Leptin

Annual Review of Physiology

Volumn 62, Issue , 2000, Pages 413-437

  Ahima, R S ^a   Flier, J S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Adipose tissue; Feeding; Metabolism; Neuroendocrine

Indexed keywords

LEPTIN;

ADIPOSE TISSUE; DIET RESTRICTION; ENERGY BALANCE; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; NEUROENDOCRINOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REVIEW;

ADIPOSE TISSUE; ANIMALS; HUMANS; LEPTIN;

EID: 0033852765     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.62.1.413     Document Type: Review

References (191)

1. The role of depot fat in the hypothalamic control of food intake in the rat
2. Adipose tissue regeneration following lipectomy
3. Dynamics of recovery of body composition after overfeeding, food restriction or starvation of mature female rats
4. Role of set point theory in regulation of body weight
5. The effects of lesions in the hypothalamus in parabiotic rats
6. Hypothalamic lesions and adiposity in the rat
7. Obesity, a new mutation in the house mouse
8. Parabiosis of normal with genetically diabetic mice
9. Effects of parabiosis of obese with diabetes and normal mice
10. Parabiosis and transplantation experiments in hereditary obese mice
11. Positional cloning of the mouse obese gene and its human homologue
12. Weight-reducing effects of the plasma protein encoded by the obese gene
13. Effects of the obese gene product on body weight regulation in ob/ob mice
14. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
15. The mouse obese gene
16. Structural organization and chromosomal assignment of the human obese gene
17. Genomic structure and promoter analysis of the human obese gene
18. Transcriptional activation of the mouse obese (Ob) gene by CCAAT/enhancer binding protein α
19. The adipocyte specific transcription factor C/EBPα modulates human ob gene expression
20. Leptin levels in human and rodent: Measurement of plasma leptin and ob mRNA in obese and weight-reduced subjects
21. Leptin levels reflect body lipid content in mice: Evidence for diet- induced resistance to leptin action
22. Serum immunoreactive leptin concentrations in normal weight and obese humans
23. Threading analysis suggests that the obese gene product may be a helical cytokine
24. Crystal structure of the obese protein leptin-E100
25. In vitro effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: Localization of leptin activity to domains between amino acid residues 106-140
26. Insulin stimulates both leptin secretion and production by rat white adipose tissue
27. Truncated human leptin (?133) associated with extreme obesity undergoes proteosomal degradation after defective intracellular transport
28. Congenital leptin deficiency is associated with severe early onset obesity in humans
29. A leptin missense mutation associated with hypogonadism and morbid obesity
30. Increased obese mRNA expression in omental fat cells from massively obese humans
31. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
32. Transient increase in obese gene expression after food intake or insulin administration
33. Early and late stimulation of ob mRNA expression in mealfed and oveffed rats
34. Responses of leptin to short-term fasting and refeeding in humans
35. Expression of ob mRNA and its encoded protein in rodents
36. Effect of fasting on serum leptin in normal human subjects
37. Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with Pituitary-Adrenal activity
38. Nocturnal rise of leptin in lean, obese and non-insulin dependent diabetes mellitus subjects
39. Regulation of ob gene mRNA levels in cultured adipocytes
40. Regulated expression of theobese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
41. Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro
42. Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects
43. Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men
44. Dexamethasone regulates obese expression in isolated rat adipocytes
45. Regulation of ob mRNA and protein by glucocorticoids and cAMP
46. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake
47. Plasma leptin levels do not change in patients with Cushing's disease shortly after correction of hypercortisolism
48. Role of leptin in the Neuroendocrine response to fasting
49. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding: Implications for energy homeostasis and neuroendocrine function
50. Human leptin levels are pulsatile and inversely related to Pituitary- Adrenal function
51. Hypoleptinernia in women athletes: Absence of a diurnal rhythm with amenorrhea
52. Developmental changes in obese gene expression and circulating leptin peptide concentrations
53. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty
54. Effects of gender, body composition and menopause on plasma concentration of leptin
55. Sexual dimorphism in plasma leptin concentration
56. Plasma leptin levels in healthy children and adolescents: Dependence on body mass index, fat mass, gender, pubertal stage, and testosterone
57. Serum leptin concentration in women: Effect of age, obesity, and estrogen administration
58. Thyroid hormones influence serum leptin concentrations in the rat
59. Leptin and the pituitary-thyroid axis: A comparative study in lean, obese, hypothyroid and hyperthyroid subjects
