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Volumn 304, Issue 10, 2013, Pages

Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin

Author keywords

Endothelial function; Endothelial nitric oxide synthase; Inflammation; Toll like receptor 2; Unfolding protein response; Vascular insulin resistance

Indexed keywords

CYTOKINE; INSULIN; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; X BOX BINDING PROTEIN 1;

EID: 84878588442     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00578.2012     Document Type: Article
Times cited : (40)

References (59)
  • 1
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2: 675-680, 2001.
    • (2001) Nat Immunol , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 2
    • 0034037949 scopus 로고    scopus 로고
    • Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: Evidence for capillary recruitment
    • Baron AD, Tarshoby M, Hook G, Lazaridis EN, Cronin J, Johnson A, Steinberg HO. Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment. Diabetes 49: 768-774, 2000.
    • (2000) Diabetes , vol.49 , pp. 768-774
    • Baron, A.D.1    Tarshoby, M.2    Hook, G.3    Lazaridis, E.N.4    Cronin, J.5    Johnson, A.6    Steinberg, H.O.7
  • 4
    • 57449083385 scopus 로고    scopus 로고
    • Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet
    • Caricilli AM, Nascimento PH, Pauli JR, Tsukumo DM, Velloso LA, Carvalheira JB, Saad MJ. Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet. J Endocrinol 199: 399-406, 2008.
    • (2008) J Endocrinol , vol.199 , pp. 399-406
    • Caricilli, A.M.1    Nascimento, P.H.2    Pauli, J.R.3    Tsukumo, D.M.4    Velloso, L.A.5    Carvalheira, J.B.6    Saad, M.J.7
  • 6
    • 21344454662 scopus 로고    scopus 로고
    • Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model
    • Chen H, Sullivan G, Quon MJ. Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model. Diabetes 54: 1914-1925, 2005.
    • (2005) Diabetes , vol.54 , pp. 1914-1925
    • Chen, H.1    Sullivan, G.2    Quon, M.J.3
  • 7
    • 77953060025 scopus 로고    scopus 로고
    • Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects
    • Dasu MR, Devaraj S, Park S, Jialal I. Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care 33: 861-868, 2010.
    • (2010) Diabetes Care , vol.33 , pp. 861-868
    • Dasu, M.R.1    Devaraj, S.2    Park, S.3    Jialal, I.4
  • 8
    • 78650762257 scopus 로고    scopus 로고
    • Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes
    • Davis JE, Braucher DR, Walker-Daniels J, Spurlock ME. Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes. J Nutr Biochem 22: 136-141, 2011.
    • (2011) J Nutr Biochem , vol.22 , pp. 136-141
    • Davis, J.E.1    Braucher, D.R.2    Walker-Daniels, J.3    Spurlock, M.E.4
  • 13
    • 58149484392 scopus 로고    scopus 로고
    • Inflammation and endoplasmic reticulum stress in obesity and diabetes
    • Hotamisligil GS. Inflammation and endoplasmic reticulum stress in obesity and diabetes. Int J Obes (Lond) 32, Suppl 7: S52-S54, 2008.
    • (2008) Int J Obes (Lond) , vol.32 , Issue.SUPPL. 7
    • Hotamisligil, G.S.1
  • 14
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 271: 665-668, 1996.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 15
  • 17
    • 34250174411 scopus 로고    scopus 로고
    • Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn
    • Kim JA, Formoso G, Li Y, Potenza MA, Marasciulo FL, Montagnani M, Quon MJ. Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem 282: 13736-13745, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 13736-13745
    • Kim, J.A.1    Formoso, G.2    Li, Y.3    Potenza, M.A.4    Marasciulo, F.L.5    Montagnani, M.6    Quon, M.J.7
  • 18
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms
    • Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 113: 1888-1904, 2006.
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.A.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 19
    • 20744448048 scopus 로고    scopus 로고
    • Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: Cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance
    • Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ. Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance. J Biol Chem 280: 23173-23183, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 23173-23183
    • Kim, J.A.1    Yeh, D.C.2    Ver, M.3    Li, Y.4    Carranza, A.5    Conrads, T.P.6    Veenstra, T.D.7    Harrington, M.A.8    Quon, M.J.9
  • 20
    • 9644268760 scopus 로고    scopus 로고
    • Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model
