Elevated body fat in rats by the dietary nitric oxide synthase inhibitor, L-Nωnitroarginine

Bioscience, Biotechnology and Biochemistry

Volumn 63, Issue 4, 1999, Pages 698-702

  Khedara, Abdelkrim ^a   Goto, Tsuyoshi ^a   Morishima, Masako ^a   Kayashita, Jun ^b   Kato, Norihisa ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Body fat; Fatty acid oxidation; Nitric oxide; Rat; Serum triglyceride

Indexed keywords

ARGININE; CARNITINE PALMITOYLTRANSFERASE; ENZYME INHIBITOR; LIPID; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BLOOD; BODY COMPOSITION; BODY WEIGHT; DIET; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; LIPID METABOLISM; LIVER; MALE; METABOLISM; RAT; WISTAR RAT;

ADIPOSE TISSUE; ANIMALS; ARGININE; BODY COMPOSITION; BODY WEIGHT; CARNITINE O-PALMITOYLTRANSFERASE; DIET; ENZYME INHIBITORS; LIPID METABOLISM; LIPIDS; LIVER; MALE; NITRIC OXIDE SYNTHASE; NITROARGININE; RATS; RATS, WISTAR; TRIGLYCERIDES;

EID: 0033113751     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.63.698     Document Type: Article

References (41)

