Akt2 regulates cardiac metabolism and cardiomyocyte survival

Journal of Biological Chemistry

Volumn 281, Issue 43, 2006, Pages 32841-32851

  DeBosch, Brian ^a   Sambandam, Nandakumar ^a   Weinheimer, Carla ^a   Courtois, Michael ^a   Muslin, Anthony J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC METABOLISM; CELLULAR PROTEIN SYNTHESIS; ISCHEMIC INJURY; LIGAND STIMULATION;

CARDIOLOGY; CYTOLOGY; METABOLISM; SYNTHESIS (CHEMICAL);

ENZYMES;

2 DEOXYGLUCOSE H 3; DEOXYGLUCOSE; ENDOTHELIN 1; INSULIN; LIGAND; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN AKT1; PROTEIN KINASE B; PROTEIN KINASE B BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME MECHANISM; GENE TARGETING; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HEART DEVELOPMENT; HEART HYPERTROPHY; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; HEART STIMULATION; HEART VENTRICLE PRESSURE; LEFT CORONARY ARTERY; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SENSITIZATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; DEOXYGLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; TIME FACTORS;

MURINAE;

EID: 33845703636     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513087200     Document Type: Article

References (29)

1. Dorn, G. W., and Force, T. (2005) J. Clin. Invest. 115, 527-537
2. Matsui, T., and Rosenzweig, A. (2005) J. Mol. Cell. Cardiol. 38, 63-71
3. Abel, E. D. (2004) Curr. Hypertens. Rep. 6, 416-423
4. Matsui, T., Li, L., Wu, J. C., Cook, S. A., Nagoshi, T., Picard, M. H., Liao, R., and Rosenzweig, A. (2002) J. Biol. Chem. 277, 22896-22901
5. Shioi, T., McMullen, J. R., Kang, P. M., Douglas, P. S., Obata, T., Franke, T. F., Cantley, L. C., and Izumo, S. (2002) Mol. Cell. Biol. 22, 2799-2809
6. Taniyama, Y., Ito, M., Sato, K., Kuester, C., Veit, K., Tremp, G., Liao, R., Colucci, W. S., Ivashchenko, Y., Walsh, K., and Shiojima, L. (2005) J. Biol. Chem. 38, 375-385
7. McMullen, J. R., Shioi, T., Zhang, L., Tarnavski, O., Sherwood, M. C., Kang, P. M., and Izumo, S. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 12355-12360
8. Rota, M., Boni, A., Urbanek, K., Padin-Iruegas, E., Kajstura, T. J., Fiore, G., Kubo, H., Sonnenblick, E. H., Musso, E., Houser, S. R., Leri, A., Sussman, M. A., and Anversa, P. (2005) Circ. Res. 97, 1332-1341
9. Somwar, R., Niu, W., Kim, D. Y., Sweeney, G., Randhawa, V. K., Huang, C., Ramlal, T., and Klip, A. (2001) J. Biol. Chem. 276, 46079-46087
10. Yamada, E., Okada, S., Saito, T., Ohshima, K., Sato, M., Tsuchiya, T., Uehara, Y., Shimizu, H., and Mori, M. (2005) J. Cell Biol. 168, 921-928
11. Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995) Nature 378, 785-789
12. Kovacic, S., Soltys, C. L., Barr, A. J., Shiojima, I., Walsh, K., and Dyck, J. R. (2003) J. Biol. Chem. 278, 39422-39427
13. Southgate, R. J., Bruce, C. R., Carey, A. L., Ateinberg, G. R., Walder, K., Monks, R., Watt, M. J., Hawley, J. A., Birnbaum, M. J., and Febbraio, M. J. (2005) FASEB J. 19, 2072-2074
14. Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., and Birnbaum, M. J. (2001) Science 292, 1728-1731
15. Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., and Birnbaum, M. J. (2001) J. Biol. Chem. 276, 38349-38352
16. Sambrano, G. R., Fraser, I., Han, H., Ni, Y., O'Connel, T., Yan, Z., and Stull, J. T. (2002) Nature 420, 712-714
17. Belke, D. D., Larsen, T. S., Lopaschuk, G. D., and Severson, D. L. (1999) Am. J. Physiol. 277, R1210-R1217
18. Harris, I. S., Zhang, S., Treskov, I., Kovacs, I., Weinheimer, C., and Muslin, A. J. (2004) Circulation 110, 718-723
19. Ren, J., Zhang, S., Kovacs, A., Wang, Y., and Muslin, A. J. (2005) J. Mol. Cell. Cardiol. 38, 617-623
20. Kanno, S., Lerner, D. L., Schuessler, R. B., Betsuyaku, T., Yamada, K. A., Saffitz, J. E., and Kovacs, A. (2002) J. Am. Soc. Echocardiogr. 15, 601-609
21. Cheatham, B. (2000) Trends Endocrinol. Metab. 11, 356-361
22. Mora, A., Sakamoto, K., McManus, E. J., and Alessi, D. R. (2005) FEBS Lett. 579, 3632-36238
23. Colao, A., Vitale, G., Pivonello, R., Ciccarelli, A., Di Somma, C., and Lombardi, G. (2004) Eur. J. Endocrinol. 151, S93-S101
24. Neri Serneri, G. G., Boddi, M., Modesti, P. A., Cecioni, I., Coppo, M., Padeletti, L., Michelucci, A., Colella, A., and Galanti, G. (2001) Circ. Res. 89, 977-982
25. Matsui, T., Li, L., del Monte, F., Fukui, Y., Franke, T. F., Hajjar, R. J., and Rosenzweig, A. (1999) Circulation 100, 2373-2379
26. Fujiko, Y., Nguyen, T., Wencker, D., Kitsis, R. N., and Walsh, K. (2000) Circulation 101, 660-667
27. DeBosch, B., Lupu, T. S., Weinheimer, C., Kovacs, A., and Muslin, A.J. (2006) Circulation 113, 2097-2104
28. Garofalo, R. S., Orena, S. J., Rafidi, K., Torchia, A. J., Stock. J. L., Hildebrandt, A. L., Coskran, T., Black, S. C., Brees, D. J., Wicks, J. R., McNeish, J. D., and Coleman, K. G. (2003) J. Clin. Invest. 112, 197-208
29. McMullen, J. R., Shioi, T., Zhang, L., Tarnavski, O., Sherwood, M. C., Dorfman, A. L., Longnus, S., Pende, M., Martin, K. A., Blenis, J., Thomas, G., and Izumo, S. (2004) Mol. Cell. Biol. 24, 6231-6240