    • Kobayashi T, Taguchi K, Yasuhiro T, Matsumoto T, Kamata K. Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model. Hypertension 44: 956-962, 2004.
    • (2004) Hypertension , vol.44 , pp. 956-962
    • Kobayashi, T.1    Taguchi, K.2    Yasuhiro, T.3    Matsumoto, T.4    Kamata, K.5
  • 21
    • 77149175962 scopus 로고    scopus 로고
    • Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3
    • Kopp A, Buechler C, Bala M, Neumeier M, Scholmerich J, Schaffler A. Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3. Endocrinology 151: 1097-1108, 2010.
    • (2010) Endocrinology , vol.151 , pp. 1097-1108
    • Kopp, A.1    Buechler, C.2    Bala, M.3    Neumeier, M.4    Scholmerich, J.5    Schaffler, A.6
  • 22
    • 63049112908 scopus 로고    scopus 로고
    • Innate immunity and adipocyte function: Ligandspecific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes
    • Kopp A, Buechler C, Neumeier M, Weigert J, Aslanidis C, Scholmerich J, Schaffler A. Innate immunity and adipocyte function: ligandspecific activation of multiple Toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes. Obesity (Silver Spring) 17: 648-656, 2009.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 648-656
    • Kopp, A.1    Buechler, C.2    Neumeier, M.3    Weigert, J.4    Aslanidis, C.5    Scholmerich, J.6    Schaffler, A.7
  • 24
    • 79953653547 scopus 로고    scopus 로고
    • Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse
    • Kuo LH, Tsai PJ, Jiang MJ, Chuang YL, Yu L, Lai KT, Tsai YS. Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse. Diabetologia 54: 168-179, 2011.
    • (2011) Diabetologia , vol.54 , pp. 168-179
    • Kuo, L.H.1    Tsai, P.J.2    Jiang, M.J.3    Chuang, Y.L.4    Yu, L.5    Lai, K.T.6    Tsai, Y.S.7
  • 26
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 276: 16683-16689, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 27
    • 38949125499 scopus 로고    scopus 로고
    • Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice
    • Lee S, Muniyappa R, Yan X, Chen H, Yue LQ, Hong EG, Kim JK, Quon MJ. Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice. Am J Physiol Endocrinol Metab 294: E261-E270, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Lee, S.1    Muniyappa, R.2    Yan, X.3    Chen, H.4    Yue, L.Q.5    Hong, E.G.6    Kim, J.K.7    Quon, M.J.8
  • 29
    • 84863940277 scopus 로고    scopus 로고
    • Protein kinase C and toll-like receptor signaling
    • Loegering DJ, Lennartz MR. Protein kinase C and toll-like receptor signaling. Enzyme Res 2011: 537821, 2011.
    • (2011) Enzyme Res , vol.2011 , pp. 537821
    • Loegering, D.J.1    Lennartz, M.R.2
  • 30
    • 77951290227 scopus 로고    scopus 로고
    • TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    • Martinon F, Chen X, Lee AH, Glimcher LH. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol 11: 411-418, 2010.
    • (2010) Nat Immunol , vol.11 , pp. 411-418
    • Martinon, F.1    Chen, X.2    Lee, A.H.3    Glimcher, L.H.4
  • 33
    • 58149240784 scopus 로고    scopus 로고
    • The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling
    • Moynagh PN. The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. Trends Immunol 30: 33-42, 2009.
    • (2009) Trends Immunol , vol.30 , pp. 33-42
    • Moynagh, P.N.1
  • 34
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen MT, Favelyukis S, Nguyen AK, Reichart D, Scott PA, Jenn A, Liu-Bryan R, Glass CK, Neels JG, Olefsky JM. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 282: 35279-35292, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6    Liu-Bryan, R.7    Glass, C.K.8    Neels, J.G.9    Olefsky, J.M.10
  • 36
    • 78650054500 scopus 로고    scopus 로고
    • Regulation of fasting fuel metabolism by toll-like receptor 4
    • Pang S, Tang H, Zhuo S, Zang YQ, Le Y. Regulation of fasting fuel metabolism by toll-like receptor 4. Diabetes 59: 3041-3048, 2010.
    • (2010) Diabetes , vol.59 , pp. 3041-3048
    • Pang, S.1    Tang, H.2    Zhuo, S.3    Zang, Y.Q.4    Le, Y.5
  • 37
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    • Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 272: 29911-29918, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 29911-29918
    • Paz, K.1    Hemi, R.2    LeRoith, D.3    Karasik, A.4    Elhanany, E.5    Kanety, H.6    Zick, Y.7
  • 38
    • 33746234763 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome
    • Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, Zhang C. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 99: 69-77, 2006.
    • (2006) Circ Res , vol.99 , pp. 69-77
