Regulation of the expression of inducible nitric oxide synthase

European Journal of Pharmacology

Volumn 500, Issue 1-3 SPEC. ISS., 2004, Pages 255-266

  Kleinert, Hartmut ^a   Pautz, Andrea ^a   Linker, Katrin ^a   Schwarz, Petra M ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Expression; iNOS (inducible nitric oxide synthase); mRNA stability; Pathway; Promoter; Protein; RNA binding; Signal transduction; Transcription factor

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; STAT1 PROTEIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

BINDING SITE; ENZYME INDUCTION; ENZYME REGULATION; GENE SEQUENCE; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS); PROTEIN BIOSYNTHESIS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 4644359359     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.07.030     Document Type: Review

References (127)

1. S. Ambs, M.O. Ogunfusika, W.G. Merriam, W.P. Bennett, T.R. Billiar, and C.C. Harris Upregulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice Proc. Natl. Acad. Sci. U. S. A. 95 1998 8823 8828
2. K.F. Beck, W. Eberhardt, S. Walpen, M. Apel, and J. Pfeilschifter Potentiation of nitric oxide synthase expression by superoxide in interleukin-1β-stimulated rat mesangial cells FEBS Lett. 435 1998 35 38
3. N.R. Bhat, D.L. Feinstein, Q. Shen, and A.N. Bhat p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells J. Biol. Chem. 277 2002 29584 29592
4. L.A. Blair, L.B. Maggi Jr., A.L. Scarim, and J.A. Corbett Role of interferon regulatory factor-1 in double-stranded RNA-induced iNOS expression by mouse islets J. Biol. Chem. 277 2002 359 365
5. J. Blanchette, M. Jaramillo, and M. Olivier Signalling events involved in interferon-gamma-inducible macrophage nitric oxide generation Immunology 108 2003 513 522
6. C. Bogdan Nitric oxide and the immune response Nat. Immunol. 2 2001 907 916
7. S. Boyault, M.A. Simonin, A. Bianchi, E. Compe, B. Liagre, D. Mainard, P. Becuwe, M. Dauca, P. Netter, B. Terlain, and K. Bordji 15-Deoxy-delta12,14- PGJ2, but not troglitazone, modulates IL-1beta effects in human chondrocytes by inhibiting NF-kappaB and AP-1 activation pathways FEBS Lett. 501 2001 24 30
8. C.M. Brennan, and J.A. Steitz HuR and mRNA stability Cell. Mol. Life Sci. 58 2001 266 277
9. D. Bruch-Gerharz, O. Schnorr, C. Suschek, K.F. Beck, J. Pfeilschifter, T. Ruzicka, and V. Kolb-Bachofen Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation Am. J. Pathol. 162 2003 203 211
10. D. Caput, B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer, and A. Cerami Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators Proc. Natl. Acad. Sci. U. S. A. 83 1986 1670 1674
11. E. Carballo, W.S. Lai, and P.J. Blackshear Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability Blood 95 2000 1891 1899
12. Y.H. Chen, M.D. Layne, S.W. Chung, K. Ejima, R.M. Baron, S.F. Yet, and M.A. Perrella Elk-3 is a transcriptional repressor of nitric-oxide synthase 2 J. Biol. Chem. 278 2003 39572 39577
13. S.C. Chu, H.P. Wu, T.C. Banks, N.T. Eissa, and J. Moss Structural diversity in the 5'-untranslated region of cytokine-stimulated human inducible nitric oxide synthase mRNA J. Biol. Chem. 270 1995 10625 10630
14. S.C. Chu, J. Marks Konczalik, H.P. Wu, T.C. Banks, and J. Moss Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters Biochem. Biophys. Res. Commun. 248 1998 871 878
15. E.I. Closs, J.S. Scheld, M. Sharafi, and U. Forstermann Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters Mol. Pharmacol. 57 2000 68 74
16. S. Daniliuc, H. Bitterman, M.A. Rahat, A. Kinarty, D. Rosenzweig, N. Lahat, and L. Nitza Hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with alpha-actinin 4 J. Immunol. 171 2003 3225 3232
17. M.I. Darville, and D.L. Eizirik Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells Diabetologia 41 1998 1101 1108
18. W.G. Deng, and K.K. Wu Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation J. Immunol. 171 2003 6581 6588
