메뉴 건너뛰기




Volumn 178, Issue 5, 2007, Pages 2623-2629

The JAK-STAT signaling pathway: Input and output integration

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 6 RECEPTOR; JANUS KINASE; JANUS KINASE 1; STAT PROTEIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING;

EID: 33847351136     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.5.2623     Document Type: Short Survey
Times cited : (985)

References (67)
  • 1
    • 4143111572 scopus 로고    scopus 로고
    • Janus kinase (Jak) subcellular localization revisited: The exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak receptor complex to be equivalent to a receptor tyrosine kinase
    • Behrmann, I., T. Smyczek, P. C. Heinrich, H. Schmitz-Van de Leur, W. Komyod, B. Giese, G. Muller-Newen, S. Haan, and C. Haan. 2004. Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak receptor complex to be equivalent to a receptor tyrosine kinase. J. Biol. Chem. 279: 35486-35493.
    • (2004) J. Biol. Chem , vol.279 , pp. 35486-35493
    • Behrmann, I.1    Smyczek, T.2    Heinrich, P.C.3    Schmitz-Van de Leur, H.4    Komyod, W.5    Giese, B.6    Muller-Newen, G.7    Haan, S.8    Haan, C.9
  • 2
    • 0036007111 scopus 로고    scopus 로고
    • Quality control of receptor-kinase signaling complexes
    • Bonifacino, J. S. 2002. Quality control of receptor-kinase signaling complexes. Dev. Cell. 2: 1-2.
    • (2002) Dev. Cell , vol.2 , pp. 1-2
    • Bonifacino, J.S.1
  • 3
    • 0242267061 scopus 로고    scopus 로고
    • Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling
    • He, K., X. Wang, J. Jiang, R. Guan, K. E. Bernstein, P. P. Sayeski, and S. J. Frank. 2003. Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling. Mol. Endocrinol. 17: 2211-2227.
    • (2003) Mol. Endocrinol , vol.17 , pp. 2211-2227
    • He, K.1    Wang, X.2    Jiang, J.3    Guan, R.4    Bernstein, K.E.5    Sayeski, P.P.6    Frank, S.J.7
  • 5
    • 0035694582 scopus 로고    scopus 로고
    • The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor
    • Huang, L. J., S. N. Constantinescu, and H. F. Lodish. 2001. The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol. Cell. 8: 1327-1338.
    • (2001) Mol. Cell , vol.8 , pp. 1327-1338
    • Huang, L.J.1    Constantinescu, S.N.2    Lodish, H.F.3
  • 6
    • 33750971445 scopus 로고    scopus 로고
    • Two domains of the erythropoietin receptor are sufficient for jak2 binding/activation and function
    • Pelletier, S., S. Gingras, M. Funakoshi-Tago, S. Howell, and J. N. Ihle. 2006. Two domains of the erythropoietin receptor are sufficient for jak2 binding/activation and function. Mol. Cell. Biol. 26: 8527-8538.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 8527-8538
    • Pelletier, S.1    Gingras, S.2    Funakoshi-Tago, M.3    Howell, S.4    Ihle, J.N.5
  • 7
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea, J. J., M. Gadina, and R. D. Schreiber. 2002. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell 109: S121-S131.
    • (2002) Cell , vol.109
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 11
    • 33645773184 scopus 로고    scopus 로고
    • Selective requirement of p38α MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses
    • Berenson, L. S., J. Yang, B. P. Sleckman, T. L. Murphy, and K. M. Murphy. 2006. Selective requirement of p38α MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J. Immunol. 176:4616-4621.
    • (2006) J. Immunol , vol.176 , pp. 4616-4621
    • Berenson, L.S.1    Yang, J.2    Sleckman, B.P.3    Murphy, T.L.4    Murphy, K.M.5
  • 13
    • 31044435286 scopus 로고    scopus 로고
    • ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo
    • Lee, P. J., X. Zhang, P. Shan, B. Ma, C. G. Lee, R. J. Homer, Z. Zhu, M. Rincon, B. T. Mossman, and J. A. Elias. 2006. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J. Clin. Invest. 116:163-173.
    • (2006) J. Clin. Invest , vol.116 , pp. 163-173
    • Lee, P.J.1    Zhang, X.2    Shan, P.3    Ma, B.4    Lee, C.G.5    Homer, R.J.6    Zhu, Z.7    Rincon, M.8    Mossman, B.T.9    Elias, J.A.10
  • 17
    • 33845897463 scopus 로고    scopus 로고
    • Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity
    • Minegishi, Y., M. Saito, T. Morio, K. Watanabe, K. Agematsu, S. Tsuchiya, H. Takada, T. Hara, N. Kawamura, T. Ariga, et al. 2006. Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity 25: 745-755.
