메뉴 건너뛰기




Volumn 33, Issue 7, 2012, Pages

Nitric oxide synthases: Regulation and function

Author keywords

(6R )5,6,7,8 Tetrahydrobiopterin; Asymmetric dimethyl L arginine; L Arginine; NADPH oxidase; Peroxynitrite

Indexed keywords

4 FLUORO N INDAN 2 YLBENZAMIDE; ALDOSTERONE; ANGIOTENSIN; ANGIOTENSIN RECEPTOR ANTAGONIST; ARGININE; ATORVASTATIN; AVE 9488; BENZAMIDE DERIVATIVE; CALMODULIN; CYTOKINE; ENALAPRIL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPLERENONE; FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RENIN; SILDENAFIL; SIMVASTATIN; TADALAFIL; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; VARDENAFIL;

EID: 84859487532     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehr304     Document Type: Review
Times cited : (3077)

References (173)
  • 2
    • 0026326187 scopus 로고
    • A requirement for the intercellular messenger nitric oxide in long-term potentiation
    • Schuman EM, Madison DV. A requirement for the intercellular messenger nitric oxide in long-term potentiation. Science 1991;254:1503-1506. (Pubitemid 21917489)
    • (1991) Science , vol.254 , Issue.5037 , pp. 1503-1506
    • Schuman, E.M.1    Madison, D.V.2
  • 3
    • 0021063422 scopus 로고
    • Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation
    • Rapoport RM, Draznin MB, Murad F. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 1983;306:174-176.
    • (1983) Nature , vol.306 , pp. 174-176
    • Rapoport, R.M.1    Draznin, M.B.2    Murad, F.3
  • 4
    • 0022607081 scopus 로고
    • Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries
    • Förstermann U, Mülsch A, Böhme E, Busse R. Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries. Circ Res 1986;58:531-538. (Pubitemid 16102209)
    • (1986) Circulation Research , vol.58 , Issue.4 , pp. 531-538
    • Forstermann, U.1    Mulsch, A.2    Bohme, E.3    Busse, R.4
  • 6
    • 0032764586 scopus 로고    scopus 로고
    • Nitric oxide and cGMP regulate gene expression in neuronal and glial cells by activating type II cGMP-dependent protein kinase
    • Gudi T, Hong GK, Vaandrager AB, Lohmann SM, Pilz RB. Nitric oxide and cGMP regulate gene expression in neuronal and glial cells by activating type II cGMP-dependent protein kinase. FASEB J 1999;13:2143-2152.
    • (1999) FASEB J , vol.13 , pp. 2143-2152
    • Gudi, T.1    Hong, G.K.2    Vaandrager, A.B.3    Lohmann, S.M.4    Pilz, R.B.5
  • 7
    • 0028929741 scopus 로고
    • Nitric oxide signaling to iron-regulatory protein: Direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts
    • Pantopoulos K, Hentze MW. Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts. Proc Natl Acad Sci USA 1995;92:1267-1271.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1267-1271
    • Pantopoulos, K.1    Hentze, M.W.2
  • 8
    • 0344974223 scopus 로고    scopus 로고
    • Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation
    • Liu XB, Hill P, Haile DJ. Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation. Blood Cells Mol Dis 2002;29:315-326.
    • (2002) Blood Cells Mol Dis , vol.29 , pp. 315-326
    • Liu, X.B.1    Hill, P.2    Haile, D.J.3
  • 11
    • 0141673128 scopus 로고    scopus 로고
    • Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms
    • DOI 10.1038/sj.onc.1206663
    • Mikkelsen RB, Wardman P. Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 2003;22:5734-5754. (Pubitemid 37176697)
    • (2003) Oncogene , vol.22 , Issue.37 REV. ISS. 3 , pp. 5734-5754
    • Mikkelsen, R.B.1    Wardman, P.2
  • 12
    • 0347695994 scopus 로고    scopus 로고
    • +-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury
    • +-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury. J Biol Chem 2003;278:51360-51371.
    • (2003) J Biol Chem , vol.278 , pp. 51360-51371
    • Lee, J.H.1    Yang, E.S.2    Park, J.W.3
  • 13
    • 1242321336 scopus 로고    scopus 로고
    • The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations
    • DOI 10.1515/BC.2004.001
    • Ridnour LA, Thomas DD, Mancardi D, Espey MG, Miranda KM, Paolocci N, Feelisch M, Fukuto J, Wink DA. The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biol Chem 2004;385:1-10. (Pubitemid 38240288)
    • (2004) Biological Chemistry , vol.385 , Issue.1 , pp. 1-10
    • Ridnour, L.A.1    Thomas, D.D.2    Mancardi, D.3    Espey, M.G.4    Miranda, K.M.5    Paolocci, N.6    Feelisch, M.7    Fukuto, J.8    Wink, D.A.9
  • 14
    • 0032571411 scopus 로고    scopus 로고
    • Structure of nitric oxide synthase oxygenase dimer with pterin and substrate
    • DOI 10.1126/science.279.5359.2121
    • Crane BR, Arvai AS, Ghosh DK, Wu C, Getzoff ED, Stuehr DJ, Tainer JA. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Science 1998;279:2121-2126. (Pubitemid 28196359)
    • (1998) Science , vol.279 , Issue.5359 , pp. 2121-2126
    • Crane, B.R.1    Arvai, A.S.2    Ghosh, D.K.3    Wu, C.4    Getzoff, E.D.5    Stuehr, D.J.6    Tainer, J.A.7
  • 15
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: Structure, function and inhibition
    • DOI 10.1042/0264-6021:3570593
    • Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001;357:593-615. (Pubitemid 32735142)
    • (2001) Biochemical Journal , vol.357 , Issue.3 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 18
    • 0035805555 scopus 로고    scopus 로고
    • Oxygen Reduction by Nitric-oxide Synthases
    • DOI 10.1074/jbc.R100011200
    • Stuehr D, Pou S, Rosen GM. Oxygen reduction by nitric-oxide synthases. J Biol Chem 2001;276:14533-14536. (Pubitemid 37373319)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.18 , pp. 14533-14536
    • Stuehr, D.1    Pou, S.2    Rosen, G.M.3
  • 20
    • 0032227694 scopus 로고    scopus 로고
    • Enzymology of nitric oxide synthases
    • Hemmens B, Mayer B. Enzymology of nitric oxide synthases. Methods Mol Biol 1998;100:1-32.
    • (1998) Methods Mol Biol , vol.100 , pp. 1-32
    • Hemmens, B.1    Mayer, B.2
  • 21
    • 0034680914 scopus 로고    scopus 로고
    • Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase
    • Hemmens B, Goessler W, Schmidt K, Mayer B. Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase. J Biol Chem 2000;275:35786-35791.
