Wound healing in mice with high-fat diet- or ob gene-induced diabetes-obesity syndromes: A comparative study

Experimental Diabetes Research

Volumn 2010, Issue , 2010, Pages

  Frank, Stefan ^a   Seitz, Oliver ^a   Schürmann, Christoph ^a   Hermes, Nadine ^a   Müller, Elke ^a   Pfeilschifter, Josef ^a   Goren, Itamar ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE ALPHA; VASCULOTROPIN; INTERLEUKIN 1BETA; LEPTIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC WOUND; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; LIPID DIET; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WOUND CLOSURE; WOUND CONTRACTION; WOUND HEALING; WOUND HEALING IMPAIRMENT; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; EXPERIMENTAL DIABETES MELLITUS; FAT INTAKE; GENETICS; INSULIN RESISTANCE; MACROPHAGE; MOUSE MUTANT; MYOFIBROBLAST; NEUTROPHIL; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FATS; FEMALE; INSULIN RESISTANCE; INTERLEUKIN-1BETA; LEPTIN; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, OBESE; MYOFIBROBLASTS; NEOVASCULARIZATION, PHYSIOLOGIC; NEUTROPHILS; OBESITY; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 79952255244     PISSN: 16875214     EISSN: 16875303     Source Type: Journal    
DOI: 10.1155/2010/476969     Document Type: Article

References (61)

