The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase

Advances in Enzyme Regulation

Volumn 44, Issue 1, 2004, Pages 279-298

  Perisic, Olga ^a   Wilson, Michael I ^a   Karathanassis, Dimitrios ^a   Bravo, Jerónimo ^b   Pacold, Michael E ^a   Ellson, Chris D ^c   Hawkins, Phillip T ^c   Stephens, Len ^c   Williams, Roger L ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONFERENCE PAPER; ENZYMOLOGY; HUMAN; METABOLISM; PHAGOCYTE; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MODELS, MOLECULAR; NADPH OXIDASE; PHAGOCYTES; PHOSPHATIDYLINOSITOLS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SUPEROXIDES;

ALLIUM CEPA;

EID: 9644259382     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.advenzreg.2003.11.003     Document Type: Conference Paper

References (96)

1. phox. J Biol Chem. 274:1999;33644-33653
2. Ago T., Takeya R., Hiroaki H., Kuribayashi F., Ito T., Kohda D., Sumimoto H. The PX domain as a novel phosphoinositide-binding module. Biochem Biophys Res Commun. 287:2001;733-738
3. phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation. Proc Natl Acad Sci USA. 100:2003;4474-4479
4. Ambruso D.R., Knall C., Abell A.N., Panepinto J., Kurkchubasche A., Thurman G., Gonzalez-Aller C., Hiester A., deBoer M., Harbeck R.J., Oyer R., Johnson G.L., Roos D. Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc Natl Acad Sci USA. 97:2000;4654-4659
5. Arcaro A., Wymann M.P. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor. the role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses Biochem J. 296:1993;297-301
6. Babior B.M. NADPH oxidase. an update Blood. 93:1999;1464-1476
7. Baggiolini M., Dewald B., Schnyder J., Ruch W., Cooper P.H., Payne T.G. Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogs. Exp Cell Res. 169:1987;408-418
8. Banfi B., Clark R.A., Steger K., Krause K.H. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 278:2003;3510-3513
9. Bokoch G.M., Diebold B.A. Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood. 100:2002;2692-2696
10. phox is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process. J Biol Chem. 273:1998;30097-30103
11. phox bound to phosphatidylinositol 3-phosphate. Mol Cell. 8:2001;829-839
12. Brown G.E., Stewart M.Q., Liu H., Hal V.-.L., Yaffe M.B. A novel assay system implicates PtdIns(3,4)P2, PtdIns(3)P, and PKCδ in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell. 11:2003;35-47
13. phox and mediates respiratory burst activity in human neutrophils. J Immunol. 170:2003;5302-5308
14. Chou M.M., Hou W., Johnson J., Graham L.K., Lee M.H., Chen C.S., Newton A.C., Schaffhausen B.S., Toker A. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol. 8:1998;1069-1077
15. 558. Biochem J. 349:2000;113-117
16. Cross A.R., Noack D., Rae J., Curnutte J.T., Heyworth P.G. Hematologically important mutations. the autosomal recessive forms of chronic granulomatous disease (first update) Blood Cells Mol Dis. 26:2000;561-565
17. phox and participates in formyl peptide-mediated neutrophil respiratory burst. J Immunol. 166:2001;1206-1213
18. Das B., Shu X., Day G.J., Han J., Krishna U.M., Falck J.R., Broek D. Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem. 275:2000;15074-15081
19. phox by a membrane-targeted phosphoinositide 3-kinase. Curr Biol. 6:1996;1271-1278
20. Diebold B.A., Bokoch G.M. Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol. 2:2001;211-215
21. Dinauer M.C. Regulation of neutrophil function by Rac GTPases. Curr Opin Hematol. 10:2003;8-15
22. phox during neutrophil activation. J Biol Chem. 269:1994;23431-23436
23. Ellson C.D., Anderson K.E., Morgan G., Chilvers E.R., Lipp P., Stephens L.R., Hawkins P.T. Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol. 11:2001;1631-1635
24. phox. Nat Cell Biol. 3:2001;679-682
25. Ellson C.D., Andrews S., Stephens L.R., Hawkins P.T. The PX domain. a new phosphoinositide-binding module J Cell Sci. 115:2002;1099-1105
26. phox, a subunit of the respiratory burst oxidase. Functions of the individual target serines as evaluated by site-directed mutagenesis. J Clin Invest. 96:1995;1499-1505
27. Finan P., Shimizu Y., Gout I., Hsuan J., Truong O., Butcher C., Bennett P., Waterfield M.D., Kellie S. An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex. J Biol Chem. 269:1994;13752-13755
28. Fleming I.N., Gray A., Downes C.P. Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem J. 351:2000;173-182
29. phox and on NADPH oxidase activation Biochemistry. 41:2002;7743-7750
30. Freeman J.L., Abo A., Lambeth J.D. Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65. J Biol Chem. 271:1996;19794-19801
31. phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem. 278:2003;20006-20012