19. M.E. de Vera, R.A. Shapiro, A.K. Nussler, J.S. Mudgett, R.L. Simmons, S.M. Morris Jr., T.R. Billiar, and D.A. Geller Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter Proc. Natl. Acad. Sci. U. S. A. 93 1996 1054 1059
20. M.E. de Vera, J.M. Wong, J.Y. Zhou, E. Tzeng, H.R. Wong, T.R. Billiar, and D.A. Geller Cytokine-induced nitric oxide synthase gene transcription is blocked by the heat shock response in human liver cells Surgery 120 1996 144 149
21. M.E. de Vera, B.S. Taylor, Q. Wang, R.A. Shapiro, T.R. Billiar, and D.A. Geller Dexamethasone suppresses iNOS gene expression by upregulating I-κB-α and inhibiting NF-κB Am. J. Physiol. 273 1997 G1290 G1296
22. M. Dlaska, and G. Weiss Central role of transcription factor NF-IL6 for cytokine and ironmediated regulation of murine inducible nitric oxide synthase expression J. Immunol. 162 1999 6171 6177
23. M. Doi, M. Shichiri, K. Katsuyama, S. Ishimaru, and Y. Hirata Cytokine-activated Jak-2 is involved in inducible nitric oxide synthase expression independent from NF-kappaB activation in vascular smooth muscle cells Atherosclerosis 160 2002 123 132
24. W. Eberhardt, C. Pluss, R. Hummel, and J. Pfeilschifter Molecular mechanisms of inducible nitric oxide synthase gene expression by IL-1β and cAMP in rat mesangial cells J. Immunol. 160 1998 4961 4969
25. N.T. Eissa, J.W. Yuan, C.M. Haggerty, E.K. Choo, C.D. Palmer, and J. Moss Cloning and characterization of human inducible nitric oxide synthase splice variants: a domain, encoded by exons 8 and 9, is critical for dimerization Proc. Natl. Acad. Sci. U. S. A. 95 1998 7625 7630
26. H. Fahmi, J.A. Di Battista, J.P. Pelletier, F. Mineau, P. Ranger, and J. Martel-Pelletier Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-1beta-induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes Arthritis Rheum. 44 2001 595 607
27. M. Fechir, C. Schneid, K. Linker, U. Förstermann, and H. Kleinert Complex regulation of human iNOS-expression by RNA binding proteins Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. 367 2003 R41 (Suppl.)
28. E. Felley-Bosco, F.C. Bender, F. Courjault-Gautier, C. Bron, and A.F. Quest Caveolin-1 downregulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells Proc. Natl. Acad. Sci. U. S. A. 97 2000 14334 14339
29. X. Feng, Z. Guo, M. Nourbakhsh, H. Hauser, R. Ganster, L. Shao, and D.A. Geller Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: the role of NF-{kappa}B-repressing factor (NRF) in basal repression of the hiNOS gene Proc. Natl. Acad. Sci. USA 15 2002 14212 14217
30. K. Forrester, S. Ambs, S.E. Lupold, R.B. Kapust, E.A. Spillare, W.C. Weinberg, E. Felley Bosco, X.W. Wang, D.A. Geller, E. Tzeng, T.R. Billiar, and C.C. Harris Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53 Proc. Natl. Acad. Sci. U. S. A. 93 1996 2442 2447
31. U. Forstermann, H. Li, P.M. Schwarz, and H. Kleinert NO synthesis and NOS regulation H.J. Forman J. Fukuto M. Torres Signal transduction by reactive oxygen and nitrogen species 2003 Kluwer Academic Dordrecht 119 154
32. M. Fujimura, T. Tominaga, I. Kato, S. Takasawa, M. Kawase, T. Taniguchi, H. Okamoto, and T. Yoshimoto Attenuation of nitric oxide synthase induction in IRF-1-deficient glial cells Brain Res. 759 1997 247 250
33. E. Galea, D.J. Reis, and D.L. Feinstein Cloning and expression of inducible nitric oxide synthase from rat astrocytes J. Neurosci. Res. 37 1994 406 414
34. R.W. Ganster, B.S. Taylor, L. Shao, and D.A. Geller Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B Proc. Natl. Acad. Sci. U. S. A. 98 2001 8638 8643
35. J. Gao, D.C. Morrison, T.J. Parmely, S.W. Russell, and W.J. Murphy An interferon-γ-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharide J. Biol. Chem. 272 1997 1226 1230
36. D.A. Geller, C.J. Lowenstein, R.A. Shapiro, A.K. Nussler, S.M. Di, S.C. Wang, D.K. Nakayama, R.L. Simmons, S.H. Snyder, and T.R. Billiar Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes Proc. Natl. Acad. Sci. U. S. A. 90 1993 3491 3495