1. Zimmet P., Alberti K. G. M. M., Shaw J., Global and societal implications of the d (Pubitemid 34000780)
2. Reiber G. E., Ledoux W. R., Williams R., Herman W., Kinmoth A. L., Wareham N. J., Epidemiology of diabetic foot ulcers and amputations: evidence for prevention The Evidence Base for Diabetes Care 2002 Chichester: UK Wiley 641 665
3. Carrington A. L., Abbott C. A., Griffiths J., Jackson N., Johnson S. R., Kulkarni J., Van Ross E. R. E., Boulton A. J. M., A foot care program for diabetic unilateral lower-limb amputees Diabetes Care 2001 24 2 216 221 (Pubitemid 32119114)
4. Reiber G. E., Lipsky B. A., Gibbons G. W., The burden of diabetic foot ulcers American Journal of Surgery 1998 176 2A 5S 10S (Pubitemid 28460652)
5. Apelqvist J., Larsson J., Agardh C. D., Long-term prognosis for diabetic patients with foot ulcers Journal of Internal Medicine 1993 233 6 485 491 (Pubitemid 23172610)
6. Faglia E., Favales F., Morabito A., New ulceration, new major amputation, and survival rates in diabetic subjects hospitalized for foot ulceration from 1990 to 1993: a 6.5-year follow-up Diabetes Care 2001 24 1 78 83 (Pubitemid 32104224)
7. Jeffcoate W. J., Harding K. G., Diabetic foot ulcers The Lancet 2003 361 9368 1545 1551 (Pubitemid 36566350)
8. Coleman D. L., Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice Diabetologia 1978 14 3 141 148 (Pubitemid 8286141)
9. Goodson W. H., Hunt T. K., Wound collagen accumulation in obese hyperglycemic mice Diabetes 1986 35 4 491 495 (Pubitemid 16078465)
10. Frank S., Stallmeyer B., Kmpfer H., Kolb N., Pfeilschifter J., Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair Journal of Clinical Investigation 2000 106 4 501 509 (Pubitemid 30666383)
11. Greenhalgh D. G., Sprugel K. H., Murray M. J., Ross R., PDGF and FGF stimulate wound healing in the genetically diabetic mouse American Journal of Pathology 1990 136 6 1235 1246 (Pubitemid 20210322)
12. Werner S., Breeden M., Hubner G., Greenhalgh D. G., Longaker M. T., Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse Journal of Investigative Dermatology 1994 103 4 469 473 (Pubitemid 24314829)
13. Wetzler C., Kampfer H., Stallmeyer B., Pfeilschifter J., Frank S., Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair Journal of Investigative Dermatology 2000 115 2 245 253 (Pubitemid 30637194)
14. Tsuboi R., Rifkin D. B., Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice Journal of Experimental Medicine 1990 172 1 245 251 (Pubitemid 20217266)
15. Frank S., Hubner G., Breier G., Longaker M. T., Greenhalgh D. G., Werner S., Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing Journal of Biological Chemistry 1995 270 21 12607 12613
16. Kmpfer H., Pfeilschifter J., Frank S., Expressional regulation of angiopoietin-1 and -2 and the Tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair Laboratory Investigation 2001 81 3 361 373 (Pubitemid 32245068)
17. Goren I., Kmpfer H., Podda M., Pfeilschifter J., Frank S., Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macrophage influx and a potential role for the scab as a sink for inflammatory cells and mediators Diabetes 2003 52 11 2821 2832 (Pubitemid 37339713)
18. Goren I., Mller E., Schiefelbein D., Christen U., Pfeilschifter J., Mhl H., Frank S., Systemic anti-TNF treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages Journal of Investigative Dermatology 2007 127 9 2259 2267 (Pubitemid 47258485)
19. Hotamisligil G. S., Shargill N. S., Spiegelman B. M., Adipose expression of tumor necrosis factor- : direct role in obesity-linked insulin resistance Science 1993 259 5091 87 91 (Pubitemid 23036092)
20. Hotamisligil G. S., Inflammation and metabolic disorders Nature 2006 444 7121 860 867 (Pubitemid 46024993)
21. Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W., Obesity is associated with macrophage accumulation in adipose tissue Journal of Clinical Investigation 2003 112 12 1796 1808 (Pubitemid 38063703)
22. Schenk S., Saberi M., Olefsky J. M., Insulin sensitivity: modulation by nutrients and inflammation Journal of Clinical Investigation 2008 118 9 2992 3002
23. Schrmann C., Seitz O., Sader R., Pfeilschifter J., Goren I., Frank S., Role of wound macrophages in skin flap loss or survival in an experimental diabetes model British Journal of Surgery 2010 97 9 1437 1451
24. Stallmeyer B., Kmpfer H., Kolb N., Pfeilschifter J., Frank S., The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization Journal of Investigative Dermatology 1999 113 6 1090 1098 (Pubitemid 30013358)
25. Frank S., Stallmeyer B., Kmpfer H., Kolb N., Pfeilschifter J., Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair FASEB Journal 1999 13 14 2002 2014 (Pubitemid 29517630)
26. Chomczynski P., Sacchi N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Analytical Biochemistry 1987 162 1 156 159 (Pubitemid 17064313)
27. Watson E., Hahm S., Mizuno T. M., Windsor J., Montgomery C., Scherer P. E., Mobbs C. V., Salton S. R. J., VGF ablation blocks the development of hyperinsulinemia and hyperglycemia in several mouse models of obesity Endocrinology 2005 146 12 5151 5163 (Pubitemid 41653029)
28. Westman S., Development of the obese-hyperglycaemic syndrome in mice Diabetologia 1968 4 3 141 149
29. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J. M., Positional cloning of the mouse obese gene and its human homologue Nature 1994 372 6505 425 432 (Pubitemid 24365442)
30. Martin P., Wound healingaiming for perfect skin regeneration Science 1997 276 5309 75 81 (Pubitemid 27161246)
31. Singer A. J., Clark R. A. F., Cutaneous wound healing The New England Journal of Medicine 1999 341 10 738 746 (Pubitemid 29407375)
