-
1
-
-
0018890516
-
Enzyme kinetics of lipolysis
-
Academic Press: New York
-
Verger, R. Enzyme kinetics of lipolysis. In: Methods of Enzymology. Vol 64. Academic Press: New York, 1980, pp 340-392.
-
(1980)
Methods of Enzymology
, vol.64
, pp. 340-392
-
-
Verger, R.1
-
2
-
-
0002508023
-
Lipid digestion and absorption
-
Johnson LR (ed). Raven Press: New York
-
Shiau YK. Lipid digestion and absorption. In: Johnson LR (ed). Physiology of the Gastrointestinal Tract. 2nd edn. Raven Press: New York, 1987, pp 1527-1556.
-
(1987)
Physiology of the Gastrointestinal Tract. 2nd Edn.
, pp. 1527-1556
-
-
Shiau, Y.K.1
-
3
-
-
0023805555
-
Calories, fat and cholesterol: Intake patterns in the US population by race, sex and age
-
Block G, Rosenberger WF, Patterson BH. Calories, fat and cholesterol: intake patterns in the US population by race, sex and age. Am J Public Health 1988; 78: 1150-1155.
-
(1988)
Am J Public Health
, vol.78
, pp. 1150-1155
-
-
Block, G.1
Rosenberger, W.F.2
Patterson, B.H.3
-
4
-
-
0022619561
-
Gastric processing and emptying of fat
-
Meyer JH, Mayer EA, Jehn D, Gu Y, Fink AS, Fried M. Gastric processing and emptying of fat. Gastroenterology 1986; 90: 1176-1187.
-
(1986)
Gastroenterology
, vol.90
, pp. 1176-1187
-
-
Meyer, J.H.1
Mayer, E.A.2
Jehn, D.3
Gu, Y.4
Fink, A.S.5
Fried, M.6
-
5
-
-
0022477263
-
Kinetic assay of human gastric lipase on short and long-chain triacylglycerol emulsions
-
Gargouri Y, Pieroni G, Riviere C, Sauniere JF, Lowe PA, Sarda L, Verger R. Kinetic assay of human gastric lipase on short and long-chain triacylglycerol emulsions. Gastroenterology 1986; 91: 919-925.
-
(1986)
Gastroenterology
, vol.91
, pp. 919-925
-
-
Gargouri, Y.1
Pieroni, G.2
Riviere, C.3
Sauniere, J.F.4
Lowe, P.A.5
Sarda, L.6
Verger, R.7
-
6
-
-
70449169903
-
Studies in intestinal digestion and absorption in the human
-
Borgstöm B, Dahlqvist A, Lundh G, Sjövall J. Studies in intestinal digestion and absorption in the human. J Clin Invest 1957; 36: 1521-1536.
-
(1957)
J Clin Invest
, vol.36
, pp. 1521-1536
-
-
Borgstöm, B.1
Dahlqvist, A.2
Lundh, G.3
Sjövall, J.4
-
7
-
-
0025239461
-
Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings
-
Staggers JE, Hernell O, Stafford RJ, Carey MC. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings. Biochemistry 1990; 29: 2028-2040.
-
(1990)
Biochemistry
, vol.29
, pp. 2028-2040
-
-
Staggers, J.E.1
Hernell, O.2
Stafford, R.J.3
Carey, M.C.4
-
8
-
-
0025264030
-
Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings
-
Hernell O, Staggers JE, Carey MC. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings. Biochemistry 1990; 29: 2041-2056.
-
(1990)
Biochemistry
, vol.29
, pp. 2041-2056
-
-
Hernell, O.1
Staggers, J.E.2
Carey, M.C.3
-
9
-
-
0027467140
-
Bile salt-activated lipase. A multiple function lipolytic enzyme
-
Wang CS, Hartsuck JA. Bile salt-activated lipase. A multiple function lipolytic enzyme. Biochem Biophys Acta 1993; 1166: 1-19.
-
(1993)
Biochem Biophys Acta
, vol.1166
, pp. 1-19
-
-
Wang, C.S.1
Hartsuck, J.A.2
-
10
-
-
0023903009
-
Concerted action of human carboxyl ester lipase and pancreatic lipase during lipid digestion in vitro: Importance of the physicochemical state of the substrate
-
Lindström MB, Sternby B, Borgström B. Concerted action of human carboxyl ester lipase and pancreatic lipase during lipid digestion in vitro: importance of the physicochemical state of the substrate. Biochem Biophys Acta 1988; 959: 178-184.