37. S. Ghosh, M.J. May, and E.B. Kopp NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses Annu. Rev. Immunol. 16 1998 225 260
38. C. Goldring, S. Reveneau, M. Algarte, and J.F. Jeannin In vivo footprinting of the mouse inducible nitric oxide synthase gene: inducible protein occupation of numerous sites including oct and NF-IL6 Nucleic Acids Res. 24 1996 1682 1687
39. C. Gueydan, L. Droogmans, P. Chalon, G. Huez, D. Caput, and V. Kruys Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA J. Biol. Chem. 274 1999 2322 2326
40. H. Guo, C.Q. Cai, and P.C. Kuo Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription J. Biol. Chem. 277 2002 5054 5060
41. H. Guo, J. Wei, Y. Inoue, F.J. Gonzalez, and P.C. Kuo Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes Am. J. Physiol., Cell Physiol. 284 2003 C1090 C1099
42. Z. Guo, L. Shao, X. Feng, K. Reid, E. Marderstein, A. Nakao, and D.A. Geller A critical role for C/EBPbeta binding to the AABS promoter response element in the human iNOS gene FASEB J. 17 2003 1718 1720
43. B.J. Hamilton, C.M. Burns, R.C. Nichols, and W.F. Rigby Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes. The roles of cytoplasmic location, transcription, and phosphorylation J. Biol. Chem. 272 1997 28732 28741
44. M. Hausding, A. Witteck, F. Rodriguez-Pascual, C. von Eichel-Streiber, U. Förstermann, and H. Kleinert Inhibition of small G proteins of the Rho family by statins or Clostridium difficile toxin B enhances cytokine-mediated induction of NO synthase II Br. J. Pharmacol. 131 2000 553 561
45. Y.J. Jeon, S.H. Han, Y.W. Lee, S.S. Yea, and K.H. Yang Inhibition of NF-kappa B/Rel nuclear translocation by dexamethasone: mechanism for the inhibition of iNOS gene expression Biochem. Mol. Biol. Int. 45 1998 435 441
46. J. Johannesen, A.E. Karlsen, F. Pociot, S.G. Roenn, and J. Nerup Strain dependent rat iNOS promoter activity-correlation to identified WT1 transcription factor binding site Autoimmunity 36 2003 167 175
47. F. Jung, L.A. Palmer, N. Zhou, and R.A. Johns Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes Circ. Res. 86 2000 319 325
48. R. Kamijo, H. Harada, T. Matsuyama, M. Bosland, J. Gerecitano, D. Shapiro, J. Le, S.I. Koh, T. Kimura, S.J. Green, T.W. Mak, T. Taniguchi, and J. Vilcek Requirement for transcription factor IRF-1 in NO synthase induction in macrophages Science 263 1994 1612 1615
49. Y.M. Kim, C.B. Ko, Y.P. Park, Y.J. Kim, and S.G. Paik Octamer motif is required for the NF-κB-mediated induction of the inducible nitric oxide synthase gene expression in RAW 264.7 macrophages Mol. Cells 9 1999 99 109
50. Y. Kitamura, H. Takahashi, Y. Nomura, and T. Taniguchi Possible involvement of Janus kinase Jak2 in interferon-γ induction of nitric oxide synthase in rat glial cells Eur. J. Pharmacol. 306 1996 297 306
51. T. Kizaki, K. Suzuki, Y. Hitomi, K. Iwabuchi, K. Onoe, S. Haga, H. Ishida, T. Ookawara, and H. Ohno Negative regulation of LPS-stimulated expression of inducible nitric oxide synthase by AP-1 in macrophage cell line J774A.1 Biochem. Biophys. Res. Commun. 289 2001 1031 1038
52. H. Kleinert, C. Euchenhofer, I. Ihrig Biedert, and U. Förstermann Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-κB Mol. Pharmacol. 49 1996 15 21
53. H. Kleinert, C. Euchenhofer, G. Fritz, I. Ihrig-Biedert, and U. Förstermann Involvement of protein kinases in the induction of NO synthase II in human DLD-1 cells Br. J. Pharmacol. 123 1998 1716 1722
54. H. Kleinert, T. Wallerath, G. Fritz, I. Ihrig-Biedert, F. Rodriguez-Pascual, D.A. Geller, and U. Förstermann Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappa B-signaling pathways Br. J. Pharmacol. 125 1998 193 201
55. H. Kleinert, D.A. Geller, and U. Förstermann Analysis of the molecular mechanism regulating the induction of the human NO synthase II promoter in human A549/8 alveolar carcinoma cells Naunyn-Schmiedeberg's Arch. Pharmacol. 359 1999 R37