32. Eming S. A., Krieg T., Davidson J. M., Inflammation in wound repair: molecular and cellular mechanisms Journal of Investigative Dermatology 2007 127 3 514 525
33. Austyn J. M., Gordon S., F4/80, a monoclonal antibody directed specifically against the mouse macrophage European Journal of Immunology 1981 11 10 805 815 (Pubitemid 12237981)
34. Daley J. M., Thomay A. A., Connolly M. D., Reichner J. S., Albina J. E., Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice Journal of Leukocyte Biology 2008 83 1 64 70
35. Gillitzer R., Goebeler M., Chemokines in cutaneous wound healing Journal of Leukocyte Biology 2001 69 4 513 521 (Pubitemid 32294835)
36. Gordon S., Alternative activation of macrophages Nature Reviews Immunology 2003 3 1 23 35 (Pubitemid 37328697)
37. Dinarello C. A., Proinflammatory cytokines Chest 2000 118 2 503 508 (Pubitemid 30637822)
38. Dinarello C. A., Immunological and inflammatory functions of the interleukin-1 family Annual Review of Immunology 2009 27 519 550
39. Kmpfer H., Brutigam L., Geisslinger G., Pfeilschifter J., Frank S., Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair Journal of Investigative Dermatology 2003 120 5 880 890 (Pubitemid 36529093)
40. Eming S. A., Krieg T., Molecular mechanisms of VEGF-A action during tissue repair Journal of Investigative Dermatology Symposium Proceedings 2006 11 1 79 86 (Pubitemid 44413148)
41. Stallmeyer B., Pfeilschifter J., Frank S., Systemically and topically supplemented leptin fails to reconstitute a normal angiogenic response during skin repair in diabetic ob/ob mice Diabetologia 2001 44 4 471 479 (Pubitemid 32324358)
42. Goren I., Mller E., Schiefelbein D., Gutwein P., Seitz O., Pfeilschifter J., Frank S., Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice Journal of Investigative Dermatology 2009 129 3 752 764
43. Brown L. F., Yeo K. T., Berse B., Yeo T. K., Senger D. R., Dvorak H. F., Van de Water L., Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing Journal of Experimental Medicine 1992 176 5 1375 1379
44. Hinz B., Formation and function of the myofibroblast during tissue repair Journal of Investigative Dermatology 2007 127 3 526 537
45. Sano S., Itami S., Takeda K., Tarutani M., Yamaguchi Y., Miura H., Yoshikawa K., Akira S., Takeda J., Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis The EMBO Journal 1999 18 17 4657 4668 (Pubitemid 29415520)
46. Hanada T., Yoshimura A., Regulation of cytokine signaling and inflammation Cytokine and Growth Factor Reviews 2002 13 4-5 413 421
47. Hayden M. S., Ghosh S., Signaling to NF- B Genes and Development 2004 18 18 2195 2224
48. Boulton A. J., Vileikyte L., Ragnarson-Tennvall G., Apelqvist J., The global burden of diabetic foot disease The Lancet 2005 366 9498 1719 1724 (Pubitemid 41587452)
49. Smiell J. M., Wieman T. J., Steed D. L., Perry B. H., Sampson A. R., Schwab B. H., Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB)in patients with nonhealing, lower extremity diabetic ulcers:a combined analysis of four randomized studies Wound Repair and Regeneration 1999 7 5 335 346 (Pubitemid 29523009)
50. Falanga V., Wound healing and its impairment in the diabetic foot The Lancet 2005 366 9498 1736 1743 (Pubitemid 41587454)
51. Lee G. H., Proenca R., Montez J. M., Carroll K. M., Darvishzadeh J. G., Lee J. I., Friedman J. M., Abnormal splicing of the leptin receptor in diabetic mice Nature 1996 379 6566 632 635 (Pubitemid 26053452)
52. Morris D. L., Rui L., Recent advances in understanding leptin signaling and leptin resistance American Journal of Physiology 2009 297 6 E1247 E1259
53. Lindstrm P., The physiology of obese-hyperglycemic mice [ ob/ob mice] The Scientific World Journal 2007 7 666 685
54. Goren I., Mller E., Pfeilschifter J., Frank S., Severely impaired insulin signaling in chronic wounds of diabetic ob/ob mice: a potential role of tumor necrosis factor- American Journal of Pathology 2006 168 3 765 777 (Pubitemid 43327729)
55. Surwit R. S., Kuhn C. M., Cochrane C., McCubbin J. A., Feinglos M. N., Diet-induced type II diabetes in C57BL/6J mice Diabetes 1988 37 9 1163 1167 (Pubitemid 19035045)
56. Frederich R. C., Lllmann B., Hamann A., Napolitano-Rosen A., Kahn B. B., Lowell B. B., Flier J. S., Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity Journal of Clinical Investigation 1995 96 3 1658 1663
57. Kim B. C., Kim H. T., Park S. H., Cha JI. S., Yufit T., Kim S. J., Falanga V., Fibroblasts from chronic wounds show altered TGF- -signaling and decreased TGF- type II receptor expression Journal of Cellular Physiology 2003 195 3 331 336 (Pubitemid 36529861)
58. Strmmer L., Wickbom M., Wang F., Herrington M. K., stenson C. G., Arnelo U., Permert J., Early impairment of insulin secretion in rats after surgical trauma European Journal of Endocrinology 2002 147 6 825 833 (Pubitemid 36032973)
59. Pastar I., Stojadinovic O., Krzyzanowska A., Barrientos S., Stuelten C., Zimmerman K., Blumenberg M., Brem H., Tomic-Canic M., Attenuation of the transforming growth factor -signaling pathway in chronic venous ulcers Molecular Medicine 2010 16 3-4 92 101
60. Kmpfer H., Schmidt R., Geisslinger G., Pfeilschifter J., Frank S., Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing Diabetes 2005 54 5 1543 1551 (Pubitemid 40586688)
61. Goldberg M. T., Han Y. P., Yan C., Shaw M. C., Garner W. L., TNF- suppresses -smooth muscle actin expression in human dermal fibroblasts: an implication for abnormal wound healing Journal of Investigative Dermatology 2007 127 11 2645 2655 (Pubitemid 47585056)