    • (2000) J Biol Chem , vol.275 , pp. 35786-35791
    • Hemmens, B.1    Goessler, W.2    Schmidt, K.3    Mayer, B.4
  • 22
    • 0032416666 scopus 로고    scopus 로고
    • Crystal structure of constitutive endothelial nitric oxide synthase: A paradigm for pterin function involving a novel metal center
    • DOI 10.1016/S0092-8674(00)81718-3
    • Raman CS, Li H, Martasek P, Kral V, Masters BS, Poulos TL. Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell 1998;95:939-950. (Pubitemid 29019046)
    • (1998) Cell , vol.95 , Issue.7 , pp. 939-950
    • Raman, C.S.1    Li, H.2    Martasek, P.3    Kral, V.4    Masters, B.S.S.5    Poulos, T.L.6
  • 23
    • 0033597930 scopus 로고    scopus 로고
    • Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase
    • Li H, Raman CS, Glaser CB, Blasko E, Young TA, Parkinson JF, Whitlow M, Poulos TL. Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. J Biol Chem 1999;274:21276-21284.
    • (1999) J Biol Chem , vol.274 , pp. 21276-21284
    • Li, H.1    Raman, C.S.2    Glaser, C.B.3    Blasko, E.4    Young, T.A.5    Parkinson, J.F.6    Whitlow, M.7    Poulos, T.L.8
  • 26
    • 0026077959 scopus 로고
    • Glutamate, nitric oxide and cell - Cell signalling in the nervous system
    • Garthwaite J. Glutamate, nitric oxide and cell - cell signalling in the nervous system. Trends Neurosci 1991;14:60-67.
    • (1991) Trends Neurosci , vol.14 , pp. 60-67
    • Garthwaite, J.1
  • 27
    • 67349230279 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase: Structure, subcellular localization, regulation, and clinical implications
    • Zhou L, Zhu DY. Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide 2009;20:223-230.
    • (2009) Nitric Oxide , vol.20 , pp. 223-230
    • Zhou, L.1    Zhu, D.Y.2
  • 29
    • 0027473029 scopus 로고
    • Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle
    • DOI 10.1016/0014-5793(93)81210-Q
    • Nakane M, Schmidt HH, Pollock JS, Förstermann U, Murad F. Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett 1993;316:175-180. (Pubitemid 23025053)
    • (1993) FEBS Letters , vol.316 , Issue.2 , pp. 175-180
    • Nakane, M.1    Schmidt, H.H.H.W.2    Pollock, J.S.3    Forstermann, U.4    Murad, F.5
  • 30
    • 0026796015 scopus 로고
    • Inhibition of long-term potentiation by NMDA-mediated nitric oxide release
    • Izumi Y, Clifford DB, Zorumski CF. Inhibition of long-term potentiation by NMDA-mediated nitric oxide release. Science 1992;257:1273-1276.
    • (1992) Science , vol.257 , pp. 1273-1276
    • Izumi, Y.1    Clifford, D.B.2    Zorumski, C.F.3
  • 31
    • 0027221126 scopus 로고
    • Nitric oxide and long-term synaptic depression in the rat hippocampus
    • Izumi Y, Zorumski CF. Nitric oxide and long-term synaptic depression in the rat hippocampus. Neuroreport 1993;4:1131-1134. (Pubitemid 23251703)
    • (1993) NeuroReport , vol.4 , Issue.9 , pp. 1131-1134
    • Izumi, Y.1    Zorumski, C.F.2
  • 32
    • 0026478029 scopus 로고
    • An inhibitor of nitric oxide synthesis prevents memory formation in the chick
    • Holscher C, Rose SP. An inhibitor of nitric oxide synthesis prevents memory formation in the chick. Neurosci Lett 1992;145:165-167.
    • (1992) Neurosci Lett , vol.145 , pp. 165-167
    • Holscher, C.1    Rose, S.P.2
  • 35
    • 0026609864 scopus 로고
    • NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?
    • Sakuma I, Togashi H, Yoshioka M, Saito H, Yanagida M, Tamura M, Kobayashi T, Yasuda H, Gross SS, Levi R. NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone? Circ Res 1992;70:607-611.
    • (1992) Circ Res , vol.70 , pp. 607-611
    • Sakuma, I.1    Togashi, H.2    Yoshioka, M.3    Saito, H.4    Yanagida, M.5    Tamura, M.6    Kobayashi, T.7    Yasuda, H.8    Gross, S.S.9    Levi, R.10
  • 36
    • 0027321828 scopus 로고
    • The central effects of a nitric oxide synthase inhibitor (N(omega)-nitro-L-arginine) on blood pressure and plasma renin
    • Elkarib AO, Sheng JJ, Betz AL, Malvin RL. The central effects of a nitric oxide synthase inhibitor (N-omega-nitro-L-arginine) on blood pressure and plasma renin. Clin Exp Hypertension 1993;15:819-832. (Pubitemid 23248998)
    • (1993) Clinical and Experimental Hypertension , vol.15 , Issue.5 , pp. 819-832
    • El, K.A.O.1    Sheng, J.2    Lorris, B.A.3    Malvin, R.L.4
  • 37
    • 70350463869 scopus 로고    scopus 로고
    • Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase
    • Toda N, Ayajiki K, Okamura T. Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase. J Hypertens 2009;27:1929-1940.
    • (2009) J Hypertens , vol.27 , pp. 1929-1940
    • Toda, N.1    Ayajiki, K.2    Okamura, T.3
  • 38
    • 0002620095 scopus 로고    scopus 로고
    • Regulation of nitric oxide synthase expression and activity
    • Mayer B, ed. Berlin: Springer
    • Förstermann U. Regulation of nitric oxide synthase expression and activity. In: Mayer B, ed. Handbook of Experimental Pharmacology-Nitric Oxide. Berlin: Springer; 2000. p71-91.
    • (2000) Handbook of Experimental Pharmacology-Nitric Oxide
    • Förstermann, U.1
  • 40
    • 0032743294 scopus 로고    scopus 로고
    • Potential functional significance of brain-type and muscle-type nitric oxide synthase I expressed in adventitia and media of rat aorta
    • Schwarz PM, Kleinert H, Förstermann U. Potential functional significance of brain-type and muscle-type nitric oxide synthase I expressed in adventitia and media of rat aorta. Arterioscler Thromb Vasc Biol 1999;19:2584-2590. (Pubitemid 29536031)
    • (1999) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.19 , Issue.11 , pp. 2584-2590
    • Schwarz, P.M.1    Kleinert, H.2    Forstermann, U.3
  • 41
    • 0025733506 scopus 로고
    • A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle
    • Kim N, Azadzoi KM, Goldstein I, Saenz de Tejada I. A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle. J Clin Invest 1991;88:112-118.
    • (1991) J Clin Invest , vol.88 , pp. 112-118
    • Kim, N.1    Azadzoi, K.M.2    Goldstein, I.3    Saenz De Tejada, I.4
  • 42
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992;326:90-94.
