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Volumn 73, Issue , 2014, Pages 383-399

Regulation of obesity and insulin resistance by nitric oxide

Author keywords

Diabetes; eNOS; Free radicals; Insulin resistance; Mitochondria; Nitric oxide; Obesity

Indexed keywords

GLUCOSE; INSULIN; LIPID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN;

EID: 84903541982     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.05.016     Document Type: Review
Times cited : (200)

References (358)
  • 1
    • 79957899067 scopus 로고    scopus 로고
    • Digging deeper into obesity
    • R.S. Ahima Digging deeper into obesity J. Clin. Invest. 121 2011 2076 2079
    • (2011) J. Clin. Invest. , vol.121 , pp. 2076-2079
    • Ahima, R.S.1
  • 3
    • 84865627930 scopus 로고    scopus 로고
    • Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006
    • R.B. Ervin Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003-2006 Natl. Health Stat. Rep. 13 2009 1 7
    • (2009) Natl. Health Stat. Rep. , vol.13 , pp. 1-7
    • Ervin, R.B.1
  • 6
    • 84891713745 scopus 로고    scopus 로고
    • The obesity epidemic: While America swallows $147 billion in obesity-related healthcare costs, physicians called on to confront the crisis
    • L. Zamosky The obesity epidemic: while America swallows $147 billion in obesity-related healthcare costs, physicians called on to confront the crisis Med. Econ 90 2013 14 17
    • (2013) Med. Econ , vol.90 , pp. 14-17
    • Zamosky, L.1
  • 7
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • Y.H. Tseng, A.M. Cypess, and C.R. Kahn Cellular bioenergetics as a target for obesity therapy Nat. Rev. Drug Discovery 9 2010 465 482
    • (2010) Nat. Rev. Drug Discovery , vol.9 , pp. 465-482
    • Tseng, Y.H.1    Cypess, A.M.2    Kahn, C.R.3
  • 8
    • 0347031460 scopus 로고    scopus 로고
    • Eating out in America, 1987-2000: Trends and nutritional correlates
    • DOI 10.1016/j.ypmed.2003.10.004
    • A.K. Kant, and B.I. Graubard Eating out in America, 1987-2000: trends and nutritional correlates Prev. Med. 38 2004 243 249 (Pubitemid 38050296)
    • (2004) Preventive Medicine , vol.38 , Issue.2 , pp. 243-249
    • Kant, A.K.1    Graubard, B.I.2
  • 10
    • 3142759931 scopus 로고    scopus 로고
    • Secular trends in dietary intake in the United States
    • DOI 10.1146/annurev.nutr.23.011702.073349
    • R.R. Briefel, and C.L. Johnson Secular trends in dietary intake in the United States Annu. Rev. Nutr. 24 2004 401 431 (Pubitemid 38938798)
    • (2004) Annual Review of Nutrition , vol.24 , pp. 401-431
    • Briefel, R.R.1    Johnson, C.L.2
  • 11
    • 0032577404 scopus 로고    scopus 로고
    • Environmental contributions to the obesity epidemic
    • DOI 10.1126/science.280.5368.1371
    • J.O. Hill, and J.C. Peters Environmental contributions to the obesity epidemic Science 280 1998 1371 1374 (Pubitemid 28264817)
    • (1998) Science , vol.280 , Issue.5368 , pp. 1371-1374
    • Hill, J.O.1    Peters, J.C.2
  • 12
    • 44449122886 scopus 로고    scopus 로고
    • Environmental pollution and diabetes: A neglected association
    • DOI 10.1016/S0140-6736(08)60147-6, PII S0140673608601476
    • O.A. Jones, M.L. Maguire, and J.L. Griffin Environmental pollution and diabetes: a neglected association Lancet 371 2008 287 288 (Pubitemid 351754775)
    • (2008) The Lancet , vol.371 , Issue.9609 , pp. 287-288
    • Jones, O.A.1    Maguire, M.L.2    Griffin, J.L.3
  • 13
    • 51349110146 scopus 로고    scopus 로고
    • Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years
    • A. Smink, N. Ribas-Fito, R. Garcia, M. Torrent, M.A. Mendez, J.O. Grimalt, and J. Sunyer Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years Acta Paediatr. 97 2008 1465 1469
    • (2008) Acta Paediatr. , vol.97 , pp. 1465-1469
    • Smink, A.1    Ribas-Fito, N.2    Garcia, R.3    Torrent, M.4    Mendez, M.A.5    Grimalt, J.O.6    Sunyer, J.7
  • 17
    • 80051488900 scopus 로고    scopus 로고
    • Enhanced insulin resistance in diet-induced obese rats exposed to fine particles by instillation
    • Y.H. Yan, C.C. Chou, C.T. Lee, J.Y. Liu, and T.J. Cheng Enhanced insulin resistance in diet-induced obese rats exposed to fine particles by instillation Inhalation Toxicol 23 2011 507 519
    • (2011) Inhalation Toxicol , vol.23 , pp. 507-519
    • Yan, Y.H.1    Chou, C.C.2    Lee, C.T.3    Liu, J.Y.4    Cheng, T.J.5
  • 18
    • 84868296575 scopus 로고    scopus 로고
    • Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner
    • J.L. Bolton, S.H. Smith, N.C. Huff, M.I. Gilmour, W.M. Foster, R.L. Auten, and S.D. Bilbo Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner FASEB J 26 2012 4743 4754
    • (2012) FASEB J , vol.26 , pp. 4743-4754
    • Bolton, J.L.1    Smith, S.H.2    Huff, N.C.3    Gilmour, M.I.4    Foster, W.M.5    Auten, R.L.6    Bilbo, S.D.7
  • 20
    • 84857699512 scopus 로고    scopus 로고
    • In utero exposure to maternal tobacco smoke and subsequent obesity, hypertension, and gestational diabetes among women in the MoBa cohort
    • L.A. Cupul-Uicab, R. Skjaerven, K. Haug, K.K. Melve, S.M. Engel, and M.P. Longnecker In utero exposure to maternal tobacco smoke and subsequent obesity, hypertension, and gestational diabetes among women in the MoBa cohort Environ. Health Perspect. 120 2012 355 360
    • (2012) Environ. Health Perspect. , vol.120 , pp. 355-360
    • Cupul-Uicab, L.A.1    Skjaerven, R.2    Haug, K.3    Melve, K.K.4    Engel, S.M.5    Longnecker, M.P.6
  • 22
    • 84856854408 scopus 로고    scopus 로고
    • Role of built environments in physical activity, obesity, and cardiovascular disease
    • J.F. Sallis, M.F. Floyd, D.A. Rodriguez, and B.E. Saelens Role of built environments in physical activity, obesity, and cardiovascular disease Circulation 125 2012 729 737
    • (2012) Circulation , vol.125 , pp. 729-737
    • Sallis, J.F.1    Floyd, M.F.2    Rodriguez, D.A.3    Saelens, B.E.4
  • 23
    • 80053380138 scopus 로고    scopus 로고
    • Neighborhood environment and physical activity among youth: A review
    • D. Ding, J.F. Sallis, J. Kerr, S. Lee, and D.E. Rosenberg Neighborhood environment and physical activity among youth: a review Am. J. Prevent. Med 41 2011 442 455
    • (2011) Am. J. Prevent. Med , vol.41 , pp. 442-455
    • Ding, D.1    Sallis, J.F.2    Kerr, J.3    Lee, S.4    Rosenberg, D.E.5
  • 24
    • 79954991697 scopus 로고    scopus 로고
    • A systematic review of built environment factors related to physical activity and obesity risk: Implications for smart growth urban planning
    • C.P. Durand, M. Andalib, G.F. Dunton, J. Wolch, and M.A. Pentz A systematic review of built environment factors related to physical activity and obesity risk: implications for smart growth urban planning Obes. Rev. 12 2011 e173 182
    • (2011) Obes. Rev. , vol.12 , pp. 173-182
    • Durand, C.P.1    Andalib, M.2    Dunton, G.F.3    Wolch, J.4    Pentz, M.A.5
  • 26
    • 78650174843 scopus 로고    scopus 로고
    • The chronobiology, etiology and pathophysiology of obesity
    • M. Garaulet, J.M. Ordovas, and J.A. Madrid The chronobiology, etiology and pathophysiology of obesity Int. J. Obes. 34 2010 1667 1683
    • (2010) Int. J. Obes. , vol.34 , pp. 1667-1683
    • Garaulet, M.1    Ordovas, J.M.2    Madrid, J.A.3
  • 27
    • 84896740388 scopus 로고    scopus 로고
    • Circadian clocks, food intake, and metabolism
    • E. Challet Circadian clocks, food intake, and metabolism Prog. Mol. Biol. Transl. Sci 119 2013 105 135
    • (2013) Prog. Mol. Biol. Transl. Sci , vol.119 , pp. 105-135
    • Challet, E.1
  • 28
    • 0028978913 scopus 로고
    • Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns
    • E. Widen, M. Lehto, T. Kanninen, J. Walston, A.R. Shuldiner, and L.C. Groop Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns N. Engl. J. Med. 333 1995 348 351
    • (1995) N. Engl. J. Med. , vol.333 , pp. 348-351
    • Widen, E.1    Lehto, M.2    Kanninen, T.3    Walston, J.4    Shuldiner, A.R.5    Groop, L.C.6
  • 30
    • 34548358843 scopus 로고    scopus 로고
    • The biological predisposition to obesity: Beyond the thrifty genotype scenario
    • DOI 10.1038/sj.ijo.0803610, PII 0803610
    • C. Bouchard The biological predisposition to obesity: beyond the thrifty genotype scenario Int. J. Obes. (London) 31 2007 1337 1339 (Pubitemid 47339919)
    • (2007) International Journal of Obesity , vol.31 , Issue.9 , pp. 1337-1339
    • Bouchard, C.1
  • 31
    • 72049098786 scopus 로고    scopus 로고
    • Thrift: A guide to thrifty genes, thrifty phenotypes and thrifty norms
    • J.C. Wells Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms Int. J. Obes. 33 2009 1331 1338
    • (2009) Int. J. Obes. , vol.33 , pp. 1331-1338
    • Wells, J.C.1
  • 32
    • 84887212384 scopus 로고    scopus 로고
    • Metabolic and behavioral compensations in response to caloric restriction: Implications for the maintenance of weight loss
    • L.M. Redman, L.K. Heilbronn, C.K. Martin, L. de Jonge, D.A. Williamson, J.P. Delany, and E Ravussin Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss PLoS One 4 2009 e4377
    • (2009) PLoS One , vol.4 , pp. 4377
    • Redman, L.M.1    Heilbronn, L.K.2    Martin, C.K.3    De Jonge, L.4    Williamson, D.A.5    Delany, J.P.6    Ravussin, E.7
  • 33
    • 0028959193 scopus 로고
    • Changes in energy expenditure resulting from altered body weight
    • R.L. Leibel, M. Rosenbaum, and J. Hirsch Changes in energy expenditure resulting from altered body weight N. Engl. J. Med. 332 1995 621 628
    • (1995) N. Engl. J. Med. , vol.332 , pp. 621-628
    • Leibel, R.L.1    Rosenbaum, M.2    Hirsch, J.3
  • 34
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • DOI 10.1016/S0092-8674(01)00240-9
    • B.M. Spiegelman, and J.S. Flier Obesity and the regulation of energy balance Cell 104 2001 531 543 (Pubitemid 32201948)
    • (2001) Cell , vol.104 , Issue.4 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 37
    • 0022873040 scopus 로고
    • Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
    • DOI 10.1016/0196-9781(86)90149-X
    • B.G. Stanley, S.E. Kyrkouli, S. Lampert, and S.F. Leibowitz Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity Peptides 7 1986 1189 1192 (Pubitemid 17226746)
    • (1986) Peptides , vol.7 , Issue.6 , pp. 1189-1192
    • Stanley, B.G.1    Kyrkouli, S.E.2    Lampert, S.3    Leibowitz, S.F.4
  • 38
    • 0028278034 scopus 로고
    • Neuropeptide y in hypothalamic paraventricular nucleus: A center coordinating energy metabolism
    • C.J. Billington, J.E. Briggs, S. Harker, M. Grace, and A.S. Levine Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism Am. J. Physiol. 266 1994 R1765 1770
    • (1994) Am. J. Physiol. , vol.266 , pp. 1765-1770
    • Billington, C.J.1    Briggs, J.E.2    Harker, S.3    Grace, M.4    Levine, A.S.5
  • 39
    • 84880605577 scopus 로고    scopus 로고
    • Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: Role in learning and memory
    • B. Beck, and G. Pourie Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory Nutr. Rev. 71 2013 541 561
    • (2013) Nutr. Rev. , vol.71 , pp. 541-561
    • Beck, B.1    Pourie, G.2
  • 40
    • 0034611784 scopus 로고    scopus 로고
    • Medicinal strategies in the treatment of obesity
    • G.A. Bray, and L.A. Tartaglia Medicinal strategies in the treatment of obesity Nature 404 2000 672 677 (Pubitemid 30205072)
    • (2000) Nature , vol.404 , Issue.6778 , pp. 672-677
    • Bray, G.A.1    Tartaglia, L.A.2
  • 41
    • 84890212884 scopus 로고    scopus 로고
    • Obesity drug therapy
    • M. Baretic Obesity drug therapy Minerva Endocrinol. 38 2013 245 254
    • (2013) Minerva Endocrinol. , vol.38 , pp. 245-254
    • Baretic, M.1
  • 44
    • 35848947008 scopus 로고    scopus 로고
    • Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: Experimental data
    • N.M. Delzenne, P.D. Cani, and A.M. Neyrinck Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data J. Nutr. 137 2007 2547S 2551S (Pubitemid 350058733)
    • (2007) Journal of Nutrition , vol.137 , Issue.11
    • Delzenne, N.M.1    Cani, P.D.2    Neyrinck, A.M.3
  • 46
    • 50949125411 scopus 로고    scopus 로고
    • The efficiency of cellular energy transduction and its implications for obesity
    • M.E. Harper, K. Green, and M.D. Brand The efficiency of cellular energy transduction and its implications for obesity Annu. Rev. Nutr. 28 2008 13 33
    • (2008) Annu. Rev. Nutr. , vol.28 , pp. 13-33
    • Harper, M.E.1    Green, K.2    Brand, M.D.3
  • 47
    • 64049089505 scopus 로고
    • Relationship between blood cholesterol and increased metabolism from dinitrophenol and thyroid
    • W.C. Cutting, D.A. Rytand, and M.L. Tainter Relationship between blood cholesterol and increased metabolism from dinitrophenol and thyroid J. Clin. Invest. 13 1934 547 552
    • (1934) J. Clin. Invest. , vol.13 , pp. 547-552
    • Cutting, W.C.1    Rytand, D.A.2    Tainter, M.L.3
  • 48
    • 0345379057 scopus 로고
    • Use of dinitrophenol in nutritional disorders: A critical survey of clinical results
    • M.L. Tainter, W.C. Cutting, and A.B. Stockton Use of dinitrophenol in nutritional disorders: a critical survey of clinical results Am. J. Public Health Nations Health 24 1934 1045 1053
    • (1934) Am. J. Public Health Nations Health , vol.24 , pp. 1045-1053
    • Tainter, M.L.1    Cutting, W.C.2    Stockton, A.B.3
  • 49
    • 34249743161 scopus 로고    scopus 로고
    • Dinitrophenol and obesity: An early twentieth-century regulatory dilemma
    • DOI 10.1016/j.yrtph.2007.03.006, PII S0273230007000426
    • E. Colman Dinitrophenol and obesity: an early twentieth-century regulatory dilemma Regul. Toxicol. Pharmacol. 48 2007 115 117 (Pubitemid 46824157)
    • (2007) Regulatory Toxicology and Pharmacology , vol.48 , Issue.2 , pp. 115-117
    • Colman, E.1
  • 50
    • 0029894407 scopus 로고    scopus 로고
    • Reduction of dietary obesity in aP2-Ucp transgenic mice: Mechanism and adipose tissue morphology
    • J. Kopecky, M. Rossmeisl, Z. Hodny, I. Syrovy, M. Horakova, and P. Kolarova Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose tissue morphology Am. J. Physiol. 270 1996 E776 786
    • (1996) Am. J. Physiol. , vol.270 , pp. 776-786
    • Kopecky, J.1    Rossmeisl, M.2    Hodny, Z.3    Syrovy, I.4    Horakova, M.5    Kolarova, P.6
  • 51
    • 0033787068 scopus 로고    scopus 로고
    • Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    • B. Li, L.A. Nolte, J.S. Ju, D.H. Han, T. Coleman, J.O. Holloszy, and C.F. Semenkovich Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice Nat. Med 6 2000 1115 1120
    • (2000) Nat. Med , vol.6 , pp. 1115-1120
    • Li, B.1    Nolte, L.A.2    Ju, J.S.3    Han, D.H.4    Coleman, T.5    Holloszy, J.O.6    Semenkovich, C.F.7
  • 52
    • 0020693920 scopus 로고
