Live-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 7, 2004, Pages 2082-2087

  Stiles, Bangyan ^a   Wang, Ying ^a   Stahl, Andreas ^c   Bassilian, Sara ^d   Lee, W Paul ^d   Kim, Yoon Jung ^e   Sherwin, Robert ^e   Devaskar, Sherin ^b   Lesche, Ralf ^a,g   Magnuson, Mark A ^f   Wu, Hong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PALO ALTO MEDICAL FOUNDATION   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g EPIGENOMICS AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLYCOGEN; INSULIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE;

ADIPOSE TISSUE; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY SPECIFICITY; ARTICLE; BIOSYNTHESIS; BLOOD; BODY FAT; CHEMISTRY; CHROMOSOME 10; CONTROLLED STUDY; DIET RESTRICTION; ENZYMOLOGY; FATTY ACID SYNTHESIS; FATTY LIVER; GENE DELETION; GENETICS; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLYCOGEN SYNTHESIS; HEPATOMEGALY; INSULIN RESISTANCE; LIVER; LIVER CELL; LIVER HISTOLOGY; METABOLISM; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NORTHERN BLOTTING; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; WESTERN BLOTTING;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; FASTING; FATTY ACIDS; FATTY LIVER; GENE DELETION; GLUCONEOGENESIS; GLUCOSE TOLERANCE TEST; GLYCOGEN; HEPATOCYTES; HEPATOMEGALY; INSULIN; INSULIN RESISTANCE; LIVER; MICE; ORGAN SPECIFICITY; RNA, MESSENGER;

ANIMALIA; MURINAE;

EID: 10744222107     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0308617100     Document Type: Article

References (50)