    • (2006) Immunity , vol.25 , pp. 745-755
    • Minegishi, Y.1    Saito, M.2    Morio, T.3    Watanabe, K.4    Agematsu, K.5    Tsuchiya, S.6    Takada, H.7    Hara, T.8    Kawamura, N.9    Ariga, T.10
  • 18
    • 33748450379 scopus 로고    scopus 로고
    • Complex modulation of cell type-specific signaling in response to type I interferons
    • van Boxel-Dezaire, A. H., M. R. Rani, and G. R. Stark. 2006. Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 25: 361-372.
    • (2006) Immunity , vol.25 , pp. 361-372
    • van Boxel-Dezaire, A.H.1    Rani, M.R.2    Stark, G.R.3
  • 21
    • 27944450018 scopus 로고    scopus 로고
    • Identification of genes involved in the initiation of human Th1 or Th2 cell commitment
    • Lund, R., H. Ahlfors, E. Kainonen, A. M. Lahesmaa, C. Dixon, and R. Lahesmaa. 2005. Identification of genes involved in the initiation of human Th1 or Th2 cell commitment. Eur. J. Immunol. 35: 3307-3319.
    • (2005) Eur. J. Immunol , vol.35 , pp. 3307-3319
    • Lund, R.1    Ahlfors, H.2    Kainonen, E.3    Lahesmaa, A.M.4    Dixon, C.5    Lahesmaa, R.6
  • 23
    • 33845398215 scopus 로고    scopus 로고
    • Biochemical and functional characterization of three activated macrophage populations
    • Edwards, J. P., X. Zhang, K. A. Frauwirth, and D. M. Mosser. 2006. Biochemical and functional characterization of three activated macrophage populations. J. Leukocyte Biol. 80: 1298-1307.
    • (2006) J. Leukocyte Biol , vol.80 , pp. 1298-1307
    • Edwards, J.P.1    Zhang, X.2    Frauwirth, K.A.3    Mosser, D.M.4
  • 24
    • 0242421851 scopus 로고    scopus 로고
    • IL-4 dependent alternatively activated macrophages have a distinctive in vivo gene expression phenotype
    • Loke, P., M. G. Nair, J. Parkinson, D. Guiliano, M. Blaxter, and J. E. Allen. 2002. IL-4 dependent alternatively activated macrophages have a distinctive in vivo gene expression phenotype. BMC Immunol. 3: 7.
    • (2002) BMC Immunol , vol.3 , pp. 7
    • Loke, P.1    Nair, M.G.2    Parkinson, J.3    Guiliano, D.4    Blaxter, M.5    Allen, J.E.6
  • 25
    • 0141989767 scopus 로고    scopus 로고
    • Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair
    • Sandler, N. G., M. M. Mentink-Kane, A. W. Cheever, and T. A. Wynn. 2003. Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. J. Immunol. 171: 3655-3667.
    • (2003) J. Immunol , vol.171 , pp. 3655-3667
    • Sandler, N.G.1    Mentink-Kane, M.M.2    Cheever, A.W.3    Wynn, T.A.4
  • 26
    • 0037044580 scopus 로고    scopus 로고
    • TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism
    • Welch, J. S., L. Escoubet-Lozach, D. B. Sykes, K. Liddiard, D. R. Greaves, and C. K. Glass. 2002. TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J. Biol. Chem. 277: 42821-42829.
    • (2002) J. Biol. Chem , vol.277 , pp. 42821-42829
    • Welch, J.S.1    Escoubet-Lozach, L.2    Sykes, D.B.3    Liddiard, K.4    Greaves, D.R.5    Glass, C.K.6
  • 29
    • 33645525963 scopus 로고    scopus 로고
    • Core erythropoietin receptor signals for late erythroblast development
    • Menon, M. P., J. Fang, and D. M. Wojchowski. 2006. Core erythropoietin receptor signals for late erythroblast development. Blood 107: 2662-2672.
    • (2006) Blood , vol.107 , pp. 2662-2672
    • Menon, M.P.1    Fang, J.2    Wojchowski, D.M.3
  • 33
    • 4744364574 scopus 로고    scopus 로고
    • Alternative activation of STAT1 and STAT3 in response to interferon-γ
    • Qing, Y., and G. R. Stark. 2004. Alternative activation of STAT1 and STAT3 in response to interferon-γ. J. Biol. Chem. 279: 41679-41685.
    • (2004) J. Biol. Chem , vol.279 , pp. 41679-41685
    • Qing, Y.1    Stark, G.R.2
  • 38
    • 33749521701 scopus 로고    scopus 로고
    • Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-α
    • Berenson, L. S., M. Gavrieli, J. D. Farrar, T. L. Murphy, and K. M. Murphy. 2006. Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-α. J. Immunol. 177: 5195-5203.