32. Glogauer M., Marchal C.C., Zhu F., Worku A., Clausen B.E., Foerster I., Marks P., Downey G.P., Dinauer M., Kwiatkowski D.J. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol. 170:2003;5652-5657
33. phox. Structure at 1.8. Å resolution and biochemical characterizations of the A128V mutant implicated in chronic granulomatous disease J Biol Chem. 276:2001;21627-21631
34. Groemping Y., Lapouge K., Smerdon S.J., Rittinger K. Molecular basis of phosphorylation-induced activation of the NADPH oxidase. Cell. 113:2003;343-355
35. phox. J Biol Chem. 273:1998;16663-16668
36. Han J., Luby-Phelps K., Das B., Shu X., Xia Y., Mosteller R.D., Krishna U.M., Falck J.R., White M.A., Broek D. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science. 279:1998;558-560
37. Heyworth P.G., Cross A.R. Chronic granulomatous disease mutations and the PX domain. Nat Cell Biol. 4:2002;E110
38. 558. J Clin Invest. 87:1991;352-356
39. Heyworth P.G., Knaus U.G., Settleman J., Curnutte J.T., Bokoch G.M. Regulation of NADPH oxidase activity by Rac GTPase activating protein(s). Mol Biol Cell. 4:1993;1217-1223
40. Hiroaki H., Ago T., Ito T., Sumimoto H., Kohda D. Solution structure of the PX domain, a target of the SH3 domain. Nat Struct Biol. 8:2001;526-530
41. Hirsch E., Katanaev L., Garlanda C., Azzolino O., Pirola L., Silengo L., Sozzani S., Mantovani A., Altruda F., Wymann M.P. Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation. Science. 287:2000;1049-1053
42. phox activity by site-specific phosphorylation. Akt-dependent activation of the NADPH oxidase Proc Natl Acad Sci USA. 100:2003;5130-5135
43. phox. J Biol Chem. 274:1999;19731-19737
44. phox, a cytosolic subunit of the leukocyte NADPH oxidase - Phosphorylation of Ser-359 or Ser-370 precedes phosphorylation at other sites and is required for activity. J Biol Chem. 273:1998;35147-35152
45. phox, Grb2 and Pex13p. EMBO J. 21:2002;4268-4276
46. phox bind to lipid products of PI(3)K. Nat Cell Biol. 3:2001;675-678
47. phox to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction. EMBO J. 21:2002;5057-5068
48. Karlsson A., Dahlgren C. Assembly and activation of the neutrophil NADPH oxidase in granule membranes. Antioxid Redox Signal. 4:2002;49-60
49. Karlsson A., Nixon J.B., McPhail L.C. Phorbol myristate acetate induces neutrophil NADPH-oxidase activity by two separate signal transduction pathways. dependent or independent of phosphatidylinositol 3-kinase J Leukoc Biol. 67:2000;396-404
50. Kobayashi T., Robinson J.M., Seguchi H. Identification of intracellular sites of superoxide production in stimulated neutrophils. J Cell Sci. 111:1998;81-91
51. phox participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase. J Biol Chem. 274:1999;25051-25060
52. phox as a positive regulator of the superoxide-producing phagocyte oxidase. EMBO J. 21:2002;6312-6320
53. Kwong C.H., Adams A.G., Leto T.L. Characterization of the effector-specifying domain of Rac involved in NADPH oxidase activation. J Biol Chem. 270:1995;19868-19872
54. Lamark T., Perander M., Outzen H., Kristiansen K., Overvatn A., Michaelsen E., Bjorkoy G., Johansen T. Interaction codes within the family of mammalian PB1 domain-containing proteins. J Biol Chem,. 278:2003;34568-34581
55. Lambeth J.D. Nox/Duox family of nicotinamide adenine dinucleotide (phosphate) oxidases. Curr Opin Hematol. 9:2002;11-17
56. phox in complex with Rac·GTP. Mol Cell. 6:2000;899-907
57. Lassegue B., Clempus R.E. Vascular NAD(P)H oxidases. specific features, expression, and regulation Am J Physiol Regul Integr Comp Physiol. 285:2003;R277-R297
58. Le Good J.A., Ziegler W.H., Parekh D.B., Alessi D.R., Cohen P., Parker P.J. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 281:1998;2042-2045
59. Leslie N.R., Biondi R.M., Alessi D.R. Phosphoinositide-regulated kinases and phosphoinositide phosphatases. Chem Rev. 101:2001;2365-2380
60. Leto T.L., Adams A.G., de Mendez I. Assembly of the phagocyte NADPH oxidase. binding of Src homology 3 domains to proline-rich targets Proc Natl Acad Sci USA. 91:1994;10650-10654
61. Li Z., Jiang H., Xie W., Zhang Z., Smrcka A.V., Wu D. Roles of PLC-2 and -3 and PI3K in chemoattractant-mediated signal transduction. Science. 287:2000;1046-1049
62. Li S., Yamauchi A., Marchal C.C., Molitoris J.K., Quilliam L.A., Dinauer M.C. Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils. preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions J Immunol. 169:2002;5043-5051
63. Missy K., Van Poucke V., Raynal P., Viala C., Mauco G., Plantavid M., Chap H., Payrastre B. Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation. J Biol Chem. 273:1998;30279-30286
