-
1
-
-
0027366440
-
-
Stephens LR, Jackson TR, Hawkins PT. Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim Biophys Acta 1993; 1179:27 75.
-
Stephens LR, Jackson TR, Hawkins PT. Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim Biophys Acta 1993; 1179:27 75.
-
-
-
-
2
-
-
0033055446
-
Pathways for phosphoinositide synthesis
-
Tolias KF, Cantley LC. Pathways for phosphoinositide synthesis. Chem Phys Lipids 1999;98:69-77.
-
(1999)
Chem Phys Lipids
, vol.98
, pp. 69-77
-
-
Tolias, K.F.1
Cantley, L.C.2
-
3
-
-
0034911881
-
Synthesis and function of 3-phosphorylated inositol lipids
-
Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC et al. Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 2001;70:535-602.
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 535-602
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Ahmadi, K.3
Timms, J.4
Katso, R.5
Driscoll, P.C.6
-
4
-
-
3242698804
-
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
-
Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 2004;37:449-471.
-
(2004)
J Mol Cell Cardiol
, vol.37
, pp. 449-471
-
-
Oudit, G.Y.1
Sun, H.2
Kerfant, B.G.3
Crackower, M.A.4
Penninger, J.M.5
Backx, P.H.6
-
7
-
-
0034912744
-
PTEN and myotubularin: Novel phosphoinositide phosphatases
-
Maehama T, Taylor GS, Dixon JE. PTEN and myotubularin: novel phosphoinositide phosphatases. Annu Rev Biochem 2001;70:247-279.
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 247-279
-
-
Maehama, T.1
Taylor, G.S.2
Dixon, J.E.3
-
8
-
-
1542569606
-
Membrane recognition and targeting by lipid-binding domains
-
DiNitto JP, Cronin TC, Lambright DG. Membrane recognition and targeting by lipid-binding domains. Sci STKE 2003;213:re16.
-
(2003)
Sci STKE
, vol.213
-
-
DiNitto, J.P.1
Cronin, T.C.2
Lambright, D.G.3
-
9
-
-
46149106818
-
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
-
Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A et al. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sd USA 2008;105: 8292-8297.
-
(2008)
Proc Natl Acad Sd USA
, vol.105
, pp. 8292-8297
-
-
Guillermet-Guibert, J.1
Bjorklof, K.2
Salpekar, A.3
Gonella, C.4
Ramadani, F.5
Bilancio, A.6
-
10
-
-
49649087385
-
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
-
Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH et al. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature 2008;454:776 779.
-
(2008)
Nature
, vol.454
, pp. 776-779
-
-
Jia, S.1
Liu, Z.2
Zhang, S.3
Liu, P.4
Zhang, L.5
Lee, S.H.6
-
11
-
-
0034997749
-
Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase
-
Kessler A, Uphues I, Ouwens DM, Till M, Eckel J. Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase. Am J Physiol Endocrinol Metab 2001 ;280: E65-E74.
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Kessler, A.1
Uphues, I.2
Ouwens, D.M.3
Till, M.4
Eckel, J.5
-
12
-
-
18644372367
-
-
Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki Tet al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002; 110:737 749.
-
Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki Tet al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002; 110:737 749.
-
-
-
-
13
-
-
0030887632
-
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101
-
Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J et al. The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 1997;89:105-114.
-
(1997)
Cell
, vol.89
, pp. 105-114
-
-
Stephens, L.R.1
Eguinoa, A.2
Erdjument-Bromage, H.3
Lui, M.4
Cooke, F.5
Coadwell, J.6
-
14
-
-
0037163065
-
Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats
-
Northcott CA, Poy MN, Najjar SM, Watts SW. Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats. Circ Res 2002;91:360-369.
-
(2002)
Circ Res
, vol.91
, pp. 360-369
-
-
Northcott, C.A.1
Poy, M.N.2
Najjar, S.M.3
Watts, S.W.4
-
15
-
-
0242381308
-
-
Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki |, Sasaki T et al. Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation 2003; 108: 2147-2152.
-
Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki |, Sasaki T et al. Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation 2003; 108: 2147-2152.
-
-
-
-
16
-
-
0035851213
-
Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2 i ) channels
-
Macrez N, Mironneau C, Carricaburu V, Quignard JF, Babich A, Czupalla C et al. Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2 i ) channels. Circ Res 2001;89:692-699.
-
(2001)
Circ Res
, vol.89
, pp. 692-699
-
-
Macrez, N.1
Mironneau, C.2
Carricaburu, V.3
Quignard, J.F.4
Babich, A.5
Czupalla, C.6
-
17
-
-
0035847014
-
Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway
-
Cieslik K, Abrams CS, Wu KK. Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma/Janus kinase 2/MEK-1-dependent pathway. J Biol Chem 2001;276:1211-1219.
-
(2001)
J Biol Chem
, vol.276
, pp. 1211-1219
-
-
Cieslik, K.1
Abrams, C.S.2
Wu, K.K.3
-
18
-
-
42549125520
-
Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells
-
Chavakis E, Carmona G, Urbich C, Gottig S, Henschler R, Penninger JM et al. Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. Circ Res 2008;102:942 949.
-
(2008)
Circ Res
, vol.102
, pp. 942-949
-
-
Chavakis, E.1
Carmona, G.2
Urbich, C.3
Gottig, S.4
Henschler, R.5
Penninger, J.M.6
-
19
-
-
0842346438
-
Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems
-
Pawson T. Specificity in signal transduction: from phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell 2004; 116: 191-203.