    • (1992) N Engl J Med , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 43
    • 0032993016 scopus 로고    scopus 로고
    • Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (type 5) by sildenafil and related compounds
    • Turko IV, Ballard SA, Francis SH, Corbin JD. Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. Mol Pharmacol 1999;56:124-130. (Pubitemid 29309820)
    • (1999) Molecular Pharmacology , vol.56 , Issue.1 , pp. 124-130
    • Turko, I.V.1    Ballard, S.A.2    Francis, S.H.3    Corbin, J.D.4
  • 44
    • 0242579616 scopus 로고    scopus 로고
    • Overview of phosphodiesterase 5 inhibition in erectile dysfunction
    • DOI 10.1016/S0002-9149(03)00824-5
    • Rosen RC, Kostis JB. Overview of phosphodiesterase 5 inhibition in erectile dysfunction. Am J Cardiol 2003;92:9M-18M. (Pubitemid 37386271)
    • (2003) American Journal of Cardiology , vol.92 , Issue.9 SUPPL. 1
    • Rosen, R.C.1    Kostis, J.B.2
  • 45
    • 77956318603 scopus 로고    scopus 로고
    • Nitric oxide signaling in brain function, dysfunction, and dementia
    • Steinert JR, Chernova T, Forsythe ID. Nitric oxide signaling in brain function, dysfunction, and dementia. Neuroscientist 2010;16:435-452.
    • (2010) Neuroscientist , vol.16 , pp. 435-452
    • Steinert, J.R.1    Chernova, T.2    Forsythe, I.D.3
  • 46
    • 0027194540 scopus 로고
    • A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
    • DOI 10.1038/364626a0
    • Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993;364:626-632. (Pubitemid 23274719)
    • (1993) Nature , vol.364 , Issue.6438 , pp. 626-632
    • Lipton, S.A.1    Choi, Y.-B.2    Pan, Z.-H.3    Lei, S.Z.4    Chen, H.-S.V.5    Sucher, N.J.6    Loscalzo, J.7    Singel, D.J.8    Stamler, J.S.9
  • 47
    • 77956012154 scopus 로고    scopus 로고
    • Nitric oxide and neuronal death
    • Brown GC. Nitric oxide and neuronal death. Nitric Oxide 2010;23:153-165.
    • (2010) Nitric Oxide , vol.23 , pp. 153-165
    • Brown, G.C.1
  • 48
    • 0025848943 scopus 로고
    • Nitric oxide mediating NANC inhibition in opossum lower esophageal sphincter
    • Tøttrup A, Svane D, Forman A. Nitric oxide mediating NANC inhibition in opossum lower esophageal sphincter. Am J Physiol 1991;260:G385-G389.
    • (1991) Am J Physiol , vol.260
    • Tøttrup, A.1    Svane, D.2    Forman, A.3
  • 49
    • 0036369009 scopus 로고    scopus 로고
    • Pharmacological characterization of the nitrergic innervation of the stomach
    • Lefebvre RA. Pharmacological characterization of the nitrergic innervation of the stomach. Verh K Acad Geneeskd Belg 2002;64:151-166.
    • (2002) Verh K Acad Geneeskd Belg , vol.64 , pp. 151-166
    • Lefebvre, R.A.1
  • 50
    • 0026034432 scopus 로고
    • Role of nitric oxide synthesis in macrophage antimicrobial activity
    • Nathan CF, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 1991;3:65-70.
    • (1991) Curr Opin Immunol , vol.3 , pp. 65-70
    • Nathan, C.F.1    Hibbs, J.B.2
  • 52
    • 0027536123 scopus 로고
    • Islet cell DNA is a target of inflammatory attack by nitric oxide
    • Fehsel K, Jalowy A, Qi S, Burkart V, Hartmann B, Kolb H. Islet cell DNA is a target of inflammatory attack by nitric oxide. Diabetes 1993;42:496-500. (Pubitemid 23066528)
    • (1993) Diabetes , vol.42 , Issue.3 , pp. 496-500
    • Fehsel, K.1    Jalowy, A.2    Qi, S.3    Burkart, V.4    Hartmann, B.5    Kolb, H.6
  • 53
    • 0025860655 scopus 로고
    • Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells
    • Li LM, Kilbourn RG, Adams J, Fidler IJ. Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res 1991;51:2531-2535.
    • (1991) Cancer Res , vol.51 , pp. 2531-2535
    • Li, L.M.1    Kilbourn, R.G.2    Adams, J.3    Fidler, I.J.4
  • 54
    • 0025050464 scopus 로고
    • Cellular mechanisms of nonspecific immunity to intracellular infection: Cytokine-induced synthesis of toxic nitrogen oxides from L-arginine by macrophages and hepatocytes
    • DOI 10.1016/0165-2478(90)90083-3
    • Green SJ, Mellouk S, Hoffman SL, Meltzer MS, Nacy CA. Cellular mechanisms of nonspecific immunity to intracellular infection: cytokine-induced synthesis of toxic nitrogen oxides from L-arginine by macrophages and hepatocytes. Immunol Lett 1990;25:15-19. (Pubitemid 20260837)
    • (1990) Immunology Letters , vol.25 , Issue.1-3 , pp. 15-19
    • Green, S.J.1    Mellouk, S.2    Hoffman, S.L.3    Meltzer, M.S.4    Nacy, C.A.5
  • 55
    • 0025753951 scopus 로고
    • Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation
    • Kröncke KD, Kolb-Bachofen V, Berschick B, Burkart V, Kolb H. Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem Biophys Res Commun 1991;175:752-758.
    • (1991) Biochem Biophys Res Commun , vol.175 , pp. 752-758
    • Kröncke, K.D.1    Kolb-Bachofen, V.2    Berschick, B.3    Burkart, V.4    Kolb, H.5
  • 57
    • 70349384629 scopus 로고    scopus 로고
    • Recent advances on the roles of NO in cancer and chronic inflammatory disorders
    • Kanwar JR, Kanwar RK, Burrow H, Baratchi S. Recent advances on the roles of NO in cancer and chronic inflammatory disorders. Curr Med Chem 2009;16:2373-2394.
    • (2009) Curr Med Chem , vol.16 , pp. 2373-2394
    • Kanwar, J.R.1    Kanwar, R.K.2    Burrow, H.3    Baratchi, S.4
  • 58
    • 77955085839 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration and mechanisms of microglial killing of neurons
    • Brown GC, Neher JJ. Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 2010;41:242-247.
    • (2010) Mol Neurobiol , vol.41 , pp. 242-247
    • Brown, G.C.1    Neher, J.J.2
  • 60
    • 63849150302 scopus 로고    scopus 로고
    • Role of nitric oxide in shock: The large animal perspective
    • Lange M, Enkhbaatar P, Nakano Y, Traber DL. Role of nitric oxide in shock: the large animal perspective. Front Biosci 2009;14:1979-1989.
