
Impaired wound healing in mouse models of diabetes is mediated by TNF-alpha dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1)
-
Siqueira MF, Li J, Chehab L, Desta T, Chino T, Krothpali N, Behl Y, Alikhani M, Yang J, Braasch C, Graves DT: Impaired wound healing in mouse models of diabetes is mediated by TNF-alpha dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1). Diabetologia 2010;53:378-388.
-
(2010)
Diabetologia
, vol.53
, pp. 378-388
-
-
Siqueira, M.F.1
Li, J.2
Chehab, L.3
Desta, T.4
Chino, T.5
Krothpali, N.6
Behl, Y.7
Alikhani, M.8
Yang, J.9
Braasch, C.10
Graves, D.T.11
-
228
-
-
45349091820
-
IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation
-
Peranteau WH, Zhang L, Muvarak N, Badillo AT, Radu A, Zoltick PW, Liechty KW: IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adult model of scar formation. J Invest Dermatol 2008;128:1852-1860.
-
(2008)
J Invest Dermatol
, vol.128
, pp. 1852-1860
-
-
Peranteau, W.H.1
Zhang, L.2
Muvarak, N.3
Badillo, A.T.4
Radu, A.5
Zoltick, P.W.6
Liechty, K.W.7
-
229
-
-
0035075706
-
Chemokines in cutaneous wound healing
-
Gillitzer R, Goebeler M: Chemokines in cutaneous wound healing. J Leukoc Biol 2001;69:513-521.
-
(2001)
J Leukoc Biol
, vol.69
, pp. 513-521
-
-
Gillitzer, R.1
Goebeler, M.2
-
230
-
-
34247192531
-
Keratinocyte-fibroblast interactions in wound healing
-
Werner S, Krieg T, Smola H: Keratinocyte-fibroblast interactions in wound healing. J Invest Dermatol 2007;127:998-1008.
-
(2007)
J Invest Dermatol
, vol.127
, pp. 998-1008
-
-
Werner, S.1
Krieg, T.2
Smola, H.3
-
231
-
-
33847351136
-
The JAK-STAT signaling pathway: Input and output integration
-
Murray PJ: The JAK-STAT signaling pathway: input and output integration. J Immunol 2007;178:2623-2629.
-
(2007)
J Immunol
, vol.178
, pp. 2623-2629
-
-
Murray, P.J.1
-
232
-
-
79952255244
-
Wound healing in mice with high-fat diet-or ob gene-induced diabetes-obesity syndromes: A comparative study
-
Seitz O, Schurmann C, Hermes N, Muller E, Pfeilschifter J, Frank S, Goren I: Wound healing in mice with high-fat diet-or ob gene-induced diabetes-obesity syndromes: a comparative study. Exp Diabetes Res 2010;2010:476969.
-
(2010)
Exp Diabetes Res
, vol.2010
, pp. 476969
-
-
Seitz, O.1
Schurmann, C.2
Hermes, N.3
Muller, E.4
Pfeilschifter, J.5
Frank, S.6
Goren, I.7
-
233
-
-
84859909661
-
Supplementation with undenatured whey protein during diabetes mellitus improves the healing and closure of diabetic wounds through the rescue of functional long-lived wound macrophages
-
Badr G: Supplementation with undenatured whey protein during diabetes mellitus improves the healing and closure of diabetic wounds through the rescue of functional long-lived wound macrophages. Cell Physiol Biochem 2012;29:571-582.
-
(2012)
Cell Physiol Biochem
, vol.29
, pp. 571-582
-
-
Badr, G.1
|