56. H. Kleinert, P.M. Schwarz, and U. Forstermann Regulation of the expression of inducible nitric oxide synthase Biol. Chem. 384 2003 1343 1364
57. A.Y. Kolyada, and N.E. Madias Transcriptional regulation of the human iNOS gene by IL-1beta in endothelial cells Mol. Med. 7 2001 329 343
58. A.Y. Kolyada, N. Savikovsky, and N.E. Madias Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages: evidence for tissue specificity Biochem. Biophys. Res. Commun. 220 1996 600 605
59. A.S. Kristof, J. Marks-Konczalik, and J. Moss Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation J. Biol. Chem. 276 2001 8445 8452
60. K.D. Kröncke, K. Fehsel, and V. Kolb-Bachofen Inducible nitric oxide synthase in human diseases Clin. Exp. Immunol. 113 1998 147 156
61. D. Kunz, G. Walker, W. Eberhardt, and J. Pfeilschifter Molecular mechanisms of dexamethasone inhibition of nitric oxide synthase expression in interleukin-1β-stimulated mesangial cells: evidence for the involvement of transcriptional and posttranscriptional regulation Proc. Natl. Acad. Sci. U. S. A. 93 1996 255 259
62. P.C. Kuo, K.Y. Abe, and R.A. Schroeder Oxidative stress increases hepatocyte iNOS gene transcription and promoter activity Biochem. Biophys. Res. Commun. 234 1997 289 292
63. P.C. Kuo, K. Abe, and R.A. Schroeder Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene Gastroenterology 118 2000 608 618
64. A. Lahti, U. Jalonen, H. Kankaanranta, and E. Moilanen c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages Mol. Pharmacol. 64 2003 308 315
65. W.S. Lai, E. Carballo, J.R. Strum, E.A. Kennington, R.S. Phillips, and P.J. Blackshear Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA Mol. Cell. Biol. 19 1999 4311 4323
66. M. Li, G. Pascual, and C.K. Glass Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene Mol. Cell. Biol. 20 2000 4699 4707
67. A.W. Lin, C.C. Chang, and C.C. McCormick Molecular cloning and expression of an avian macrophage nitric-oxide synthase cDNA and the analysis of the genomic 5′-flanking region J. Biol. Chem. 271 1996 11911 11919
68. K. Linker, M. Fechir, C. Schneid, U. Förstermann, and H. Kleinert The RNA binding protein KSRP negatively regulates human iNOS expression Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. 369 2004 R40 (Suppl.)
69. S.C. Linn, P.J. Morelli, I. Edry, S.E. Cottongim, C. Szabo, and A.L. Salzman Transcriptional regulation of human inducible nitric oxide synthase gene in an intestinal epithelial cell line Am. J. Physiol. 272 1997 G1499 G1508
70. P. Linscheid, A. Schaffner, and G. Schoedon Modulation of inducible nitric oxide synthase mRNA stability by tetrahydrobiopterin in vascular smooth muscle cells Biochem. Biophys. Res. Commun. 243 1998 137 141
71. C.J. Lowenstein, E.W. Alley, P. Raval, A.M. Snowman, S.H. Snyder, S.W. Russell, and W.J. Murphy Macrophage nitric oxide synthase gene- two upstream regions mediate induction by interferon-γ and lipopolysaccharide Proc. Natl. Acad. Sci. U. S. A. 90 1993 9730 9734
72. H. Luss, R.K. Li, R.A. Shapiro, E. Tzeng, F.X. McGowan, T. Yoneyama, K. Hatakeyama, D.A. Geller, D.A. Mickle, R.L. Simmons, and T.R. Billiar Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS J. Mol. Cell. Cardiol. 29 1997 1153 1165
73. C.R. Lyons, G.J. Orloff, and J.M. Cunningham Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line J. Biol. Chem. 267 1992 6370 6374
74. J. MacMicking, Q.W. Xie, and C. Nathan Nitric oxide and macrophage function Annu. Rev. Immunol. 15 1997 323 350
75. P.L. Majano, J. Medina, I. Zubia, L. Sunyer, E. Lara-Pezzi, A. Maldonado-Rodriguez, M. Lopez-Cabrera, and R. Moreno-Otero N-Acetyl-cysteine modulates inducible nitric oxide synthase gene expression in human hepatocytes J. Hepatol. 40 2004 632 637
76. K. Mangasser-Stephan, A. Bouazzaoui, U. Förstermann, and H. Kleinert Interaction of the RNA-binding protein AUF1 with the human iNOS mRNA Naunyn-Schmiedeberg's Arch. Pharmacol., Suppl. 365 2002 R39 (Suppl.)