    • Luxuskonsumption, diet-induced thermogenesis and brown fat: The case in favour
    • N.J. Rothwell, and M.J. Stock Luxuskonsumption, diet-induced thermogenesis and brown fat: the case in favour Clin. Sci. (London) 64 1983 19 23 (Pubitemid 13207247)
    • (1983) Clinical Science , vol.64 , Issue.1 , pp. 19-23
    • Rothwell, N.J.1    Stock, M.J.2
  • 53
    • 0031040576 scopus 로고    scopus 로고
    • Brown adipose tissue, β3-adrenergic receptors, and obesity
    • DOI 10.1146/annurev.med.48.1.307
    • B.B. Lowell, and J.S. Flier Brown adipose tissue, beta 3-adrenergic receptors, and obesity Annu. Rev. Med 48 1997 307 316 (Pubitemid 27101833)
    • (1997) Annual Review of Medicine , vol.48 , pp. 307-316
    • Lowell, B.B.1    Flier, J.S.2
  • 56
    • 0033834808 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in energy expenditure
    • L.P. Kozak, and M.E. Harper Mitochondrial uncoupling proteins in energy expenditure Annu. Rev. Nutr. 20 2000 339 363
    • (2000) Annu. Rev. Nutr. , vol.20 , pp. 339-363
    • Kozak, L.P.1    Harper, M.E.2
  • 57
    • 0031560941 scopus 로고    scopus 로고
    • UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
    • DOI 10.1006/bbrc.1997.6740
    • A. Vidal-Puig, G. Solanes, D. Grujic, J.S. Flier, and B.B. Lowell UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue Biochem. Biophys. Res. Commun. 235 1997 79 82 (Pubitemid 27302688)
    • (1997) Biochemical and Biophysical Research Communications , vol.235 , Issue.1 , pp. 79-82
    • Vidal-Puig, A.1    Solanes, G.2    Grujic, D.3    Flier, J.S.4    Lowell, B.B.5
  • 58
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • DOI 10.1016/S0092-8674(00)81410-5
    • P. Puigserver, Z. Wu, C.W. Park, R. Graves, M. Wright, and B.M. Spiegelman A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis Cell 92 1998 829 839 (Pubitemid 28155321)
    • (1998) Cell , vol.92 , Issue.6 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 59
    • 33845596500 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ coactivator 1 coactivators, energy homeostasis, and metabolism
    • DOI 10.1210/er.2006-0037
    • C. Handschin, and B.M. Spiegelman Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism Endocr. Rev. 27 2006 728 735 (Pubitemid 44936056)
    • (2006) Endocrine Reviews , vol.27 , Issue.7 , pp. 728-735
    • Handschin, C.1    Spiegelman, B.M.2
  • 62
    • 77953752629 scopus 로고    scopus 로고
    • What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology
    • B.G. Hill, B.P. Dranka, S.M. Bailey, J.R. Lancaster Jr, and V.M. Darley-Usmar What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology J. Biol. Chem. 285 2010 19699 19704
    • (2010) J. Biol. Chem. , vol.285 , pp. 19699-19704
    • Hill, B.G.1    Dranka, B.P.2    Bailey, S.M.3    Lancaster, Jr.J.R.4    Darley-Usmar, V.M.5
  • 63
    • 0036211626 scopus 로고    scopus 로고
    • Humphry Davy; His researches in respiratory physiology and his debt to Antoine Lavoisier
    • J.S. Sir Sprigge Humphry Davy; his researches in respiratory physiology and his debt to Antoine Lavoisier Anaesthesia 57 2002 357 364
    • (2002) Anaesthesia , vol.57 , pp. 357-364
    • Sprigge, J.S.S.1
  • 64
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • DOI 10.1042/0264-6021:3570593
    • W.K. Alderton, C.E. Cooper, and R.G. Knowles Nitric oxide synthases: structure, function and inhibition Biochem. J. 357 2001 593 615 (Pubitemid 32735142)
    • (2001) Biochemical Journal , vol.357 , Issue.3 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 65
    • 10444280038 scopus 로고    scopus 로고
    • Structure-function studies on nitric oxide synthases
    • DOI 10.1016/j.jinorgbio.2004.10.016, PII S0162013404003216, Heme-Diatomic Interactions, Part 1
    • H. Li, and T.L. Poulos Structure-function studies on nitric oxide synthases J. Inorg. Biochem. 99 2005 293 305 (Pubitemid 39642983)
    • (2005) Journal of Inorganic Biochemistry , vol.99 , Issue.1 , pp. 293-305
    • Li, H.1    Poulos, T.L.2
  • 66
    • 34250731849 scopus 로고    scopus 로고
    • Life history of eNOS: Partners and pathways
    • DOI 10.1016/j.cardiores.2007.03.023, PII S0008636307001484
    • D.M. Dudzinski, and T. Michel Life history of eNOS: partners and pathways Cardiovasc. Res. 75 2007 247 260 (Pubitemid 46961923)
    • (2007) Cardiovascular Research , vol.75 , Issue.2 , pp. 247-260
    • Dudzinski, D.M.1    Michel, T.2
  • 67
    • 79551501886 scopus 로고    scopus 로고
    • Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway
    • W. Shen, J. Hao, Z. Feng, C. Tian, W. Chen, L. Packer, X. Shi, W. Zang, and J. Liu Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway Br. J. Pharmacol. 162 2011 1213 1224
    • (2011) Br. J. Pharmacol. , vol.162 , pp. 1213-1224
    • Shen, W.1    Hao, J.2    Feng, Z.3    Tian, C.4    Chen, W.5    Packer, L.6    Shi, X.7    Zang, W.8    Liu, J.9
  • 69
    • 80055053633 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice
    • Y. Mei, and S. Thevananther Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice Hepatology 54 2011 1777 1789
    • (2011) Hepatology , vol.54 , pp. 1777-1789
    • Mei, Y.1    Thevananther, S.2
  • 71
    • 0030273532 scopus 로고    scopus 로고
    • Decreased constitutive hepatic nitric oxide synthase expression in secondary biliary fibrosis and its changes after Roux-en-Y choledocho- jejunostomy in the rat
    • DOI 10.1016/S0168-8278(96)80218-2
    • H. Zimmermann, P. Kurzen, W. Klossner, E.L. Renner, and U. Marti Decreased constitutive hepatic nitric oxide synthase expression in secondary biliary fibrosis and its changes after Roux-en-Y choledocho-jejunostomy in the rat J. Hepatol. 25 1996 567 573 (Pubitemid 26345903)
    • (1996) Journal of Hepatology , vol.25 , Issue.4 , pp. 567-573
    • Zimmermann, H.1    Kurzen, P.2    Klossner, W.3    Renner, E.L.4    Marti, U.5
  • 72
    • 33744988179 scopus 로고    scopus 로고
    • Subcellular targeting and trafficking of nitric oxide synthases
    • DOI 10.1042/BJ20060321
    • S. Oess, A. Icking, D. Fulton, R. Govers, and W. Muller-Esterl Subcellular targeting and trafficking of nitric oxide synthases Biochem. J. 396 2006 401 409 (Pubitemid 44228155)
    • (2006) Biochemical Journal , vol.396 , Issue.3 , pp. 401-409
    • Oess, S.1    Icking, A.2    Fulton, D.3    Govers, R.4    Muller-Esterl, W.5
  • 73
    • 3042730959 scopus 로고    scopus 로고
    • Enos at a glance
    • DOI 10.1242/jcs.01165
    • W.C. Sessa eNOS at a glance J. Cell Sci. 117 2004 2427 2429 (Pubitemid 38877838)
    • (2004) Journal of Cell Science , vol.117 , Issue.12 , pp. 2427-2429
    • Sessa, W.C.1
  • 74
    • 64749090979 scopus 로고    scopus 로고
    • ENOS activation by physical forces: From short-term regulation of contraction to chronic remodeling of cardiovascular tissues
    • J.L. Balligand, O. Feron, and C. Dessy eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues Physiol. Rev. 89 2009 481 534
    • (2009) Physiol. Rev. , vol.89 , pp. 481-534
    • Balligand, J.L.1    Feron, O.2    Dessy, C.3
  • 75
    • 0038486928 scopus 로고    scopus 로고
    • Protein interactions with nitric oxide synthases: Controlling the right time, the right place, and the right amount of nitric oxide
    • B.C. Kone, T. Kuncewicz, W. Zhang, and Z.Y. Yu Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide Am. J. Physiol. Renal Physiol 285 2003 F178 190
    • (2003) Am. J. Physiol. Renal Physiol , vol.285 , pp. 178-190
    • Kone, B.C.1    Kuncewicz, T.2    Zhang, W.3    Yu, Z.Y.4
  • 76
    • 4644359359 scopus 로고    scopus 로고
    • Regulation of the expression of inducible nitric oxide synthase
    • DOI 10.1016/j.ejphar.2004.07.030, PII S0014299904007393
    • H. Kleinert, A. Pautz, K. Linker, and P.M. Schwarz Regulation of the expression of inducible nitric oxide synthase Eur. J. Pharmacol. 500 2004 255 266 (Pubitemid 39304013)
    • (2004) European Journal of Pharmacology , vol.500 , Issue.1-3 SPEC. ISSUE. , pp. 255-266
    • Kleinert, H.1    Pautz, A.2    Linker, K.3    Schwarz, P.M.4
  • 78
    • 33744494822 scopus 로고    scopus 로고
    • Critical overview of mitochondrial nitric-oxide synthase
    • DOI 10.2741/2002
    • K. Kato, and C. Giulivi Critical overview of mitochondrial nitric-oxide synthase Front. Biosci. 11 2006 2725 2738 (Pubitemid 43806574)
    • (2006) Frontiers in Bioscience , vol.11 , Issue.SUPPL. 2 , pp. 2725-2738
    • Kato, K.1    Giulivi, C.2
  • 79
    • 79960948536 scopus 로고    scopus 로고
    • Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy
    • D.A. Vitturi, and R.P. Patel Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy Free Radic. Biol. Med. 51 2011 805 812
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 805-812
    • Vitturi, D.A.1    Patel, R.P.2
  • 82
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • DOI 10.1152/physrev.00029.2006
    • P. Pacher, J.S. Beckman, and L. Liaudet Nitric oxide and peroxynitrite in health and disease Physiol. Rev. 87 2007 315 424 (Pubitemid 46217686)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 83
    • 46449115525 scopus 로고    scopus 로고
    • Peroxynitrite detoxification and its biologic implications
    • M. Trujillo, G. Ferrer-Sueta, and R. Radi Peroxynitrite detoxification and its biologic implications Antioxid. Redox Signaling 10 2008 1607 1620
    • (2008) Antioxid. Redox Signaling , vol.10 , pp. 1607-1620
    • Trujillo, M.1    Ferrer-Sueta, G.2    Radi, R.3
  • 84
    • 34547673497 scopus 로고    scopus 로고
    • Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics
    • DOI 10.1038/nrd2222, PII NRD2222
    • C. Szabo, H. Ischiropoulos, and R. Radi Peroxynitrite: biochemistry, pathophysiology and development of therapeutics Nat. Rev. Drug Discovery 6 2007 662 680 (Pubitemid 47207751)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.8 , pp. 662-680
    • Szabo, C.1    Ischiropoulos, H.2    Radi, R.3
  • 85
    • 64749105877 scopus 로고    scopus 로고
    • Understanding peroxynitrite biochemistry and its potential for treating human diseases
    • J.S. Beckman Understanding peroxynitrite biochemistry and its potential for treating human diseases Arch. Biochem. Biophys. 484 2009 114 116
    • (2009) Arch. Biochem. Biophys. , vol.484 , pp. 114-116
    • Beckman, J.S.1
  • 87
    • 0346100520 scopus 로고    scopus 로고
    • Peroxynitrite reactivity with amino acids and proteins
    • DOI 10.1007/s00726-003-0018-8
    • B. Alvarez, and R. Radi Peroxynitrite reactivity with amino acids and proteins Amino Acids 25 2003 295 311 (Pubitemid 38041267)
    • (2003) Amino Acids , vol.25 , Issue.3-4 , pp. 295-311
    • Alvarez, B.1    Radi, R.2
  • 89
    • 28844488772 scopus 로고    scopus 로고
    • Mitochondria and regulated tyrosine nitration
    • DOI 10.1042/BST20051399
    • T. Koeck, D.J. Stuehr, and K.S. Aulak Mitochondria and regulated tyrosine nitration Biochem. Soc. Trans. 33 2005 1399 1403 (Pubitemid 41779698)
    • (2005) Biochemical Society Transactions , vol.33 , Issue.6 , pp. 1399-1403
    • Koeck, T.1    Stuehr, D.J.2    Aulak, K.S.3
  • 92
    • 0036174890 scopus 로고    scopus 로고
    • The biochemistry and physiology of S-nitrosothiols
    • DOI 10.1146/annurev.pharmtox.42.092501.104328
    • N. Hogg The biochemistry and physiology of S-nitrosothiols Annu. Rev. Pharmacol. Toxicol. 42 2002 585 600 (Pubitemid 34160536)
    • (2002) Annual Review of Pharmacology and Toxicology , vol.42 , pp. 585-600
    • Hogg, N.1
  • 93
    • 33847021426 scopus 로고    scopus 로고
    • Role of glutathiolation in preservation, restoration and regulation of protein function
    • B.G. Hill, and A. Bhatnagar Role of glutathiolation in preservation, restoration and regulation of protein function IUBMB Life 59 2007 21 26
    • (2007) IUBMB Life , vol.59 , pp. 21-26
    • Hill, B.G.1    Bhatnagar, A.2
  • 94
    • 84859487532 scopus 로고    scopus 로고
    • Nitric oxide synthases: Regulation and function
    • (837a-837d)
    • U. Forstermann, and W.C. Sessa Nitric oxide synthases: regulation and function Eur. Heart J. 33 2012 829 837 (837a-837d)
    • (2012) Eur. Heart J. , vol.33 , pp. 829-837
    • Forstermann, U.1    Sessa, W.C.2
  • 95
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    • DOI 10.1038/288373a0
    • R.F. Furchgott, and J.V. Zawadzki The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 1980 373 376 (Pubitemid 11169009)
    • (1980) Nature , vol.288 , Issue.5789 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 96
    • 0021063422 scopus 로고
    • Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation
    • R.M. Rapoport, M.B. Draznin, and F. Murad Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation Nature 306 1983 174 176 (Pubitemid 14228339)
    • (1983) Nature , vol.306 , Issue.5939 , pp. 174-176
    • Rapoport, R.M.1    Draznin, M.B.2    Murad, F.3
  • 97
    • 0020676334 scopus 로고
    • Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP
    • R.M. Rapoport, and F. Murad Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP Circ. Res. 52 1983 352 357 (Pubitemid 13158751)
    • (1983) Circulation Research , vol.52 , Issue.3 , pp. 352-357
    • Rapoport, R.M.1    Murad, F.2
  • 98
    • 0022607081 scopus 로고
    • Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries
    • U. Forstermann, A. Mulsch, E. Bohme, and R. Busse Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries Circ. Res. 58 1986 531 538 (Pubitemid 16102209)
    • (1986) Circulation Research , vol.58 , Issue.4 , pp. 531-538
    • Forstermann, U.1    Mulsch, A.2    Bohme, E.3    Busse, R.4
  • 99
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • J. Rajfer, W.J. Aronson, P.A. Bush, F.J. Dorey, and L.J. Ignarro Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission N. Engl. J. Med. 326 1992 90 94
    • (1992) N. Engl. J. Med. , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 101
    • 0022552077 scopus 로고
    • Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells
    • R.J. Gryglewski, S. Moncada, and R.M. Palmer Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells Br. J. Pharmacol. 87 1986 685 694 (Pubitemid 16047532)
    • (1986) British Journal of Pharmacology , vol.87 , Issue.4 , pp. 685-694
    • Gryglewski, R.J.1    Moncada, S.2    Palmer, R.M.J.3
  • 102
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • DOI 10.1038/327524a0
    • R.M. Palmer, A.G. Ferrige, and S. Moncada Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Nature 327 1987 524 526 (Pubitemid 17085822)
    • (1987) Nature , vol.327 , Issue.6122 , pp. 524-526
    • Palmer, R.M.J.1    Ferrige, A.G.2    Moncada, S.3
  • 105
    • 0026609864 scopus 로고
    • NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: A role for nitric oxide in the central regulation of sympathetic tone?