-
(2004)
Cell
, vol.116
, pp. 191-203
-
-
Pawson, T.1
-
20
-
-
0037421204
-
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma
-
Brock C, Schaefer M, Reusch HP, Czupalla C, Michalke M, Spicher K et al. Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma. J Cell Biol 2003; 160: 89-99.
-
(2003)
J Cell Biol
, vol.160
, pp. 89-99
-
-
Brock, C.1
Schaefer, M.2
Reusch, H.P.3
Czupalla, C.4
Michalke, M.5
Spicher, K.6
-
21
-
-
0345505745
-
-
Analysis of class, phosphoinositide 3-kinase autophosphorylation sites by mass spectrometry
-
Czupalla C, Nurnberg B, Krause E. Analysis of class | phosphoinositide 3-kinase autophosphorylation sites by mass spectrometry. Rapid Commun Mass Spectrom 2003;17:690-696.
-
(2003)
Rapid Commun Mass Spectrom
, vol.17
, pp. 690-696
-
-
Czupalla, C.1
Nurnberg, B.2
Krause, E.3
-
22
-
-
0036181869
-
PTEN: The down side of Pl 3-kinase signalling
-
Leslie NR, Downes CP. PTEN: the down side of Pl 3-kinase signalling. Cell Signal 2002;14:285-295.
-
(2002)
Cell Signal
, vol.14
, pp. 285-295
-
-
Leslie, N.R.1
Downes, C.P.2
-
23
-
-
44449171291
-
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress
-
Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH et al. Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc Res 2008;78: 505-514.
-
(2008)
Cardiovasc Res
, vol.78
, pp. 505-514
-
-
Oudit, G.Y.1
Kassiri, Z.2
Zhou, J.3
Liu, Q.C.4
Liu, P.P.5
Backx, P.H.6
-
24
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998;95:29-39.
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
Suzuki, A.2
de la Pompa, J.L.3
Brothers, G.M.4
Mirtsos, C.5
Sasaki, T.6
-
25
-
-
0038272084
-
Membrane-binding and activation mechanism of PTEN
-
Das S, Dixon JE, Cho W. Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sd USA 2003;100:7491 7496.
-
(2003)
Proc Natl Acad Sd USA
, vol.100
, pp. 7491-7496
-
-
Das, S.1
Dixon, J.E.2
Cho, W.3
-
26
-
-
2342631914
-
The tumoursuppressor function of PTEN requires an N-terminal lipid-binding motif
-
Walker SM, Leslie NR, Perera NM, Batty IH, Downes CP. The tumoursuppressor function of PTEN requires an N-terminal lipid-binding motif. Biochem J 2004;379:301 307.
-
(2004)
Biochem J
, vol.379
, pp. 301-307
-
-
Walker, S.M.1
Leslie, N.R.2
Perera, N.M.3
Batty, I.H.4
Downes, C.P.5
-
27
-
-
0141817911
-
Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate
-
Campbell RB, Liu F, Ross AH. Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate. J Biol Chem 2003;278: 33617-33620.
-
(2003)
J Biol Chem
, vol.278
, pp. 33617-33620
-
-
Campbell, R.B.1
Liu, F.2
Ross, A.H.3
-
29
-
-
0037036358
-
Reversible inactivation of the tumor suppressor PTEN by H202
-
Lee SR, Yang KS, Kwon J, Lee C, Jeong W, Rhee SG. Reversible inactivation of the tumor suppressor PTEN by H202. J Biol Chem 2002; 277: 20336-20342.
-
(2002)
J Biol Chem
, vol.277
, pp. 20336-20342
-
-
Lee, S.R.1
Yang, K.S.2
Kwon, J.3
Lee, C.4
Jeong, W.5
Rhee, S.G.6
-
30
-
-
13044305289
-
-
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J et al. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA 1999;96:6199-6204.
-
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J et al. PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA 1999;96:6199-6204.
-
-
-
-
31
-
-
0035929596
-
The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival
-
Schwartzbauer G, Robbins J. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J Biol Chem 2001 ;276:35786- 35793.
-
(2001)
J Biol Chem
, vol.276
, pp. 35786-35793
-
-
Schwartzbauer, G.1
Robbins, J.2
-
32
-
-
0037192768
-
PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects
-
Huang J, Kontos CD. PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. J Biol Chem 2002; 277:10760-10766.
-
(2002)
J Biol Chem
, vol.277
, pp. 10760-10766
-
-
Huang, J.1
Kontos, C.D.2
-
33
-
-
0036550053
-
3'-phosphoinositide-dependent kinase-1 (PDK-1) in Pl 3-kinase signaling
-
Storz P, Toker A. 3'-phosphoinositide-dependent kinase-1 (PDK-1) in Pl 3-kinase signaling. Front Biosci 2002;7:d886-d902.
-
(2002)
Front Biosci
, vol.7
-
-
Storz, P.1
Toker, A.2
-
34
-
-
0141737071
-
-
Mora A, Davies AM, Bertrand L, Sharif |, Budas GR, Jovanovic S et al. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J 2003;22:4666-4676.
-
Mora A, Davies AM, Bertrand L, Sharif |, Budas GR, Jovanovic S et al. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J 2003;22:4666-4676.
