Transcriptional control of human adipose tissue blood flow

Obesity

Volumn 17, Issue 4, 2009, Pages 681-688

  Perez Matute, Patricia ^a   Neville, Matthew J ^a   Tan, Garry D ^a   Frayn, Keith N ^a   Karpe, Fredrik ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR RECEPTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NATRIURETIC PEPTIDE RECEPTOR A;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; BLOOD FLOW; BODY MASS; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MALE; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTPRANDIAL STATE; SUBCUTANEOUS FAT; VASCULARIZATION; VASODILATATION;

ALGORITHMS; BODY MASS INDEX; HUMANS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; NITRIC OXIDE SYNTHASE TYPE III; OBESITY; OVERWEIGHT; POSTPRANDIAL PERIOD; RECEPTORS, ATRIAL NATRIURETIC FACTOR; REGIONAL BLOOD FLOW; SUBCUTANEOUS FAT; TRANSCRIPTION, GENETIC; VASODILATION;

EID: 63049112009     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.606     Document Type: Article

References (43)

1. Samra JS, Simpson EJ, Clark ML et al. Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism. Am J Physiol 1996;271:E834-E839.
2. Bulow J, Madsen J. Adipose tissue blood flow during prolonged, heavy exercise. Pflugers Arch 1976;363:231-234.
3. Hansen M, Jacobsen E, Madsen J. Influence of hypoxia and hyperoxia on subcutaneous adipose tissue blood flow in man. Scand J Clin Lab Invest 1976;36:655-660.
4. Bulow J, Astrup A, Christensen NJ, Kastrup J. Blood flow in skin, subcutaneous adipose tissue and skeletal muscle in the forearm of normal man during an oral glucose load. Acta Physiol Scand 1987;130:657-661.
5. Karpe F, Fielding BA, Ilic V, Humphreys SM, Frayn KN. Monitoring adipose tissue blood flow in man: a comparison between the (133)xenon washout method and microdialysis. Int J Obes Relat Metab Disord 2002;26:1-5.
6. Coppack SW, Evans RD, Fisher RM et al. Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism 1992;41:264-272.
7. Tan GD, Neville MJ, Liverani E et al. The in vivo effects of the Pro12Ala PPAR?2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank. Diabetologia 2006;49:158-168.
8. Evans K, Clark ML, Frayn KN. Effects of an oral and intravenous fat load on adipose tissue and forearm lipid metabolism. Am J Physiol 1999;276: E241-E248.
9. Frayn KN, Karpe F, Fielding BA, Macdonald IA, Coppack SW. Integrative physiology of human adipose tissue. Int J Obes Relat Metab Disord 2003;27:875-888.
10. Ardilouze JL, Fielding BA, Currie JM, Frayn KN, Karpe F. Nitric oxide and ?-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans. Circulation 2004;109:47-52.
11. Blaak EE, van Baak MA, Kemerink GJ et al. ?-adrenergic stimulation and abdominal subcutaneous fat blood flow in lean, obese, and reduced-obese subjects. Metabolism 1995;44:183-187.
12. Goossens GH, McQuaid SE, Dennis AL et al. Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans. J Physiol 2006;571:451-460.
13. Karpe F, Fielding BA, Ardilouze JL et al. Effects of insulin on adipose tissue blood flow in man. J Physiol 2002;540:1087-1093.
14. Jansson PA, Larsson A, Lonnroth PN. Relationship between blood pressure, metabolic variables and blood flow in obese subjects with or without noninsulin-dependent diabetes mellitus. Eur J Clin Invest 1998;28:813-818.
15. Summers LK, Samra JS, Humphreys SM, Morris RJ, Frayn KN. Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity. Clin Sci (Lond) 1996;91:679-683.
16. Summers LK, Samra JS, Frayn KN. Impaired postprandial tissue regulation of blood flow in insulin resistance: a determinant of cardiovascular risk? Atherosclerosis 1999;147:11-15.
17. Karpe F, Fielding BA, Ilic V et al. Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes 2002;51: 2467-2473.
18. Frayn K, Macdonald I. Adipose tissue circulation. In: Bennett T, Gardiner S (eds). Nervous Control of Blood Vessels. Harwood Academic: Amsterdam, 1996, pp 505-539.
19. Altshuler D, Hirschhorn JN, Klannemark M et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000;26:76-80.
20. Deeb SS, Fajas L, Nemoto M et al. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998;20:284-287.
21. Ek J, Andersen G, Urhammer SA et al. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene in relation to insulin sensitivity among glucose tolerant caucasians. Diabetologia 2001;44:1170-1176.
22. Hara K, Okada T, Tobe K et al. The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun 2000;271:212-216.
23. Koch M, Rett K, Maerker E et al. The PPARγ2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. Diabetologia 1999;42:758-762.
24. Evans K, Burdge GC, Wootton SA, Clark ML, Frayn KN. Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes 2002;51:2684-2690.
25. Larsen OA, Lassen NA, Quaade F. Blood flow through human adipose tissue determined with radioactive xenon. Acta Physiol Scand 1966;66: 337-345.
26. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
27. Urs S, Smith C, Campbell B et al. Gene expression profiling in human preadipocytes and adipocytes by microarray analysis. J Nutr 2004;134: 762-770.
28. Cooke JP. The endothelium: a new target for therapy. Vasc Med 2000;5: 49-53.
29. Sydow K, Mondon CE, Cooke JP. Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA. Vasc Med 2005;10(Suppl 1):S35-S43.
30. Galitzky J, Lafontan M, Nordenstrom J, Arner P. Role of vascular α-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J Clin Invest 1993;91:1997-2003.
31. Moro C, Polak J, Richterova B et al. Differential regulation of atrial natriuretic peptide-and adrenergic receptor-dependent lipolytic pathways in human adipose tissue. Metabolism 2005;54:122-131.
32. Galitzky J, Sengenes C, Thalamas C et al. The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men. J Lipid Res 2001;42:536-544.
33. Sengenes C, Berlan M, De Glisezinski I, Lafontan M, Galitzky J. Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB J 2000;14:1345-1351.
34. Engeli S, Sharma AM. The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension. J Mol Med 2001;79:21-29.
35. Wang TJ, Larson MG, Levy D et al. Impact of obesity on plasma natriuretic peptide levels. Circulation 2004;109:594-600.
36. Elizalde M, Ryden M, van Harmelen V et al. Expression of nitric oxide synthases in subcutaneous adipose tissue of nonobese and obese humans. J Lipid Res 2000;41:1244-1251.
37. Engeli S, Janke J, Gorzelniak K et al. Regulation of the nitric oxide system in human adipose tissue. J Lipid Res 2004;45:1640-1648.
38. Cooke JP. Asymmetrical dimethylarginine: the Uber marker? Circulation 2004;109:1813-1818.
39. Sydow K, Mondon CE, Cooke JP. Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA. Vasc Med 2005; 10(Suppl 1):S35-S43.
40. Cardillo C, Kilcoyne CM, Cannon RO III, Panza JA. Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo. Hypertension 2000;35: 1237-1241.
41. Mather KJ, Lteif A, Steinberg HO, Baron AD. Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes. Diabetes 2004;53:2060-2066.
42. Verhaar MC, Strachan FE, Newby DE et al. Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. Circulation 1998;97: 752-756.
43. Levin ER. Endothelins. N Engl J Med 1995;333:356-363.