    • I. Sakuma, H. Togashi, M. Yoshioka, H. Saito, M. Yanagida, M. Tamura, T. Kobayashi, H. Yasuda, S.S. Gross, and R. Levi NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone? Circ. Res. 70 1992 607 611
    • (1992) Circ. Res. , vol.70 , pp. 607-611
    • Sakuma, I.1    Togashi, H.2    Yoshioka, M.3    Saito, H.4    Yanagida, M.5    Tamura, M.6    Kobayashi, T.7    Yasuda, H.8    Gross, S.S.9    Levi, R.10
  • 106
    • 0027321828 scopus 로고
    • The central effects of a nitric oxide synthase inhibitor (N(ω)-nitro-L-arginine) on blood pressure and plasma renin
    • A.O. el Karib, J. Sheng, A.L. Betz, and R.L. Malvin The central effects of a nitric oxide synthase inhibitor (N omega-nitro-L-arginine) on blood pressure and plasma renin Clin. Exp. Hypertens. 15 1993 819 832 (Pubitemid 23248998)
    • (1993) Clinical and Experimental Hypertension , vol.15 , Issue.5 , pp. 819-832
    • El Karib, A.O.1    Sheng, J.2    Lorris Betz, A.3    Malvin, R.L.4
  • 107
    • 70350463869 scopus 로고    scopus 로고
    • Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase
    • N. Toda, K. Ayajiki, and T. Okamura Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase J. Hypertens. 27 2009 1929 1940
    • (2009) J. Hypertens. , vol.27 , pp. 1929-1940
    • Toda, N.1    Ayajiki, K.2    Okamura, T.3
  • 108
    • 0025733506 scopus 로고
    • A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle
    • N. Kim, K.M. Azadzoi, I. Goldstein, and I. Saenz de Tejada A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle J. Clin. Invest. 88 1991 112 118
    • (1991) J. Clin. Invest. , vol.88 , pp. 112-118
    • Kim, N.1    Azadzoi, K.M.2    Goldstein, I.3    Saenz De Tejada, I.4
  • 109
    • 11344250253 scopus 로고    scopus 로고
    • Nitroxia: The pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway
    • DOI 10.1016/j.freeradbiomed.2004.10.037, PII S089158490400886X
    • S. Shiva, J.Y. Oh, A.L. Landar, E. Ulasova, A. Venkatraman, S.M. Bailey, and V.M. Darley-Usmar Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway Free Radic. Biol. Med. 38 2005 297 306 (Pubitemid 40075573)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.3 , pp. 297-306
    • Shiva, S.1    Oh, J.-Y.2    Landar, A.L.3    Ulasova, E.4    Venkatraman, A.5    Bailey, S.M.6    Darley-Usmar, V.M.7
  • 110
    • 34447509483 scopus 로고    scopus 로고
    • Nitric oxide regulation of mitochondrial oxygen consumption. II. Molecular mechanism and tissue physiology
    • C.E. Cooper, and C. Giulivi Nitric oxide regulation of mitochondrial oxygen consumption. II. Molecular mechanism and tissue physiology Am. J. Physiol. Cell Physiol 292 2007 C1993 2003
    • (2007) Am. J. Physiol. Cell Physiol , vol.292 , pp. 1993-2003
    • Cooper, C.E.1    Giulivi, C.2
  • 111
    • 0032848295 scopus 로고    scopus 로고
    • Biochemical characterization of S-nitrosohemoglobin: Mechanisms underlying synthesis, no release, and biological activity
    • M. Wolzt, R.J. MacAllister, D. Davis, M. Feelisch, S. Moncada, P. Vallance, and A.J. Hobbs Biochemical characterization of S-nitrosohemoglobin: mechanisms underlying synthesis, no release, and biological activity J. Biol. Chem. 274 1999 28983 28990
    • (1999) J. Biol. Chem. , vol.274 , pp. 28983-28990
    • Wolzt, M.1    Macallister, R.J.2    Davis, D.3    Feelisch, M.4    Moncada, S.5    Vallance, P.6    Hobbs, A.J.7
  • 112
    • 0033016469 scopus 로고    scopus 로고
    • Biochemical characterization of human S-nitrosohemoglobin: Effects on oxygen binding and transnitrosation
    • R.P. Patel, N. Hogg, N.Y. Spencer, B. Kalyanaraman, S. Matalon, and V.M. Darley-Usmar Biochemical characterization of human S-nitrosohemoglobin: effects on oxygen binding and transnitrosation J. Biol. Chem. 274 1999 15487 15492
    • (1999) J. Biol. Chem. , vol.274 , pp. 15487-15492
    • Patel, R.P.1    Hogg, N.2    Spencer, N.Y.3    Kalyanaraman, B.4    Matalon, S.5    Darley-Usmar, V.M.6
  • 113
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • DOI 10.1101/gad.1177604
    • D.P. Kelly, and R.C. Scarpulla Transcriptional regulatory circuits controlling mitochondrial biogenesis and function Genes Dev. 18 2004 357 368 (Pubitemid 38316342)
    • (2004) Genes and Development , vol.18 , Issue.4 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 116
    • 34547903856 scopus 로고    scopus 로고
    • Diet-induced obesity and diabetes reduce coronary responses to nitric oxide due to reduced bioavailability in isolated mouse hearts
    • DOI 10.1111/j.1463-1326.2006.00650.x
    • S.B. Bender, E.K. Herrick, N.D. Lott, and R.E. Klabunde Diet-induced obesity and diabetes reduce coronary responses to nitric oxide due to reduced bioavailability in isolated mouse hearts Diabetes Obes. Metab. 9 2007 688 696 (Pubitemid 47261850)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.5 , pp. 688-696
    • Bender, S.B.1    Herrick, E.K.2    Lott, N.D.3    Klabunde, R.E.4
  • 118
    • 0034769936 scopus 로고    scopus 로고
    • Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension
    • DOI 10.1016/S0895-7061(01)02191-4, PII S0895706101021914
    • Y. Higashi, S. Sasaki, K. Nakagawa, H. Matsuura, K. Chayama, and T. Oshima Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension Am. J. Hypertens. 14 2001 1038 1045 (Pubitemid 32978077)
    • (2001) American Journal of Hypertension , vol.14 , Issue.10 , pp. 1038-1045
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3    Matsuura, H.4    Chayama, K.5    Oshima, T.6
  • 120
    • 79951776633 scopus 로고    scopus 로고
    • Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with type 2 diabetes
    • A. Georgescu, D. Popov, A. Constantin, M. Nemecz, N. Alexandru, D. Cochior, and A. Tudor Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with type 2 diabetes Clin. Sci. 120 2011 463 472
    • (2011) Clin. Sci. , vol.120 , pp. 463-472
    • Georgescu, A.1    Popov, D.2    Constantin, A.3    Nemecz, M.4    Alexandru, N.5    Cochior, D.6    Tudor, A.7
  • 125
    • 0029122777 scopus 로고
    • Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells
    • M.A. Awolesi, W.C. Sessa, and B.E. Sumpio Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells J. Clin. Invest. 96 1995 1449 1454
    • (1995) J. Clin. Invest. , vol.96 , pp. 1449-1454
    • Awolesi, M.A.1    Sessa, W.C.2    Sumpio, B.E.3
  • 126
    • 0029060686 scopus 로고
    • Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine
    • A. Zembowicz, J.L. Tang, and K.K. Wu Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine J. Biol. Chem. 270 1995 17006 17010
    • (1995) J. Biol. Chem. , vol.270 , pp. 17006-17010
    • Zembowicz, A.1    Tang, J.L.2    Wu, K.K.3
  • 127
    • 0029021173 scopus 로고
    • Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells
    • K. Hirata, N. Miki, Y. Kuroda, T. Sakoda, S. Kawashima, and M. Yokoyama Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells Circ. Res. 76 1995 958 962
    • (1995) Circ. Res. , vol.76 , pp. 958-962
    • Hirata, K.1    Miki, N.2    Kuroda, Y.3    Sakoda, T.4    Kawashima, S.5    Yokoyama, M.6
  • 128
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    • G. Zeng, F.H. Nystrom, L.V. Ravichandran, L.N. Cong, M. Kirby, H. Mostowski, and M.J. Quon Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells Circulation 101 2000 1539 1545 (Pubitemid 30180890)
    • (2000) Circulation , vol.101 , Issue.13 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3    Cong, L.-N.4    Kirby, M.5    Mostowski, H.6    Quon, M.J.7
  • 130
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • G.S. Hotamisligil, N.S. Shargill, and B.M. Spiegelman Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 1993 87 91 (Pubitemid 23036092)
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 131
    • 0027050606 scopus 로고
    • Molecular cloning of constitutive endothelial nitric oxide synthase: Evidence for a family of related genes
    • T. Michel, and S. Lamas Molecular cloning of constitutive endothelial nitric oxide synthase: evidence for a family of related genes J. Cardiovasc. Pharmacol. 20 Suppl. 12 1992 S45 49
    • (1992) J. Cardiovasc. Pharmacol. , vol.20 , Issue.SUPPL. 12 , pp. 45-49
    • Michel, T.1    Lamas, S.2
  • 132
    • 0038771921 scopus 로고    scopus 로고
    • Downregulation of eNOS mRNA expression by TNFα: Identification and functional characterization of RNA-protein interactions in the 3′UTR
    • DOI 10.1016/S0008-6363(03)00296-7
    • P.F. Lai, F. Mohamed, J.C. Monge, and D.J. Stewart Downregulation of eNOS mRNA expression by TNFalpha: identification and functional characterization of RNA-protein interactions in the 3′UTR Cardiovasc. Res. 59 2003 160 168 (Pubitemid 36776382)
    • (2003) Cardiovascular Research , vol.59 , Issue.1 , pp. 160-168
    • Lai, P.F.H.1    Mohamed, F.2    Monge, J.-C.3    Stewart, D.J.4
  • 134
    • 0346463072 scopus 로고    scopus 로고
    • Tumor necrosis factor-α inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells
    • DOI 10.1074/jbc.M309552200
    • H.D. Anderson, D. Rahmutula, and D.G. Gardner Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells J. Biol. Chem. 279 2004 963 969 (Pubitemid 38082617)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.2 , pp. 963-969
    • Anderson, H.D.I.1    Rahmutula, D.2    Gardner, D.G.3
  • 135
    • 1842373296 scopus 로고    scopus 로고
    • Endothelial cytosolic proteins bind to the 3' untranslated region of endothelial nitric oxide synthase mRNA: Regulation by tumor necrosis factor alpha
    • J. Alonso, L. Sanchez de Miguel, M. Monton, S. Casado, and A. Lopez-Farre Endothelial cytosolic proteins bind to the 3′ untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha Mol. Cell. Biol. 17 1997 5719 5726 (Pubitemid 27411079)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.10 , pp. 5719-5726
    • Alonso, J.1    Sanchez De Miguel, L.2    Monton, M.3    Casado, S.4    Lopez-Farre, A.5
  • 137
    • 0027233868 scopus 로고
    • Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life
    • M. Yoshizumi, M.A. Perrella, J.C. Burnett Jr, and M.E. Lee Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life Circ. Res. 73 1993 205 209 (Pubitemid 23173071)
    • (1993) Circulation Research , vol.73 , Issue.1 , pp. 205-209
    • Yoshizumi, M.1    Perrella, M.A.2    Burnett Jr., J.C.3    Lee, M.-E.4
  • 138
    • 53249149631 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1
    • G. Yan, B. You, S.P. Chen, J.K. Liao, and J. Sun Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1 Circ. Res. 103 2008 591 597
    • (2008) Circ. Res. , vol.103 , pp. 591-597
    • Yan, G.1    You, B.2    Chen, S.P.3    Liao, J.K.4    Sun, J.5
  • 139
    • 0035794181 scopus 로고    scopus 로고
    • Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha: A novel feedback mechanism regulating cell death
    • S. Bulotta, R. Barsacchi, D. Rotiroti, N. Borgese, and E. Clementi Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel feedback mechanism regulating cell death J. Biol. Chem. 276 2001 6529 6536
    • (2001) J. Biol. Chem. , vol.276 , pp. 6529-6536
    • Bulotta, S.1    Barsacchi, R.2    Rotiroti, D.3    Borgese, N.4    Clementi, E.5
  • 140
    • 0036151948 scopus 로고    scopus 로고
    • Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-α via the PI 3-kinase-Akt signaling pathway
    • DOI 10.1053/jhep.2002.30958
    • H. Kawanaka, M.K. Jones, I.L. Szabo, D. Baatar, R. Pai, K. Tsugawa, K. Sugimachi, I.J. Sarfeh, and A.S. Tarnawski Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway Hepatology 35 2002 393 402 (Pubitemid 34106380)
    • (2002) Hepatology , vol.35 , Issue.2 , pp. 393-402
    • Kawanaka, H.1    Jones, M.K.2    Szabo, I.L.3    Baatar, D.4    Pai, R.5    Tsugawa, K.6    Sugimachi, K.7    Sarfeh I.James8    Tarnawski, A.S.9
  • 141
    • 0037382346 scopus 로고    scopus 로고
    • Activation of endothelial nitric-oxide synthase by tumor necrosis factor-α: A novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt
    • DOI 10.1124/mol.63.4.886
    • R. Barsacchi, C. Perrotta, S. Bulotta, S. Moncada, N. Borgese, and E. Clementi Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt Mol. Pharmacol. 63 2003 886 895 (Pubitemid 36368996)
    • (2003) Molecular Pharmacology , vol.63 , Issue.4 , pp. 886-895
    • Barsacchi, R.1    Perrotta, C.2    Bulotta, S.3    Moncada, S.4    Borgese, N.5    Clementi, E.6
  • 142
    • 33644819311 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase activation by tumor necrosis factor α through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: A novel pathway relevant to the pathophysiology of endothelium
    • DOI 10.1161/01.ATV.0000194074.59584.42, PII 0004360520060100000017
    • C. De Palma, E. Meacci, C. Perrotta, P. Bruni, and E. Clementi Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium Arterioscler. Thromb. Vasc. Biol. 26 2006 99 105 (Pubitemid 43732234)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.1 , pp. 99-105
    • De Palma, C.1    Meacci, E.2    Perrotta, C.3    Bruni, P.4    Clementi, E.5
  • 143
    • 0033404954 scopus 로고    scopus 로고
    • CGMP-mediated negative-feedback regulation of endothelial nitric oxide synthase expression by nitric oxide
    • N.D. Vaziri, and X.Q. Wang cGMP-mediated negative-feedback regulation of endothelial nitric oxide synthase expression by nitric oxide Hypertension 34 1999 1237 1241