1. Moncada, S., Palmer, R. M., and Higgs, E. A., Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142 (1991).
2. Bredt, D. S. and Snyder, S. H. Nitric oxide: a physiologic messenger molecule. Ann. Rev. Biochem., 63, 175-195 (1994).
3. Wink, D. A., Hanbauer, I., Krishna, M. C., DeGraff, W., Gamson, J., and Mitchell, J., Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proc. Natl. Acad. Sci. USA, 90, 9813-9817 (1993).
4. Hayashi, T., Yamada, K., Esaki, T., Kuzuya, M., Satake, S., Ishikawa, T., Hidaka, H., and Iguchi, A., Estrogen increases endothelial nitric oxide by a receptor-mediated system. Biochim. Biophys. Res. Commun., 214, 847-855 (1995).
5. Stadler, J., Stefanovic-Racic, M., Billiar, T. R., Curran, R. D., McIntyre, L. A., Greorgescu, H. I., Simmons, R. L., and Evans, C. H., Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J. Immunol., 147, 3915-3920 (1991).
6. Bernstein, R. D., Ochoa, F. Y., Xu, X., Forfia, P., Shen, W., Thompson, C. I., and Hintze, T. H., Function and production of nitric oxide in the coronary circulation of the conscious dog during exercise. Circ. Res., 79, 840-848 (1996).
7. Koizumi, T., Hermo, C. I., Bjertnaes, L. J., Banerjee, M., Newman, J. H., and Kubo, K., Nitric oxide and nitroglycerin reversal of pulmonary vasoconstriction induced by alpha-activation during exercise. Am. J. Physiol., 270, H875-880 (1996).
8. Umans, J. G. and Levi, R., Nitric oxide in the regulation of blood flow and arterial pressure. Ann. Rev. Physiol., 57, 771-790 (1995).
9. Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A., and Salvetti, A., Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation, 91, 2222-2229 (1998).
10. Shimokawa, H., Lam, J. Y. T., Chesebro, J. H., Bowie, E. J. W., and Vanhoutte, P. M., Effects of dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries. Circulation, 76, 898-905 (1987).
11. Boulanger, C., Schini, V. B., Hendrickson, H., and Vauhoutte, P. M., Chronic exposure of cultured endothelial cells to ei-cosapentaenic acid potentiates the release of endothelium-derived relaxating factor(s). Br. J. Pharmacol., 99, 176-180 (1990).
12. Shimokawa, H., and Vanhoutte, P. M., Dietary cod-liver oil improves endothelium-dependent responses in hypercholesterolem-ic and atherosclerotic porcine coronary arteries. Circulation, 78, 1421-1430 (1988).
13. Khedara, A., Kawai, Y., Kayashita, J., and Kato, N., Feeding rats the nitric oxide synthase inhibitor, l-N“nitroarginine, elevates serum triglyceride and cholesterol and lowers hepatic fatty acid oxidation. J. Nutr., 126, 2563-2567 (1996).
14. Khedara, A., Goto, T., Kayashita, J., and Kato, N., Hyper-cholesterolemic effect in rats of a dietary addition of the nitric oxide synthase inhibitor, L-Nwnitroarginine, by less synthesis of bile acids. Biosci. Biotechnol. Biochem., 62, 773-777 (1998).
15. Azuma, H., Ishikawa, M., and Sekizaki, S., Endothelium-dependent inhibition of platelet aggregation. Br. J. Pharmacol., 88, 411-415 (1986).
16. Radomski, M. W., Palmer, R. M. J., and Moncada, S., The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochim. Biophys. Res. Commun., 148, 1482-1489 (1987).
17. Kurowska, E. M., and Carroll, K. K., Hypocholesterolemic properties of nitric oxide. In vivo and in vitro studies using nitric oxide donors. Biochim. Biophys. Acta, 1392, 41-50 (1998).
18. Albert, P. R., Insulin resistance, obesity and hypertension. J. Nutr., 125, 1718-1724 (1995).
19. Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., and Fishman, M. C., Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature, 377, 239-242 (1995).
20. Albert, P. R., Insulin resistance, obesity and hypertension. J. Nutr., 125, 1718-1724 (1995).
21. Kaplan, N. M., The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch. Intern. Med., 149, 1514-1520 (1989).
22. Rocchini, A. P., Insulin resistance and blood pressure regulation in obese and non-obese subjects. Hypertension, 17, 837-842 (1991).
23. American Institute of Nutrition, Report of the American Institute of Nutrition and ad hoc committee on standards for nutritional studies. J. Nutr., 107, 1340-1348 (1977).
24. Folch, J., Lees, M., and Sloane-Stanley, G. H., A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem., 226, 497-509 (1957).
25. Freedland, R. A., Effect of progressive starvation on rat liver enzyme activities. J. Nutr., 91, 489-495 (1967).
26. Martin, D. B., Horning, M. G., and Vagelos, P. R., Fatty acid synthesis in adipose tissue, I. Purification and properties of a long chain fatty acid-synthesizing system. J. Biol. Chem., 236, 663-668 (1961).
27. Bieber, L. L. and Fiol, C., Purification and assay of carnitine acyltransferases. Methods in Enzymol., 12, 276-284 (1985).
28. Shimomura, Y., Tamura, T., and Suzuki, M., Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet. J. Nutr., 120, 1291-1296 (1990).
29. Nilsson-Ehle, P. and Schotz, M. E., A stable, radioactive substrate emulsion for assay of lipoprotein lipase. J. Lipid Res., 17, 536 (1976).
30. Garfinkel, A. S., Nilsson-Ehle, P., and Schotz, M. C., Regulation of lipoprotein lipase: Induction by insulin. Biochim. Biophys. Acta, 424, 264-273 (1976).
31. Nilsson-Ehle, P., Tornquist, H., and Belfrage P., Rapid determination of lipoprotein lipase activity in human adipose tissue. Clin. Chim. Acta, 42, 338-390 (1972).
32. Duncan, D. B., Multiple range test for correlated and heter-oscedatic means. Biometrics, 13, 164-176 (1957).
33. Morley, J. E. and Flood, J. F., Competitive antagonism of nitric oxide synthase causes weight loss in mice. Life Sci., 51, 1285-1289 (1992).
34. Squadrito, F., Calapai, G., Altavilla, D., Cucinotta, D., Zingarelli, B., Arcoraci, V., Campo, G. M., and Caputi, A. P., Central serotoninergic system involvement in the anorexia induced by NG-nitro-L-arginine, an inhibitor of nitric oxide synthase. Eur. J. Pharmacol., 255, 51-55 (1994).
35. Ikeda, K., Gutierrez, Jr., O. G., and Yamori, Y., Dietary NG-nitro-L-arginine induces sustained hypertension in normotensive Wistar-Kyoto rats. Clin. Exp. Pharmacol. Physiol., 19, 583-586 (1992).
36. Michael, W. B., John, E. H., Bruce, N. V. V., Magdalena, A. G., Guillermo, A. H., and Dion, Z., Obesity and hypertension: roles of hyperinsulinemia, sympathetic nervous system and in-trarenal mechanisms. J. Nutr., 125, 1725S-1731S (1995).
37. Harano, Y., Kashiwagi, A., Kojima, H., Suzuki, M., Hashimoto, T., and Shigeta, Y., Phosphorylation of carnitine palmitoyltransferase and activation by glucagon in isolated rat hepatocytes. FEBS Lett., 188, 267-272 (1985).
38. Baldo, A., Sniderman, A. D., Luce, S. St., Zhang, X.-J., and Cianflone, K. K., Single transduction pathway of acylation stimulating protein: involvement of protein kinase C. J. Lipid Res., 36, 1415-1426 (1995).
39. Gopalakrishna, R., Chen, Z. H., and Gundimela, U., Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J. Biol. Chem., 268, 27180-27185 (1993).
40. Gaudiot, N., Jaubert, A. M., Charbonnier, E., Sabouraut, D., Lacasa, D., Giudicelli, Y., and Ribiere, C., Modulation of white adipose tissue lipolysis by nitric oxide. J. Biol. Chem., 273, 13475-13481 (1998).
41. Friedman, J. M., Leptin, Leptin receptors, and the control of body weight. Nutrition Reviews, 56, S38-S46 (1998)