    • Picchi, A.1    Gao, X.2    Belmadani, S.3    Potter, B.J.4    Focardi, M.5    Chilian, W.M.6    Zhang, C.7
  • 40
  • 41
    • 33845516684 scopus 로고    scopus 로고
    • Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance
    • Potenza MA, Marasciulo FL, Tarquinio M, Quon MJ, Montagnani M. Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance. Diabetes 55: 3594-3603, 2006.
    • (2006) Diabetes , vol.55 , pp. 3594-3603
    • Potenza, M.A.1    Marasciulo, F.L.2    Tarquinio, M.3    Quon, M.J.4    Montagnani, M.5
  • 42
    • 0036173913 scopus 로고    scopus 로고
    • QUICKI is a useful and accurate index of insulin sensitivity
    • Quon MJ. QUICKI is a useful and accurate index of insulin sensitivity. J Clin Endocrinol Metab 87: 949-951, 2002.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 949-951
    • Quon, M.J.1
  • 48
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitateinduced insulin resistance in myotubes
    • Senn JJ. Toll-like receptor-2 is essential for the development of palmitateinduced insulin resistance in myotubes. J Biol Chem 281: 26865-26875, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 26865-26875
    • Senn, J.J.1
  • 50
    • 48749088352 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages
    • Shin DM, Yang CS, Lee JY, Lee SJ, Choi HH, Lee HM, Yuk JM, Harding CV, Jo EK. Mycobacterium tuberculosis lipoprotein-induced association of TLR2 with protein kinase C zeta in lipid rafts contributes to reactive oxygen species-dependent inflammatory signalling in macrophages. Cell Microbiol 10: 1893-1905, 2008.
    • (2008) Cell Microbiol , vol.10 , pp. 1893-1905
    • Shin, D.M.1    Yang, C.S.2    Lee, J.Y.3    Lee, S.J.4    Choi, H.H.5    Lee, H.M.6    Yuk, J.M.7    Harding, C.V.8    Jo, E.K.9
  • 51
    • 65649147143 scopus 로고    scopus 로고
    • Innate immunity, Toll-like receptors, and atherosclerosis: Mouse models and methods
    • Sorrentino R, Arditi M. Innate immunity, Toll-like receptors, and atherosclerosis: mouse models and methods. Methods Mol Biol 517: 381-399, 2009.
    • (2009) Methods Mol Biol , vol.517 , pp. 381-399
    • Sorrentino, R.1    Arditi, M.2
  • 52
    • 0028030813 scopus 로고
    • Insulinmediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release
    • Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulinmediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 94: 1172-1179, 1994.
    • (1994) J Clin Invest , vol.94 , pp. 1172-1179
    • Steinberg, H.O.1    Brechtel, G.2    Johnson, A.3    Fineberg, N.4    Baron, A.D.5
  • 53
    • 0029977757 scopus 로고    scopus 로고
    • Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
    • Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 97: 2601-2610, 1996.
    • (1996) J Clin Invest , vol.97 , pp. 2601-2610
    • Steinberg, H.O.1    Chaker, H.2    Leaming, R.3    Johnson, A.4    Brechtel, G.5    Baron, A.D.6
  • 54
    • 70350435712 scopus 로고    scopus 로고
    • Macrophage apoptosis in advanced atherosclerosis
    • Tabas I, Seimon T, Timmins J, Li G, Lim W. Macrophage apoptosis in advanced atherosclerosis. Ann NY Acad Sci 1173, Suppl 1: E40-E45, 2009.
    • (2009) Ann NY Acad Sci , vol.1173 , Issue.SUPPL. 1
    • Tabas, I.1    Seimon, T.2    Timmins, J.3    Li, G.4    Lim, W.5
  • 56
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389: 610-614, 1997.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 57
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    • Zeng G, Nystrom FH, Ravichandran LV, Cong LN, Kirby M, Mostowski H, Quon MJ. Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 101: 1539-1545, 2000.
    • (2000) Circulation , vol.101 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3    Cong, L.N.4    Kirby, M.5    Mostowski, H.6    Quon, M.J.7
  • 58
    • 0029789432 scopus 로고    scopus 로고
    • Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells
    • Zeng G, Quon MJ. Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest 98: 894-898, 1996.
    • (1996) J Clin Invest , vol.98 , pp. 894-898
    • Zeng, G.1    Quon, M.J.2
  • 59
    • 31544440725 scopus 로고    scopus 로고
    • Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles
    • Zhang C, Hein TW, Wang W, Ren Y, Shipley RD, Kuo L. Activation of JNK and xanthine oxidase by TNF-alpha impairs nitric oxide-mediated dilation of coronary arterioles. J Mol Cell Cardiol 40: 247-257, 2006.
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 247-257
    • Zhang, C.1    Hein, T.W.2    Wang, W.3    Ren, Y.4    Shipley, R.D.5    Kuo, L.6


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