-
-
-
-
35
-
-
0032881288
-
-
Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 1999; 68:965-1014.
-
Chan TO, Rittenhouse SE, Tsichlis PN. AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 1999; 68:965-1014.
-
-
-
-
36
-
-
1542328927
-
Structure, regulation and function of PKB/AKT a major therapeutic target
-
Hanada M, Feng J, Hemmings BA. Structure, regulation and function of PKB/AKT a major therapeutic target. Biochim Biophys Acta 2004; 1697: 3-16.
-
(2004)
Biochim Biophys Acta
, vol.1697
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
37
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
38
-
-
0036849331
-
PKB binding proteins. Getting in on the Akt
-
Brazil DP, Park J, Hemmings BA. PKB binding proteins. Getting in on the Akt. Cell 2002;111:293-303.
-
(2002)
Cell
, vol.111
, pp. 293-303
-
-
Brazil, D.P.1
Park, J.2
Hemmings, B.A.3
-
39
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296: 1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
40
-
-
0037383322
-
GSK-3: Tricks of the trade for a multi-tasking kinase
-
Doble BW, Woodgett JR. GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sd 2003;116:1175-1186.
-
(2003)
J Cell Sd
, vol.116
, pp. 1175-1186
-
-
Doble, B.W.1
Woodgett, J.R.2
-
41
-
-
33845703636
-
Akt2 regulates cardiac metabolism and cardiomyocyte survival
-
DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem 2006;281:32841-32851.
-
(2006)
J Biol Chem
, vol.281
, pp. 32841-32851
-
-
DeBosch, B.1
Sambandam, N.2
Weinheimer, C.3
Courtois, M.4
Muslin, A.J.5
-
42
-
-
33646449520
-
Akt1 is required for physiological cardiac growth
-
DeBosch B, Treskov I, Lupu TS, Weinheimer C, KovacsA, Courtois M et al. Akt1 is required for physiological cardiac growth. Circulation 2006; 113: 2097-2104.
-
(2006)
Circulation
, vol.113
, pp. 2097-2104
-
-
DeBosch, B.1
Treskov, I.2
Lupu, T.S.3
Weinheimer, C.4
Kovacs, A.5
Courtois, M.6
-
43
-
-
12144291084
-
-
Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi | et al. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res 2004;94:514-524.
-
Torella D, Rota M, Nurzynska D, Musso E, Monsen A, Shiraishi | et al. Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res 2004;94:514-524.
-
-
-
-
44
-
-
33747386867
-
Effects of Akt on cardiac myocytes: Location counts
-
Catalucci D, Condorelli G. Effects of Akt on cardiac myocytes: location counts. Circ Res 2006;99:339-341.
-
(2006)
Circ Res
, vol.99
, pp. 339-341
-
-
Catalucci, D.1
Condorelli, G.2
-
45
-
-
0036200937
-
Akt/protein kinase B promotes organ growth in transgenic mice
-
Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF et al. Akt/protein kinase B promotes organ growth in transgenic mice. Mol CellBiol 2002;22:2799-2809.
-
(2002)
Mol CellBiol
, vol.22
, pp. 2799-2809
-
-
Shioi, T.1
McMullen, J.R.2
Kang, P.M.3
Douglas, P.S.4
Obata, T.5
Franke, T.F.6
-
46
-
-
0037125980
-
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
-
Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, laccarino G et al. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci USA 2002;99:12333- 12338.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12333-12338
-
-
Condorelli, G.1
Drusco, A.2
Stassi, G.3
Bellacosa, A.4
Roncarati, R.5
laccarino, G.6
-
47
-
-
0037151101
-
Transcriptional effects of chronic Akt activation in the heart
-
Cook SA, Matsui T, Li L, Rosenzweig A. Transcriptional effects of chronic Akt activation in the heart. J Biol Chem 2002;277:22528 22533.
-
(2002)
J Biol Chem
, vol.277
, pp. 22528-22533
-
-
Cook, S.A.1
Matsui, T.2
Li, L.3
Rosenzweig, A.4
-
48
-
-
0037151104
-
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
-
Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH et al. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem 2002;277:22896 22901.
-
(2002)
J Biol Chem
, vol.277
, pp. 22896-22901
-
-
Matsui, T.1
Li, L.2
Wu, J.C.3
Cook, S.A.4
Nagoshi, T.5
Picard, M.H.6
-
49
-
-
10744225737
-
Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt
-
Kim YK, Kim SJ, Yatani A, Huang Y, Castelli G, Vatner DE et al. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J Biol Chem 2003;278:47622-47628.
-
(2003)
J Biol Chem
, vol.278
, pp. 47622-47628
-
-
Kim, Y.K.1
Kim, S.J.2
Yatani, A.3
Huang, Y.4
Castelli, G.5
Vatner, D.E.6
-
50
-
-
1842841258
-
Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts
-
Gross ER, Hsu AK, Gross GJ. Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res 2004;94:960-966.
-
(2004)
Circ Res
, vol.94
, pp. 960-966
-
-
Gross, E.R.1
Hsu, A.K.2
Gross, G.J.3
-
51
-
-
40349098058
-
Glycogen synthase kinase 3 (GSK3) in the heart: A point of integration in hypertrophic signalling and a therapeutic target? A critical analysis
-
Sugden PH, Fuller SJ, Weiss SC, Clerk A. Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis. Sr J Pharmacol 2008; 153(Suppl. 1):S137-S153.