    • (1999) Hypertension , vol.34 , pp. 1237-1241
    • Vaziri, N.D.1    Wang, X.Q.2
  • 144
    • 24944536752 scopus 로고    scopus 로고
    • A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription
    • DOI 10.1016/j.yjmcc.2005.06.012, PII S0022282805001975
    • I.M. Grumbach, W. Chen, S.A. Mertens, and D.G. Harrison A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription J. Mol. Cell. Cardiol. 39 2005 595 603 (Pubitemid 41331048)
    • (2005) Journal of Molecular and Cellular Cardiology , vol.39 , Issue.4 , pp. 595-603
    • Grumbach, I.M.1    Chen, W.2    Mertens, S.A.3    Harrison, D.G.4
  • 147
    • 15944384240 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity
    • DOI 10.2337/diabetes.54.4.1082
    • B.T. Noronha, J.M. Li, S.B. Wheatcroft, A.M. Shah, and M.T. Kearney Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity Diabetes 54 2005 1082 1089 (Pubitemid 40446322)
    • (2005) Diabetes , vol.54 , Issue.4 , pp. 1082-1089
    • Noronha, B.T.1    Li, J.-M.2    Wheatcroft, S.B.3    Shall, A.M.4    Kearney, M.T.5
  • 148
  • 150
    • 17844367159 scopus 로고    scopus 로고
    • A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice
    • DOI 10.2337/diabetes.54.5.1340
    • M. Fujimoto, N. Shimizu, K. Kunii, J.A. Martyn, K. Ueki, and M. Kaneki A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice Diabetes 54 2005 1340 1348 (Pubitemid 40586662)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1340-1348
    • Fujimoto, M.1    Shimizu, N.2    Kunii, K.3    Martyn, J.A.J.4    Ueki, K.5    Kaneki, M.6
  • 152
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • DOI 10.1172/JCI29881
    • C.N. Lumeng, J.L. Bodzin, and A.R. Saltiel Obesity induces a phenotypic switch in adipose tissue macrophage polarization J. Clin. Invest. 117 2007 175 184 (Pubitemid 46048464)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 153
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • C.N. Lumeng, S.M. Deyoung, J.L. Bodzin, and A.R. Saltiel Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity Diabetes 56 2007 16 23
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 154
    • 0033711024 scopus 로고    scopus 로고
    • Nitric oxide-dependent downregulation of adipocyte UCP-2 expression by tumor necrosis factor-alpha
    • C. Merial, A. Bouloumie, V. Trocheris, M. Lafontan, and J. Galitzky Nitric oxide-dependent downregulation of adipocyte UCP-2 expression by tumor necrosis factor-alpha Am. J. Physiol. Cell Physiol 279 2000 C1100 1106
    • (2000) Am. J. Physiol. Cell Physiol , vol.279 , pp. 1100-1106
    • Merial, C.1    Bouloumie, A.2    Trocheris, V.3    Lafontan, M.4    Galitzky, J.5
  • 155
    • 3042735813 scopus 로고    scopus 로고
    • Reduced ventromedial hypothalamic neuronal nitric oxide synthase and increased sensitivity to NOS inhibition in dietary obese rats: Further evidence of a role for nitric oxide in the regulation of energy balance
    • DOI 10.1016/j.brainres.2004.05.007, PII S0006899304007309
    • C.J. Sadler, and J.P. Wilding Reduced ventromedial hypothalamic neuronal nitric oxide synthase and increased sensitivity to NOS inhibition in dietary obese rats: further evidence of a role for nitric oxide in the regulation of energy balance Brain Res. 1016 2004 222 228 (Pubitemid 38887705)
    • (2004) Brain Research , vol.1016 , Issue.2 , pp. 222-228
    • Sadler, C.J.1    Wilding, J.P.H.2
  • 157
    • 68149137621 scopus 로고    scopus 로고
    • Metabolic syndrome and cardiovascular disease
    • P.L. eNOS Huang metabolic syndrome and cardiovascular disease Trends Endocrinol. Metab. 20 2009 295 302
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 295-302
    • Huang, P.L.E.1
  • 158
    • 80052758036 scopus 로고    scopus 로고
    • ENOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity
    • R. Rafikov, F.V. Fonseca, S. Kumar, D. Pardo, C. Darragh, S. Elms, D. Fulton, and S.M. Black eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity J. Endocrinol. 210 2011 271 284
    • (2011) J. Endocrinol. , vol.210 , pp. 271-284
    • Rafikov, R.1    Fonseca, F.V.2    Kumar, S.3    Pardo, D.4    Darragh, C.5    Elms, S.6    Fulton, D.7    Black, S.M.8
  • 159
    • 0030853953 scopus 로고    scopus 로고
    • Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity
    • DOI 10.1074/jbc.272.30.18522
    • H. Ju, R. Zou, V.J. Venema, and R.C. Venema Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity J. Biol. Chem. 272 1997 18522 18525 (Pubitemid 27318186)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.30 , pp. 18522-18525
    • Ju, H.1    Zou, R.2    Venema, V.J.3    Venema, R.C.4
  • 161
    • 34548426113 scopus 로고    scopus 로고
    • High-fat diet up-regulates caveolin-1 expression in aorta of diet-induced obese but not in diet-resistant rats
    • DOI 10.1016/j.cardiores.2007.05.028, PII S000863630700260X
    • N. Yang, C. Ying, M. Xu, X. Zuo, X. Ye, L. Liu, Y. Nara, and X. Sun High-fat diet up-regulates caveolin-1 expression in aorta of diet-induced obese but not in diet-resistant rats Cardiovasc. Res. 76 2007 167 174 (Pubitemid 47362043)
    • (2007) Cardiovascular Research , vol.76 , Issue.1 , pp. 167-174
    • Yang, N.1    Ying, C.2    Xu, M.3    Zuo, X.4    Ye, X.5    Liu, L.6    Nara, Y.7    Sun, X.8
  • 162
    • 80555124939 scopus 로고    scopus 로고
    • Ceramides as modulators of cellular and whole-body metabolism
    • B.T. Bikman, and S.A. Summers Ceramides as modulators of cellular and whole-body metabolism J. Clin. Invest. 121 2011 4222 4230
    • (2011) J. Clin. Invest. , vol.121 , pp. 4222-4230
    • Bikman, B.T.1    Summers, S.A.2
  • 164
    • 0034698050 scopus 로고    scopus 로고
    • Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro: Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1
    • DOI 10.1074/jbc.M001644200
    • J.P. Gratton, J. Fontana, D.S. O'Connor, G. Garcia-Cardena, T.J. McCabe, and W.C. Sessa Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro: evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1 J. Biol. Chem. 275 2000 22268 22272 (Pubitemid 30621809)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.29 , pp. 22268-22272
    • Gratton, J.-P.1    Fontana, J.2    O'Connor, D.S.3    Garcia-Cardena, G.4    McCabe, T.J.5    Sessa, W.C.6
  • 165
    • 0034054493 scopus 로고    scopus 로고
    • Enhanced electron flux and reduced calmodulin dissociation may explain 'calcium-independent' eNOS activation by phosphorylation
    • DOI 10.1074/jbc.275.9.6123
    • T.J. McCabe, D. Fulton, L.J. Roman, and W.C. Sessa Enhanced electron flux and reduced calmodulin dissociation may explain "calcium-independent" eNOS activation by phosphorylation J. Biol. Chem. 275 2000 6123 6128 (Pubitemid 30129896)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.9 , pp. 6123-6128
    • McCabe, T.J.1    Fulton, D.2    Roman, L.J.3    Sessa, W.C.4
  • 166
    • 33746234766 scopus 로고    scopus 로고
    • Enos gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: A role for enos uncoupling
    • DOI 10.1161/01.RES.0000231306.03510.77, PII 0000301220060707000013
    • J.W. Elrod, M.R. Duranski, W. Langston, J.J. Greer, L. Tao, T.R. Dugas, C.G. Kevil, H.C. Champion, and D.J. Lefer eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling Circ. Res. 99 2006 78 85 (Pubitemid 44297058)
    • (2006) Circulation Research , vol.99 , Issue.1 , pp. 78-85
    • Elrod, J.W.1    Duranski, M.R.2    Langston, W.3    Greer, J.J.M.4    Tao, L.5    Dugas, T.R.6    Kevil, C.G.7    Champion, H.C.8    Lefer, D.J.9
  • 167
    • 34247876193 scopus 로고    scopus 로고
    • Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice
    • DOI 10.1016/j.cardiores.2007.02.002, PII S000863630700051X
    • J.C. Zhong, X.Y. Yu, Y. Huang, L.M. Yung, C.W. Lau, and S.G. Lin Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice Cardiovasc. Res. 74 2007 388 395 (Pubitemid 46693698)
    • (2007) Cardiovascular Research , vol.74 , Issue.3 , pp. 388-395
    • Zhong, J.-C.1    Yu, X.-Y.2    Huang, Y.3    Yung, L.-M.4    Lau, C.-W.5    Lin, S.-G.6
  • 169
    • 79961038726 scopus 로고    scopus 로고
    • Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice
    • K. Taguchi, T. Kobayashi, T. Matsumoto, and K. Kamata Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice Am. J. Physiol. Heart Circ. Physiol 301 2011 H571 583
    • (2011) Am. J. Physiol. Heart Circ. Physiol , vol.301 , pp. 571-583
    • Taguchi, K.1    Kobayashi, T.2    Matsumoto, T.3    Kamata, K.4
  • 173
    • 34047098350 scopus 로고    scopus 로고
    • Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats
    • DOI 10.2337/db05-1147
    • H.G. Zecchin, F.B. Priviero, C.T. Souza, K.G. Zecchin, P.O. Prada, J.B. Carvalheira, L.A. Velloso, E. Antunes, and M.J. Saad Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats Diabetes 56 2007 1014 1024 (Pubitemid 46525080)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1014-1024
    • Zecchin, H.G.1    Priviero, F.B.M.2    Souza, C.T.3    Zecchin, K.G.4    Prada, P.O.5    Carvalheira, J.B.C.6    Velloso, L.A.7    Antunes, E.8    Saad, M.J.A.9
  • 176
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • S. Dimmeler, I. Fleming, B. Fisslthaler, C. Hermann, R. Busse, and A.M. Zeiher Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 399 1999 601 605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 181
    • 33747135139 scopus 로고    scopus 로고
    • Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta
    • DOI 10.1042/CS20060001
    • I. Edirisinghe, K. McCormick Hallam, and C.T. Kappagoda Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta Clin. Sci. 111 2006 145 151 (Pubitemid 44220528)
    • (2006) Clinical Science , vol.111 , Issue.2 , pp. 145-151
    • Edirisinghe, I.1    McCormick Hallam, K.2    Kappagoda, C.T.3
  • 182
    • 33645509709 scopus 로고    scopus 로고
    • Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
    • X. Du, D. Edelstein, S. Obici, N. Higham, M.H. Zou, and M. Brownlee Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation J. Clin. Invest. 116 2006 1071 1080
    • (2006) J. Clin. Invest. , vol.116 , pp. 1071-1080
    • Du, X.1    Edelstein, D.2    Obici, S.3    Higham, N.4    Zou, M.H.5    Brownlee, M.6
  • 183
    • 0033944950 scopus 로고    scopus 로고
    • Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production
    • H.O. Steinberg, G. Paradisi, G. Hook, K. Crowder, J. Cronin, and A.D. Baron Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production Diabetes 49 2000 1231 1238 (Pubitemid 30439100)
    • (2000) Diabetes , vol.49 , Issue.7 , pp. 1231-1238
    • Steinberg, H.O.1    Paradisi, G.2    Hook, G.3    Crowder, K.4    Cronin, J.5    Baron, A.D.6
  • 185
    • 79551492488 scopus 로고    scopus 로고
    • Insulin says NO to cardiovascular disease
    • Q. Yu, F. Gao, and X.L. Ma Insulin says NO to cardiovascular disease Cardiovasc. Res. 89 2011 516 524
    • (2011) Cardiovasc. Res. , vol.89 , pp. 516-524
    • Yu, Q.1    Gao, F.2    Ma, X.L.3
  • 186
    • 84878588442 scopus 로고    scopus 로고
    • Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin
    • H.J. Jang, H.S. Kim, D.H. Hwang, M.J. Quon, and J.A. Kim Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin Am. J. Physiol. Endocrinol. Metab. 304 2013 E1077 1088
    • (2013) Am. J. Physiol. Endocrinol. Metab. , vol.304 , pp. 1077-1088
    • Jang, H.J.1    Kim, H.S.2    Hwang, D.H.3    Quon, M.J.4    Kim, J.A.5
  • 187
    • 0035180299 scopus 로고    scopus 로고
    • Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
    • DOI 10.1172/JCI200111235
    • X.L. Du, D. Edelstein, S. Dimmeler, Q. Ju, C. Sui, and M. Brownlee Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site J. Clin. Invest. 108 2001 1341 1348 (Pubitemid 33107762)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.9 , pp. 1341-1348
    • Du, X.L.1    Edelstein, D.2    Dimmeler, S.3    Ju, Q.4    Sui, C.5    Brownlee, M.6
  • 188
    • 0037231474 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands increase release of nitric oxide from endothelial cells
    • DOI 10.1161/01.ATV.0000044461.01844.C9
    • D.S. Calnek, L. Mazzella, S. Roser, J. Roman, and C.M. Hart Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells Arterioscler. Thromb. Vasc. Biol. 23 2003 52 57 (Pubitemid 36091625)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.1 , pp. 52-57
    • Calnek, D.S.1    Mazzella, L.2    Roser, S.3    Roman, J.4    Hart, C.M.5
  • 189
    • 1542652475 scopus 로고    scopus 로고
    • Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: Evidence for involvement of peroxisome proliferator-activated receptor (PPAR) γ-dependent and PPARγ-independent signaling pathways
    • DOI 10.1074/jbc.M309451200
    • D.H. Cho, Y.J. Choi, S.A. Jo, and I. Jo Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: evidence for involvement of peroxisome proliferator-activated receptor (PPAR) gamma-dependent and PPARgamma-independent signaling pathways J. Biol. Chem. 279 2004 2499 2506 (Pubitemid 38114233)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.4 , pp. 2499-2506
    • Cho, D.-H.1    Choi, Y.J.2    Jo, S.A.3    Jo, I.4
  • 190
    • 24144448954 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor γ-dependent mechanisms
    • DOI 10.1161/01.ATV.0000177805.65864.d4
    • J.A. Polikandriotis, L.J. Mazzella, H.L. Rupnow, and C.M. Hart Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms Arterioscler. Thromb. Vasc. Biol. 25 2005 1810 1816 (Pubitemid 41243447)