60. Short-term hyperthyroidism has no effect on leptin levels in man
61. Thyroid hormones modulate serum leptin levels: Observations in thyrotoxic and hypothyroid women
62. The effects of thyroid status on plasma leptin levels in women
63. Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm in cortisol and leptin secretion
64. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters
65. Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
66. Interleukin 1 alpha increases serum leptin concentrations in humans
67. Neuroendocrine responses to starvation and weight loss
68. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
69. Acute cold-induced suppression of Ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic nervous system
70. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates Leptin-Independent inhibition of food intake in mice
71. Isoproterenol and somatostatin decrease plasma leptin in humans: A novel mechanism regulating leptin secretion
72. Beta 3-adrenergic-mediated suppression of leptin gene expression in rats
73. Nonadipose production of leptin: Leptin as a novel Placenta-Derived hormone in humans
74. Presence of leptin in colostrum and/or breast milk from lactating mothers: A potential role in the regulation of neonatal food intake
75. The stomach is a source of leptin
76. A Nutrient-Sensing pathway regulates leptin gene expression in muscle and fat
77. Augumented placental production of leptin in pre-eclampsia: Possible involvement of placental hypoxia
78. Neonatal cord blood leptin: Its relationship to birth weight, body mass index, maternal diabetes, and steroids
79. Identification and expression cloning of a leptin receptor
80. Abnormal splicing of the leptin receptor in diabetic mice
81. A novel leptin receptor isoform in rat
82. The leptin receptor
83. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
84. Leptin activation of Stat3 in the hypothalamus of wild type and ob/ob mice but not db/db mice
85. Defective STAT signaling by the leptin receptor in diabetic mice
86. Divergent signaling capacities of the long and short isoforms of the leptin receptor
87. Leptin and the regulation of body weight in mammals
88. Nonsense mutation of leptin receptor in the obese spontaneously hypertensive Koletsky rat
89. Constitutive and impaired signaling of leptin receptors containing the Gln-Pro extracellular domain mutation
90. Absence of soluble leptin receptor in plasma from db(Pas)/db(Pas) and other db/db mice
91. Hypothalamic and genetic obesity in experimental animals: An autonomic and endocrine hypothesis
92. Functional properties of leptin receptor isoforms containing the Gln- Pro extracellular domain mutation of the fatty rat
93. The weight reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals
94. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats
95. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): Evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Kolestsky obese rat
96. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
97. Evidence for leptin binding to proteins in serum of rodents and humans: Modulation with obesity
98. Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting
99. Leptin: Its pharmacokinefics and tissue distribution
100. Leptin activates neurons in the ventrobasal hypothalamus and brainstem
101. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
102. Identification of targets of leptin action in rat hypothalamus
103. Localization of leptin mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
104. Distributions of leptin receptor isoforms in the rat brain
105. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus
106. Transcription factor STAT3 in leptin target neurons of the rat hypothalamus
107. Expression of leptin receptor isoforrns in brain microvessels
108. Leptin enters the brain by a saturable system independent of insulin
109. Receptor-mediated peptide transport through the blood-brain barrier
110. Insulin in the brain: A hormonal regulator of energy balance
111. Human blood-brain barrier leptin receptor: Binding and endocytosis in isolated human brain microvessels
112. Cerebrospinal fluid leptin concentrations: Relationship to plasma levels and to adiposity in humans
113. Regional leptin kinetics in humans
114. Role of the kidney in human leptin metabolism
115. Plasma leptin is partly cleared by the kidney and elevated in hemodialysis patients
116. Increased plasma leptin concentration in end-stage renal disease
117. Characterization and localization of leptin receptors in the rat kidney
118. Functional properties of leptin receptor isoforms. Internalization and degradation of leptin and ligand-induced receptor downregulation
119. An increase of circulating leptin in patients with liver cirrhosis
120. Gender-dependent alterations in serum leptin in alcoholic cirrhosis
121. Transdifferentiation of rat hepatic stellate cells results in leptin expression
122. Toward a new neurobiology of energy balance, appetite and obesity: The anatomists weigh in
123. From lesions to leptin: Hypothalamic control of food intake and body weight
124. Obesity and the hypothalamus: Novel peptides for new pathways
125. Melanocortin receptors in leptin effects
126. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
127. Synergistic interaction between leptin and cholecystokinin to reduce Short-Term food intake in lean mice
128. Hypothalamic CART is a new anorectic peptide regulated by leptin
129. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
130. Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor
131. Role of Y5 neuropeptide Y receptor in feeding and obesity
132. Leptin-Independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
133. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
134. Mice lacking melanin-concentrating hormone are hypophagic and lean
135. Leptin prevents fasting-induced suppression of Prothyrotropin- Releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus
136. Arcuate nucleus ablation prevents fasting-induced suppression of ProTRH mRNA in the hypothalamic paraventricular nucleus
137. Role of leptin in hypothalamic-pituitary function
138. The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkey
139. Stimulation of corticotropin-releasing hormone release by obese (ob) gene product, leptin, from hypothalamic explants
140. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
141. Identification of SOCS-3 as a potential mediator of central leptin resistance
142. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
143. + channels in pancreatic β-cells
144. Leptin depolarizes rat hypothalamic paraventricular nucleus neurons
145. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus
146. Two types of leptin-responsive gastric vagal afferent terminals: An in vitro single-unit study in rats
147. Abnormal regulation of the leptin gene in the pathogenesis of obesity
148. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
149. Direct antidiabetic effect of leptin through triglyceride depletion of tissues
150. Brain administration of leptin causes deletion of adipocytes by apoptosis
151. Clinical review 94: What's in a name? In search of leptin's physiologic role
152. Adipogenesis and obesity: Rounding out the big picture
153. Decreased cerebrospinal fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance
154. Diet-induced obese mice develop peripheral, but not central, resistance to leptin
155. Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with ob receptor
156. Adrenal function and effect of a high fat diet on C57BL/6J and C57BL/6J ob/ob mice
157. Effects of adrenalectomy and corticosterone adminstration on hypothalamic obesity in rats
158. Gold thioglucose-induced hypothalamic damage, hyperphagia, and obesity: Dependence on the adrenal gland
159. Hypercortisolism and obesity
160. Hypothalamic response to starvation: Implications for the study of wasting disorders
161. Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression
162. Leptin selectively increases energy expenditure of food-restricted lean mice
163. Hormone-fuel interrelationships during fasting
164. Endocrine and metabolic adaptation to obesity and starvation
165. Dieting causes menstrual irregularities in normal weight young women through impairment of episodic luteinizing hormone secretion
166. Evidence for a leptin-neuropeptide Y axis for the regulation of growth hormone secretion in the rat
167. Evidence for GnRH regulation by leptin: Leptin administration prevents reduced pulsatile LH secretion during fasting
168. Relatively low plasma leptin concentrations precede weight gain in Pima Indians
169. Leptin concentrations do not predict weight gain: The Mexico City Diabetes Study
170. Cerebrospinal fluid leptin in anorexia nervosa: Correlation with nutritional status and potential role in resistance to weight gain
171. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
172. Early onset of reproductive function in normal female mice treated with leptin
173. Leptin accelerates the onset of puberty in normal female mice
174. Leptin facilitates and inhibits sexual behavior in female hamsters
175. Direct intraovarian effects of leptin: Impairment of the synergistic action on insulin-like growth factor I on follicle stimulating hormone dependent estradiol 17 beta production by rat ovarian granulosa cells
176. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: Leptin inhibits cortisol release directly
177. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland
178. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action
179. Acute stimulation of glucose metabolism in mice by leptin treatment
180. 13C NMR study of the effects of leptin treatment on kinetics of hepatic intermediary metabolism
181. Direct effect of leptin on brown and white adipose tissue
182. Leptin action in intestinal cells
183. Sympathetic and cardiorenal actions of leptin
184. Leptin increases uncoupling protein expression and energy expenditure
185. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta
186. Leptin can induce proliferation, differentiation and functional activation of hemopoietic cells
187. Biologic action of leptin as an angiogenic factor
188. Altered neuroanatomical organization in the central nervous system of genetically obese (ob/ob) mice
189. Brain myelin of genetically obese mice
190. A role for leptin in brain development
191. Regulation of neuronal and glial proteins by leptin: Implications for brain development