-
(1988)
Biochem Biophys Acta
, vol.959
, pp. 178-184
-
-
Lindström, M.B.1
Sternby, B.2
Borgström, B.3
-
11
-
-
0021369735
-
Colipase and lipase secretion in childhood-onset pancreatic insufficiency. Delineation of patients with steatorrhea secondary to relative colipase deficiency
-
Gaskin KJ, Durie PR, Lee L, Hill R, Forstner GG. Colipase and lipase secretion in childhood-onset pancreatic insufficiency. Delineation of patients with steatorrhea secondary to relative colipase deficiency. Gastroenterology 1984; 86: 1-7.
-
(1984)
Gastroenterology
, vol.86
, pp. 1-7
-
-
Gaskin, K.J.1
Durie, P.R.2
Lee, L.3
Hill, R.4
Forstner, G.G.5
-
13
-
-
0025601659
-
Isolated lipase and colipase deficiency in two brothers
-
Ligumsky M, Granot E, Branski D, Stankiewicz H, Goldstein R. Isolated lipase and colipase deficiency in two brothers. Gut 1990; 31: 1416-1418.
-
(1990)
Gut
, vol.31
, pp. 1416-1418
-
-
Ligumsky, M.1
Granot, E.2
Branski, D.3
Stankiewicz, H.4
Goldstein, R.5
-
14
-
-
0027388770
-
News from the interface: The molecular structure of triacylglyceride lipases
-
Derewenda ZS, Sharp AM. News from the interface: the molecular structure of triacylglyceride lipases. Trends Biochem Sci 1993; 18: 20-25.
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 20-25
-
-
Derewenda, Z.S.1
Sharp, A.M.2
-
15
-
-
0023626926
-
Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity
-
Weibel EK, Hadvary P, Hochuli E, Kupfer E, Lengsfeld H. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J Antibiotics 1987; 40: 1081-1085.
-
(1987)
J Antibiotics
, vol.40
, pp. 1081-1085
-
-
Weibel, E.K.1
Hadvary, P.2
Hochuli, E.3
Kupfer, E.4
Lengsfeld, H.5
-
16
-
-
0023620073
-
Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation
-
Hochuli E, Kupfer E, Maurer R, Meister W, Mercadel Y, Schmidt K. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation. J Antibiotics 1987; 40: 1086-1091.
-
(1987)
J Antibiotics
, vol.40
, pp. 1086-1091
-
-
Hochuli, E.1
Kupfer, E.2
Maurer, R.3
Meister, W.4
Mercadel, Y.5
Schmidt, K.6
-
17
-
-
8544265483
-
Ro 18-0647/002 drug substance: Physical and chemical characterization, quality control IND specifications and directions for testing, methods validation, and stability
-
January 3
-
Kafil J, Manius G, Babinski E, Bhattacharyya P, Calabrese F, Manalili F, Shumway M. Ro 18-0647/002 drug substance: physical and chemical characterization, quality control IND specifications and directions for testing, methods validation, and stability. Research Report N-124'891, January 3, 1989.
-
(1989)
Research Report N-124'891
-
-
Kafil, J.1
Manius, G.2
Babinski, E.3
Bhattacharyya, P.4
Calabrese, F.5
Manalili, F.6
Shumway, M.7
-
18
-
-
0023791240
-
Mode of action of tetrahydrolipstatin: A derivative of the naturally occurring lipase inhibitor lipstatin
-
Borgström B. Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin. Biochem Biophys Acta 1988; 962: 308-316.
-
(1988)
Biochem Biophys Acta
, vol.962
, pp. 308-316
-
-
Borgström, B.1
-
19
-
-
0026590627
-
Large spectral changes accompany the conformational transition of human pancreatic lipase induced by acylation with the inhibitor tetrahydrolipstatin
-
Lüthi-Peng Q, Winkler FK. Large spectral changes accompany the conformational transition of human pancreatic lipase induced by acylation with the inhibitor tetrahydrolipstatin. Eur J Biochem 1992; 205: 383-390.
-
(1992)
Eur J Biochem
, vol.205
, pp. 383-390
-
-
Lüthi-Peng, Q.1
Winkler, F.K.2
-
20
-
-
0027738967
-
Inactivation of pancreatic lipases by amphiphilic reagents 5-(dodecyldithio)-2-nitrobenzoic acid and tetrahydrolipstatin. Dependence upon partitioning between micellar and oil phases
-
Cudrey C, van Tilebeurgh H, Gargouri Y, Verger R. Inactivation of pancreatic lipases by amphiphilic reagents (5-(dodecyldithio)-2-nitrobenzoic acid and tetrahydrolipstatin. Dependence upon partitioning between micellar and oil phases. Biochemistry 1993; 32: 13800-13808.