1. Baudry, A., Leroux, L., Jackerott, M. & Joshi, R. L. (2002) EMBO Rep. 3, 323-328.
2. Bruning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Horsch, D., Accili, D., Goodyear, L. J. & Kahn, C. R. (1998) Mol. Cell 2, 559-569.
3. Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A. & Kahn, C. R. (2000) Mol. Cell 6, 87-97.
4. Abel, E. D., Peroni, O., Kim, J. K., Kim, Y. B., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I. & Kahn, B. B. (2001) Nature 409, 729-733.
5. Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., et al. (2000) Nat. Med. 6, 924-928.
6. Koteish, A. & Mae Diehl, A. (2002) Best Pract. Res. Clin. Gastroenterol. 16, 679-690.
7. Accili, D., Kido, Y., Nakae, J., Lauro, D. & Park, B. C. (2001) Curr. Mol. Med. 1, 9-23.
8. Huisamen, B., van Zyl, M., Keyser, A. & Lochner, A. (2001) Mol. Cell. Biochem. 223, 15-25.
9. Nakae, J., Kitamura, T., Silver, D. L. & Accili, D. (2001) J. Clin. Invest. 108, 1359-1367.
10. Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., III, Kaestner, K. H., Bartolomei, M. S., Shulman, G. I. & Birnbaum, M. J. (2001) Science 292, 1728-1731,
11. Sun, H., Lesche, R., Li, D. M., Liliental, J., Zhang, H., Gao, J., Gavrilova, N., Mueller, B., Liu, X. & Wu, H. (1999) Proc. Natl. Acad. Sci. USA 96, 6199-6204.
12. Ogg, S. & Ruvkun, G, (1998) Mol. Cell 2, 887-893.
13. Mihaylova, V. T., Borland, C. Z., Manjarrez, L., Stern, M. J. & Sun, H. (1999) Proc. Natl. Acad. Sci. USA 96, 7427-7432.
14. Rouault, J. P., Kuwabara, P. E., Sinilnikova, O. M., Duret, L., Thierry-Mieg, D. & Billaud, M. (1999) Curr. Biol. 9, 329-332
15. Gil, E. B., Malone Link, E., Liu, L. X., Johnson, C. D. & Lees, J. A. (1999) Proc. Natl. Acad. Sci. USA 96, 2925-2930.
16. Stiles, B., Gilman, V., Khanzenzon, N., Lesche, R., Li, A., Qiao, R., Liu, X. & Wu, H. (2002) Mol. Cell. Biol. 22, 3842-3851.
17. Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P. & Mak, T. W. (1998) Cell 95, 29-39.
18. Di Cristofano, A., Pesce, B., Cordon-Cardo, C. & Pandolfi, P. P. (1998) Nat. Genet. 19, 348-355.
19. Suzuki, A., de la Pompa, J. L., Stambolic, V., Elia, A. J., Sasaki, T., del Barco Barrantes, I., Ho, A., Wakeham, A., Itie, A., Khoo, W., et al. (1998) Curr. Biol. 8, 1169-1178.
20. Podsypanina, K., Ellenson, L. H., Nemes, A., Gu, J., Tamura, M., Yamada, K. M., Cordon-Cardo, C., Catoretti, G., Fisher, P. E. & Parsons, R. (1999) Proc. Natl. Acad. Sci. USA 96, 1563-1568.
21. Butler, M., McKay, R. A., Popoff, I. J., Gaarde, W. A., Witchell, D., Murray, S. F., Dean, N. M., Bhanot, S. & Monja, B. P. (2002) Diabetes 51, 1028-1034.
22. Lesche, R., Groszer, M., Gao, J., Wang, Y., Messing, A., Sun, H., Liu, X. & Wu, H. (2002) Genesis 32, 148-149.
23. Postic, C. & Magnuson, M. A. (2000) Genesis 26, 149-150.
24. Stahl, A., Hirsch, D. J., Gimeno, R. E., Punreddy, S., Ge, P., Watson, N., Patel, S., Kotler, M., Raimondi, A., Tartaglia, L. A. & Lodish, H. F. (1999) Mol. Cell 4, 299-308.
25. Lee, W. N., Bassilian, S., Guo, Z., Schoeller, D., Edmond, J., Bergner, E. A. & Byerley, L. O. (1994) Am. J. Physiol. 266, E372-E383.
26. Lee, W. N., Bassilian, S., Lim, S. & Boros, L. G. (2000) Am. J. Physiol. 279, E425-E432.
27. Li, X., Catalina, F., Grundy, S. M. & Patel, S. (1996) J. Lipid Res. 37, 210-220.
28. Stahl, A., Gimeno, R. E., Tartaglia, L. A. & Lodish, H. F. (2001) Trends Endocrinol. Metab. 12, 266-273.
29. Barac-Nieto, M. & Gupta, R. K. (1996) J. Magn. Reson. Imaging 6, 235-238.
30. Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M. & Hemmings, B. A. (1995) Nature 378, 785-789.
31. Asante-Appiah, E. & Kennedy, B. P. (2003) Am. J. Physiol. 284, E663-E670.
32. Elchebly, M., Payette, P., Michaliszyn, E., Cromlish, W., Collins, S., Loy, A. L., Normandin, D., Cheng, A., Himms-Hagen, J., Chan, C. C., et al. (1999) Science 283, 1544-1548.
33. Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y. B., Sharpe, A. H., et al. (2000) Mol. Cell. Biol. 20, 5479-5489.
34. Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) Biochem. Biophys. Res. Commun. 257, 79-83.
35. Matsubara, M., Katayose, S. & Maruoka, S. (2003) Eur. J. Endocrinol. 148, 343-350.
36. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) Nature 423, 762-769.
37. Austin, B. P., Garthwaite, T. L., Hagen, T, C., Stevens, J. O. & Menahan, L. A. (1984) Exp. Gerontol. 19, 121-132.
38. Yang, S. Q., Lin, H. Z., Mandal, A. K., Huang, J. & Diehl, A. M. (2001) Hepatology 34, 694-706.
39. Shimomura, I., Hammer, R. E. Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L. & Brown, M. S. (1998) Genes Dev. 12, 3182-3194.
40. Bluher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B. & Kahn, C. R. (2002) Dev. Cell 3, 25-38.
41. Chanussot, F., Ulmer, M., Ratanasavanh, R., Max, J. P. & Debry, G. (1984) Int. J. Obes. 8, 259-270.
42. Clark, J. M. & Diehl, A. M, (2002) Curr. Diab. Rep. 2, 210-215.
43. Petersen, K. F., Oral, E. A., Dufour, S., Befroy, D., Ariyan, C., Yu, C., Cline, G. W., DePaoli, A. M., Taylor, S. I., Gorden, P. & Shulman, G. I. (2002) J. Clin. Invest. 109, 1345-1350.
44. Kraegen, E. W., Clark, P. W., Jenkins, A. B., Daley, E. A., Chisholm, D. J. & Storlien, L. H. (1991) Diabetes 40, 1397-1403.
45. Goetze, S., Bungenstock, A., Czupalla, C., Eilers, F., Stawowy, P., Kintscher, U., Spencer-Hansch, C., Graf, K., Nurnberg, B., Law, R. E., et al. (2002) Hypertension 40, 748-754.
46. Carvalheira, J. B., Ribeiro, E. B., Folli, F., Velloso, L. A. & Saad, M. J. (2003) Biol. Chem. Hoppe-Seyler 384, 151-159.
47. Bruning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Muller-Wieland, D. & Kahn, C. R. (2000) Science 289, 2122-2125.
48. Guo, S., Rena, G., Cichy, S., He, X., Cohen, P. & Unterman, T. (1999) J. Biol. Chem. 274, 17184-17192.
49. Zabolotny, J. M., Bence-Hanulec, K. K., Stricker-Krongrad, A., Haj, F., Wang, Y., Minokoshi, Y., Kim, Y. B., Elmquist, J. K., Tartaglia, L. A., Kahn, B. B. & Neel, B. G. (2002) Dev. Cell 2, 489-495.
50. Kim, J. K., Zisman, A., Fillmore, J. J., Peroni, O. D., Kotani, K., Perret, P., Zong, H., Dong, J., Kahn, C. R., Kahn, B. B. & Shulman, G. I. (2001) J. Clin. Invest. 108, 153-160.