    • (2009) Front Biosci , vol.14 , pp. 1979-1989
    • Lange, M.1    Enkhbaatar, P.2    Nakano, Y.3    Traber, D.L.4
  • 63
    • 0037183525 scopus 로고    scopus 로고
    • Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: Implications in NOS regulation
    • DOI 10.1021/bi026060u
    • Song Y, Cardounel AJ, Zweier JL, Xia Y. Inhibition of superoxide generation from neuronal nitric oxide synthase by heat shock protein 90: implications in NOS regulation. Biochemistry 2002;41:10616-10622. (Pubitemid 34913320)
    • (2002) Biochemistry , vol.41 , Issue.34 , pp. 10616-10622
    • Song, Y.1    Cardounel, A.J.2    Zweier, J.L.3    Xia, Y.4
  • 66
    • 0034698050 scopus 로고    scopus 로고
    • Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro: Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1
    • DOI 10.1074/jbc.M001644200
    • Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem 2000;275:22268-22272. (Pubitemid 30621809)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.29 , pp. 22268-22272
    • Gratton, J.-P.1    Fontana, J.2    O'Connor, D.S.3    Garcia-Cardena, G.4    McCabe, T.J.5    Sessa, W.C.6
  • 69
    • 0034054493 scopus 로고    scopus 로고
    • Enhanced electron flux and reduced calmodulin dissociation may explain 'calcium-independent' eNOS activation by phosphorylation
    • McCabe TJ, Fulton D, Roman LJ, Sessa WC. Enhanced electron flux and reduced calmodulin dissociation may explain 'calcium-independent' eNOS activation by phosphorylation. J Biol Chem 2000;275:6123-6128.
    • (2000) J Biol Chem , vol.275 , pp. 6123-6128
    • McCabe, T.J.1    Fulton, D.2    Roman, L.J.3    Sessa, W.C.4
  • 71
    • 0242666181 scopus 로고    scopus 로고
    • Phosphorylation of Threonine 497 in Endothelial Nitric-oxide Synthase Coordinates the Coupling of L-Arginine Metabolism to Efficient Nitric Oxide Production
    • DOI 10.1074/jbc.M302836200
    • Lin MI, Fulton D, Babbitt R, Fleming I, Busse R, Pritchard KA Jr, Sessa WC. Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. J Biol Chem 2003;278:44719-44726. (Pubitemid 37377229)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.45 , pp. 44719-44726
    • Lin, M.I.1    Fulton, D.2    Babbitt, R.3    Fleming, I.4    Busse, R.5    Pritchard Jr., K.A.6    Sessa, W.C.7
  • 72
    • 77955285843 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the activation of eNOS
    • Fleming I. Molecular mechanisms underlying the activation of eNOS. Pflugers Arch 2010;459:793-806.
    • (2010) Pflugers Arch , vol.459 , pp. 793-806
    • Fleming, I.1
  • 73
    • 0022461711 scopus 로고
    • Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: Stimulation by acetylcholine, bradykinin and arachidonic acid
    • Ignarro LJ, Harbison RG, Wood KS, Kadowitz PJ. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J Pharmacol Exp Ther 1986;237:893-900. (Pubitemid 16088110)
    • (1986) Journal of Pharmacology and Experimental Therapeutics , vol.237 , Issue.3 , pp. 893-900
    • Ignarro, L.J.1    Harbison, R.G.2    Wood, K.S.3    Kadowitz, P.J.4
  • 76
    • 0023200353 scopus 로고
    • Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets
    • DOI 10.1016/0049-3848(87)90361-6
    • Alheid U, Frö lich JC, Förstermann U. Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. Thromb Res 1987;47:561-571. (Pubitemid 17141991)
    • (1987) Thrombosis Research , vol.47 , Issue.5 , pp. 561-571
    • Alheid, U.1    Frolich, J.C.2    Forstermann, U.3
  • 78
    • 0023446425 scopus 로고
    • The anti-aggregating properties of vascular endothelium: Interactions between prostacyclin and nitric oxide
    • Radomski MW, Palmer RM, Moncada S. The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br J Pharmacol 1987;92:639-646.
    • (1987) Br J Pharmacol , vol.92 , pp. 639-646
    • Radomski, M.W.1    Palmer, R.M.2    Moncada, S.3
  • 80
    • 0029047323 scopus 로고
    • Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells
    • Zeiher AM, Fisslthaler B, Schray-Utz B, Busse R. Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells. Circ Res 1995;76:980-986.
    • (1995) Circ Res , vol.76 , pp. 980-986
    • Zeiher, A.M.1    Fisslthaler, B.2    Schray-Utz, B.3    Busse, R.4
  • 81
    • 0027467495 scopus 로고
    • Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats
    • Arndt H, Smith CW, Granger DN. Leukocyte-endothelial cell adhesion in spontaneously hypertensive and normotensive rats. Hypertension 1993;21:667-673. (Pubitemid 23120222)
    • (1993) Hypertension , vol.21 , Issue.5 , pp. 667-673
    • Arndt, H.1    Smith, C.W.2    Granger, D.N.3
  • 83
    • 0032750425 scopus 로고    scopus 로고
    • Nitric oxide - An endothelial cell survival factor
    • Dimmeler S, Zeiher AM. Nitric oxide-an endothelial cell survival factor. Cell Death Differ 1999;6:964-968. (Pubitemid 29520797)
    • (1999) Cell Death and Differentiation , vol.6 , Issue.10 , pp. 964-968
    • Dimmeler, S.1    Zeiher, A.M.2
  • 84
    • 0024553336 scopus 로고
    • Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
    • Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1774-1777. (Pubitemid 19124139)
    • (1989) Journal of Clinical Investigation , vol.83 , Issue.5 , pp. 1774-1777
    • Garg, U.C.1    Hassid, A.2
  • 85
    • 0025204692 scopus 로고
    • Inhibition by nitric oxide and nitric oxideproducing vasodilators of DNA synthesis in vascular smooth muscle cells
    • Nakaki T, Nakayama M, Kato R. Inhibition by nitric oxide and nitric oxideproducing vasodilators of DNA synthesis in vascular smooth muscle cells. Eur J Pharmacol 1990;189:347-353.
    • (1990) Eur J Pharmacol , vol.189 , pp. 347-353
    • Nakaki, T.1    Nakayama, M.2    Kato, R.3
  • 86
    • 0026441233 scopus 로고
    • Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation
    • Nunokawa Y, Tanaka S. Interferon-gamma inhibits proliferation of rat vascular smooth muscle cells by nitric oxide generation. Biochem Biophys Res Commun 1992;188:409-415.
