Cutting edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival

Journal of Immunology

Volumn 176, Issue 9, 2006, Pages 5167-5171

  Furumoto, Yasuko ^a   Brooks, Steve ^a   Olivera, Ana ^a   Takagi, Yasuomi ^e   Miyagishi, Makoto ^d   Taira, Kazunari ^d   Casellas, Rafael ^b   Beaven, Michael A ^a   Gilfillan, Alasdair M ^c   Rivera, Juan ^a,b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

^e iGENE Therapeutics Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CD34 ANTIGEN; FC EPSILON RECEPTOR; FC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DEPHOSPHORYLATION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; LENTIVIRINAE; MAST CELL; MAST CELL DEGRANULATION; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; RNA GENE; TUMOR SUPPRESSOR GENE;

EID: 33646007018     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.9.5167     Document Type: Article

References (20)

1. 2+ influx by enhancing inositol 1,4,5-trisphosphate production. J. Biol. Chem. 276: 17213-17220.
2. Gu, H., K. Saito, L. D. Klaman, J. Shen, T. Fleming, Y. Wang, J. C. Pratt, G. Lin, B. Lim, J. P. Kinet, and B. G. Neel. 2001. Essential role for Gab2 in the allergic response. Nature 412: 186-190.
3. Parravicini, V., M. Gadina, M. Kovarova, S. Odom, C. Gonzalez-Espinosa, Y. Furumoto, S. Saitoh, L. E. Samelson, J. J. O'Shea, and J. Rivera. 2002. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat. Immunol. 3: 741-748.
4. Ali, K., A. Bilancio, M. Thomas, W. Pearce, A. M. Gilfillan, C. Tkaczyk, N. Kuehn, A. Gray, J. Giddings, E. Peskett, et al. 2004. Essential role for the p110δ phosphoinositide 3-kinase in the allergic response. Nature 431: 1007-1011.
5. Huber, M., C. D. Helgason, J. E. Damen, L. Liu, R. K. Humphries, and G. Krystal. 1998. The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc. Natl. Acad. Sci. USA 95: 11330-11335.
6. Odom, S., G. Gomez, M. Kovarova, Y. Furumoto, J. J. Ryan, H. V. Wright, C. Gonzalez-Espinosa, M. L. Hibbs, K. W. Harder, and J. Rivera. 2004. Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J. Exp. Med. 199: 1491-1502.
7. Cantley, L. C., and B. G. Neel. 1999. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. USA 96: 4240-4245.
8. Di Cristofano, A., B. Pesce, C. Cordon-Cardo, and P. P. Pandolfi. 1998. Pten is essential for embryonic development and tumour suppression. Nat. Genet 19: 348-355.
9. Tkaczyk, C., M. A. Beaven, S. M. Brachman, D. D. Metcalfe, and A. M. Gilfillan. 2003. The phospholipase Cγ1-dependent pathway of FcεRI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J. Biol. Chem. 278: 48474-48484.
10. Gomez, G., C. Gonzalez-Espinosa, S. Odom, G. Baez, M. E. Cid, J. J. Ryan, and J. Rivera. 2005. Impaired FcεRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn-deficiency in mast cells. J. Immunol. 175: 7602-7610.
11. Nilsson, G., T. Blom, M. Kusche-Gullberg, L. Kjellen, J. H. Butterfield, C. Sundstrom, K. Nilsson, and L. Hellman. 1994. Phenotypic characterization of the human mast-cell line HMC-1. Scand. J. Immunol. 39: 489-498.
12. Tkaczyk, C., D. D. Metcalfe, and A. M. Gilfillan. 2002. Determination of protein phosphorylation in FcεRI-activated human mast cells by immunoblot analysis requires protein extraction under denaturing conditions. J. Immunol. Methods 268: 239-243.
13. Hundley, T. R., A. M. Gilfillan, C. Tkaczyk, M. V. Andrade, D. D. Metcalfe, and M. A. Beaven. 2004. Kit and FcεRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells. Blood 104: 2410-2417.
14. Miyagishi, M., S. Matsumoto, and K. Taira. 2004. Generation of an shRNAi expression library against the whole human transcripts. Virus Res. 102: 117-124.
15. Downward, J. 2004. PI 3-kinase, Akt, and cell survival. Semin. Cell Dev. Biol. 15: 177-182.
16. Saitoh, S., S. Odom, G. Gomez, C. L. Sommers, H. A. Young, J. Rivera, and L. E. Samelson. 2003. The four distal tyrosines are required for LAT-dependent signaling in FcεRI-mediated mast cell activation. J. Exp. Med. 198: 831-843.
17. Karin, M. 1998. Mitogen-activated protein kinase cascades as regulators of stress responses. Ann. NY Acad. Sci. 851: 139-146.
18. Himes, S. R., L. S. Coles, R. Katsikeros, R. K. Lang, and M. F. Shannon. 1993. HTLV-1 tax activation of the GM-CSF and G-CSF promoters requires the interaction of NF-κB with other transcription factor families. Oncogene 8: 3189-3197.
19. Marin, V., C. Farnarier, S. Gres, S. Kaplanski, M. S. Su, C. A. Dinarello, and G. Kaplanski. 2001. The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment. Blood 98: 667-673.
20. Lazar-Molnar, E., H. Hegyesi, S. Toth, and A. Falus. 2000. Autocrine and paracrine regulation by cytokines and growth factors in melanoma. Cytokine 12: 547-554.