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , Issue.9 , pp. 1810-1816
    • Polikandriotis, J.A.1    Mazzella, L.J.2    Rupnow, H.L.3    Hart, C.M.4
  • 192
    • 33644747421 scopus 로고    scopus 로고
    • Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    • DOI 10.2337/diabetes.55.02.06.db05-1064
    • B.J. Davis, Z. Xie, B. Viollet, and M.H. Zou Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase Diabetes 55 2006 496 505 (Pubitemid 43343281)
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 496-505
    • Davis, B.J.1    Xie, Z.2    Viollet, B.3    Zou, M.-H.4
  • 193
    • 0034121698 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene
    • DOI 10.1128/MCB.20.13.4699-4707.2000
    • M. Li, G. Pascual, and C.K. Glass Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene Mol. Cell. Biol. 20 2000 4699 4707 (Pubitemid 30396117)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.13 , pp. 4699-4707
    • Li, M.1    Pascual, G.2    Glass, C.K.3
  • 194
    • 0343415083 scopus 로고    scopus 로고
    • 2 and troglitazone evidence for heat shock-dependent and-independent inhibition of cytokine-induced inducible nitric oxide synthase expression
    • L.B. Maggi Jr, H. Sadeghi, C. Weigand, A.L. Scarim, M.R. Heitmeier, and J.A. Corbett Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression Diabetes 49 2000 346 355 (Pubitemid 30131779)
    • (2000) Diabetes , vol.49 , Issue.3 , pp. 346-355
    • Maggi Jr., L.B.1    Sadeghi, H.2    Weigand, C.3    Scarim, A.L.4    Heitmeier, M.R.5    Corbett, J.A.6
  • 195
    • 0034666289 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo
    • M.T. Heneka, T. Klockgether, and D.L. Feinstein Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo J. Neurosci. 20 2000 6862 6867
    • (2000) J. Neurosci. , vol.20 , pp. 6862-6867
    • Heneka, M.T.1    Klockgether, T.2    Feinstein, D.L.3
  • 196
    • 0142027566 scopus 로고    scopus 로고
    • Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat
    • DOI 10.1016/S0014-2999(03)01932-0
    • P.C. Konturek, T. Brzozowski, J. Kania, S.J. Konturek, S. Kwiecien, R. Pajdo, and E.G. Hahn Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat Eur. J. Pharmacol. 472 2003 213 220 (Pubitemid 37271918)
    • (2003) European Journal of Pharmacology , vol.472 , Issue.3 , pp. 213-220
    • Konturek, P.C.1    Brzozowski, T.2    Kania, J.3    Konturek, S.J.4    Kwiecien, S.5    Pajdo, R.6    Hahn, E.G.7
  • 197
    • 0141928147 scopus 로고    scopus 로고
    • 2 synthase, and inducible nitric oxide synthase in cardiac myocytes
    • DOI 10.1161/01.HYP.0000085332.69777.D1
    • M. Mendez, and M.C. LaPointe PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes Hypertension 42 2003 844 850 (Pubitemid 37237334)
    • (2003) Hypertension , vol.42 , pp. 844-850
    • Mendez, M.1    LaPointe, M.C.2
  • 198
    • 11844289634 scopus 로고    scopus 로고
    • Peroxisome proliferation-activated receptor (PPAR)γ is not necessary for synthetic PPARγ agonist inhibition of inducible nitric-oxide synthase and nitric oxide
    • DOI 10.1124/jpet.104.074005
    • M.B. Crosby, J.L. Svenson, J. Zhang, C.J. Nicol, F.J. Gonzalez, and G.S. Gilkeson Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide J. Pharmacol. Exp. Ther. 312 2005 69 76 (Pubitemid 40096454)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.1 , pp. 69-76
    • Crosby, M.B.1    Svenson, J.L.2    Zhang, J.3    Nicol, C.J.4    Gonzalez, F.J.5    Gilkeson, G.S.6
  • 199
    • 0029889353 scopus 로고    scopus 로고
    • Endothelial nitric-oxide synthase: Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation
    • I. Rodriguez-Crespo, N.C. Gerber, and P.R. Ortiz de Montellano Endothelial nitric-oxide synthase: expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation J. Biol. Chem. 271 1996 11462 11467
    • (1996) J. Biol. Chem. , vol.271 , pp. 11462-11467
    • Rodriguez-Crespo, I.1    Gerber, N.C.2    Ortiz De Montellano, P.R.3
  • 200
    • 0030446051 scopus 로고    scopus 로고
    • Human endothelial nitric oxide synthase: Expression in Escherichia coli, coexpression with calmodulin, and characterization
    • DOI 10.1006/abbi.1996.0543
    • I. Rodriguez-Crespo, and P.R. Ortiz de Montellano Human endothelial nitric oxide synthase: expression in Escherichia coli, coexpression with calmodulin, and characterization Arch. Biochem. Biophys. 336 1996 151 156 (Pubitemid 26423761)
    • (1996) Archives of Biochemistry and Biophysics , vol.336 , Issue.1 , pp. 151-156
    • Rodriguez-Crespo, I.1    Ortiz De Montellano, P.R.2
  • 201
    • 1542283780 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
    • DOI 10.1161/01.ATV.0000110785.96039.f6
    • N.J. Alp, and K.M. Channon Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease Arterioscler. Thromb. Vasc. Biol. 24 2004 413 420 (Pubitemid 38326132)
    • (2004) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.24 , Issue.3 , pp. 413-420
    • Alp, N.J.1    Channon, K.M.2
  • 202
    • 84879411196 scopus 로고    scopus 로고
    • Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease
    • H. Li, and U. Forstermann Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease Curr. Opin. Pharmacol. 13 2013 161 167
    • (2013) Curr. Opin. Pharmacol. , vol.13 , pp. 161-167
    • Li, H.1    Forstermann, U.2
  • 203
    • 79954608953 scopus 로고    scopus 로고
    • S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling
    • J.L. Zweier, C.A. Chen, and L.J. Druhan S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling Antioxid. Redox Signaling 14 2011 1769 1775
    • (2011) Antioxid. Redox Signaling , vol.14 , pp. 1769-1775
    • Zweier, J.L.1    Chen, C.A.2    Druhan, L.J.3
  • 204
    • 84870195554 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: A vascular redox target to improve endothelial function
    • K.M. Channon Tetrahydrobiopterin: a vascular redox target to improve endothelial function Curr. Vasc. Pharmacol 10 2012 705 708
    • (2012) Curr. Vasc. Pharmacol , vol.10 , pp. 705-708
    • Channon, K.M.1
  • 205
    • 77955290312 scopus 로고    scopus 로고
    • Endothelial dysfunction in diabetes: Multiple targets for treatment
    • H. Ding, and C.R. Triggle Endothelial dysfunction in diabetes: multiple targets for treatment Pflugers Arch. 459 2010 977 994
    • (2010) Pflugers Arch. , vol.459 , pp. 977-994
    • Ding, H.1    Triggle, C.R.2
  • 206
    • 4344625264 scopus 로고    scopus 로고
    • Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: Prevention by chronic therapy with a peroxynitrite scavenger ebselen
    • DOI 10.1097/01.ASN.0000135971.88164.2C
    • P.N. Chander, O. Gealekman, S.V. Brodsky, S. Elitok, A. Tojo, M. Crabtree, S.S. Gross, and M.S. Goligorsky Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen J. Am. Soc. Nephrol. 15 2004 2391 2403 (Pubitemid 39159339)
    • (2004) Journal of the American Society of Nephrology , vol.15 , Issue.9 , pp. 2391-2403
    • Chander, P.N.1    Gealekman, O.2    Brodsky, S.V.3    Elitok, S.4    Tojo, A.5    Crabtree, M.6    Gross, S.S.7    Goligorsky, M.S.8
  • 208
    • 0036271495 scopus 로고    scopus 로고
    • Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: Role of decreased tetrahydrobiopterin bioavailability
    • M. Pannirselvam, S. Verma, T.J. Anderson, and C.R. Triggle Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability Br. J. Pharmacol. 136 2002 255 263 (Pubitemid 34587672)
    • (2002) British Journal of Pharmacology , vol.136 , Issue.2 , pp. 255-263
    • Pannirselvam, M.1    Verma, S.2    Anderson, T.J.3    Triggle, C.R.4
  • 209
    • 13844281183 scopus 로고    scopus 로고
    • Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells
    • DOI 10.1016/j.cardiores.2004.10.040
    • S. Cai, J. Khoo, and K.M. Channon Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells Cardiovasc. Res. 65 2005 823 831 (Pubitemid 40249727)
    • (2005) Cardiovascular Research , vol.65 , Issue.4 , pp. 823-831
    • Cai, S.1    Khoo, J.2    Channon, K.M.3
  • 210
    • 41849144894 scopus 로고    scopus 로고
    • Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. Superoxide production by eNOS
    • M.J. Crabtree, C.L. Smith, G. Lam, M.S. Goligorsky, and S.S. Gross Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS Am. J. Physiol. Heart Circ. Physiol 294 2008 H1530 1540
    • (2008) Am. J. Physiol. Heart Circ. Physiol , vol.294 , pp. 1530-1540
    • Crabtree, M.J.1    Smith, C.L.2    Lam, G.3    Goligorsky, M.S.4    Gross, S.S.5
  • 211
    • 80051978810 scopus 로고    scopus 로고
    • Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling
    • U. Forstermann, and H. Li Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling Br. J. Pharmacol. 164 2011 213 223
    • (2011) Br. J. Pharmacol. , vol.164 , pp. 213-223
    • Forstermann, U.1    Li, H.2
  • 212
    • 84857438179 scopus 로고    scopus 로고
    • Tackling endothelial dysfunction by modulating NOS uncoupling: New insights into its pathogenesis and therapeutic possibilities
    • R. Kietadisorn, R.P. Juni, and A.L. Moens Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities Am. J. Physiol. Endocrinol. Metab. 302 2012 E481 495
    • (2012) Am. J. Physiol. Endocrinol. Metab. , vol.302 , pp. 481-495
    • Kietadisorn, R.1    Juni, R.P.2    Moens, A.L.3
  • 213
    • 80051549032 scopus 로고    scopus 로고
    • Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
    • M.J. Crabtree, and K.M. Channon Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease Nitric Oxide 25 2011 81 88
    • (2011) Nitric Oxide , vol.25 , pp. 81-88
    • Crabtree, M.J.1    Channon, K.M.2
  • 214
    • 84859994521 scopus 로고    scopus 로고
    • Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats
    • A. Sanchez, C. Contreras, M.P. Martinez, B. Climent, S. Benedito, A. Garcia-Sacristan, M. Hernandez, and D. Prieto Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats PLoS One 7 2012 e36027
    • (2012) PLoS One , vol.7 , pp. 36027
    • Sanchez, A.1    Contreras, C.2    Martinez, M.P.3    Climent, B.4    Benedito, S.5    Garcia-Sacristan, A.6    Hernandez, M.7    Prieto, D.8
  • 215
    • 20444457010 scopus 로고    scopus 로고
    • Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice
    • DOI 10.1161/01.RES.0000168634.74330.ed
    • J. Molnar, S. Yu, N. Mzhavia, C. Pau, I. Chereshnev, and H.M. Dansky Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice Circ. Res. 96 2005 1178 1184 (Pubitemid 40827693)
    • (2005) Circulation Research , vol.96 , Issue.11 , pp. 1178-1184
    • Molnar, J.1    Yu, S.2    Mzhavia, N.3    Pau, C.4    Chereshnev, I.5    Dansky, H.M.6
  • 216
    • 1242275127 scopus 로고    scopus 로고
    • Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen
    • DOI 10.1161/01.RES.0000111802.09964.EF
    • S.V. Brodsky, O. Gealekman, J. Chen, F. Zhang, N. Togashi, M. Crabtree, S.S. Gross, A. Nasjletti, and M.S. Goligorsky Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen Circ. Res. 94 2004 377 384 (Pubitemid 38240730)
    • (2004) Circulation Research , vol.94 , Issue.3 , pp. 377-384
    • Brodsky, S.V.1    Gealekman, O.2    Chen, J.3    Zhang, F.4    Togashi, N.5    Crabtree, M.6    Gross, S.S.7    Nasjletti, A.8    Goligorsky, M.S.9
  • 217
    • 84897843508 scopus 로고    scopus 로고
    • Belin de Chantemele, E.; Feher, A.; Romero, M. J.; Bagi, Z. Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients
    • J. Cassuto, H. Dou, I. Czikora, A. Szabo, V.S. Patel, and V. Kamath Belin de Chantemele, E.; Feher, A.; Romero, M. J.; Bagi, Z. Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients Diabetes 63 2014 1381 1393
    • (2014) Diabetes , vol.63 , pp. 1381-1393
    • Cassuto, J.1    Dou, H.2    Czikora, I.3    Szabo, A.4    Patel, V.S.5    Kamath, V.6
  • 221
    • 33751178591 scopus 로고    scopus 로고
    • Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: Role of NAD(P)H oxidase-derived superoxide and peroxynitrite
    • J. Xu, Z. Xie, R. Reece, D. Pimental, and M.H. Zou Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite Arterioscler. Thromb. Vasc. Biol. 26 2006 2688 2695
    • (2006) Arterioscler. Thromb. Vasc. Biol. , vol.26 , pp. 2688-2695
    • Xu, J.1    Xie, Z.2    Reece, R.3    Pimental, D.4    Zou, M.H.5
  • 224
    • 0035711258 scopus 로고    scopus 로고
    • 100 years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry
    • DOI 10.1179/135100001101536517
    • W.H. Koppenol 100 years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry Redox Rep. 6 2001 339 341 (Pubitemid 34134324)
    • (2001) Redox Report , vol.6 , Issue.6 , pp. 339-341
    • Koppenol, W.H.1
  • 225
    • 53649087556 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance
    • K. Toutouzas, M. Riga, E. Stefanadi, and C. Stefanadis Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance Horm. Metab. Res. 40 2008 655 659
    • (2008) Horm. Metab. Res. , vol.40 , pp. 655-659
    • Toutouzas, K.1    Riga, M.2    Stefanadi, E.3    Stefanadis, C.4
  • 226
    • 84893138988 scopus 로고    scopus 로고
    • Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction
    • M.G. Risbano, and M.T. Gladwin Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction Handb. Exp. Pharmacol 218 2013 315 349
    • (2013) Handb. Exp. Pharmacol , vol.218 , pp. 315-349
    • Risbano, M.G.1    Gladwin, M.T.2
  • 228