77. J. Marks-Konczalik, S.C. Chu, and J. Moss Cytokine-mediated transcriptional induction of the human inducible nitric oxide synthase gene requires both activator protein 1 and nuclear factor-κB-binding sites J. Biol. Chem. 273 1998 22201 22208
78. E. Martin, C. Nathan, and Q.W. Xie Role of interferon regulatory factor 1 in induction of nitric oxide synthase J. Exp. Med. 180 1994 977 984
79. G. Melillo, T. Musso, A. Sica, L.S. Taylor, G.W. Cox, and L. Varesio A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter J. Exp. Med. 182 1995 1683 1693
80. M.A. Meraz, J.M. White, K.C.F. Sheehan, E.A. Bach, S.J. Rodig, A.S. Dighe, D.H. Kaplan, J.K. Riley, A.C. Greenlund, D. Campbell, K. Carver-Moore, R.N. DuBois, R. Clark, M. Aguet, and R.D. Schreiber Targeted disruption of the STAT1 gene in mice reveals unexpected physiologic specificity in the JAK-SAT signaling pathway Cell 84 1996 431 442
81. C.M. Misquitta, V.R. Iyer, E.S. Werstiuk, and A.K. Grover The role of 3′-untranslated region (3′-UTR) mediated mRNA stability in cardiovascular pathophysiology Mol. Cell. Biochem. 224 2001 53 67
82. P. Mitchell, and D. Tollervey mRNA stability in eukaryotes Curr. Opin. Genet. Dev. 10 2000 193 198
83. M. Mori, and T. Gotoh Regulation of nitric oxide production by arginine metabolic enzymes Biochem. Biophys. Res. Commun. 275 2000 715 719
84. H. Muhl, and J. Pfeilschifter Tetrahydrobiopterin is a limiting factor of nitric oxide generation in interleukin 1 beta-stimulated rat glomerular mesangial cells Kidney Int. 46 1994 1302 1306
85. N. Mukaida, M. Morita, Y. Ishikawa, N. Rice, S. Okamoto, T. Kasahara, and K. Matsushima Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-κB is target for glucocorticoid-mediated interleukin 8 gene repression J. Biol. Chem. 269 1994 13289 13295
86. A. Musial, and N.T. Eissa Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway J. Biol. Chem. 276 2001 24268 24273
87. T. Nishiya, T. Uehara, H. Edamatsu, Y. Kaziro, H. Itoh, and Y. Nomura Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21ras FEBS Lett. 408 1997 33 38
88. S. Nuedling, R.H. Karas, M.E. Mendelsohn, J.A. Katzenellenbogen, B.S. Katzenellenbogen, R. Meyer, H. Vetter, and C. Grohe Activation of estrogen receptor beta is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes FEBS Lett. 502 2001 103 108
89. Y. Nunokawa, S. Oikawa, and S. Tanaka Human inducible nitric oxide synthase gene is transcriptionally regulated by nuclear factor-κB dependent mechanism Biochem. Biophys. Res. Commun. 223 1996 347 352
90. A. Pellacani, P. Wiesel, S. Razavi, V. Vasilj, M.W. Feinberg, M.T. Chin, R. Reeves, and M.A. Perrella Down-regulation of high mobility group-I(Y) protein contributes to the inhibition of nitric-oxide synthase 2 by transforming growth factor-beta1 J. Biol. Chem. 276 2001 1653 1659
91. E.A. Ratovitski, M.R. Alam, R.A. Quick, A. McMillan, C. Bao, C. Kozlovsky, T.A. Hand, R.C. Johnson, R.E. Mains, B.A. Eipper, and C.J. Lowenstein Kalirin inhibition of inducible nitric-oxide synthase J. Biol. Chem. 274 1999 993 999
92. E.A. Ratovitski, C. Bao, R.A. Quick, A. McMillan, C. Kozlovsky, and C.J. Lowenstein An inducible nitric-oxide synthase (NOS)-associated protein inhibits NOS dimerization and activity J. Biol. Chem. 274 1999 30250 30257
