메뉴 건너뛰기




Volumn 5, Issue 3, 2011, Pages

Akt isoform-specific signaling in breast cancer: Uncovering an anti-migratory role of palladin

Author keywords

Akt isoforms; Breast cancer; Metastasis; Migration; Palladin

Indexed keywords

ACTIN; ANDROGEN RECEPTOR; BETA1 INTEGRIN; INITIATION FACTOR 4E; INTERLEUKIN ENHANCER BINDING FACTOR 2; MAMMALIAN TARGET OF RAPAMYCIN; MERLIN; MK 2206; PALLADIN PROTEIN; PERIFOSINE; PROTEIN; PROTEIN KINASE B; SHORT HAIRPIN RNA; SOMATOMEDIN C RECEPTOR; TRICIRIBINE; TUBERIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; ISOPROTEIN; PALLADIN PROTEIN, HUMAN; PHOSPHOPROTEIN;

EID: 84555191987     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (71)

References (31)
  • 1
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • Bellacosa A, Testa JR, Staal SP, Tsichlis PN. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 1991; 254:274-7. (Pubitemid 21917339)
    • (1991) Science , vol.254 , Issue.5029 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 2
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • DOI 10.1038/sj.onc.1209085, PII 1209085
    • Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005; 24:7455-64. (Pubitemid 41637985)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 3
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • DOI 10.1038/nrg1879, PII NRG1879
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006; 7:606-19. (Pubitemid 44100518)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.8 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 4
    • 0035008874 scopus 로고    scopus 로고
    • Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
    • DOI 10.1128/MCB.21.6.2203-2212.2001
    • Hutchinson J, Jin J, Cardiff RD, Woodgett JR, Muller WJ. Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 2001; 21:2203-12. (Pubitemid 32479640)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.6 , pp. 2203-2212
    • Hutchinson, J.1    Jin, J.2    Cardiff, R.D.3    Woodgett, J.R.4    Muller, W.J.5
  • 9
    • 60349088457 scopus 로고    scopus 로고
    • Perifosine: Update on a novel Akt inhibitor
    • Gills JJ, Dennis PA. Perifosine: update on a novel Akt inhibitor. Curr Oncol Rep 2009; 11:102-10.
    • (2009) Curr Oncol Rep , vol.11 , pp. 102-110
    • Gills, J.J.1    Dennis, P.A.2
  • 10
    • 77949430065 scopus 로고    scopus 로고
    • The Akt/PKB family of protein kinases: A review of small molecule inhibitors and progress towards target validation: A 2009 update
    • Lindsley CW. The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update. Curr Top Med Chem 2010; 10:458-77.
    • (2010) Curr Top Med Chem , vol.10 , pp. 458-477
    • Lindsley, C.W.1
  • 11
    • 2342527930 scopus 로고    scopus 로고
    • Activation of Akt-1 (PKB-alpha) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion
    • DOI 10.1158/0008-5472.CAN-03-3465
    • Hutchinson JN, Jin J, Cardiff RD, Woodgett JR, Muller WJ. Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res 2004; 64:3171-8. (Pubitemid 38581419)
    • (2004) Cancer Research , vol.64 , Issue.9 , pp. 3171-3178
    • Hutchinson, J.N.1    Jin, J.2    Cardiff, R.D.3    Woodgett, J.R.4    Muller, W.J.5
  • 12
    • 33846416534 scopus 로고    scopus 로고
    • Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/Neu and MMTV-polyoma middle T transgenic mice
    • DOI 10.1158/0008-5472.CAN-06-3782
    • Maroulakou IG, Oemler W, Naber SP, Tsichlis PN. Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res 2007; 67:167-77. (Pubitemid 46142772)
    • (2007) Cancer Research , vol.67 , Issue.1 , pp. 167-177
    • Maroulakou, I.G.1    Oemler, W.2    Naber, S.P.3    Tsichlis, P.N.4
  • 14
    • 27944446105 scopus 로고    scopus 로고
    • Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
    • DOI 10.1016/j.molcel.2005.10.033, PII S1097276505017284
    • Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005; 20:539-50. (Pubitemid 41668639)
    • (2005) Molecular Cell , vol.20 , Issue.4 , pp. 539-550
    • Yoeli-Lerner, M.1    Yiu, G.K.2    Rabinovitz, I.3    Erhardt, P.4    Jauliac, S.5    Toker, A.6
  • 16
    • 33645213629 scopus 로고    scopus 로고
    • Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
    • Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, et al. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci USA 2006; 103:4134-9.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4134-4139
    • Liu, H.1    Radisky, D.C.2    Nelson, C.M.3    Zhang, H.4    Fata, J.E.5    Roth, R.A.6
  • 17
    • 0037229714 scopus 로고    scopus 로고
    • Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells
    • Arboleda MJ, Lyons JF, Kabbinavar FF, Bray MR, Snow BE, Ayala R, et al. Overexpression of AKT2/protein kinase Bbeta leads to upregulation of beta1 integrins, increased invasion and metastasis of human breast and ovarian cancer cells. Cancer Res 2003; 63:196-206. (Pubitemid 36070440)
    • (2003) Cancer Research , vol.63 , Issue.1 , pp. 196-206
    • Arboleda, M.J.1    Lyons, J.F.2    Kabbinavar, F.F.3    Bray, M.R.4    Snow, B.E.5    Ayala, R.6    Danino, M.7    Karlan, B.Y.8    Slamon, D.J.9
  • 18
    • 67449136114 scopus 로고    scopus 로고
    • Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression
    • Dillon RL, Marcotte R, Hennessy BT, Woodgett JR, Mills GB, Muller WJ. Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res 2009; 69:5057-64.
    • (2009) Cancer Res , vol.69 , pp. 5057-5064
    • Dillon, R.L.1    Marcotte, R.2    Hennessy, B.T.3    Woodgett, J.R.4    Mills, G.B.5    Muller, W.J.6
  • 19
    • 59749095009 scopus 로고    scopus 로고
    • Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer
    • Chin YR, Toker A. Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell Signal 2009; 21:470-6.
    • (2009) Cell Signal , vol.21 , pp. 470-476
    • Chin, Y.R.1    Toker, A.2
  • 20
    • 15044363028 scopus 로고    scopus 로고
    • Recent advances in the protein kinase B signaling pathway
    • DOI 10.1016/j.ceb.2005.02.010, Cell Regulation
    • Woodgett JR. Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol 2005; 17:150-7. (Pubitemid 40380938)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.2 , pp. 150-157
    • Woodgett, J.R.1
  • 22
    • 0034680838 scopus 로고    scopus 로고
    • Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
    • Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem 2000; 275:36108-15.
    • (2000) J Biol Chem , vol.275 , pp. 36108-36115
    • Obata, T.1    Yaffe, M.B.2    Leparc, G.G.3    Piro, E.T.4    Maegawa, H.5    Kashiwagi, A.6
  • 23
    • 77951962854 scopus 로고    scopus 로고
    • The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration
    • Chin YR, Toker A. The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Mol Cell 2010; 38:333-44.
    • (2010) Mol Cell , vol.38 , pp. 333-344
    • Chin, Y.R.1    Toker, A.2
  • 24
    • 44449099311 scopus 로고    scopus 로고
    • Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin
    • Dixon RD, Arneman DK, Rachlin AS, Sundaresan NR, Costello MJ, Campbell SL, et al. Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. J Biol Chem 2008; 283:6222-31.
    • (2008) J Biol Chem , vol.283 , pp. 6222-6231
    • Dixon, R.D.1    Arneman, D.K.2    Rachlin, A.S.3    Sundaresan, N.R.4    Costello, M.J.5    Campbell, S.L.6
  • 25
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB Signaling: Navigating Downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129:1261-74. (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 26
    • 34848921532 scopus 로고    scopus 로고
    • Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation
    • DOI 10.1038/ncb1641, PII NCB1641
    • Tang X, Jang SW, Wang X, Liu Z, Bahr SM, Sun SY, et al. Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation. Nat Cell Biol 2007; 9:1199-207. (Pubitemid 47500497)
    • (2007) Nature Cell Biology , vol.9 , Issue.10 , pp. 1199-1207
    • Tang, X.1    Jang, S.-W.2    Wang, X.3    Liu, Z.4    Bahr, S.M.5    Sun, S.-Y.6    Brat, D.7    Gutmann, D.H.8    Ye, K.9
  • 27
    • 0036683093 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
    • DOI 10.1093/emboj/cdf406
    • Lin HK, Wang L, Hu YC, Altuwaijri S, Chang C. Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J 2002; 21:4037-48. (Pubitemid 34857436)
    • (2002) EMBO Journal , vol.21 , Issue.15 , pp. 4037-4048
    • Lin, H.-K.1    Wang, L.2    Hu, Y.-C.3    Altuwaijri, S.4    Chang, C.5
  • 28
    • 78649658961 scopus 로고    scopus 로고
    • Akt2 regulates expression of the actin-bundling protein palladin
    • Chin YR, Toker A. Akt2 regulates expression of the actin-bundling protein palladin. FEBS Lett 2010; 584:4769-74.
    • (2010) FEBS Lett , vol.584 , pp. 4769-4774
    • Chin, Y.R.1    Toker, A.2
  • 30
    • 78649982907 scopus 로고    scopus 로고
    • The dynamic roles of TGF-beta in cancer
    • Meulmeester E, Ten Dijke P. The dynamic roles of TGF-beta in cancer. J Pathol 2010; 223:205-18.
    • (2010) J Pathol , vol.223 , pp. 205-218
    • Meulmeester, E.1    Ten Dijke, P.2
  • 31
    • 77957039464 scopus 로고    scopus 로고
    • WASP and WAVE family proteins: Friends or foes in cancer invasion?
    • Kurisu S, Takenawa T. WASP and WAVE family proteins: friends or foes in cancer invasion? Cancer Sci 2010; 101:2093-104.
    • (2010) Cancer Sci , vol.101 , pp. 2093-2104
    • Kurisu, S.1    Takenawa, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.