    • 84906794400 scopus 로고    scopus 로고
    • Molecular mechanisms of endothelial NO synthase uncoupling
    • H. Lei, S. Luo, H. Qin, and Y. Xia Molecular mechanisms of endothelial NO synthase uncoupling Curr. Pharm. Des 20 2013 3548 3553
    • (2013) Curr. Pharm. des , vol.20 , pp. 3548-3553
    • Lei, H.1    Luo, S.2    Qin, H.3    Xia, Y.4
  • 229
    • 0036276724 scopus 로고    scopus 로고
    • Obesity, atherosclerosis and the vascular endothelium: Mechanisms of reduced nitric oxide bioavailability in obese humans
    • DOI 10.1038/sj.ijo.0801995
    • I.L. Williams, S.B. Wheatcroft, A.M. Shah, and M.T. Kearney Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans Int. J. Obes. Relat. Metab. Disord 26 2002 754 764 (Pubitemid 34620866)
    • (2002) International Journal of Obesity , vol.26 , Issue.6 , pp. 754-764
    • Williams, I.L.1    Wheatcroft, S.2    Shah, A.M.3    Kearney, M.T.4
  • 230
    • 0029977757 scopus 로고    scopus 로고
    • Obesity/insulin resistance is associated with endothelial dysfunction: Implications for the syndrome of insulin resistance
    • H.O. Steinberg, H. Chaker, R. Leaming, A. Johnson, G. Brechtel, and A.D. Baron Obesity/insulin resistance is associated with endothelial dysfunction: implications for the syndrome of insulin resistance J. Clin. Invest. 97 1996 2601 2610
    • (1996) J. Clin. Invest. , vol.97 , pp. 2601-2610
    • Steinberg, H.O.1    Chaker, H.2    Leaming, R.3    Johnson, A.4    Brechtel, G.5    Baron, A.D.6
  • 232
    • 41749097015 scopus 로고    scopus 로고
    • Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists
    • G.P. Van Guilder, B.L. Stauffer, J.J. Greiner, and C.A. Desouza Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists Am. J. Physiol. Heart Circ. Physiol 294 2008 H1685 1692
    • (2008) Am. J. Physiol. Heart Circ. Physiol , vol.294 , pp. 1685-1692
    • Van Guilder, G.P.1    Stauffer, B.L.2    Greiner, J.J.3    Desouza, C.A.4
  • 234
    • 0031977203 scopus 로고    scopus 로고
    • Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone
    • DOI 10.1007/s001250050948
    • C.J. Tack, M.K. Ong, J.A. Lutterman, and P. Smits Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance: effects of troglitazone Diabetologia 41 1998 569 576 (Pubitemid 28206828)
    • (1998) Diabetologia , vol.41 , Issue.5 , pp. 569-576
    • Tack, C.J.J.1    Ong, M.K.E.2    Lutterman, J.A.3    Smits, P.4
  • 235
    • 0033066242 scopus 로고    scopus 로고
    • Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity
    • J. Westerbacka, S. Vehkavaara, R. Bergholm, I. Wilkinson, J. Cockcroft, and H. Yki-Jarvinen Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity Diabetes 48 1999 821 827 (Pubitemid 29153082)
    • (1999) Diabetes , vol.48 , Issue.4 , pp. 821-827
    • Westerbacka, J.1    Vehkavaara, S.2    Bergholm, R.3    Wilkinson, I.4    Cockcroft, J.5    Yki-Jarvinen, H.6
  • 238
    • 77956943194 scopus 로고    scopus 로고
    • Abnormalities in circadian blood pressure variability and endothelial function: Pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults
    • A.K. Gupta, G. Cornelissen, F.L. Greenway, V. Dhoopati, F. Halberg, and W.D. Johnson Abnormalities in circadian blood pressure variability and endothelial function: pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults Cardiovasc. Diabetol. 9 2010 58
    • (2010) Cardiovasc. Diabetol. , vol.9 , pp. 58
    • Gupta, A.K.1    Cornelissen, G.2    Greenway, F.L.3    Dhoopati, V.4    Halberg, F.5    Johnson, W.D.6
  • 242
    • 79955706455 scopus 로고    scopus 로고
    • Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans
    • K.A. Han, Y. Patel, A.A. Lteif, R. Chisholm, and K.J. Mather Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans Diabetes Metab. Res. Rev 27 2011 354 361
    • (2011) Diabetes Metab. Res. Rev , vol.27 , pp. 354-361
    • Han, K.A.1    Patel, Y.2    Lteif, A.A.3    Chisholm, R.4    Mather, K.J.5
  • 245
    • 71849101023 scopus 로고    scopus 로고
    • Impaired vascular function in obese adolescents with insulin resistance
    • F.H. Mahmud, D.J. Hill, M.S. Cuerden, and C.L. Clarson Impaired vascular function in obese adolescents with insulin resistance J. Pediatr. 155 2009 678 682
    • (2009) J. Pediatr. , vol.155 , pp. 678-682
    • Mahmud, F.H.1    Hill, D.J.2    Cuerden, M.S.3    Clarson, C.L.4
  • 246
    • 77649135513 scopus 로고    scopus 로고
    • Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing
    • R. Bhattacharjee, W.H. Alotaibi, L. Kheirandish-Gozal, O.S. Capdevila, and D. Gozal Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing BMC Pediatr. 10 2010 8
    • (2010) BMC Pediatr. , vol.10 , pp. 8
    • Bhattacharjee, R.1    Alotaibi, W.H.2    Kheirandish-Gozal, L.3    Capdevila, O.S.4    Gozal, D.5
  • 247
    • 84863229469 scopus 로고    scopus 로고
    • Endothelial dysfunction in children without hypertension: Potential contributions of obesity and obstructive sleep apnea
    • R. Bhattacharjee, J. Kim, W.H. Alotaibi, L. Kheirandish-Gozal, O.S. Capdevila, and D. Gozal Endothelial dysfunction in children without hypertension: potential contributions of obesity and obstructive sleep apnea Chest 141 2012 682 691
    • (2012) Chest , vol.141 , pp. 682-691
    • Bhattacharjee, R.1    Kim, J.2    Alotaibi, W.H.3    Kheirandish-Gozal, L.4    Capdevila, O.S.5    Gozal, D.6
  • 251
    • 0025776498 scopus 로고
    • Evidence that nitric oxide modulates food intake in mice
    • J.E. Morley, and J.F. Flood Evidence that nitric oxide modulates food intake in mice Life Sci. 49 1991 707 711
    • (1991) Life Sci. , vol.49 , pp. 707-711
    • Morley, J.E.1    Flood, J.F.2
  • 252
    • 0026671092 scopus 로고
    • Competitive antagonism of nitric oxide synthetase causes weight loss in mice
    • J.E. Morley, and J.F. Flood Competitive antagonism of nitric oxide synthetase causes weight loss in mice Life Sci. 51 1992 1285 1289
    • (1992) Life Sci. , vol.51 , pp. 1285-1289
    • Morley, J.E.1    Flood, J.F.2
  • 253
    • 0028031998 scopus 로고
    • Effect of competitive antagonism of NO synthetase on weight and food intake in obese and diabetic mice
    • J.E. Morley, and J.F. Flood Effect of competitive antagonism of NO synthetase on weight and food intake in obese and diabetic mice Am. J. Physiol. 266 1994 R164 168
    • (1994) Am. J. Physiol. , vol.266 , pp. 164-168
    • Morley, J.E.1    Flood, J.F.2
  • 256
    • 8444244926 scopus 로고    scopus 로고
    • Central administration of a nitric oxide precursor abolishes both the hypothalamic serotonin release and the hypophagia induced by interleukin-1β in obese Zucker rats
    • DOI 10.1016/j.regpep.2004.07.007, PII S0167011504002423
    • A. Iuras, M.M. Telles, C.R. Bertoncini, G.M. Ko, I.S. de Andrade, V.L. Silveira, and E.B. Ribeiro Central administration of a nitric oxide precursor abolishes both the hypothalamic serotonin release and the hypophagia induced by interleukin-1beta in obese Zucker rats Regul. Pept. 124 2005 145 150 (Pubitemid 39488352)
    • (2005) Regulatory Peptides , vol.124 , Issue.1-3 , pp. 145-150
    • Iuras, A.1    Telles, M.M.2    Bertoncini, C.R.A.3    Ko, G.M.4    De Andrade, I.S.5    Silveira, V.L.F.6    Ribeiro, E.B.7
  • 258
    • 0029655548 scopus 로고    scopus 로고
    • Nitric oxide mediates hyperphagia of obese Zucker rats: Relation to specific changes in the microstructure of feeding behavior
    • A. Stricker-Krongrad, B. Beck, and C. Burlet Nitric oxide mediates hyperphagia of obese Zucker rats: relation to specific changes in the microstructure of feeding behavior Life Sci. 58 1996 (PL9-15)
    • (1996) Life Sci. , vol.58
    • Stricker-Krongrad, A.1    Beck, B.2    Burlet, C.3
  • 259
    • 34748845045 scopus 로고    scopus 로고
    • Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice
    • DOI 10.1210/en.2006-1371
    • K. Tsuchiya, H. Sakai, N. Suzuki, F. Iwashima, T. Yoshimoto, M. Shichiri, and Y. Hirata Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice Endocrinology 148 2007 4548 4556 (Pubitemid 47481508)
    • (2007) Endocrinology , vol.148 , Issue.10 , pp. 4548-4556
    • Tsuchiya, K.1    Sakai, H.2    Suzuki, N.3    Iwashima, F.4    Yoshimoto, T.5    Shichiri, M.6    Hirata, Y.7
  • 260
    • 0032189341 scopus 로고    scopus 로고
    • Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action
    • R. Shankar, J.S. Zhu, B. Ladd, D. Henry, H.Q. Shen, and A.D. Baron Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action J. Clin. Invest. 102 1998 1403 1412 (Pubitemid 28467569)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.7 , pp. 1403-1412
    • Shankar, R.1    Zhu, J.-S.2    Ladd, B.3    Henry, D.4    Shen, H.-Q.5    Baron, A.D.6
  • 261
    • 0021908434 scopus 로고
    • Insulin levels, hunger, and food intake: An example of feedback loops in body weight regulation
    • J. Rodin Insulin levels, hunger, and food intake: an example of feedback loops in body weight regulation Health Psychol. 4 1985 1 24
    • (1985) Health Psychol. , vol.4 , pp. 1-24
    • Rodin, J.1
  • 263
  • 266
    • 0030605222 scopus 로고    scopus 로고
    • Effects of a nitric oxide synthase inhibitor on 5-HT(1A) receptor agonist 8-OH-DPAT-induced hyperphagia in rats
    • DOI 10.1016/S0014-2999(96)00657-7, PII S0014299996006577
    • J. Yamada, Y. Sugimoto, T. Yoshikawa, and K. Horisaka Effects of a nitric oxide synthase inhibitor on 5-HT1A receptor agonist 8-OH-DPAT-induced hyperphagia in rats Eur. J. Pharmacol. 316 1996 23 26 (Pubitemid 26426924)
    • (1996) European Journal of Pharmacology , vol.316 , Issue.1 , pp. 23-26
    • Yamada, J.1    Sugimoto, Y.2    Yoshikawa, T.3    Horisaka, K.4
  • 267
    • 0032991857 scopus 로고    scopus 로고
    • A neuronal nitric oxide synthase inhibitor 7-nitroindazole reduces the 5-HT(1A) receptor agonist 8-OH-DPAT-elicited hyperphagia in rats
    • DOI 10.1016/S0014-2999(99)00378-7, PII S0014299999003787
    • Y. Sugimoto, J. Yamada, and T. Yoshikawa A neuronal nitric oxide synthase inhibitor 7-nitroindazole reduces the 5-HT1A receptor against 8-OH-DPAT-elicited hyperphagia in rats Eur. J. Pharmacol. 376 1999 1 5 (Pubitemid 29320163)
    • (1999) European Journal of Pharmacology , vol.376 , Issue.1-2 , pp. 1-5
    • Sugimoto, Y.1    Yamada, J.2    Yoshikawa, T.3
  • 268
    • 0034467705 scopus 로고    scopus 로고
    • Involvement of nitric oxide in the 5-HT1A autoreceptor-mediated hyperphagia in rats
    • Y. Sugimoto, T. Yoshikawa, and J. Yamada Involvement of nitric oxide in the 5-HT1A autoreceptor-mediated hyperphagia in rats Adv. Exp. Med. Biol. 467 1999 109 111
    • (1999) Adv. Exp. Med. Biol. , vol.467 , pp. 109-111
    • Sugimoto, Y.1    Yoshikawa, T.2    Yamada, J.3
  • 269
    • 0141887631 scopus 로고    scopus 로고
    • G-nitro-L-arginine methyl ester, attenuates lipoprivic feeding in mice
    • DOI 10.1016/S0031-9384(03)00220-8
    • D.A. Czech, M.R. Kazel, and J. Harris A nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, attenuates lipoprivic feeding in mice Physiol. Behav. 80 2003 75 79 (Pubitemid 37249375)
    • (2003) Physiology and Behavior , vol.80 , Issue.1 , pp. 75-79
    • Czech, D.A.1    Kazel, M.R.2    Harris, J.3
  • 270
    • 33744946529 scopus 로고    scopus 로고
    • The weight loss elicited by cobalt protoporphyrin is related to decreased activity of nitric oxide synthase in the hypothalamus
    • DOI 10.1152/japplphysiol.01169.2005
    • M. Li, M.A. Vizzard, D.M. Jaworski, and R.A. Galbraith The weight loss elicited by cobalt protoporphyrin is related to decreased activity of nitric oxide synthase in the hypothalamus J. Appl. Physiol. (1985) 100 2006 1983 1991 (Pubitemid 43845874)
    • (2006) Journal of Applied Physiology , vol.100 , Issue.6 , pp. 1983-1991
    • Li, M.1    Vizzard, M.A.2    Jaworski, D.M.3    Galbraith, R.A.4
  • 272
    • 33751161061 scopus 로고    scopus 로고
    • Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients
    • P. Lucotti, E. Setola, L.D. Monti, E. Galluccio, S. Costa, E.P. Sandoli, I. Fermo, G. Rabaiotti, R. Gatti, and P. Piatti Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients Am. J. Physiol. Endocrinol. Metab. 291 2006 E906 912
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291 , pp. 906-912
    • Lucotti, P.1    Setola, E.2    Monti, L.D.3    Galluccio, E.4    Costa, S.5    Sandoli, E.P.6    Fermo, I.7    Rabaiotti, G.8    Gatti, R.9    Piatti, P.10
  • 273
    • 84861168954 scopus 로고    scopus 로고
    • Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: A randomized, double-blind, placebo-controlled trial
    • M. Alizadeh, A. Safaeiyan, A. Ostadrahimi, R. Estakhri, S. Daneghian, A. Ghaffari, and B.P. Gargari Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: a randomized, double-blind, placebo-controlled trial Ann. Nutr. Metab. 60 2012 157 168
    • (2012) Ann. Nutr. Metab. , vol.60 , pp. 157-168
    • Alizadeh, M.1    Safaeiyan, A.2    Ostadrahimi, A.3    Estakhri, R.4    Daneghian, S.5    Ghaffari, A.6    Gargari, B.P.7
  • 274
    • 84864223457 scopus 로고    scopus 로고
    • Effect of 3-month L-arginine supplementation on insulin resistance and tumor necrosis factor activity in patients with visceral obesity
    • P. Bogdanski, J. Suliburska, K. Grabanska, K. Musialik, A. Cieslewicz, A. Skoluda, and A. Jablecka Effect of 3-month L-arginine supplementation on insulin resistance and tumor necrosis factor activity in patients with visceral obesity Eur. Rev. Med. Sci 16 2012 816 823