-
(2008)
Sr J Pharmacol
, vol.153
, Issue.SUPPL. 1
-
-
Sugden, P.H.1
Fuller, S.J.2
Weiss, S.C.3
Clerk, A.4
-
52
-
-
58549083120
-
-
Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B et al. Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci USA 2008; 105:20900 20905.
-
Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B et al. Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci USA 2008; 105:20900 20905.
-
-
-
-
53
-
-
0037154168
-
-
AntosCL, McKinsey TA, FreyN, KutschkeW, McAnally J, Shelton JM el. Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci USA 2002;99:907-912.
-
AntosCL, McKinsey TA, FreyN, KutschkeW, McAnally J, Shelton JM el. Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci USA 2002;99:907-912.
-
-
-
-
54
-
-
0037418939
-
Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter
-
Sanbe A, Gulick J, Hanks MC, Liang Q, Osinska H, Robbins J. Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res 2003;92:609-616.
-
(2003)
Circ Res
, vol.92
, pp. 609-616
-
-
Sanbe, A.1
Gulick, J.2
Hanks, M.C.3
Liang, Q.4
Osinska, H.5
Robbins, J.6
-
55
-
-
0034644525
-
-
Schmelzte T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253 262.
-
Schmelzte T, Hall MN. TOR, a central controller of cell growth. Cell 2000;103:253 262.
-
-
-
-
57
-
-
0033604521
-
Ribosomal S6 kinase signaling and the control of translation
-
Dufner A, Thomas G. Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res 1999;253:100-109.
-
(1999)
Exp Cell Res
, vol.253
, pp. 100-109
-
-
Dufner, A.1
Thomas, G.2
-
58
-
-
0037382861
-
Rapamycin attenuates load-induced cardiac hypertrophy in mice
-
Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ et al. Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 2003;107:1664-1670.
-
(2003)
Circulation
, vol.107
, pp. 1664-1670
-
-
Shioi, T.1
McMullen, J.R.2
Tarnavski, O.3
Converso, K.4
Sherwood, M.C.5
Manning, W.J.6
-
59
-
-
0032538890
-
-
Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC. Disruption of the p70(s6 k)/p85(s6 k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMSO J 1998; 17:6649 6659.
-
Shima H, Pende M, Chen Y, Fumagalli S, Thomas G, Kozma SC. Disruption of the p70(s6 k)/p85(s6 k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMSO J 1998; 17:6649 6659.
-
-
-
-
60
-
-
3042707485
-
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy
-
McMullen JR, Shioi T, Zhang L, Tarnavski O, Sherwood MC, Dorfman AL et al. Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Mol Cell Biol 2004;24: 6231-6240.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6231-6240
-
-
McMullen, J.R.1
Shioi, T.2
Zhang, L.3
Tarnavski, O.4
Sherwood, M.C.5
Dorfman, A.L.6
-
61
-
-
0034623819
-
The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase
-
Chesley A, Lundberg MS, Asai T, Xiao RP, Ohtani S, Lakatta EG et al. The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3'-kinase. Circ Res 2000;87:1172-1179.
-
(2000)
Circ Res
, vol.87
, pp. 1172-1179
-
-
Chesley, A.1
Lundberg, M.S.2
Asai, T.3
Xiao, R.P.4
Ohtani, S.5
Lakatta, E.G.6
-
62
-
-
37349123107
-
Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway
-
Kim KH, Oudit GY, Backx PH. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent pathway. J Pharmacol Exp Ther 2008;324:160 169.
-
(2008)
J Pharmacol Exp Ther
, vol.324
, pp. 160-169
-
-
Kim, K.H.1
Oudit, G.Y.2
Backx, P.H.3
-
63
-
-
0037310664
-
Physiological functions of Pten in mouse tissues
-
Kishimoto H, Hamada K, Saunders M, Backman S, Sasaki T, Nakano T et al. Physiological functions of Pten in mouse tissues. Cell Struct Funct 2003;28:11-21.
-
(2003)
Cell Struct Funct
, vol.28
, pp. 11-21
-
-
Kishimoto, H.1
Hamada, K.2
Saunders, M.3
Backman, S.4
Sasaki, T.5
Nakano, T.6
-
64
-
-
0034213075
-
-
Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, Lawitts J et al. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMSO J 2000; 19:2537-2548.
-
Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, Lawitts J et al. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMSO J 2000; 19:2537-2548.
-
-
-
-
65
-
-
0034681226
-
Gbetagammadependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy
-
Naga Prasad SV, Esposito G, Mao L, Koch WJ, Rockman HA. Gbetagammadependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. J Biol Chem 2000;275:4693-4698.
-
(2000)
J Biol Chem
, vol.275
, pp. 4693-4698
-
-
Naga Prasad, S.V.1
Esposito, G.2
Mao, L.3
Koch, W.J.4
Rockman, H.A.5
-
66
-
-
0142027759
-
Phosphoinositide 3-kinase(p1 IOalpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
-
McMullen JR, Shioi T, Zhang L, Tarnavski O, Sherwood MC, Kang PM et al. Phosphoinositide 3-kinase(p1 IOalpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci USA 2003;100:12355-12360.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12355-12360
-
-
McMullen, J.R.1
Shioi, T.2
Zhang, L.3
Tarnavski, O.4
Sherwood, M.C.5
Kang, P.M.6
-
67
-
-
4344714889
-
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
-
Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M et al. PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 2004;118:375-387.