    • (1992) Biochem Biophys Res Commun , vol.188 , pp. 409-415
    • Nunokawa, Y.1    Tanaka, S.2
  • 87
    • 0026713726 scopus 로고
    • Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus
    • Hogan M, Cerami A, Bucala R. Advanced glycosylation endproducts block the antiproliferative effect of nitric oxide. Role in the vascular and renal complications of diabetes mellitus. J Clin Invest 1992;90:1110-1115.
    • (1992) J Clin Invest , vol.90 , pp. 1110-1115
    • Hogan, M.1    Cerami, A.2    Bucala, R.3
  • 88
    • 0025340170 scopus 로고
    • Serum-induced proliferation of rabbit aortic smooth muscle cells from the contractile state is inhibited by 8-Br-cAMP but not 8-Br-cGMP
    • DOI 10.1016/0021-9150(90)90150-H
    • Southgate K, Newby AC. Serum-induced proliferation of rabbit aortic smooth muscle cells from the contractile state is inhibited by 8-Br-cAMP but not 8-Br-cGMP. Atherosclerosis 1990;82:113-123. (Pubitemid 20170548)
    • (1990) Atherosclerosis , vol.82 , Issue.1-2 , pp. 113-123
    • Southgate, K.1    Newby, A.C.2
  • 89
    • 44449162751 scopus 로고    scopus 로고
    • Oxidative stress in vascular disease: Causes, defense mechanisms and potential therapies
    • DOI 10.1038/ncpcardio1211, PII NCPCARDIO1211
    • Förstermann U. Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med 2008;5:338-349. (Pubitemid 351761708)
    • (2008) Nature Clinical Practice Cardiovascular Medicine , vol.5 , Issue.6 , pp. 338-349
    • Forstermann, U.1
  • 90
    • 29444450878 scopus 로고    scopus 로고
    • Defective lung vascular development in endothelial nitric oxide synthase-deficient mice
    • DOI 10.1016/j.tcm.2005.11.004, PII S1050173805002185
    • Han RN, Stewart DJ. Defective lung vascular development in endothelial nitric oxide synthase-deficient mice. Trends Cardiovasc Med 2006;16:29-34. (Pubitemid 43012039)
    • (2006) Trends in Cardiovascular Medicine , vol.16 , Issue.1 , pp. 29-34
    • Han, R.N.N.1    Stewart, D.J.2
  • 95
    • 20844431696 scopus 로고    scopus 로고
    • Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase
    • DOI 10.1161/01.CIR.0000143232.67642.7A
    • Landmesser U, Engberding N, Bahlmann FH, Schaefer A, Wiencke A, Heineke A, Spiekermann S, Hilfiker-Kleiner D, Templin C, Kotlarz D, Mueller M, Fuchs M, Hornig B, Haller H, Drexler H. Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental myocardial infarction requires endothelial nitric oxide synthase. Circulation 2004;110:1933-1939. (Pubitemid 39331904)
    • (2004) Circulation , vol.110 , Issue.14 , pp. 1933-1939
    • Landmesser, U.1    Engberding, N.2    Bahlmann, F.H.3    Schaefer, A.4    Wiencke, A.5    Heineke, A.6    Spiekermann, S.7    Hilfiker-Kleiner, D.8    Templin, C.9    Kotlarz, D.10    Mueller, M.11    Fuchs, M.12    Hornig, B.13    Haller, H.14    Drexler, H.15
  • 96
    • 0036672483 scopus 로고    scopus 로고
    • Nitric oxide synthase gene therapy for cardiovascular disease
    • DOI 10.1254/jjp.89.327
    • Chen AF, Ren J, Miao CY. Nitric oxide synthase gene therapy for cardiovascular disease. Jpn J Pharmacol 2002;89:327-336. (Pubitemid 35021646)
    • (2002) Japanese Journal of Pharmacology , vol.89 , Issue.4 , pp. 327-336
    • Chen, A.F.1    Ren, J.2    Miao, C.-Y.3
  • 97
    • 67650391207 scopus 로고    scopus 로고
    • Nitric oxide synthase gene therapy: Progress and prospects
    • O'Connor DM, O'Brien T. Nitric oxide synthase gene therapy: progress and prospects. Expert Opin Biol Ther 2009;9:867-878.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 867-878
    • O'Connor, D.M.1    O'Brien, T.2
  • 100
    • 0033527413 scopus 로고    scopus 로고
    • Oxidation of tetrahydrobiopterin by peroxynitrite: Implications for vascular endothelial function
    • DOI 10.1006/bbrc.1999.1422
    • Milstien S, Katusic Z. Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function. Biochem Biophys Res Commun 1999;263:681-684. (Pubitemid 29490686)
    • (1999) Biochemical and Biophysical Research Communications , vol.263 , Issue.3 , pp. 681-684
    • Milstien, S.1    Katusic, Z.2
  • 102
    • 0036199685 scopus 로고    scopus 로고
    • Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
    • DOI 10.1172/JCI200214442
    • Zou MH, Shi C, Cohen RA. Oxidation of the zinc - thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 2002;109:817-826. (Pubitemid 34263158)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.6 , pp. 817-826
    • Zou, M.-H.1    Shi, C.2    Cohen, R.A.3
  • 104
    • 33344463217 scopus 로고    scopus 로고
    • Antioxidants and endothelial nitric oxide synthesis
    • Heller R, Werner-Felmayer G, Werner ER. Antioxidants and endothelial nitric oxide synthesis. Eur J Clin Pharmacol 2006;62(Suppl. 13):21-28.
    • (2006) Eur J Clin Pharmacol , vol.62 , Issue.SUPPL. 13 , pp. 21-28
    • Heller, R.1    Werner-Felmayer, G.2    Werner, E.R.3
  • 106
    • 0028196891 scopus 로고
    • Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity
    • Rosenkranz-Weiss P, Sessa WC, Milstien S, Kaufman S, Watson CA, Pober JS. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest 1994;93:2236-2243.
    • (1994) J Clin Invest , vol.93 , pp. 2236-2243
    • Rosenkranz-Weiss, P.1    Sessa, W.C.2    Milstien, S.3    Kaufman, S.4    Watson, C.A.5    Pober, J.S.6
  • 107
    • 0033512422 scopus 로고    scopus 로고
    • - imbalance in insulin- resistant rat aorta
    • Shinozaki K, Kashiwagi A, Nishio Y, Okamura T, Yoshida Y, Masada M, Toda N, Kikkawa R. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2 2 imbalance in insulinresistant rat aorta. Diabetes 1999;48:2437-2445. (Pubitemid 30395437)
    • (1999) Diabetes , vol.48 , Issue.12 , pp. 2437-2445
    • Shinozaki, K.1    Kashiwagi, A.2    Nishio, Y.3    Okamura, T.4    Yoshida, Y.5    Masada, M.6    Toda, N.7    Kikkawa, R.8
  • 108
    • 0035726142 scopus 로고    scopus 로고
    • Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats
    • Hong H-J, Hsiao G, Cheng T-H, Yen M-H. Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 2001;38:1044-1048. (Pubitemid 34252803)
    • (2001) Hypertension , vol.38 , Issue.5 , pp. 1044-1048
    • Hong, H.-J.1    Hsiao, G.2    Cheng, T.-H.3    Yen, M.-H.4
  • 109
    • 0035814951 scopus 로고    scopus 로고
    • Endothelial regulation of vasomotion in ApoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin
    • Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 2001;103:1282-1288. (Pubitemid 32221353)
    • (2001) Circulation , vol.103 , Issue.9 , pp. 1282-1288
    • Laursen, J.B.1    Somers, M.2    Kurz, S.3    McCann, L.4    Warnholtz, A.5    Freeman, B.A.6    Tarpey, M.7    Fukai, T.8    Harrison, D.G.9
  • 111
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
    • Heitzer T, Krohn K, Albers S, Meinertz T. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 2000;43:1435-1438.