93. F. Rodriguez-Pascual, M. Hausding, I. Ihrig-Biedert, H. Furneaux, A.P. Levy, U. Forstermann, and H. Kleinert Complex contribution of the 3′-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR J. Biol. Chem. 275 2000 26040 26049
94. S. Rudders, J. Gaspar, R. Madore, C. Voland, F. Grall, A. Patel, A. Pellacani, M.A. Perrella, T.A. Libermann, and P. Oettgen ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene J. Biol. Chem. 276 2001 3302 3309
95. K. Sakitani, M. Nishizawa, K. Inoue, Y. Masu, T. Okumura, and S. Ito Synergistic regulation of inducible nitric oxide synthase gene by CCAAT/enhancer-binding protein beta and nuclear factor-κB in hepatocytes Genes Cells 3 1998 321 330
96. M. Saura, D. Perez Sala, F.J. Canada, and S. Lamas Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells J. Biol. Chem. 271 1996 14290 14295
97. M. Saura, C. Zaragoza, M. Diaz-Cazorla, O. Hernandez-Perera, E. Eng, C.J. Lowenstein, D. Perez-Sala, and S. Lamas Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells Kidney Int. 53 1998 38 49
98. C. Schindler, and J.E. Darnell Transcriptional responses to polypeptide ligands: the JAK-STAT pathway Annu. Rev. Biochem. 64 1995 621 651
99. A. Shiraishi, J. Dudler, and M. Lotz Role of IFN regulatory factor-1 in synovitis and nitric oxide production J. Immunol. 159 1997 3549 3554
100. K. Singh, J.L. Balligand, T.A. Fischer, T.W. Smith, and R.A. Kelly Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and STAT1 alpha J. Biol. Chem. 271 1996 1111 1117
101. A. Sirsjo, A.C. Gidlof, A. Olsson, H. Torma, M. Ares, H. Kleinert, U. Förstermann, and G.K. Hansson Retinoic acid inhibits nitric oxide synthase-2 expression through the retinoic acid receptor-alpha Biochem. Biophys. Res. Commun. 270 2000 846 851
102. M. Soderberg, F. Raffalli-Mathieu, and M.A. Lang Inflammation Modulates the Interaction of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) I/Polypyrimidine Tract Binding Protein and hnRNP L with the 3′Untranslated Region of the Murine Inducible Nitric-Oxide Synthase mRNA Mol. Pharmacol. 62 2002 423 431
103. J. Spink, and T. Evans Binding of the transcription factor interferon regulatory factor-1 to the inducible nitric-oxide synthase promoter J. Biol. Chem. 272 1997 24417 24425
104. J.M. Spink, J. Cohen, and T. Evans Delineation of the vsmc iNOS enhancer and its interaction with the transcription factor, relA Endothelium 3 1995 S-50
105. B.S. Taylor, and D.A. Geller Molecular regulation of the human inducible nitric oxide synthase (iNOS) gene Shock 13 2000 413 424
106. B.S. Taylor, M.E. de Vera, R.W. Ganster, Q. Wang, R.A. Shapiro, S.M. Morris Jr., T.R. Billiar, and D.A. Geller Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene J. Biol. Chem. 273 1998 15148 15156
107. E. Tedeschi, M. Menegazzi, D. Margotto, H. Suzuki, U. Forstermann, and H. Kleinert Antiinflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation J. Pharmacol. Exp. Ther. 307 2003 254 261
108. E. Tedeschi, M. Menegazzi, Y. Yao, H. Suzuki, U. Forstermann, and H. Kleinert Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha activation Mol. Pharmacol. 65 2004 111 120
109. X. Teng, D. Li, J.D. Catravas, and R.A. Johns C/EBP-beta mediates iNOS induction by hypoxia in rat pulmonary microvascular smooth muscle cells Circ. Res. 90 2002 125 127
110. X. Teng, H. Zhang, C. Snead, and J.D. Catravas Molecular mechanisms of iNOS induction by IL-1 beta and IFN-gamma in rat aortic smooth muscle cells Am. J. Physiol., Cell Physiol. 282 2002 C144 C152