-
(2004)
Cell
, vol.118
, pp. 375-387
-
-
Patrucco, E.1
Notte, A.2
Barberis, L.3
Selvetella, G.4
Maffei, A.5
Brancaccio, M.6
-
68
-
-
0034705239
-
Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes
-
Pham FH, Sugden PH, Clerk A. Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circ Res 2000;86:1252 1258.
-
(2000)
Circ Res
, vol.86
, pp. 1252-1258
-
-
Pham, F.H.1
Sugden, P.H.2
Clerk, A.3
-
69
-
-
33846318098
-
Protective effects of exercise and phosphoinositide 3-kinase(p1 IOalpha) signaling in dilated and hypertrophic cardiomyopathy
-
McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA et al. Protective effects of exercise and phosphoinositide 3-kinase(p1 IOalpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sd USA 2007;104:612 617.
-
(2007)
Proc Natl Acad Sd USA
, vol.104
, pp. 612-617
-
-
McMullen, J.R.1
Amirahmadi, F.2
Woodcock, E.A.3
Schinke-Braun, M.4
Bouwman, R.D.5
Hewitt, K.A.6
-
70
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 2001;276:38349-38352.
-
(2001)
J Biol Chem
, vol.276
, pp. 38349-38352
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
71
-
-
85047693926
-
Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure
-
Nienaber JJ, Tachibana H, Naga Prasad SV, Esposito G, Wu D, Mao L et al. Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure. J Clin Invest 2003;112:1067-1079.
-
(2003)
J Clin Invest
, vol.112
, pp. 1067-1079
-
-
Nienaber, J.J.1
Tachibana, H.2
Naga Prasad, S.V.3
Esposito, G.4
Wu, D.5
Mao, L.6
-
72
-
-
37349012900
-
-
Oudit GY, Kassiri Z. Role of PI3 kinase gamma in excitation contraction coupling and heart disease. Cardiovasc Hematol Disord Drug Targets 2007;7:295-304. 73. Houslay MD, Baillie GS, Maurice DH. cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ Res 2007;100:950-966.
-
Oudit GY, Kassiri Z. Role of PI3 kinase gamma in excitation contraction coupling and heart disease. Cardiovasc Hematol Disord Drug Targets 2007;7:295-304. 73. Houslay MD, Baillie GS, Maurice DH. cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ Res 2007;100:950-966.
-
-
-
-
73
-
-
0038464639
-
Phospholamban: A crucial regulator of cardiac contractility
-
MacLennan DH, Kranias EG. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 2003;4:566 577.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 566-577
-
-
MacLennan, D.H.1
Kranias, E.G.2
-
74
-
-
34547959389
-
-
Kerfant BG, Zhao D, Lorenzen-Schmidt |, Wilson LS, Cai S, Chen SR et al. PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circ Res 2007; 101:400 408.
-
Kerfant BG, Zhao D, Lorenzen-Schmidt |, Wilson LS, Cai S, Chen SR et al. PI3Kgamma is required for PDE4, not PDE3, activity in subcellular microdomains containing the sarcoplasmic reticular calcium ATPase in cardiomyocytes. Circ Res 2007; 101:400 408.
-
-
-
-
75
-
-
0037067463
-
Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation
-
Jo SH, Leblais V, Wang PH, Crow MT, Xiao RP. Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent G(s) signaling during beta2-adrenergic stimulation. Circ Res 2002;91:46-53.
-
(2002)
Circ Res
, vol.91
, pp. 46-53
-
-
Jo, S.H.1
Leblais, V.2
Wang, P.H.3
Crow, M.T.4
Xiao, R.P.5
-
76
-
-
10744230726
-
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility
-
Alloatti G, Levi R, Malan D, Del Sorbo L, Bosco O, Barberis L et al. Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. Cardiovasc Res 2003;60:242-249.
-
(2003)
Cardiovasc Res
, vol.60
, pp. 242-249
-
-
Alloatti, G.1
Levi, R.2
Malan, D.3
Del Sorbo, L.4
Bosco, O.5
Barberis, L.6
-
77
-
-
0037050009
-
Seven-transmembrane-spanning receptors and heart function
-
Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature 2002;415:206-212.
-
(2002)
Nature
, vol.415
, pp. 206-212
-
-
Rockman, H.A.1
Koch, W.J.2
Lefkowitz, R.J.3
-
78
-
-
57049126282
-
Temporally controlled overexpression of cardiac-specific PI3Kalpha induces enhanced myocardial contractility a new transgenic model
-
Yano N, Tseng A, Zhao TC, Robbins J, Padbury JF, Tseng YT. Temporally controlled overexpression of cardiac-specific PI3Kalpha induces enhanced myocardial contractility a new transgenic model. Am J Physiol Heart Circ Physiol 2008;295:H1690-H1694.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.295
-
-
Yano, N.1
Tseng, A.2
Zhao, T.C.3
Robbins, J.4
Padbury, J.F.5
Tseng, Y.T.6
-
79
-
-
0037423666
-
Insulin-like growth factor-1 exerts Ca2 dependent positive inotropic effects in failing human myocardium
-
von Lewinski D, Voss K, Hulsmann S, Kogler H, Pieske B. Insulin-like growth factor-1 exerts Ca2 dependent positive inotropic effects in failing human myocardium. Circ Res 2003;92:169 176.