    • (2000) Diabetologia , vol.43 , pp. 1435-1438
    • Heitzer, T.1    Krohn, K.2    Albers, S.3    Meinertz, T.4
  • 112
    • 0036100972 scopus 로고    scopus 로고
    • Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
    • DOI 10.1016/S0895-7061(01)02317-2, PII S0895706101023172
    • Higashi Y, Sasaki S, Nakagawa K, Fukuda Y, Matsuura H, Oshima T, Chayama K. Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am J Hypertens 2002;15:326-332. (Pubitemid 34408972)
    • (2002) American Journal of Hypertension , vol.15 , Issue.4 I , pp. 326-332
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3    Fukuda, Y.4    Matsuura, H.5    Oshima, T.6    Chayama, K.7
  • 115
    • 0026338964 scopus 로고
    • Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine
    • Drexler H, Zeiher AM, Meinzer K, Just H. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet 1991;338:1546-1550.
    • (1991) Lancet , vol.338 , pp. 1546-1550
    • Drexler, H.1    Zeiher, A.M.2    Meinzer, K.3    Just, H.4
  • 116
    • 0025906819 scopus 로고
    • L-Arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits
    • Rossitch E, Alexander E, Black PM, Cooke JP. L-Arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. J Clin Invest 1991;87:1295-1299.
    • (1991) J Clin Invest , vol.87 , pp. 1295-1299
    • Rossitch, E.1    Alexander, E.2    Black, P.M.3    Cooke, J.P.4
  • 117
    • 0033986606 scopus 로고    scopus 로고
    • Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: Role of cationic amino acid transporters
    • Closs EI, Scheld JS, Sharafi M, Förstermann U. Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol Pharmacol 2000;57:68-74. (Pubitemid 30033261)
    • (2000) Molecular Pharmacology , vol.57 , Issue.1 , pp. 68-74
    • Closs, E.I.1    Scheld, J.-S.2    Sharafi, M.3    Forstermann, U.4
  • 119
    • 0242298632 scopus 로고    scopus 로고
    • Role of Neutral Amino Acid Transport and Protein Breakdown for Substrate Supply of Nitric Oxide Synthase in Human Endothelial Cells
    • DOI 10.1161/01.RES.0000097761.19223.0D
    • Simon A, Plies L, Habermeier A, Martine U, Reining M, Closs EI. Role of neutral amino acid transport and protein breakdown for substrate supply of nitric oxide synthase in human endothelial cells. Circ Res 2003;93:813-820. (Pubitemid 37363055)
    • (2003) Circulation Research , vol.93 , Issue.9 , pp. 813-820
    • Simon, A.1    Plies, L.2    Habermeier, A.3    Martine, U.4    Reining, M.5    Closs, E.I.6
  • 120
    • 0025018196 scopus 로고
    • The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: Cultured endothelial cells recycle L-citrulline to L-arginine
    • Hecker M, Sessa WC, Harris HJ, Anggard EE, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc Natl Acad Sci USA 1990;87:8612-8616.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8612-8616
    • Hecker, M.1    Sessa, W.C.2    Harris, H.J.3    Anggard, E.E.4    Vane, J.R.5
  • 123
    • 0142023863 scopus 로고    scopus 로고
    • Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels
    • DOI 10.1161/01.CIR.0000092948.04444.C7
    • Berkowitz DE, White R, Li D, Minhas KM, Cernetich A, Kim S, Burke S, Shoukas AA, Nyhan D, Champion HC, Hare JM. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation 2003;108:2000-2006. (Pubitemid 37296546)
    • (2003) Circulation , vol.108 , Issue.16 , pp. 2000-2006
    • Berkowitz, D.E.1    White, R.2    Li, D.3    Minhas, K.M.4    Cernetich, A.5    Kim, S.6    Burke, S.7    Shoukas, A.A.8    Nyhan, D.9    Champion, H.C.10    Hare, J.M.11
  • 124
    • 20844459470 scopus 로고    scopus 로고
    • Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: Implications for atherosclerotic endothelial dysfunction
    • DOI 10.1161/01.CIR.0000142867.26182.32
    • Ming XF, Barandier C, Viswambharan H, Kwak BR, Mach F, Mazzolai L, Hayoz D, Ruffieux J, Rusconi S, Montani JP, Yang Z. Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. Circulation 2004;110:3708-3714. (Pubitemid 39665261)
    • (2004) Circulation , vol.110 , Issue.24 , pp. 3708-3714
    • Ming, X.-F.1    Barandier, C.2    Viswambharan, H.3    Kwak, B.R.4    Mach, F.5    Mazzolai, L.6    Hayoz, D.7    Ruffieux, J.8    Rusconi, S.9    Montani, J.-P.10    Yang, Z.11
  • 125
    • 0030464496 scopus 로고    scopus 로고
    • Tetrahydrobiopterin-free neuronal nitric oxide synthase: Evidence for two identical highly anticooperative pteridine binding sites
    • DOI 10.1021/bi961931j
    • Gorren AC, List BM, Schrammel A, Pitters E, Hemmens B, Werner ER, Schmidt K, Mayer B. Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites. Biochemistry 1996;35:16735-16745. (Pubitemid 27020518)
    • (1996) Biochemistry , vol.35 , Issue.51 , pp. 16735-16745
    • Gorren, A.C.F.1    List, B.M.2    Schrammel, A.3    Pitters, E.4    Hemmens, B.5    Werner, E.R.6    Schmidt, K.7    Mayer, B.8
  • 127
    • 1242273844 scopus 로고    scopus 로고
    • ADMA and oxidative stress
    • DOI 10.1016/S1567-5688(03)00033-3
    • Sydow K, Munzel T. ADMA and oxidative stress. Atheroscler Suppl 2003;4:41-51. (Pubitemid 38234494)
    • (2003) Atherosclerosis Supplements , vol.4 , Issue.4 , pp. 41-51
    • Sydow, K.1    Munzel, T.2
  • 129
  • 130
    • 0037143637 scopus 로고    scopus 로고
    • Impaired nitric oxide synthase pathway in diabetes mellitus: Role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase
    • DOI 10.1161/01.CIR.0000027109.14149.67
    • Lin KY, Ito A, Asagami T, Tsao PS, Adimoolam S, Kimoto M, Tsuji H, Reaven GM, Cooke JP. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation 2002;106:987-992. (Pubitemid 34925335)
    • (2002) Circulation , vol.106 , Issue.8 , pp. 987-992
    • Lin, K.Y.1    Ito, A.2    Asagami, T.3    Tsao, P.S.4    Adimoolam, S.5    Kimoto, M.6    Tsuji, H.7    Reaven, G.M.8    Cooke, J.P.9
  • 131
    • 0034698038 scopus 로고    scopus 로고
    • LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: Involvement of S-adenosylmethionine-dependent methyltransferases