111. A.C. Tiscornia, A. Cayota, A.I. Landoni, C. Brito, P. Oppezzo, F. Vuillier, C. Robello, G. Dighiero, R. Gabus, and O. Pritsch Post-transcriptional regulation of inducible nitric oxide synthase in chronic lymphocytic leukemia B cells in pro- and antiapoptotic culture conditions Leukemia 18 2004 48 56
112. A. Toell, K.D. Kroncke, H. Kleinert, and C. Carlberg Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands J. Cell. Biochem. 85 2002 72 82
113. K. Uchimura, M. Nakamuta, M. Enjoji, T. Irie, R. Sugimoto, T. Muta, H. Iwamoto, and H. Nawata Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells Hepatology 33 2001 91 99
114. M. Upreti, S. Kumar, and P.C. Rath Replacement of 198MQMDII203 of mouse IRF-1 by 197IPVEVV202 of human IRF-1 abrogates induction of IFN-beta, iNOS, and COX-2 gene expression by IRF-1 Biochem. Biophys. Res. Commun. 314 2004 737 744
115. Y. Vodovotz, C. Bogdan, J. Paik, Q.W. Xie, and C. Nathan Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor-β J. Exp. Med. 178 1993 605 613
116. T. Wang, M. Ward, P. Grabowski, and C.J. Secombes Molecular cloning, gene organization and expression of rainbow trout (Oncorhynchus mykiss) inducible nitric oxide synthase (iNOS) gene Biochem. J. 358 2001 747 755
117. V.G. Warke, M.P. Nambiar, S. Krishnan, K. Tenbrock, D.A. Geller, N.P. Koritschoner, J.L. Atkins, D.L. Farber, and G.C. Tsokos Transcriptional activation of the human inducible nitricoxide synthase promoter by Kruppel-like factor 6 J. Biol. Chem. 278 2003 14812 14819
118. F. Werner, M.K. Jain, M.W. Feinberg, N.E. Sibinga, A. Pellacani, P. Wiesel, M.T. Chin, J.N. Topper, M.A. Perrella, and M.E. Lee Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3 J. Biol. Chem. 275 2000 36653 36658
119. Q. Xie A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase J. Biol. Chem. 272 1997 14867 14872
120. Q.W. Xie, R. Whisnant, and C. Nathan Promoter of the mouse gene encoding calciumindependent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide J. Exp. Med. 177 1993 1779 1784
121. Q.W. Xie, Y. Kashiwabara, and C. Nathan Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase J. Biol. Chem. 269 1994 4705 4708
122. H. Xiong, C. Zhu, H. Li, F. Chen, L. Mayer, K. Ozato, J.C. Unkeless, and S.E. Plevy Complex formation of the interferon (IFN) consensus sequence-binding protein with IRF-1 is essential for murine macrophage IFN-gamma-induced iNOS gene expression J. Biol. Chem. 278 2003 2271 2277
123. W. Xu, S.A. Comhair, S. Zheng, S.C. Chu, J. Marks-Konczalik, J. Moss, S.J. Haque, and S.C. Erzurum STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation Am. J. Physiol., Lung Cell. Mol. Physiol. 285 2003 L137 L148
124. Y. Yao, M. Hausding, G. Erkel, T. Anke, U. Forstermann, and H. Kleinert Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi Mol. Pharmacol. 63 2003 383 391
125. H.J. You, J.Y. Kim, and H.G. Jeong 17 beta-estradiol increases inducible nitric oxide synthase expression in macrophages Biochem. Biophys. Res. Commun. 303 2003 1129 1134
126. Z. Yu, W. Zhang, and B.C. Kone Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB Biochem. J. 11 2002 97 105
127. H. Zhang, X. Chen, X. Teng, C. Snead, and J.D. Catravas Molecular cloning and analysis of the rat inducible nitric oxide synthase gene promoter in aortic smooth muscle cells Biochem. Pharmacol. 55 1998 1873 1880