-
(2003)
Circ Res
, vol.92
, pp. 169-176
-
-
von Lewinski, D.1
Voss, K.2
Hulsmann, S.3
Kogler, H.4
Pieske, B.5
-
80
-
-
33745387361
-
-
Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2 currents via increased P|3Kalpha/PKB signaling
-
Sun H, Kerfant BG, Zhao D, Trivieri MG, Oudit GY, Penninger JM et al. Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2 currents via increased P|3Kalpha/PKB signaling. Circ Res 2006; 98:1390-1397.
-
(2006)
Circ Res
, vol.98
, pp. 1390-1397
-
-
Sun, H.1
Kerfant, B.G.2
Zhao, D.3
Trivieri, M.G.4
Oudit, G.Y.5
Penninger, J.M.6
-
81
-
-
0035802119
-
Protein kinase B phosphorylates AHNAK and regulates its subcellular localization
-
Sussman J, Stokoe D, Ossina N, Shtivelman E. Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. J Cell Biol 2001 ; 154:1019-1030.
-
(2001)
J Cell Biol
, vol.154
, pp. 1019-1030
-
-
Sussman, J.1
Stokoe, D.2
Ossina, N.3
Shtivelman, E.4
-
82
-
-
0036325857
-
The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2 channels and the actin-based cytoskeleton
-
Hohaus A, Person V, Behlke J, Schaper J, Morano I, Haase H. The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2 channels and the actin-based cytoskeleton. FASEB J 2002; 16:1205-1216.
-
(2002)
FASEB J
, vol.16
, pp. 1205-1216
-
-
Hohaus, A.1
Person, V.2
Behlke, J.3
Schaper, J.4
Morano, I.5
Haase, H.6
-
83
-
-
0347381131
-
Signaling mechanisms that mediate nitric oxide production induced by acetylcholine exposure and withdrawal in cat atrial myocytes
-
Dedkova EN, JiX, Wang YG, Blatter LA, Lipsius SL. Signaling mechanisms that mediate nitric oxide production induced by acetylcholine exposure and withdrawal in cat atrial myocytes. Circ Res 2003;93:1233-1240.
-
(2003)
Circ Res
, vol.93
, pp. 1233-1240
-
-
Dedkova, E.N.1
Ji, X.2
Wang, Y.G.3
Blatter, L.A.4
Lipsius, S.L.5
-
84
-
-
0037071897
-
Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies
-
Lopes CM, Zhang H, Rohacs T, Jin T, Yang J, Logothetis DE. Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Neuron 2002;34:933-944.
-
(2002)
Neuron
, vol.34
, pp. 933-944
-
-
Lopes, C.M.1
Zhang, H.2
Rohacs, T.3
Jin, T.4
Yang, J.5
Logothetis, D.E.6
-
85
-
-
0037448440
-
Normal function of HERG K channels expressed in HEK293 cells requires basal protein kinase B activity
-
Zhang Y, Wang H, Wang J, Han H, Nattel S, Wang Z. Normal function of HERG K channels expressed in HEK293 cells requires basal protein kinase B activity. FEBS Lett 2003;534:125-132.
-
(2003)
FEBS Lett
, vol.534
, pp. 125-132
-
-
Zhang, Y.1
Wang, H.2
Wang, J.3
Han, H.4
Nattel, S.5
Wang, Z.6
-
86
-
-
0141925771
-
Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart
-
Kovacic S, Soltys CL, Barr AJ, Shiojima I, Walsh K, Dyck JR. Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart. J Biot Chem 2003;278:39422-39427.
-
(2003)
J Biot Chem
, vol.278
, pp. 39422-39427
-
-
Kovacic, S.1
Soltys, C.L.2
Barr, A.J.3
Shiojima, I.4
Walsh, K.5
Dyck, J.R.6
-
87
-
-
34548850040
-
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy
-
O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J et al. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab 2007;6:294-306.
-
(2007)
Cell Metab
, vol.6
, pp. 294-306
-
-
O'Neill, B.T.1
Kim, J.2
Wende, A.R.3
Theobald, H.A.4
Tuinei, J.5
Buchanan, J.6
-
89
-
-
0347381135
-
Akt, and mechanotransduction in the cardiac myocyte
-
Sugden PH. Ras, Akt, and mechanotransduction in the cardiac myocyte. Circ Res 2003;93:1179-1192.
-
(2003)
Circ Res
, vol.93
, pp. 1179-1192
-
-
Ras, S.P.H.1
-
90
-
-
0034653639
-
Molecular mechanisms of contraction-regulated cardiac glucose transport
-
Till M, Ouwens DM, Kessler A, Eckel J. Molecular mechanisms of contraction-regulated cardiac glucose transport. Biochem J 2000; 346: 841-847.
-
(2000)
Biochem J
, vol.346
, pp. 841-847
-
-
Till, M.1
Ouwens, D.M.2
Kessler, A.3
Eckel, J.4
-
91
-
-
10744230103
-
Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: Myocardial mechanotransduction-sensitivity as a possible molecular mechanism
-
Baba HA, Stypmann J, Grabellus F, Kirchhof P, Sokoll A, Schafers M et al. Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism. Cardiovasc Res 2003;59:390-399.