    • Böger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-Böger SM. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S- adenosylmethionine-dependent methyltransferases. Circ Res 2000;87:99-105. (Pubitemid 30616904)
    • (2000) Circulation Research , vol.87 , Issue.2 , pp. 99-105
    • Boger, R.H.1    Sydow, K.2    Borlak, J.3    Thum, T.4    Lenzen, H.5    Schubert, B.6    Tsikas, D.7    Bode-Boger, S.M.8
  • 133
    • 79954608953 scopus 로고    scopus 로고
    • S-glutathionylation reshapes our understanding of eNOS Uncoupling and NO/ROS-mediated signaling
    • Zweier J, Chen CA, Druhan LJ. S-glutathionylation reshapes our understanding of eNOS Uncoupling and NO/ROS-mediated signaling. Antioxid Redox Signal 2011;14:1769-1775.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1769-1775
    • Zweier, J.1    Chen, C.A.2    Druhan, L.J.3
  • 134
    • 39749139508 scopus 로고    scopus 로고
    • Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability
    • DOI 10.1161/HYPERTENSIONAHA.107.104299, PII 0000426820080300000028
    • Imanishi T, Ikejima H, Tsujioka H, Kuroi A, Kobayashi K, Muragaki Y, Mochizuki S, Goto M, Yoshida K, Akasaka T. Addition of eplerenone to an angiotensinconverting enzyme inhibitor effectively improves nitric oxide bioavailability. Hypertension 2008;51:734-741. (Pubitemid 351301528)
    • (2008) Hypertension , vol.51 , Issue.3 , pp. 734-741
    • Imanishi, T.1    Ikejima, H.2    Tsujioka, H.3    Kuroi, A.4    Kobayashi, K.5    Muragaki, Y.6    Mochizuki, S.7    Goto, M.8    Yoshida, K.9    Akasaka, T.10
  • 135
    • 0034677947 scopus 로고    scopus 로고
    • NAD(P)H oxidase: Role in cardiovascular biology and disease
    • Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000;86:494-501. (Pubitemid 30165039)
    • (2000) Circulation Research , vol.86 , Issue.5 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 136
    • 0344541709 scopus 로고    scopus 로고
    • Statinsensitive dysregulated AT1 receptor function and density in hypercholesterolemic men
    • Nickenig G, Baumer AT, Temur Y, Kebben D, Jockenhovel F, Bohm M. Statinsensitive dysregulated AT1 receptor function and density in hypercholesterolemic men. Circulation 1999;100:2131-2134.
    • (1999) Circulation , vol.100 , pp. 2131-2134
    • Nickenig, G.1    Baumer, A.T.2    Temur, Y.3    Kebben, D.4    Jockenhovel, F.5    Bohm, M.6
  • 139
    • 0036064052 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor antagonism improves hypercholesterolemia- associated endothelial dysfunction
    • DOI 10.1161/01.ATV.0000022847.38083.B6
    • Wassmann S, Hilgers S, Laufs U, Bohm M, Nickenig G. Angiotensin II type 1 receptor antagonism improves hypercholesterolemia-associated endothelial dysfunction. Arterioscler Thromb Vasc Biol 2002;22:1208-1212. (Pubitemid 34764875)
    • (2002) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.22 , Issue.7 , pp. 1208-1212
    • Wassmann, S.1    Hilgers, S.2    Laufs, U.3    Bohm, M.4    Nickenig, G.5
  • 142
    • 0035852775 scopus 로고    scopus 로고
    • Comparative effect of ACE inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: Role of superoxide dismutase
    • Hornig B, Landmesser U, Kohler C, Ahlersmann D, Spiekermann S, Christoph A, Tatge H, Drexler H. Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase. Circulation 2001;103:799-805. (Pubitemid 32163876)
    • (2001) Circulation , vol.103 , Issue.6 , pp. 799-805
    • Hornig, B.1    Landmesser, U.2    Kohler, C.3    Ahlersmann, D.4    Spiekermann, S.5    Christoph, A.6    Tatge, H.7    Drexler, H.8
  • 143
    • 39749083959 scopus 로고    scopus 로고
    • More NO-no more ROS: Combined selective mineralocorticoid receptor blockade and angiotensin-converting enzyme inhibition for vascular protection
    • DOI 10.1161/HYPERTENSIONAHA.107.106625, PII 0000426820080300000011
    • Bauersachs J, Fraccarollo D. More NO-no more ROS: combined selective mineralocorticoid receptor blockade and angiotensin-converting enzyme inhibition for vascular protection. Hypertension 2008;51:624-625. (Pubitemid 351301511)
    • (2008) Hypertension , vol.51 , Issue.3 , pp. 624-625
    • Bauersachs, J.1    Fraccarollo, D.2
  • 144
    • 56749182381 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy
    • Satoh M, Fujimoto S, Arakawa S, Yada T, Namikoshi T, Haruna Y, Horike H, Sasaki T, Kashihara N. Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy. Nephrol Dial Transplant 2008;23:3806-3813.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3806-3813
    • Satoh, M.1    Fujimoto, S.2    Arakawa, S.3    Yada, T.4    Namikoshi, T.5    Haruna, Y.6    Horike, H.7    Sasaki, T.8    Kashihara, N.9
  • 145
    • 0036829777 scopus 로고    scopus 로고
    • Beyond lipid lowering: The role of statins in vascular protection
    • DOI 10.1016/S0167-5273(02)00195-X, PII S016752730200195X
    • Liao JK. Beyond lipid lowering: the role of statins in vascular protection. Int J Cardiol 2002;86:5-18. (Pubitemid 35247880)
    • (2002) International Journal of Cardiology , vol.86 , Issue.1 , pp. 5-18
    • Liao, J.K.1
  • 147
    • 0032555170 scopus 로고    scopus 로고
    • Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients: A randomized, placebo-controlled, double- blind study
    • John S, Schlaich M, Langenfeld M, Weihprecht H, Schmitz G, Weidinger G, Schmieder RE. Increased bioavailability of nitric oxide after lipid-lowering therapy in hypercholesterolemic patients: a randomized, placebo-controlled, double-blind study. Circulation 1998;98:211-216. (Pubitemid 28337611)
    • (1998) Circulation , vol.98 , Issue.3 , pp. 211-216
    • John, S.1    Schlaich, M.2    Langenfeld, M.3    Weihprecht, H.4    Schmitz, G.5    Weidinger, G.6    Schmieder, R.E.7
  • 148
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • DOI 10.1074/jbc.273.37.24266
    • Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 1998;273:24266-24271. (Pubitemid 28435775)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.37 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 149
    • 0035830412 scopus 로고    scopus 로고
    • Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease caveolin abundance
    • Feron O, Dessy C, Desager JP, Balligand JL. Hydroxy-methylglutaryl- coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation 2001;103:113-118. (Pubitemid 32050445)
    • (2001) Circulation , vol.103 , Issue.1 , pp. 113-118
    • Feron, O.1    Dessy, C.2    Desager, J.-P.3    Balligand, J.-L.4
  • 150
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, Sessa WC, Walsh K. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000;6:1004-1010.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3    Bialik, A.4    Fulton, D.5    Lefer, D.J.6    Sessa, W.C.7    Walsh, K.8
  • 151
    • 0343048978 scopus 로고    scopus 로고
    • Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation
    • Wagner AH, Kohler T, Ruckschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 2000;20:61-69. (Pubitemid 30048347)
    • (2000) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.20 , Issue.1 , pp. 61-69
    • Wagner, A.H.1    Kohler, T.2    Ruckschloss, U.3    Just, I.4    Hecker, M.5
  • 152
    • 0345532411 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells
    • DOI 10.1161/01.ATV.0000054659.72231.A1
    • Hattori Y, Nakanishi N, Akimoto K, Yoshida M, Kasai K. HMG-CoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells. Arterioscler Thromb Vasc Biol 2003;23:176-182. (Pubitemid 36231925)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.2 , pp. 176-182
    • Hattori, Y.1    Nakanishi, N.2    Akimoto, K.3    Yoshida, M.4    Kasai, K.5
  • 155
    • 33947303030 scopus 로고    scopus 로고
    • A review of high-dose statin therapy: Targeting cholesterol and inflammation in atherosclerosis
    • DOI 10.1093/eurheartj/ehl445
    • Patel TN, Shishehbor MH, Bhatt DL. A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis. Eur Heart J 2007;28:664-672. (Pubitemid 46439226)
    • (2007) European Heart Journal , vol.28 , Issue.6 , pp. 664-672
    • Patel, T.N.1    Shishehbor, M.H.2    Bhatt, D.L.3
  • 158
    • 0028129526 scopus 로고
    • Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major
    • DOI 10.1084/jem.180.3.783
    • Stenger S, Thuring H, Rollinghoff M, Bogdan C. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J Exp Med 1994;180:783-793. (Pubitemid 24256592)
    • (1994) Journal of Experimental Medicine , vol.180 , Issue.3 , pp. 783-793
    • Stenger, S.1    Thuring, H.2    Rollinghoff, M.3    Bogdan, C.4
  • 161
    • 0029437227 scopus 로고
    • Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation
    • Wong JM, Billiar TR. Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation. Adv Pharmacol 1995;34:155-170.
    • (1995) Adv Pharmacol , vol.34 , pp. 155-170
    • Wong, J.M.1    Billiar, T.R.2
  • 162
    • 0342723791 scopus 로고    scopus 로고
    • Nitric oxide in the pathogenesis of vascular disease
    • DOI 10.1002/(SICI)1096-9896(200002)190:3<244::AID-PATH575>3.0.CO;2- 8
    • Li H, Förstermann U. Nitric oxide in the pathogenesis of vascular disease. J Pathol 2000;190:244-254. (Pubitemid 30141371)
    • (2000) Journal of Pathology , vol.190 , Issue.3 , pp. 244-254
    • Li, H.1    Forstermann, U.2
  • 163
    • 0029929385 scopus 로고    scopus 로고
    • Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin
    • DOI 10.1074/jbc.271.13.7336
    • Klatt P, Pfeiffer S, List BM, Lehner D, Glatter O, Bachinger HP, Werner ER, Schmidt K, Mayer B. Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin. J Biol Chem 1996;271:7336-7342. (Pubitemid 26106999)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.13 , pp. 7336-7342
    • Klatt, P.1    Pfeiffer, S.2    List, B.M.3    Lehner, D.4    Glatter, O.5    Bachinger, H.P.6    Werner, E.R.7    Schmidt, K.8    Mayer, B.9
  • 164
    • 0034654022 scopus 로고    scopus 로고
    • Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide
    • DOI 10.1042/0264-6021:3460767
    • Kotsonis P, Frohlich LG, Shutenko ZV, Horejsi R, Pfleiderer W, Schmidt HH. Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide. Biochem J 2000;346(Pt 3):767-776. (Pubitemid 30171039)
    • (2000) Biochemical Journal , vol.346 , Issue.3 , pp. 767-776
    • Kotsonis, P.1    Frohlich, L.G.2    Shutenko, Z.V.3    Horejsi, R.4    Pfleiderer, W.5    Schmidt, H.H.H.W.6
  • 166
    • 0030948345 scopus 로고    scopus 로고
    • Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: Tetrahydrobiopterin binding kinetics and role of haem in dimerization
    • List BM, Klosch B, Volker C, Gorren AC, Sessa WC, Werner ER, Kukovetz WR, Schmidt K, Mayer B. Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. Biochem J 1997;323(Pt 1):159-165. (Pubitemid 27153889)
    • (1997) Biochemical Journal , vol.323 , Issue.1 , pp. 159-165
    • List, B.M.1    Klosch, B.2    Volker, C.3    Gorren, A.C.F.4    Sessa, W.C.5    Werner, E.R.6    Kukovetz, W.R.7    Schmidt, K.8    Mayer, B.9
  • 167
    • 0032535511 scopus 로고    scopus 로고
    • Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization
    • DOI 10.1021/bi981138l
    • Brunner K, Tortschanoff A, Hemmens B, Andrew PJ, Mayer B, Kungl AJ. Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization. Biochemistry 1998;37:17545-17553. (Pubitemid 29013756)
    • (1998) Biochemistry , vol.37 , Issue.50 , pp. 17545-17553
    • Brunner, K.1
  • 170
    • 0033952940 scopus 로고    scopus 로고
    • Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide
    • Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res 2000;86:347-354. (Pubitemid 30108830)
    • (2000) Circulation Research , vol.86 , Issue.3 , pp. 347-354
    • Drummond, G.R.1    Cai, H.2    Davis, M.E.3    Ramasamy, S.4    Harrison, D.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.