Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats

Diabetes

Volumn 56, Issue 4, 2007, Pages 1014-1024

  Zecchin, Henrique G ^a   Priviero, Fernanda B M ^a   Souza, Claudio T ^a   Zecchin, Karina G ^a   Prada, Patrícia O ^a   Carvalheira, José B C ^a   Velloso, Licio A ^a   Antunes, Edson ^a   Saad, Mario J A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; INSULIN RECEPTOR SUBSTRATE 1; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; INSULIN DEFICIENCY; INSULIN RESISTANCE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ACETYLCHOLINE; ANIMALS; DIETARY FATS; ENDOTHELIUM, VASCULAR; ENERGY INTAKE; ENZYME INDUCTION; INSULIN; JANUS KINASE 2; MALE; NITRIC OXIDE SYNTHASE TYPE III; OBESITY; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 34047098350     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1147     Document Type: Article

References (47)

1. King GL, Goodman AD, Buzney S, Moses A, Kahn CR: Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest 75:1028-1036, 1985
2. Obata T, Kashiwagi A, Maegawa H, Nishio Y, Ugi S, Hidaka H, Kikkawa R: Insulin signaling and its regulation of system A amino acid uptake in cultured rat vascular smooth muscle cells. Circ Res 79:1167-1176, 1996
3. Zeng G, Quon MJ: Insulin-stimulated production of nitric oxide is inhibited by wortmannin: direct measurement in vascular endothelial cells. J Clin Invest 98:894-898, 1996
4. Anderson PW, Zhang XY, Tian J, Correale JD, Xi XP, Yang D, Graf K, Law RE, Hsueh WA: Insulin and angiotensin II are additive in stimulating TGF-beta 1 and matrix mRNAs in mesangial cells. Kidney Int 50:745-753, 1996
5. Tamaroglio TA, Lo CS: Regulation of fibronectin by insulin-like growth factor-I in cultured rat thoracic aortic smooth muscle cells and glomerular mesangial cells. Exp Cell Res 215:338-346, 1994
6. Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T, Feener EP, Herbert TP, Rhodes CJ, King GL: Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation 101:676-681, 2000
7. Papapetropoulos A, Rudic RD, Sessa WC: Molecular control of nitric oxide synthases in the cardiovascular system. Cardiovasc Res 43:509-520, 1999
8. Saltiel AR, Kahn CR: Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806, 2001
9. Virkamaki A, Ueki K, Kahn CR: Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943, 1999
10. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605, 1999
11. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399:597-601, 1999
12. Sasaoka T, Ishiki M, Sawa T, Ishihara H, Takata Y, Imamura T, Usui I, Olefsky JM, Kobayashi M: Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways. Endocrinology 137:4427-4434, 1996
13. Sasaoka T, Rose DW, Jhun BH, Saltiel AR, Draznin B, Olefsky JM: Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem 269:13689-13694, 1994
14. Jiang ZY, Lin YW, Clemont A, Feener EP, Hein KD, Igarashi M, Yamauchi T, White MF, King GL: Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 104:447-457, 1999
15. Zecchin HG, Bezerra RM, Carvalheira JB, Carvalho-Filho MA, Metze K, Franchini KG, Saad MJ: Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance: the obese middle-aged and the spontaneously hypertensive rats. Diabetologia 46:479-491, 2003
16. Stuehr DJ: Structure-function aspects in the nitric oxide synthases. Annu Rev Pharmacol Toxicol 37:339-359, 1997
17. Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC: Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro: evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. J Biol Chem 275:22268-22272, 2000
18. Kitayama J, Kitazono T, Ibayashi S, Wakisaka M, Watanabe Y, Kamouchi M, Nagao T, Fujishima M: Role of phosphatidylinositol 3-kinase in acetylcholine-induced dilatation of rat basilar artery. Stroke 31:2487-2493, 2000
19. Gallo-Payet N, Guillon G: Regulation of adrenocortical function by vasopressin. Horm Metab Res 30:360-367, 1998
20. Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE: Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor. Nature 375:247-250, 1995
21. Saad MJ, Velloso LA, Carvalho CR: Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with phosphatidylinositol 3-kinase in rat heart. Biochem J 310:741-744, 1995
22. Velloso LA, Folli F, Sun XJ, White MF, Saad MJ, Kahn CR: Cross-talk between the insulin and angiotensin signaling systems. Proc Natl Acad Sci U S A 93:12490-12495, 1996