    • (2006) J. Immunol , vol.177 , pp. 5195-5203
    • Berenson, L.S.1    Gavrieli, M.2    Farrar, J.D.3    Murphy, T.L.4    Murphy, K.M.5
  • 39
    • 0034232047 scopus 로고    scopus 로고
    • Interferon α/β-mediated inhibition and promotion of interferon γ. STAT1 resolves a paradox
    • Nguyen, K. B., L. P. Cousens, L. A. Doughty, G. C. Pien, J. E. Durbin, and C. A. Biron. 2000. Interferon α/β-mediated inhibition and promotion of interferon γ. STAT1 resolves a paradox. Nat. Immunol. 1: 70-76.
    • (2000) Nat. Immunol , vol.1 , pp. 70-76
    • Nguyen, K.B.1    Cousens, L.P.2    Doughty, L.A.3    Pien, G.C.4    Durbin, J.E.5    Biron, C.A.6
  • 42
  • 43
    • 0035102228 scopus 로고    scopus 로고
    • STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation
    • McLemore, M. L., S. Grewal, F. Liu, A. Archambault, J. Poursine-Laurent, J. Haug, and D. C. Link. 2001. STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 14: 193-204.
    • (2001) Immunity , vol.14 , pp. 193-204
    • McLemore, M.L.1    Grewal, S.2    Liu, F.3    Archambault, A.4    Poursine-Laurent, J.5    Haug, J.6    Link, D.C.7
  • 45
    • 0033180176 scopus 로고    scopus 로고
    • Semerad, C. L. J. Poursine-Laurent, F. Liu, and D. C. Link. 1999. A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation. Immunity 11: 153-161.
    • Semerad, C. L. J. Poursine-Laurent, F. Liu, and D. C. Link. 1999. A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation. Immunity 11: 153-161.
  • 47
    • 2542478996 scopus 로고    scopus 로고
    • The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response
    • Alexander, W. S., and D. J. Hilton. 2004. The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu. Rev. Immunol. 22: 503-529.
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 503-529
    • Alexander, W.S.1    Hilton, D.J.2
  • 49
    • 11144224785 scopus 로고    scopus 로고
    • Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling
    • Gingras, S., E. Parganas, A. de Pauw, J. N. Ihle, and P. J. Murray. 2004. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J. Biol. Chem. 279: 54702-54707.
    • (2004) J. Biol. Chem , vol.279 , pp. 54702-54707
    • Gingras, S.1    Parganas, E.2    de Pauw, A.3    Ihle, J.N.4    Murray, P.J.5
  • 50
    • 0038807434 scopus 로고    scopus 로고
    • Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
    • Eyles, J. L., D. Metcalf, M. J. Grusby, D. J. Hilton, and R. Starr. 2002. Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J. Biol. Chem. 277: 43735-43740.
    • (2002) J. Biol. Chem , vol.277 , pp. 43735-43740
    • Eyles, J.L.1    Metcalf, D.2    Grusby, M.J.3    Hilton, D.J.4    Starr, R.5
  • 51
    • 33846523494 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling
    • Dickensheets, H-, N. Vazquez, F. Sheikh, S. Gingras, P. J. Murray, J. J. Ryan, and R. P. Donnelly. 2007. Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling. Genes Immun. 8:21-27.
    • (2007) Genes Immun , vol.8 , pp. 21-27
    • Dickensheets, H.1    Vazquez, N.2    Sheikh, F.3    Gingras, S.4    Murray, P.J.5    Ryan, J.J.6    Donnelly, R.P.7
  • 52
    • 0037927824 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γ c-dependent cytokines in peripheral T cells
    • Cornish, A. L., M. M. Chong, G. M. Davey, R. Darwiche, N. A. Nicola, D. J. Hilton, T. W. Kay, R. Starr, and W. S. Alexander. 2003. Suppressor of cytokine signaling-1 regulates signaling in response to interleukin-2 and other γ c-dependent cytokines in peripheral T cells. J. Biol. Chem. 278: 22755-22761.
    • (2003) J. Biol. Chem , vol.278 , pp. 22755-22761
    • Cornish, A.L.1    Chong, M.M.2    Davey, G.M.3    Darwiche, R.4    Nicola, N.A.5    Hilton, D.J.6    Kay, T.W.7    Starr, R.8    Alexander, W.S.9
  • 55
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp 130
    • Schmitz, J., M. Weissenbach, S. Haan, P. C. Heinrich, and F. Schaper. 2000. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp 130. J. Biol. Chem. 275: 12848-12856.
    • (2000) J. Biol. Chem , vol.275 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3    Heinrich, P.C.4    Schaper, F.5
  • 56
    • 33646833974 scopus 로고    scopus 로고
    • Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism
    • Stross, C., S. Radtke, T. Clahsen, C. Gerlach, R. Volkmer-Engert, F. Schaper, P. C. Heinrich, and H. M. Hermanns. 2006. Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. J. Biol. Chem. 281: 8458-8468.