-
(2003)
Cardiovasc Res
, vol.59
, pp. 390-399
-
-
Baba, H.A.1
Stypmann, J.2
Grabellus, F.3
Kirchhof, P.4
Sokoll, A.5
Schafers, M.6
-
92
-
-
23644439061
-
-
Shiojima |, Sato K, Izumiya Y, SchiekoferS, ItoM, Liao R et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 2005;115:2108-2118.
-
Shiojima |, Sato K, Izumiya Y, SchiekoferS, ItoM, Liao R et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 2005;115:2108-2118.
-
-
-
-
93
-
-
33845711358
-
Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
-
Shiojima I, Walsh K. Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes Dev 2006;20: 3347 3365.
-
(2006)
Genes Dev
, vol.20
, pp. 3347-3365
-
-
Shiojima, I.1
Walsh, K.2
-
94
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlesinger J. Cell signaling by receptor tyrosine kinases. Cell 2000; 103:211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlesinger, J.1
-
95
-
-
0347991871
-
Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: Role in absorption and differentiation
-
Li X, Leu S, Cheong A, Zhang H, Baibakov B, Shih C et al. Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation. Gastroenterology 2004;126:122-135.
-
(2004)
Gastroenterology
, vol.126
, pp. 122-135
-
-
Li, X.1
Leu, S.2
Cheong, A.3
Zhang, H.4
Baibakov, B.5
Shih, C.6
-
96
-
-
0036644058
-
Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation
-
Birle D, Bottini N, Williams S, Huynh H, deBelle I, Adamson E et al. Negative feedback regulation of the tumor suppressor PTEN by phosphoinositide-induced serine phosphorylation. J Immunol 2002; 169:286-291.
-
(2002)
J Immunol
, vol.169
, pp. 286-291
-
-
Birle, D.1
Bottini, N.2
Williams, S.3
Huynh, H.4
deBelle, I.5
Adamson, E.6
-
97
-
-
0141994730
-
Src family proteintyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKTcascades
-
Lu Y, Yu Q, Liu JH, Zhang J, Wang H, Koul D et al. Src family proteintyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKTcascades. J Biot Chem 2003;278:40057-40066.
-
(2003)
J Biot Chem
, vol.278
, pp. 40057-40066
-
-
Lu, Y.1
Yu, Q.2
Liu, J.H.3
Zhang, J.4
Wang, H.5
Koul, D.6
-
98
-
-
0141751749
-
Preconditioning the myocardium: From cellular physiology to clinical cardiology
-
Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 2003;83:1113 1151.
-
(2003)
Physiol Rev
, vol.83
, pp. 1113-1151
-
-
Yellon, D.M.1
Downey, J.M.2
-
99
-
-
0042330513
-
Preconditioning: Is the Akt-ion in the PI3K pathway?
-
Murphy E, Tong H, Steenbergen C. Preconditioning: is the Akt-ion in the PI3K pathway? J Mol Cell Cardiol 2003;35:1021-1025.
-
(2003)
J Mol Cell Cardiol
, vol.35
, pp. 1021-1025
-
-
Murphy, E.1
Tong, H.2
Steenbergen, C.3
-
100
-
-
53249113791
-
Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
-
Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S et al. Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res 2008; 103: 643-653.
-
(2008)
Circ Res
, vol.103
, pp. 643-653
-
-
Ban, K.1
Cooper, A.J.2
Samuel, S.3
Bhatti, A.4
Patel, M.5
Izumo, S.6
-
101
-
-
34250746978
-
Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery
-
Arab S, Konstantinov IE, Boscarino C, Cukerman E, Mori A, Li J et al. Early gene expression profiles during intraoperative myocardial ischemia-reperfusion in cardiac surgery. J Thorac Cardiovasc Surg 2007;134:74-81.
-
(2007)
J Thorac Cardiovasc Surg
, vol.134
, pp. 74-81
-
-
Arab, S.1
Konstantinov, I.E.2
Boscarino, C.3
Cukerman, E.4
Mori, A.5
Li, J.6
-
102
-
-
0036623989
-
PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning
-
Mocanu MM, Bell RM, Yellon DM. PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning. J Mol Cell Cardiol 2002;34:661-668.
-
(2002)
J Mol Cell Cardiol
, vol.34
, pp. 661-668
-
-
Mocanu, M.M.1
Bell, R.M.2
Yellon, D.M.3
-
103
-
-
0042410540
-
Second window of protection following myocardial preconditioning: An essential role for PI3 kinase and p70S6 kinase
-
Kis A, Yellon DM, Baxter GF. Second window of protection following myocardial preconditioning: an essential role for PI3 kinase and p70S6 kinase. J Mol Cell Cardiol 2003;35:1063 1071.
-
(2003)
J Mol Cell Cardiol
, vol.35
, pp. 1063-1071
-
-
Kis, A.1
Yellon, D.M.2
Baxter, G.F.3
-
104
-
-
0037040856
-
Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3- kinase-dependent pathway is cardioprotective
-
Tong H, lmahashi K, Steenbergen C, Murphy E. Phosphorylation of glycogen synthase kinase-3beta during preconditioning through a phosphatidylinositol-3- kinase-dependent pathway is cardioprotective. Circ Res 2002; 90:377 379.
-
(2002)
Circ Res
, vol.90
, pp. 377-379
-
-
Tong, H.1
lmahashi, K.2
Steenbergen, C.3
Murphy, E.4
-
105
-
-
0035970539
-
Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1
-
Yamashita K, Kajstura J, Discher DJ, Wasserlauf BJ, Bishopric NH, Anversa P et al. Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1. Circ Res 2001;88:609-614.