23. Prada PO, Zecchin HG, Gasparetti AL, Torsoni MA, Ueno M, Hirata AE, Corezola do Amaral ME, Hoer NF, Boschero AC, Saad MJ: Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate 1ser307 phosphorylation in a tissue-specific fashion. Endocrinology 146:1576-1587, 2005
24. Eizirik DL, Welsh N, Niemann A, Velloso LA, Malaisse WJ: Succinic acid monomethyl ester protects rat pancreatic islet secretory potential against interleukin-1 beta (IL-1 beta) without affecting glutamate decarboxylase expression or nitric oxide production. FEBS Lett 337:298-302, 1994
25. Trinder P: Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 22:158-161, 1969
26. Rieder MJ, Carmona R, Krieger JE, Pritchard KA Jr, Greene AS: Suppression of angiotensin-converting enzyme expression and activity by shear stress. Circ Res 80:312-319, 1997
27. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76:4350-4354, 1979
28. Saad MJ, Carvalho CR, Thirone AC, Velloso LA: Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. J Biol Chem 271:22100-22104, 1996
29. Prada P, Okamoto MM, Furukawa LN, Machado UF, Heimann JC, Dolnikoff MS: High- or low-salt diet from weaning to adulthood: effect on insulin sensitivity in Wistar rats. Hypertension 35:424-429, 2000
30. Yamakoshi KI, Shimazu H, Togawa T: Indirect measurement of instantaneous arterial blood pressure in the rat. Am J Physiol 237:H632-H637, 1979
31. Priviero FM, Baracat JS, Teixeira CE, Claudino MA, DeNucci G, Antunes E: Mechanisms underlying relaxation of rabbit aorta by BAY41-2272, a nitric oxide independent soluble guanylate cyclase activator. Clin Exp Pharmacol Physiol 32:728-734, 2005
32. i. J Biol Chem 276:27071-27076, 2001
33. Anter E, Thomas SR, Schulz E, Shapira OM, Vita JA, Keaney JF Jr: Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols. J Biol Chem 279:46637-46643, 2004
34. Brandes RP, Kim D, Schmitz-Winnenthal FH, Amidi M, Godecke A, Mulsch A, Busse R: Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: role of soluble guanylyl cyclase. Hypertension 35:231-236, 2000
35. Adami A, Cuzzolin L, Minuz P, Crivellente F, Lechi A, Benoni G: Vasodilating properties of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on rat aortic rings. Pharmacol Res 33:239-244, 1996
36. Thirone AC, Carvalho CR, Saad MJ: Growth hormone stimulates the tyrosine kinase activity of JAK2 and induces tyrosine phosphorylation of insulin receptor substrates and Shc in rat tissues. Endocrinology 140:55-62, 1999
37. Carvalho CR, Carvalheira JB, Lima MH, Zimmerman SF, Caperuto LC, Amanso A, Gasparetti AL, Meneghetti V, Zimmerman LF, Velloso LA, Saad MJ: Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways. Endocrinology 144:638-647, 2003
38. Thirone AC, JeBailey L, Bilan PJ, Klip A: Opposite effect of JAK2 on insulin-dependent activation of mitogen-activated protein kinases and Akt in muscle cells: possible target to ameliorate insulin resistance. Diabetes 55:942-951, 2006
39. Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG: A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93-104, 1992
40. Guo FF, Kumahara E, Saffen D: A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2. J Biol Chem 276:25568-25581, 2001
41. Tsuneki H, Ito K, Sekizaki N, Ma EL, You Y, Kawakami J, Adachi I, Sasaoka T, Kimura I: Nicotinic enhancement of proliferation in bovine and porcine cerebral microvascular endothelial cells. Biol Pharm Bull 27:1951-1956, 2004
42. Kondo T, Vicent D, Suzuma K, Yanagisawa M, King GL, Holzenberger M, Kahn CR: Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization. J Clin Invest 111:1835-1842, 2003
43. Roberts CK, Barnard RJ, Sindhu RK, Jurczak M, Ehdaie A, Vaziri ND: A highfat, refined-carbohydrate diet induces endothelial dysfunction and oxidant/antioxidant imbalance and depresses NOS protein expression. J Appl Physiol 98:203-210, 2005
44. Barnard RJ, Roberts CK, Varon SM, Berger JJ: Diet-induced insulin resistance precedes other aspects of the metabolic syndrome. J Appl Physiol 84:1311-1315, 1998
45. Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF: Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277:1531-1537, 2002
46. Aguirre V, Uchida T, Yenush L, Davis R, White MF: The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-9054, 2000
47. Abe H, Yamada N, Kamata K, Kuwaki T, Shimada M, Osuga J, Shionoiri F, Yahagi N, Kadowaki T, Tamemoto H, Ishibashi S, Yazaki Y, Makuuchi M: Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest 101:1784-1788, 1998