    • (2006) J. Biol. Chem , vol.281 , pp. 8458-8468
    • Stross, C.1    Radtke, S.2    Clahsen, T.3    Gerlach, C.4    Volkmer-Engert, R.5    Schaper, F.6    Heinrich, P.C.7    Hermanns, H.M.8
  • 58
    • 0000413462 scopus 로고    scopus 로고
    • Regulation of interferon-γ- activated STAT1 by the ubiquitin-proteasome pathway
    • Kim, T. K., and T. Maniatis. 1996. Regulation of interferon-γ- activated STAT1 by the ubiquitin-proteasome pathway. Science 273: 1717-1719.
    • (1996) Science , vol.273 , pp. 1717-1719
    • Kim, T.K.1    Maniatis, T.2
  • 59
    • 0030983549 scopus 로고    scopus 로고
    • Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
    • Yu, C. L., and S. J. Burakoff. 1997. Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. J. Biol. Chem. 272: 14017-14020.
    • (1997) J. Biol. Chem , vol.272 , pp. 14017-14020
    • Yu, C.L.1    Burakoff, S.J.2
  • 60
    • 0034327736 scopus 로고    scopus 로고
    • Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways
    • Ahmed, S. T., and L. B. Ivashkiv. 2000. Inhibition of IL-6 and IL-10 signaling and Stat activation by inflammatory and stress pathways. J. Immunol. 165: 5227-5237.
    • (2000) J. Immunol , vol.165 , pp. 5227-5237
    • Ahmed, S.T.1    Ivashkiv, L.B.2
  • 61
    • 0036659520 scopus 로고    scopus 로고
    • Inhibition of IL-6 signaling by a p38-dependent pathway occurs in the absence of new protein synthesis
    • Ahmed, S. T., A. Mayer, J. D. Ji, and L. B. Ivashkiv. 2002. Inhibition of IL-6 signaling by a p38-dependent pathway occurs in the absence of new protein synthesis. J. Leukocyte Biol. 72: 154-162.
    • (2002) J. Leukocyte Biol , vol.72 , pp. 154-162
    • Ahmed, S.T.1    Mayer, A.2    Ji, J.D.3    Ivashkiv, L.B.4
  • 62
    • 0037443661 scopus 로고    scopus 로고
    • Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
    • Niemand, C., A. Nimmesgern, S. Haan, P. Fischer, F. Schaper, R. Rossaint, P. C. Heinrich, and G. Muller-Newen. 2003. Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3. J. Immunol. 170: 3263-3272.
    • (2003) J. Immunol , vol.170 , pp. 3263-3272
    • Niemand, C.1    Nimmesgern, A.2    Haan, S.3    Fischer, P.4    Schaper, F.5    Rossaint, R.6    Heinrich, P.C.7    Muller-Newen, G.8
  • 63
    • 33745700364 scopus 로고    scopus 로고
    • Understanding and exploiting the endogenous interleukin-10/ STAT3-mediated anti-inflammatory response
    • Murray, P. J. 2006. Understanding and exploiting the endogenous interleukin-10/ STAT3-mediated anti-inflammatory response. Curr. Opin. Pharmacol. 6: 379-386.
    • (2006) Curr. Opin. Pharmacol , vol.6 , pp. 379-386
    • Murray, P.J.1
  • 64
    • 20844434815 scopus 로고    scopus 로고
    • The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription
    • Murray, P. J. 2005. The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc. Natl. Acad. Sci. USA 102: 8686-8691.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 8686-8691
    • Murray, P.J.1
  • 65
    • 8144226985 scopus 로고    scopus 로고
    • Interleukin-10 suppression of myeloid cell activation-a continuing puzzle
    • Williams, L. M., G. Ricchetti, U. Sarma, T. Smallie, and B. M. Foxwell. 2004. Interleukin-10 suppression of myeloid cell activation-a continuing puzzle. Immunology 113: 281-292.
    • (2004) Immunology , vol.113 , pp. 281-292
    • Williams, L.M.1    Ricchetti, G.2    Sarma, U.3    Smallie, T.4    Foxwell, B.M.5
  • 66
    • 34147095832 scopus 로고    scopus 로고
    • Expression of constitutively active STAT3 can replicate the cytokine suppressive activity of IL-10 in human primary macrophages
    • In press
    • Williams, L. M., U. Sarma, K. Willens, T. Smallie, F. Brennan, and B. M. Foxwell. 2007. Expression of constitutively active STAT3 can replicate the cytokine suppressive activity of IL-10 in human primary macrophages. J. Biol. Chem. In press.
    • (2007) J. Biol. Chem
    • Williams, L.M.1    Sarma, U.2    Willens, K.3    Smallie, T.4    Brennan, F.5    Foxwell, B.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.