PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

Journal of Clinical Investigation

Volumn 112, Issue 6, 2003, Pages 935-944

  Matsumoto, Michihiro ^a   Ogawa, Wataru ^a   Akimoto, Kazunori ^b   Inoue, Hiroshi ^a   Miyake, Kazuaki ^a   Furukawa, Kensuke ^a   Hayashi, Yoshitake ^a   Iguchi, Haruhisa ^c   Matsuki, Yasushi ^c   Hiramatsu, Ryuji ^c   Shimano, Hitoshi ^d   Yamada, Nobuhiro ^d   Ohno, Shigeo ^b   Kasuga, Masato ^a   Noda, Tetsuo ^e  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

^e CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FATTY ACID; GLUCOSE; INSULIN; LEPTIN; PROTEIN KINASE C; PROTEIN KINASE C LAMBDA; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; CCAAT ENHANCER BINDING PROTEIN; DNA BINDING PROTEIN; ISOENZYME; PROTEIN KINASE C ETA; SREBF1 PROTEIN, HUMAN; SREBF1 PROTEIN, MOUSE; SREBF1 PROTEIN, RAT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ARTICLE; BODY MASS; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; GENE EXPRESSION; GENE TRANSFER; GLUCOSE BLOOD LEVEL; HORMONE ACTION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIVER; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; ANIMAL; CELL CULTURE; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LIPID METABOLISM; LIVER CELL; MALE; METABOLISM; MOUSE MUTANT; PHENOTYPE; PHYSIOLOGY; RAT; TISSUE DISTRIBUTION;

ANIMALS; BLOOD GLUCOSE; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; INSULIN; ISOENZYMES; LIPID METABOLISM; LIVER; MALE; MICE; MICE, KNOCKOUT; PHENOTYPE; PROTEIN KINASE C; RATS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TISSUE DISTRIBUTION; TRANSCRIPTION FACTORS;

EID: 0142217895     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200318816     Document Type: Article

References (46)

1. DeFronzo, R.A. 1997. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetic genes. Diabetes Rev. 5:177-269.
2. Michael, M.D., et al. 2000. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6:87-97.
3. Ogawa, W., Matozaki, T., and Kasuga, M. 1998. Role of binding proteins to IRS-1 in insulin signalling. Mol. Cell. Biochem. 182:13-22.
4. Shepherd, P.R., Withers, D.J., and Siddle, K. 1998. Phosphoinosiride 3-kinase: the key switch mechanism in insulin signalling. Biochem. J. 333:471-490.
5. Miyake, K., et al. 2002. Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. J. Clin. Invest. 110:1483-1491. doi: 10.1172/JCI200215880.
6. Suzuki, A., Akimoto, K., and Ohno, S. 2003. Protein kinase C λ/ι (PKC λ/ι): a PKC isoform essential for the development of multicellular organisms. J. Biochem. (Tokyo). 133:9-16.
7. Akimoto, K., et al. 1996. EGF or PDGF receptors activate atypical PKCλ through phosphatidylinosirol 3-kinase. EMBOJ. 15:788-798.
8. Kotani, K., et al. 1998. Requirement of atypical protein kinase Cλ for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol. Cell. Biol. 18:6971-6982.
9. Williams, M.R., et al. 2000. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol. 10:439-448.
10. Le Good, J.A., et al. 1998. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 281:2042-2045.
11. Tabuse, Y. 1998. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorbabditis elegans. Development. 125:3607-3614.
12. Wodarz, A., Ramrath, A., Grimm, A., and Knust, E. 2000. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J. Cell Biol. 150:1361-1374.
13. Yakar, S., et al. 1999. Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc. Natl. Acad. Sci. U. S. A. 96:7324-7329.
14. Yahagi, N., et al. 1999. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J. Biol. Chem. 274:35840-35844.
15. Matsumoto, M., et al. 2002. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes. Diabetes. 51:1672-1680.
16. Repa, J.J., et al. 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev. 14:2819-2830.
17. Katsurada, A., et al. 1990. Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of fatty acid synthase in rat liver. Eur. J. Biochem. 190:427-433.
18. Kitamura, T., et al. 1999. Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt. Mol. Cell. Biol. 19:6286-6296.
19. Horton, J.D., Goldstein, J.L., and Brown, M.S. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109:1125-1131. doi:10.1172/JCI200215593.
20. Shimano, H., et al. 1999. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J. Biol. Chem. 274:35832-35839.
21. Horton, J.D., Bashmakov, Y., Shimomura, I., and Shimano, H. 1998. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc. Natl. Acad. Sci. U. S. A. 95:5987-5992.
22. Shimomura, I., et al. 1999. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl. Acad. Sci. U. S. A. 96:13656-13661.
23. Fleischmann, M., and Iynedjian, P.B. 2000. Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt. Biochem. J. 349:13-17.
24. Schultz, J.R., et al. 2000. Role of LXRs in control of lipogenesis. Genes Dev. 14:2831-2838.
25. Foretz, M., et al. 1999. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol. Cell. Biol. 19:3760-3768.
26. Shimomura, I., et al . 2000. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodysrrophic and ob/ob mice. Mol. Cell. 6:77-86.
27. Cho, H., et al. 2001. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB β). Science. 292:1728-1731.
28. Ohno, S. 2001. Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr. Opin. Cell Biol. 13:641-648.
29. Fausto, N., and Campbell, J.S. 2003. The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech. Dev. 120:117-130.
30. Bluher, M., et al. 2002. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev. Cell. 3:325-338.
31. Bachmann, O.P., et al. 2001. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes. 50:2579-2584.
32. Ryysy, L., et al. 2000. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes. 49:749-758.
33. Krssak, M., et al. 1999. Incramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a IH NMR spectroscopy study. Diabetologia. 42:113-116.
34. Kakuma, T., et al. 2000. Leptin, troglitazone, and the expression of scerol regulatory element binding proteins in liver and pancreatic islets. Proc. Natl. Acad. Sci. U. S. A. 97:8536-8541.
35. Yamauchi, T. et al. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7:941-946.
36. Petersen, K.F., et al. 2002. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Invest. 109:1345-1350. doi:10.1172/JCI200215001.
37. Kim, J.K., et al. 2001. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 98:7522-7527.
38. Uysal, K.T., Wiesbrock, S.M., Mario, M.W., and Hotamisligil, G.S. 1997. Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature. 389:610-614.
39. Muller, G., et al. 1995. PKCζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBOJ. 14:1961-1969.
40. Limatola, C., Barabino, C., Nista, A., and Santoni, A. 1997. Interleukin 1-β-induced protein kinase C-activation is mimicked by exogenous phospholipase D. Biochem. J. 321:497-501.
41. Lallena, M.J., Diaz-Meco, M.T., Bren, G., Paya, C.V., and Moscat, J. 1999. Activation of IκB kinase β by protein kinase C isoforms. Mol. Cell. Biol. 19:2180-2188.
42. Yin, M.J., Yamamoto, Y., and Gaynor, R.B. 1998. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature. 396:77-80.
43. Hundal, R.S., et al. 2002. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J. Clin. Invest. 109:1321-1326. doi:10.1172/JCI200214955.
44. Yuan, M., et al. 2001. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science. 293:1673-1677.
45. Liu, Y.F., et al. 2001 Insulin stimulates PKCζ-mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. J. Biol. Chem. 276:14459-14465.
46. Tobe, K., et al. 2001. Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver. J. Biol. Chem. 276:38337-38340.