-
(2001)
Circ Res
, vol.88
, pp. 609-614
-
-
Yamashita, K.1
Kajstura, J.2
Discher, D.J.3
Wasserlauf, B.J.4
Bishopric, N.H.5
Anversa, P.6
-
106
-
-
33748177384
-
Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway
-
Zhu M, Feng J, Lucchinetti E, Fischer G, Xu L, Pedrazzini T et al. Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc Res 2006;72:152-162.
-
(2006)
Cardiovasc Res
, vol.72
, pp. 152-162
-
-
Zhu, M.1
Feng, J.2
Lucchinetti, E.3
Fischer, G.4
Xu, L.5
Pedrazzini, T.6
-
107
-
-
33845225092
-
Protective effects of erythropoietin in cardiac ischemia: From bench to bedside
-
Lipsic E, Schoemaker RG, van der Meer P, Voors AA, van Veldhuisen DJ, van Gilst WH. Protective effects of erythropoietin in cardiac ischemia: from bench to bedside. J Am Coll Cardiol 2006;48:2161-2167.
-
(2006)
J Am Coll Cardiol
, vol.48
, pp. 2161-2167
-
-
Lipsic, E.1
Schoemaker, R.G.2
van der Meer, P.3
Voors, A.A.4
van Veldhuisen, D.J.5
van Gilst, W.H.6
-
108
-
-
33644687454
-
PTEN activity is modulated during ischemia and reperfusion: Involvement in the induction and decay of preconditioning
-
Cai Z, Semenza GL. PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning. Circ Res 2005; 97:1351 -1359.
-
(2005)
Circ Res
, vol.97
, pp. 1351-1359
-
-
Cai, Z.1
Semenza, G.L.2
-
109
-
-
53949106975
-
Ischemia-reperfusion injury and cardioprotection: Investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency
-
Siddall HK, Warrell CE, Yellon DM, Mocanu MM. Ischemia-reperfusion injury and cardioprotection: investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency. Basic Res Cardiol 2008;103:560 568.
-
(2008)
Basic Res Cardiol
, vol.103
, pp. 560-568
-
-
Siddall, H.K.1
Warrell, C.E.2
Yellon, D.M.3
Mocanu, M.M.4
-
110
-
-
0037304190
-
Impaired cardiac function and IGF-I response in myocytes from calmodulindiabetic mice: Role of Akt and RhoA
-
Duan J, Zhang HY, Adkins SD, Ren BH, Norby FL, Zhang X et al. Impaired cardiac function and IGF-I response in myocytes from calmodulindiabetic mice: role of Akt and RhoA. Am J Physiol Endocrinol Metab 2003;284:E366-E376.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
-
-
Duan, J.1
Zhang, H.Y.2
Adkins, S.D.3
Ren, B.H.4
Norby, F.L.5
Zhang, X.6
-
111
-
-
0036772579
-
Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth
-
Taniyama Y, Walsh K. Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth. J Mol Cell Cardiol 2002;34:1241 1247.
-
(2002)
J Mol Cell Cardiol
, vol.34
, pp. 1241-1247
-
-
Taniyama, Y.1
Walsh, K.2
-
112
-
-
0141796313
-
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
-
Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS et al. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003;9: 1195-1201.
-
(2003)
Nat Med
, vol.9
, pp. 1195-1201
-
-
Mangi, A.A.1
Noiseux, N.2
Kong, D.3
He, H.4
Rezvani, M.5
Ingwall, J.S.6
-
113
-
-
13844253989
-
Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors
-
Kassiri Z, Khokha R. Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors. Thromb Haemost 2005;93: 212-219.
-
(2005)
Thromb Haemost
, vol.93
, pp. 212-219
-
-
Kassiri, Z.1
Khokha, R.2
-
114
-
-
33749438378
-
Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling
-
Curcio A, Noma T, Naga Prasad SV, Wolf MJ, Lemaire A, Perrino C et al. Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. Am J Physiol Heart Circ Physiol 2006;291: H1754-H1760.
-
(2006)
Am J Physiol Heart Circ Physiol
, vol.291
-
-
Curcio, A.1
Noma, T.2
Naga Prasad, S.V.3
Wolf, M.J.4
Lemaire, A.5
Perrino, C.6
-
115
-
-
41949113903
-
Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/AKT pathway
-
Kruger M, Sachse C, Zimmermann WH, Eschenhagen T, Klede S, Linke WA. Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/AKT pathway. Circ Res 2008; 102:439 447.
-
(2008)
Circ Res
, vol.102
, pp. 439-447
-
-
Kruger, M.1
Sachse, C.2
Zimmermann, W.H.3
Eschenhagen, T.4
Klede, S.5
Linke, W.A.6
-
116
-
-
44349119736
-
Angiogenesis selectively requires the p1 IOalpha isoform of PI3K to control endothelial cell migration
-
Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A et al. Angiogenesis selectively requires the p1 IOalpha isoform of PI3K to control endothelial cell migration. Nature 2008; 453:662 666.
-
(2008)
Nature
, vol.453
, pp. 662-666
-
-
Graupera, M.1
Guillermet-Guibert, J.2
Foukas, L.C.3
Phng, L.K.4
Cain, R.J.5
Salpekar, A.6
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