    • (2012) Eur. Rev. Med. Sci , vol.16 , pp. 816-823
    • Bogdanski, P.1    Suliburska, J.2    Grabanska, K.3    Musialik, K.4    Cieslewicz, A.5    Skoluda, A.6    Jablecka, A.7
  • 275
    • 84878976899 scopus 로고    scopus 로고
    • Supplementation with L-arginine favorably influences plasminogen activator inhibitor type 1 concentration in obese patients: A randomized, double blind trial
    • P. Bogdanski, M. Szulinska, J. Suliburska, D. Pupek-Musialik, A. Jablecka, and H. Witmanowski Supplementation with L-arginine favorably influences plasminogen activator inhibitor type 1 concentration in obese patients: a randomized, double blind trial J. Endocrinol. Invest. 36 2013 221 226
    • (2013) J. Endocrinol. Invest. , vol.36 , pp. 221-226
    • Bogdanski, P.1    Szulinska, M.2    Suliburska, J.3    Pupek-Musialik, D.4    Jablecka, A.5    Witmanowski, H.6
  • 276
    • 84896690790 scopus 로고    scopus 로고
    • Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation
    • J. Suliburska, P. Bogdanski, M. Szulinska, D. Pupek-Musialik, and A. Jablecka Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation Eur. J. Nutr. 53 2014 387 393
    • (2014) Eur. J. Nutr. , vol.53 , pp. 387-393
    • Suliburska, J.1    Bogdanski, P.2    Szulinska, M.3    Pupek-Musialik, D.4    Jablecka, A.5
  • 277
    • 84872688525 scopus 로고    scopus 로고
    • L-Arginine enriched biscuits improve endothelial function and glucose metabolism: A pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome
    • L.D. Monti, M.C. Casiraghi, E. Setola, E. Galluccio, M.A. Pagani, L. Quaglia, E. Bosi, and P. Piatti L-Arginine enriched biscuits improve endothelial function and glucose metabolism: a pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome Metabolism 62 2013 255 264
    • (2013) Metabolism , vol.62 , pp. 255-264
    • Monti, L.D.1    Casiraghi, M.C.2    Setola, E.3    Galluccio, E.4    Pagani, M.A.5    Quaglia, L.6    Bosi, E.7    Piatti, P.8
  • 278
    • 84867045005 scopus 로고    scopus 로고
    • L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances
    • C. Clemmensen, A.N. Madsen, S. Smajilovic, B. Holst, and H. Brauner-Osborne L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances Amino Acids 43 2012 1265 1275
    • (2012) Amino Acids , vol.43 , pp. 1265-1275
    • Clemmensen, C.1    Madsen, A.N.2    Smajilovic, S.3    Holst, B.4    Brauner-Osborne, H.5
  • 280
    • 60249098019 scopus 로고    scopus 로고
    • Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats
    • W. Jobgen, C.J. Meininger, S.C. Jobgen, P. Li, M.J. Lee, S.B. Smith, T.E. Spencer, S.K. Fried, and G. Wu Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats J. Nutr. 139 2009 230 237
    • (2009) J. Nutr. , vol.139 , pp. 230-237
    • Jobgen, W.1    Meininger, C.J.2    Jobgen, S.C.3    Li, P.4    Lee, M.J.5    Smith, S.B.6    Spencer, T.E.7    Fried, S.K.8    Wu, G.9
  • 281
    • 67349263590 scopus 로고    scopus 로고
    • Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs
    • B. Tan, Y. Yin, Z. Liu, X. Li, H. Xu, X. Kong, R. Huang, W. Tang, I. Shinzato, S.B. Smith, and G. Wu Dietary L-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs Amino Acids 37 2009 169 175
    • (2009) Amino Acids , vol.37 , pp. 169-175
    • Tan, B.1    Yin, Y.2    Liu, Z.3    Li, X.4    Xu, H.5    Kong, X.6    Huang, R.7    Tang, W.8    Shinzato, I.9    Smith, S.B.10    Wu, G.11
  • 283
    • 34047094881 scopus 로고    scopus 로고
    • Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice
    • DOI 10.2337/db06-0883
    • J.E. Ayala, D.P. Bracy, B.M. Julien, J.N. Rottman, P.T. Fueger, and D.H. Wasserman Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice Diabetes 56 2007 1025 1033 (Pubitemid 46525081)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1025-1033
    • Ayala, J.E.1    Bracy, D.P.2    Julien, B.M.3    Rottman, J.N.4    Fueger, P.T.5    Wasserman, D.H.6
  • 285
    • 84856855686 scopus 로고    scopus 로고
    • Effects of type 5-phosphodiesterase inhibition on energy metabolism and mitochondrial biogenesis in human adipose tissue ex vivo
    • L. De Toni, G. Strapazzon, L. Gianesello, N. Caretta, C. Pilon, A. Bruttocao, and C. Foresta Effects of type 5-phosphodiesterase inhibition on energy metabolism and mitochondrial biogenesis in human adipose tissue ex vivo J. Endocrinol. Invest. 34 2011 738 741
    • (2011) J. Endocrinol. Invest. , vol.34 , pp. 738-741
    • De Toni, L.1    Strapazzon, G.2    Gianesello, L.3    Caretta, N.4    Pilon, C.5    Bruttocao, A.6    Foresta, C.7
  • 286
    • 84890963093 scopus 로고    scopus 로고
    • Nitric oxide directly promotes vascular endothelial insulin transport
    • H. Wang, A.X. Wang, K. Aylor, and E.J. Barrett Nitric oxide directly promotes vascular endothelial insulin transport Diabetes 62 2013 4030 4042
    • (2013) Diabetes , vol.62 , pp. 4030-4042
    • Wang, H.1    Wang, A.X.2    Aylor, K.3    Barrett, E.J.4
  • 287
    • 0028784603 scopus 로고
    • Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor L-NMMA in rats
    • A.D. Baron, J.S. Zhu, S. Marshall, O. Irsula, G. Brechtel, and C. Keech Insulin resistance after hypertension induced by the nitric oxide synthesis inhibitor L-NMMA in rats Am. J. Physiol. 269 1995 E709 715
    • (1995) Am. J. Physiol. , vol.269 , pp. 709-715
    • Baron, A.D.1    Zhu, J.S.2    Marshall, S.3    Irsula, O.4    Brechtel, G.5    Keech, C.6
  • 288
    • 69249213467 scopus 로고    scopus 로고
    • Hepatic insulin resistance, metabolic syndrome and cardiovascular disease
    • R. Meshkani, and K. Adeli Hepatic insulin resistance, metabolic syndrome and cardiovascular disease Clin. Biochem. 42 2009 1331 1346
    • (2009) Clin. Biochem. , vol.42 , pp. 1331-1346
    • Meshkani, R.1    Adeli, K.2
  • 289
    • 0034235409 scopus 로고    scopus 로고
    • Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency
    • DOI 10.1042/0264-6021:3490353
    • C.J. Meininger, R.S. Marinos, K. Hatakeyama, R. Martinez-Zaguilan, J.D. Rojas, K.A. Kelly, and G. Wu Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency Biochem. J. 349 2000 353 356 (Pubitemid 30440201)
    • (2000) Biochemical Journal , vol.349 , Issue.1 , pp. 353-356
    • Meininger, C.J.1    Marinos, R.S.2    Hatakeyama, K.3    Martinez-Zaguilan, R.4    Rojas, J.D.5    Kelly, K.A.6    Wu, G.7
  • 290
    • 34548134851 scopus 로고    scopus 로고
    • Proteasome-dependent degradation of guanosine 5′-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    • DOI 10.1161/CIRCULATIONAHA.106.684795, PII 0000301720070821000012
    • J. Xu, Y. Wu, P. Song, M. Zhang, S. Wang, and M.H. Zou Proteasome-dependent degradation of guanosine 5′-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus Circulation 116 2007 944 953 (Pubitemid 47300919)
    • (2007) Circulation , vol.116 , Issue.8 , pp. 944-953
    • Xu, J.1    Wu, Y.2    Song, P.3    Zhang, M.4    Wang, S.5    Zou, M.-H.6
  • 291
    • 10044245949 scopus 로고    scopus 로고
    • GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats
    • DOI 10.1096/fj.04-1702fje
    • C.J. Meininger, S. Cai, J.L. Parker, K.M. Channon, K.A. Kelly, E.J. Becker, M.K. Wood, L.A. Wade, and G. Wu GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats FASEB J 18 2004 1900 1902 (Pubitemid 39602277)
    • (2004) FASEB Journal , vol.18 , Issue.15 , pp. 1900-1902
    • Meininger, C.J.1    Cai, S.2    Parker, J.L.3    Channon, K.M.4    Kelly, K.A.5    Becker, E.J.6    Wood, M.K.7    Wade, L.A.8    Wu, G.9
  • 293
    • 0032806256 scopus 로고    scopus 로고
    • Blockade of hepatic nitric oxide synthase causes insulin resistance
    • P. Sadri, and W.W. Lautt Blockade of hepatic nitric oxide synthase causes insulin resistance Am. J. Physiol. 277 1999 G101 108
    • (1999) Am. J. Physiol. , vol.277 , pp. 101-108
    • Sadri, P.1    Lautt, W.W.2
  • 295
    • 33646565956 scopus 로고    scopus 로고
    • Co-administration of glutathione and nitric oxide enhances insulin sensitivity in Wistar rats
    • M.P. Guarino, and M.P. Macedo Co-administration of glutathione and nitric oxide enhances insulin sensitivity in Wistar rats Br. J. Pharmacol. 147 2006 959 965
    • (2006) Br. J. Pharmacol. , vol.147 , pp. 959-965
    • Guarino, M.P.1    Macedo, M.P.2
  • 297
    • 3042750029 scopus 로고    scopus 로고
    • A new paradigm for diabetes and obesity: The hepatic insulin sensitizing substance (HISS) hypothesis
    • DOI 10.1254/jphs.95.9
    • W.W. Lautt A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis J. Pharmacol. Sci. 95 2004 9 17 (Pubitemid 38856040)
    • (2004) Journal of Pharmacological Sciences , vol.95 , Issue.1 , pp. 9-17
    • Lautt, W.W.1
  • 298
    • 21144441141 scopus 로고    scopus 로고
    • Insulin sensitivity in skeletal muscle regulated by a hepatic hormone, HISS
    • W.W. Lautt Insulin sensitivity in skeletal muscle regulated by a hepatic hormone, HISS Can. J. Appl. Physiol. 30 2005 304 312 (Pubitemid 40880710)
    • (2005) Canadian Journal of Applied Physiology , vol.30 , Issue.3 , pp. 304-312
    • Lautt, W.W.1
  • 299
    • 79251475292 scopus 로고    scopus 로고
    • HISS, not insulin, causes vasodilation in response to administered insulin
    • Z. Ming, and W.W. Lautt HISS, not insulin, causes vasodilation in response to administered insulin J. Appl. Physiol. (1985) 110 2011 60 68
    • (2011) J. Appl. Physiol. (1985) , vol.110 , pp. 60-68
    • Ming, Z.1    Lautt, W.W.2
  • 300
    • 0028030813 scopus 로고
    • Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent: A novel action of insulin to increase nitric oxide release
    • H.O. Steinberg, G. Brechtel, A. Johnson, N. Fineberg, and A.D. Baron Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent: a novel action of insulin to increase nitric oxide release J. Clin. Invest. 94 1994 1172 1179
    • (1994) J. Clin. Invest. , vol.94 , pp. 1172-1179
    • Steinberg, H.O.1    Brechtel, G.2    Johnson, A.3    Fineberg, N.4    Baron, A.D.5
  • 302
    • 0028085621 scopus 로고
    • Hemodynamic actions of insulin
    • A.D. Baron Hemodynamic actions of insulin Am. J. Physiol. 267 1994 E187 202
    • (1994) Am. J. Physiol. , vol.267 , pp. 187-202
    • Baron, A.D.1
  • 304
    • 0035699836 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition decreases output of hepatic insulin sensitizing substance (HISS), which is reversed by SIN-1 but not by nitroprusside
    • M.P. Guarino, N.C. Correia, J. Raposo, and M.P. Macedo Nitric oxide synthase inhibition decreases output of hepatic insulin sensitizing substance (HISS), which is reversed by SIN-1 but not by nitroprusside Proc. West. Pharmacol. Soc. 44 2001 25 26 (Pubitemid 34087701)
    • (2001) Proceedings of the Western Pharmacology Society , vol.44 , pp. 25-26
    • Guarino, M.P.1    Correia, N.C.2    Raposo, J.3    Macedo, M.P.4
  • 307
    • 0035553960 scopus 로고    scopus 로고
    • Neural hormonal regulation of exocrine pancreatic secretion
    • W.Y. Chey, and T. Chang Neural hormonal regulation of exocrine pancreatic secretion Pancreatology 1 2001 320 335 (Pubitemid 33758409)
    • (2001) Pancreatology , vol.1 , Issue.4 , pp. 320-335
    • Chey, W.Y.1    Chang, T.-M.2
  • 310
    • 0032579373 scopus 로고    scopus 로고
    • Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic β cells develop insulin-dependent diabetes without insulitis
    • DOI 10.1074/jbc.273.5.2493
    • T. Takamura, I. Kato, N. Kimura, T. Nakazawa, H. Yonekura, S. Takasawa, and H. Okamoto Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis J. Biol. Chem. 273 1998 2493 2496 (Pubitemid 28133886)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.5 , pp. 2493-2496
    • Takamura, T.1    Kato, I.2    Kimura, N.3    Nakazawa, T.4    Yonekura, H.5    Takasawa, S.6    Okamoto, H.7
  • 311
    • 0025721872 scopus 로고
    • L-Arginine stimulates cyclic guanosine 3′,5′-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: Evidence for L-arginine:nitric oxide synthase
    • S.G. Laychock, M.E. Modica, and C.T. Cavanaugh L-Arginine stimulates cyclic guanosine 3′,5′-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: evidence for L-arginine:nitric oxide synthase Endocrinology 129 1991 3043 3052
    • (1991) Endocrinology , vol.129 , pp. 3043-3052
    • Laychock, S.G.1    Modica, M.E.2    Cavanaugh, C.T.3
  • 312
    • 0026561920 scopus 로고
    • Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides
    • H.H. Schmidt, T.D. Warner, K. Ishii, H. Sheng, and F. Murad Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides Science 255 1992 721 723
    • (1992) Science , vol.255 , pp. 721-723
    • Schmidt, H.H.1    Warner, T.D.2    Ishii, K.3    Sheng, H.4    Murad, F.5
  • 313
    • 0031750019 scopus 로고    scopus 로고
    • The early phase of glucose-stimulated insulin secretion requires nitric oxide
    • DOI 10.1007/s001250050906
    • G.A. Spinas, R. Laffranchi, I. Francoys, I. David, C. Richter, and M. Reinecke The early phase of glucose-stimulated insulin secretion requires nitric oxide Diabetologia 41 1998 292 299 (Pubitemid 28254823)
    • (1998) Diabetologia , vol.41 , Issue.3 , pp. 292-299
    • Spinas, G.A.1    Laffranchi, R.2    Francoys, I.3    David, I.4    Richter, C.5    Reinecke, M.6
  • 314
    • 0002328264 scopus 로고    scopus 로고
    • The dual role of nitric oxide in islet beta-cells
    • G.A. Spinas The dual role of nitric oxide in islet beta-cells News Physiol. Sci. 14 1999 49 54
