Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

Molecular and Cellular Biology

Volumn 28, Issue 10, 2008, Pages 3258-3272

  Bayascas, Jose R ^a,d   Wullschleger, Stephan ^a   Sakamoto, Kei ^a   García Martínez, Juan M ^a   Clacher, Carol ^a   Komander, David ^a,e   Van Aalten, Daan M F ^a   Boini, Krishna M ^b   Lang, Florian ^b   Lipina, Christopher ^a   Logie, Lisa ^a   Sutherland, Calum ^a   Chudek, John A ^a   Van Diepen, Janna A ^c   Voshol, Peter J ^c   Lucocq, John M ^a   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d INSTITUT DE NEUROCIÈNCIES   (Spain)

^e MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITIDE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; S6 KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEEDING; FEMALE; HYPERINSULINEMIA; INSULIN RESISTANCE; MALE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SHORT STATURE;

ANIMALIA; MUS;

EID: 43249093752     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.02032-07     Document Type: Article

References (64)