Phosphoinositides and signal transduction

Cellular and Molecular Life Sciences

Volumn 59, Issue 5, 2002, Pages 761-779

  Toker, A ^a  

^a BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

PH domains; Phosphoinositide kinases; Phosphoinositide phosphatases; Phosphoinositides; Protein kinases; Signal transduction

Indexed keywords

BINDING PROTEIN; LIPID; PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE; PHOSPHOTRANSFERASE; PLECKSTRIN;

APOPTOSIS; BINDING AFFINITY; CELL FUNCTION; CELL GROWTH; CELL MEMBRANE; CELL PROLIFERATION; CELL VACUOLE; CYTOSKELETON; INSULIN SYNTHESIS; METABOLISM; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

BIOLOGICAL TRANSPORT; CYTOSKELETON; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASES; PHOSPHORIC MONOESTER HYDROLASES; SECOND MESSENGER SYSTEMS;

EID: 0036280038     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8465-z     Document Type: Review

References (168)

1. The role of phosphoinositide 3-kinase lipid products in cell function
2. Signalling through phosphoinositide 3-kinases: The lipids take centre stage
3. PIPkins1, their substrates and their products: New functions for old enzymes
4. Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes
5. Structure and function of phosphoinositide 3-kinases
6. Phosphatidylinositol 4-kinases
7. A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
8. The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases
9. Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast
10. Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5- phosphate
11. Structure of type IIbeta phosphatidylinositol phosphate kinase: A protein kinase fold flattened for interfacial phosphorylation
12. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation
13. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
14. An inositol tetrakisphosphate-containing phospholipid in activated neutrophils
15. Phosphatidylinositol-3-OH kinase as a direct target of Ras
16. A novel phosphoinositide 3-kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits
17. Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
18. Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain
19. Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain
20. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
21. A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole
22. Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities
23. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of Vacuolar/Lysosomal membrane trafficking pathways
24. Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150. Ptdins 3-kinase complex
25. The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase
26. A presynaptic inositol-5-phosphatase
27. p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
28. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
29. Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein
30. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
31. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
32. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
33. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
34. The role of phosphatases in inositol signaling reactions
35. Identification of multiple phosphoinositide-specific phospholipases D as new regulatory enzymes for phosphatidylinositol 3,4,5-trisphosphate
36. Families of phosphoinositide-specific phospholipase C: Structure and function
37. Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta
38. Structural mapping of the catalytic mechanism for a mammalian phosphoinositide-specific phospholipase C
39. Interaction site of GTP binding Gh (transglutaminase II) with phospholipase C
40. Regulation of inositol lipid-specific phospholipase cdelta by changes in Ca2+ ion concentrations
41. Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1
42. D-myo-inositol 1,4,5-trisphosphate inhibits binding of phospholipase C-delta 1 to bilayer membranes
43. Regulation of phosphoinositide-specific phospholipase C isozymes
44. Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate
45. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain- mediated membrane targeting
46. Phosphatidylinositol 3,4,5-trisphosphate-dependent stimulation of phospholipase C-gamma2 is an early key event in FcgammaRIIA-mediated activation of human platelets
47. When is a lipid kinase not a lipid kinase? When it is a protein kinase
48. A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity
49. PI 3-kinase is a dual specificity enzyme: Autoregulation by an intrinsic protein-serine kinase activity
50. Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK
51. A novel integrin-activated pathway forms PKB/Akt- stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets
52. A type II phosphoinositide 3-kinase is stimulated via activated integrin in platelets. A source of phosphatidylinositol 3-phosphate
53. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets
54. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger
55. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
56. Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase
57. FYVE fingers bind PtdIns(3)P
58. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes
59. A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 alpha subunit. Implications for the endocytic pathway
60. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
61. High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
62. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
63. A specific product of PI 3-K directly activates the protein kinase Akt through its pleckstrin homology domain
64. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
65. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
66. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
67. Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
68. Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate
69. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
70. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3
71. Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase
72. Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes
73. Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
74. Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin
75. Localization of a binding site for phosphatidylinositol 4,5- bisphosphate on human profilin
76. Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity
77. Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein
78. D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate
79. Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly
80. Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: Possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway
81. Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: An essential role for ezrin/radixin/moesin proteins
82. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
83. Structural characterization of the interaction between a pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate
84. Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains
85. Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis
86. Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D
87. ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity
88. Role of protein-phospholipid interactions in the activation of ARF1 by the guanine nucleotide exchange factor Arno
89. A human exchange factor for ARF contains Sec7 and PH domains
90. Signal transduction and membrane traffic: The PITP/phosphoinositide connection
91. GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acid phospholipids
92. Biologically active lipids are regulators of Rac. GDI complexation
93. Phosphatidylinositol 4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs
94. A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains
95. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains
96. High affinity binding of the pleckstrin homology domain of mSos1 to phosphatidylinositol (4,5)-bisphosphate
97. The role of the PH domain in the signal-dependent membrane targeting of Sos
98. Identification of the binding site for acidic phospholipids on the pH domain of dynamin: Implications for stimulation of GTPase activity
99. Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase
100. Regulation of dynamin I GTPase activity by G protein betagamma subunits and phosphatidylinositol 4,5-bisphosphate
101. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
102. Translocation of PDK-1 to the plasma membrane is important in allowoing PDK-1 to activate protein kinase B
103. Mechanism of activation of protein kinase B by insulin and IGF-1
104. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
105. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
106. EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase
107. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1
108. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
109. Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta
110. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)
111. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
112. Phosphorylation and activation of p70s6k by PDK1
113. Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase
114. Signals from the Ras, Rac and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts
115. Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
116. Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases
117. Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: A target for SHIP-mediated inhibitory signals
118. The emerging field of receptor-mediated inhibitory signaling: SHP or SHIP?
119. Mutation of the pleckstrin homology domain of BTK in immunodeficiency impaired IP4 binding capacity
120. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
121. Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase
122. Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage
123. PDGF stimulates an increase in GTP-rac via activation of phosphoinositide 3-kinase
124. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
125. Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation
126. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
127. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
128. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing plecks-trin and Sec7 homology domains
129. Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate
130. Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain
131. Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins
132. Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling
133. Evidence that a phosphatidylinositol 3,4,5-trisphosphate-binding protein can function in nucleus
134. Een DAG uit het leven van de inositide signalering in de nucleus
135. Oncogenes and signal transduction
136. Phospholipase C-gamma 1 and phosphatidylinositol 3-kinase are the downstream mediators of the PDGF receptor's mitogenic signal
137. Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression
138. The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors
139. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
140. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
141. Protein kinase C zeta isoform is critical for mitogenic signal transduction
142. Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor stimulated NIH 3T3 fibroblasts
143. Transformation of chicken cells by the gene encoding for the catalytic subunit of PI 3-kinase
144. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
145. Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo
146. An SH2 domain-containing 5′ inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement
147. Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts
148. Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac
149. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
150. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts
151. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C
152. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
153. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
154. ATP-dependent inositide phosphorylation required for Ca(2+)-activated secretion
155. Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase
156. Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation
157. Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites
158. The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae
159. PI 3-K and membrane traffic
160. Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin
161. Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate
162. Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
163. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
164. Insulin increases the association of Akt-2 with Glut4-containing vesicles
165. Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes
166. Insulin stimulates guanine nucleotide exchange on Rab4 via a wortmannin-sensitive signaling pathway in rat adipocytes