    • (1999) News Physiol. Sci. , vol.14 , pp. 49-54
    • Spinas, G.A.1
  • 315
    • 0029568030 scopus 로고
    • Nitric oxide (nitrogen monoxide, NO) stimulates insulin secretion by inducing calcium release from mitochondria
    • DOI 10.1006/bbrc.1995.2815
    • R. Laffranchi, V. Gogvadze, C. Richter, and G.A. Spinas Nitric oxide (nitrogen monoxide, NO) stimulates insulin secretion by inducing calcium release from mitochondria Biochem. Biophys. Res. Commun. 217 1995 584 591 (Pubitemid 26011751)
    • (1995) Biochemical and Biophysical Research Communications , vol.217 , Issue.2 , pp. 584-591
    • Laffranchi, R.1    Gogvadze, V.2    Richter, C.3    Spinas, G.A.4
  • 316
    • 0026761165 scopus 로고
    • Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans
    • P.M. Jones, S.J. Persaud, T. Bjaaland, J.D. Pearson, and S.L. Howell Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans Diabetologia 35 1992 1020 1027
    • (1992) Diabetologia , vol.35 , pp. 1020-1027
    • Jones, P.M.1    Persaud, S.J.2    Bjaaland, T.3    Pearson, J.D.4    Howell, S.L.5
  • 317
    • 0026480937 scopus 로고
    • Contribution of neural intrapancreatic non-cholinergic non-adrenergic mechanisms to glucose-induced insulin release in the isolated rat pancreas
    • N. Weigert, M. Dollinger, R. Schmid, and V. Schusdziarra Contribution of neural intrapancreatic non-cholinergic non-adrenergic mechanisms to glucose-induced insulin release in the isolated rat pancreas Diabetologia 35 1992 1133 1139
    • (1992) Diabetologia , vol.35 , pp. 1133-1139
    • Weigert, N.1    Dollinger, M.2    Schmid, R.3    Schusdziarra, V.4
  • 318
    • 0036435682 scopus 로고    scopus 로고
    • Association of -786t-C mutation of endothelial nitric oxide synthase gene with insulin resistance
    • DOI 10.1007/s00125-002-0922-6
    • K. Ohtoshi, Y. Yamasaki, S. Gorogawa, R. Hayaishi-Okano, K. Node, M. Matsuhisa, Y. Kajimoto, and M. Hori Association of (-)786T-C mutation of endothelial nitric oxide synthase gene with insulin resistance Diabetologia 45 2002 1594 1601 (Pubitemid 35352054)
    • (2002) Diabetologia , vol.45 , Issue.11 , pp. 1594-1601
    • Ohtoshi, K.1    Yamasaki, Y.2    Gorogawa, S.3    Hayaishi-Okano, R.4    Node, K.5    Matsuhisa, M.6    Kajimoto, Y.7    Hori, M.8
  • 320
    • 84866780220 scopus 로고    scopus 로고
    • T(-786)→C polymorphism of the endothelial nitric oxide synthase gene is associated with insulin resistance in patients with ischemic or non ischemic cardiomyopathy
    • C. Vecoli, M.G. Andreassi, R. Liga, M.G. Colombo, M. Coceani, C. Carpeggiani, A. L'Abbate, and D. Neglia T(-786)→C polymorphism of the endothelial nitric oxide synthase gene is associated with insulin resistance in patients with ischemic or non ischemic cardiomyopathy BMC Med. Genet. 13 2012 92
    • (2012) BMC Med. Genet. , vol.13 , pp. 92
    • Vecoli, C.1    Andreassi, M.G.2    Liga, R.3    Colombo, M.G.4    Coceani, M.5    Carpeggiani, C.6    L'Abbate, A.7    Neglia, D.8
  • 324
    • 0035038370 scopus 로고    scopus 로고
    • Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease
    • DOI 10.1042/CS20000223
    • B.J. Morris, C.L. Glenn, D.E. Wilcken, and X.L. Wang Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease Clin. Sci. 100 2001 551 556 (Pubitemid 32434121)
    • (2001) Clinical Science , vol.100 , Issue.5 , pp. 551-556
    • Morris, B.J.1    Glenn, C.L.2    Wilcken, D.E.L.3    Wang, X.L.4
  • 325
    • 77953135609 scopus 로고    scopus 로고
    • Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with type 2 diabetes
    • R.A. Bagarolli, M.J. Saad, and S.T. Saad Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with type 2 diabetes J. Diabetes Complications 24 2010 192 198
    • (2010) J. Diabetes Complications , vol.24 , pp. 192-198
    • Bagarolli, R.A.1    Saad, M.J.2    Saad, S.T.3
  • 327
    • 3242745195 scopus 로고    scopus 로고
    • Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet - Induced insulin resistance and arterial hypertension
    • DOI 10.2337/diabetes.53.8.2067
    • S. Cook, O. Hugli, M. Egli, B. Menard, S. Thalmann, C. Sartori, C. Perrin, P. Nicod, B. Thorens, P. Vollenweider, U. Scherrer, and R. Burcelin Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension Diabetes 53 2004 2067 2072 (Pubitemid 38970756)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2067-2072
    • Cook, S.1    Hugli, O.2    Egli, M.3    Menard, B.4    Thalmann, S.5    Sartori, C.6    Perrin, C.7    Nicod, P.8    Thorens, B.9    Vollenweider, P.10    Scherrer, U.11    Burcelin, R.12
  • 328
  • 329
    • 0013054309 scopus 로고    scopus 로고
    • Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance
    • R.R. Shankar, Y. Wu, H.Q. Shen, J.S. Zhu, and A.D. Baron Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance Diabetes 49 2000 684 687 (Pubitemid 30339980)
    • (2000) Diabetes , vol.49 , Issue.5 , pp. 684-687
    • Shankar, R.R.1    Wu, Y.2    Shen, H.-Q.3    Zhu, J.-S.4    Baron, A.D.5
  • 332
    • 35748985277 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase (eNOS) knockout mice have defective mitochondrial β-oxidation
    • DOI 10.2337/db06-1228
    • E. Le Gouill, M. Jimenez, C. Binnert, P.Y. Jayet, S. Thalmann, P. Nicod, U. Scherrer, and P. Vollenweider Endothelial nitric oxide synthase (eNOS) knockout mice have defective mitochondrial beta-oxidation Diabetes 56 2007 2690 2696 (Pubitemid 350044910)
    • (2007) Diabetes , vol.56 , Issue.11 , pp. 2690-2696
    • Le Gouill, E.1    Jimenez, M.2    Binnert, C.3    Jayet, P.-Y.4    Thalmann, S.5    Nicod, P.6    Scherrer, U.7    Vollenweider, P.8
  • 335
    • 78549291345 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase transgenic models of endothelial dysfunction
    • D.N. Atochin, and P.L. Huang Endothelial nitric oxide synthase transgenic models of endothelial dysfunction Pflugers Arch. 460 2010 965 974
    • (2010) Pflugers Arch. , vol.460 , pp. 965-974
    • Atochin, D.N.1    Huang, P.L.2
  • 337
    • 0029836694 scopus 로고    scopus 로고
    • Feeding rats the nitric oxide synthase inhibitor, L-N(ω) nitroarginine, elevates serum triglyceride and cholesterol and lowers hepatic fatty acid oxidation
    • A. Khedara, Y. Kawai, J. Kayashita, and N. Kato Feeding rats the nitric oxide synthase inhibitor, L-N(omega)nitroarginine, elevates serum triglyceride and cholesterol and lowers hepatic fatty acid oxidation J. Nutr. 126 1996 2563 2567 (Pubitemid 26339671)
    • (1996) Journal of Nutrition , vol.126 , Issue.10 , pp. 2563-2567
    • Khedara, A.1    Kawai, Y.2    Kayashita, J.3    Kato, N.4
  • 340
    • 0037333221 scopus 로고    scopus 로고
    • Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes
    • DOI 10.1016/S0006-2952(02)01623-4
    • J. Garcia-Villafranca, A. Guillen, and J. Castro Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes Biochem. Pharmacol. 65 2003 807 812 (Pubitemid 36293697)
    • (2003) Biochemical Pharmacology , vol.65 , Issue.5 , pp. 807-812
    • Garcia-Villafranca, J.1    Guillen, A.2    Castro, J.3
  • 341
    • 0032946792 scopus 로고    scopus 로고
    • Feeding the nitric oxide synthase inhibitor L-N(ω)nitroarginine elevates serum very low density lipoprotein and hepatic triglyceride synthesis in rats
    • DOI 10.1016/S0955-2863(99)00008-X, PII S095528639900008X
    • T. Goto, S. Ohnomi, A. Khedara, N. Kato, H. Ogawa, and T. Yanagita Feeding the nitric oxide synthase inhibitor L-N(omega)nitroarginine elevates serum very low density lipoprotein and hepatic triglyceride synthesis in rats J. Nutr. Biochem. 10 1999 274 278 (Pubitemid 29219495)
    • (1999) Journal of Nutritional Biochemistry , vol.10 , Issue.5 , pp. 274-278
    • Goto, T.1    Ohnomi, S.2    Khedara, A.3    Kato, N.4    Ogawa, H.5    Yanagita, T.6
  • 342
  • 343
    • 33644652183 scopus 로고    scopus 로고
    • Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
    • DOI 10.1172/JCI27989
    • P. Lefebvre, G. Chinetti, J.C. Fruchart, and B. Staels Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis J. Clin. Invest. 116 2006 571 580 (Pubitemid 43326861)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.3 , pp. 571-580
    • Lefebvre, P.1    Chinetti, G.2    Fruchart, J.-C.3    Staels, B.4
  • 344
    • 84872577684 scopus 로고    scopus 로고
    • Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation
    • P.T. Doulias, M. Tenopoulou, J.L. Greene, K. Raju, and H. Ischiropoulos Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation Sci. Signaling 6 2013 rs1
    • (2013) Sci. Signaling , vol.6 , pp. 1
    • Doulias, P.T.1    Tenopoulou, M.2    Greene, J.L.3    Raju, K.4    Ischiropoulos, H.5
  • 345
    • 0034770292 scopus 로고    scopus 로고
    • Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
    • DOI 10.1038/nm1001-1138
    • M. Perreault, and A. Marette Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle Nat. Med 7 2001 1138 1143 (Pubitemid 33010023)
    • (2001) Nature Medicine , vol.7 , Issue.10 , pp. 1138-1143
    • Perreault, M.1    Marette, A.2
  • 346
    • 15944378147 scopus 로고    scopus 로고
    • S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: A novel mechanism of insulin resistance
    • DOI 10.2337/diabetes.54.4.959
    • M.A. Carvalho-Filho, M. Ueno, S.M. Hirabara, A.B. Seabra, J.B. Carvalheira, M.G. de Oliveira, L.A. Velloso, R. Curi, and M.J. Saad S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance Diabetes 54 2005 959 967 (Pubitemid 40446309)
    • (2005) Diabetes , vol.54 , Issue.4 , pp. 959-967
    • Carvalho-Filho, M.A.1    Ueno, M.2    Hirabara, S.M.3    Seabra, A.B.4    Carvalheira, J.B.C.5    De Oliveira, M.G.6    Velloso, L.A.7    Curi, R.8    Saad, M.J.A.9
  • 347
    • 33748470543 scopus 로고    scopus 로고
    • Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice
    • M.A. Carvalho-Filho, M. Ueno, J.B. Carvalheira, L.A. Velloso, and M.J. Saad Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice Am. J. Physiol. Endocrinol. Metab. 291 2006 E476 482
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291 , pp. 476-482
    • Carvalho-Filho, M.A.1    Ueno, M.2    Carvalheira, J.B.3    Velloso, L.A.4    Saad, M.J.5
  • 348
    • 38149095759 scopus 로고    scopus 로고
    • Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats
    • J.R. Pauli, E.R. Ropelle, D.E. Cintra, M.A. Carvalho-Filho, J.C. Moraes, C.T. De Souza, L.A. Velloso, J.B. Carvalheira, and M.J. Saad Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats J. Physiol. 586 2008 659 671
    • (2008) J. Physiol. , vol.586 , pp. 659-671
    • Pauli, J.R.1    Ropelle, E.R.2    Cintra, D.E.3    Carvalho-Filho, M.A.4    Moraes, J.C.5    De Souza, C.T.6    Velloso, L.A.7    Carvalheira, J.B.8    Saad, M.J.9
  • 349
    • 14244269416 scopus 로고
    • On the treatment of glycosuria and diabetes mellitus with sodium salicylate
    • R.T. Williamson On the treatment of glycosuria and diabetes mellitus with sodium salicylate Br. Med. J 1 1901 760 762
    • (1901) Br. Med. J , vol.1 , pp. 760-762
    • Williamson, R.T.1
  • 350
    • 0006440925 scopus 로고
    • The effect of salicylate on glycosuria, blood glucose and liver glycogen of the alloxan-diabetic rat
    • M.J. Smith, and B.W. Meade The effect of salicylate on glycosuria, blood glucose and liver glycogen of the alloxan-diabetic rat Biochem. J. 51 1952 18 20
    • (1952) Biochem. J. , vol.51 , pp. 18-20
    • Smith, M.J.1    Meade, B.W.2
  • 353
    • 70349852830 scopus 로고    scopus 로고
    • Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt
    • M.A. Carvalho-Filho, E.R. Ropelle, R.J. Pauli, D.E. Cintra, D.M. Tsukumo, L.R. Silveira, R. Curi, J.B. Carvalheira, L.A. Velloso, and M.J. Saad Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRbeta/IRS-1 and Akt Diabetologia 52 2009 2425 2434
    • (2009) Diabetologia , vol.52 , pp. 2425-2434
    • Carvalho-Filho, M.A.1    Ropelle, E.R.2    Pauli, R.J.3    Cintra, D.E.4    Tsukumo, D.M.5    Silveira, L.R.6    Curi, R.7    Carvalheira, J.B.8    Velloso, L.A.9    Saad, M.J.10
  • 354
    • 80053400882 scopus 로고    scopus 로고
    • Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice
    • S. Shinozaki, C.S. Choi, N. Shimizu, M. Yamada, M. Kim, T. Zhang, G. Shiota, H.H. Dong, Y.B. Kim, and M. Kaneki Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice J. Biol. Chem. 286 2011 34959 34975
    • (2011) J. Biol. Chem. , vol.286 , pp. 34959-34975
    • Shinozaki, S.1    Choi, C.S.2    Shimizu, N.3    Yamada, M.4    Kim, M.5    Zhang, T.6    Shiota, G.7    Dong, H.H.8    Kim, Y.B.9    Kaneki, M.10
  • 356
    • 77955843072 scopus 로고    scopus 로고
    • Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance
    • H.N. Cha, Y.W. Kim, J.Y. Kim, Y.D. Kim, I.H. Song, K.N. Min, and S.Y. Park Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance Exp. Gerontol. 45 2010 711 718
    • (2010) Exp. Gerontol. , vol.45 , pp. 711-718
    • Cha, H.N.1    Kim, Y.W.2    Kim, J.Y.3    Kim, Y.D.4    Song, I.H.5    Min, K.N.6    Park, S.Y.7
  • 357
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • DOI 10.1038/nrm1837, PII NRM1837
    • C.M. Taniguchi, B. Emanuelli, and C.R. Kahn Critical nodes in signalling pathways: insights into insulin action Nat. Rev. Mol. Cell Biol. 7 2006 85 96 (Pubitemid 43278292)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3


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