64. phox in the activation of neutrophil NADPH oxidase. Arch Biochem Biophys. 416:2003;92-100
65. phox, SH3 domain-containing cytosolic factors of the phagocyte NADPH oxidase Eur J Biochem. 251:1998;583-589
66. 558. J Biol Chem. 274:1999;22999-23005
67. phox component of phagocyte NADPH oxidase. Hum Genet. 105:1999;460-467
68. Noda Y., Koljima M., Izaki T., Ota K., Yoshinaga S., Inagaki F., Ito T., Sumimoto H. Molecular recognition in dimerization between PB1 domains. J Biol Chem. 278:2003;43516-43524
69. 558 liposomes by atomic force microscopy Biochemistry. 39:2000;9302-9310
70. Palicz A., Foubert T.R., Jesaitis A.J., Marodi L., McPhail L.C. Phosphatidic acid and diacylglycerol directly activate NADPH oxidase by interacting with enzyme components. J Biol Chem. 276:2001;3090-3097
71. Park J.W. Phosphatidic acid-induced translocation of cytosolic components in a cell-free system of NADPH oxidase. mechanism of activation and effect of diacylglycerol Biochem Biophys Res Commun. 229:1996;758-763
72. phox. Blood. 94:1999;2505-2514
73. phox mutants with unmasked SH3 (Src homology 3) domains. full reconstitution of oxidase activity in a semi-recombinant cell-free system lacking arachidonic acid Biochem J. 373:2003;221-229
74. Ponting C.P. Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases. binding partners of SH3 domains? Protein Sci. 5:1996;2353-2357
75. Price M.O., McPhail L.C., Lambeth J.D., Han C.H., Knaus U.G., Dinauer M.C. Creation of a genetic system for analysis of the phagocyte respiratory burst. high-level reconstitution of the NADPH oxidase in a nonhematopoietic system Blood. 99:2002;2653-2661
76. + flux. Nature. 416:2002;291-297
77. Roberts A.W., Kim C., Zhen L., Lowe J.B., Kapur R., Petryniak B., Spaetti A., Pollock J.D., Borneo J.B., Bradford G.B., Atkinson S.J., Dinauer M.C., Williams D.A. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 10:1999;183-196
78. Sasaki T., Irie-Sasaki J., Jones R.G., Oliveira-dos-Santos A.J., Stanford W.L., Bolon B., Wakeham A., Itie A., Bouchard D., Kozieradzki I., Joza N., Mak T.W., Ohashi P.S., Suzuki A., Penninger J.M. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration. Science. 287:2000;1040-1046
79. phox down-regulates NADPH oxidase activity through interactions with its SH3 domain. J Biol Chem. 272:1997;9141-9146
80. Shinohara M., Terada Y., Iwamatsu A., Shinohara A., Mochizuki N., Higuchi M., Gotoh Y., Ihara S., Nagata S., Itoh H., Fukui Y., Jessberger R. SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling. Nature. 416:2002;759-763
81. phox. J Biol Chem. 278:2003;14469-14479
82. phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem. 278:2003;25234-25246
83. Tamura M., Ogata K., Takeshita M. Phosphatidic acid-induced superoxide generation in electropermeabilized human neutrophils. Arch Biochem Biophys. 305:1993;477-482
84. Tao W., Filippi M.D., Bailey J.R., Atkinson S.J., Connors B., Evan A., Williams D.A. The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization. Blood. 100:2002;1679-1688
85. Vaissiere C., Le Cabec V. Maridonneau-Parini I. NADPH oxidase is functionally assembled in specific granules during activation of human neutrophils. J Leukoc Biol. 65:1999;629-634
86. Vieira O.V., Botelho R.J., Rameh L., Brachmann S.M., Matsuo T., Davidson H.W., Schreiber A., Backer J.M., Cantley L.C., Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J Cell Biol. 155:2001;19-25
87. Vignais P.V. The superoxide-generating NADPH oxidase. structural aspects and activation mechanism Cell Mol Life Sci. 59:2002;1428-1459
88. Welch H.C., Coadwell W.J., Ellson C.D., Ferguson G.J., Andrews S.R., Erdjument-Bromage H., Tempst P., Hawkins P.T., Stephens L.R. P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac. Cell. 108:2002;809-821
89. Welch H.C., Coadwell W.J., Stephens L.R., Hawkins P.T. Phosphoinositide 3-kinase-dependent activation of Rac. FEBS Lett. 546:2003;93-97
90. phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain Src homology 3 domains. Biochem J. 296:1993;557-561
91. phox bind to moesin through their PX domain. Biochem Biophys Res Commun. 289:2001;382-388
92. Wientjes F.B., Segal A.W. PX domain takes shape. Curr Opin Hematol. 10:2003;2-7
93. Wilson M.I., Gill D.J., Perisic O., Quinn M.T., Williams R.L. PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62. Mol Cell. 12:2003;39-50
94. phox PX domain. two heads are better than one! Structure (Camb). 10:2002;1288-1290
95. phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J Biol Chem. 277:2002;4512-4518
96. Zhao X., Carnevale K.A., Cathcart M.K. Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex. J Biol Chem,. 278:2003;40788-40792