-
(1993)
Biochemistry
, vol.32
, pp. 13800-13808
-
-
Cudrey, C.1
Van Tilebeurgh, H.2
Gargouri, Y.3
Verger, R.4
-
21
-
-
0024202729
-
Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin
-
Hadvary P, Lengsfeld H, Wolfer H. Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin. Biochem J 1988; 256: 357-361.
-
(1988)
Biochem J
, vol.256
, pp. 357-361
-
-
Hadvary, P.1
Lengsfeld, H.2
Wolfer, H.3
-
22
-
-
0026039544
-
Inactivation of pancreatic and gastric lipases by tetrahydrolipstatin and alkyldithio-5-(2-nitrobenzoic acid). A kinetic study with 1,2-didecanoyl-sn-glycerol monolayers
-
Ransac S, Gargouri Y, Morau H, Verger R. Inactivation of pancreatic and gastric lipases by tetrahydrolipstatin and alkyldithio-5-(2-nitrobenzoic acid). A kinetic study with 1,2-didecanoyl-sn-glycerol monolayers. Eur J Biochem 1991; 202: 395-400.
-
(1991)
Eur J Biochem
, vol.202
, pp. 395-400
-
-
Ransac, S.1
Gargouri, Y.2
Morau, H.3
Verger, R.4
-
23
-
-
0025121051
-
Tetrahydrolipstatin: Thermal and hydrolytic degradation
-
Stalder H, Schneider PR, Oesterhelt G. Tetrahydrolipstatin: thermal and hydrolytic degradation. Helv Chim Acta 1990; 73: 1022-1036.
-
(1990)
Helv Chim Acta
, vol.73
, pp. 1022-1036
-
-
Stalder, H.1
Schneider, P.R.2
Oesterhelt, G.3
-
24
-
-
0024806806
-
Gastric lipases: Biochemical and physiological studies
-
Gargouri Y, Morau H, Verger R. Gastric lipases: biochemical and physiological studies. Biochem Biophys Acta 1989; 1006: 255-271.
-
(1989)
Biochem Biophys Acta
, vol.1006
, pp. 255-271
-
-
Gargouri, Y.1
Morau, H.2
Verger, R.3
-
25
-
-
0025975873
-
cDNA cloning of carboxyl ester lipase from human pancreas reveals an unique proline-rich repeat unit
-
Reue K, Zambax J, Wong H, Lee G, Leete TH, Ronk M, Shively JE, Sternby B, Borgström B, Ameis D, Schotz MC. cDNA cloning of carboxyl ester lipase from human pancreas reveals an unique proline-rich repeat unit. J Lipid Res 1991; 32: 267-276.
-
(1991)
J Lipid Res
, vol.32
, pp. 267-276
-
-
Reue, K.1
Zambax, J.2
Wong, H.3
Lee, G.4
Leete, T.H.5
Ronk, M.6
Shively, J.E.7
Sternby, B.8
Borgström, B.9
Ameis, D.10
Schotz, M.C.11
-
26
-
-
0023795353
-
Hormone-sensitive lipase: Sequence, expression, and chromosomal localization to 19 cent-q 13.3
-
Holm C, Kirchgessner TG, Svenson KL, Fredrikson G, Nilsson S, Miller CG, Shively JE, Heinzmann C, Sparkes RS, Mohandas T, Lusis AJ, Schotz MC. Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q 13.3. Science 1988; 241: 1503-1506.
-
(1988)
Science
, vol.241
, pp. 1503-1506
-
-
Holm, C.1
Kirchgessner, T.G.2
Svenson, K.L.3
Fredrikson, G.4
Nilsson, S.5
Miller, C.G.6
Shively, J.E.7
Heinzmann, C.8
Sparkes, R.S.9
Mohandas, T.10
Lusis, A.J.11
Schotz, M.C.12
-
27
-
-
0025062291
-
Structure of human pancreatic lipase
-
Winkler FK, D'Arcy A, Hunziker W. Structure of human pancreatic lipase. Nature 1990; 343: 771-774.
-
(1990)
Nature
, vol.343
, pp. 771-774
-
-
Winkler, F.K.1
D'Arcy, A.2
Hunziker, W.3
-
28
-
-
0025057072
-
A serine protease triad forms the catalytic centre of a triacylglycerol lipase
-
Brady L, Brzozowski AM, Derewanda ZS, Dodson E, Dodson G, Tolley S, Turkenburg JP, Christiansen L, Huge-Jensen B, Norskov L, Thim L, Menge U. A serine protease triad forms the catalytic centre of a triacylglycerol lipase. Nature 1990; 343: 767-770.
-
(1990)
Nature
, vol.343
, pp. 767-770
-
-
Brady, L.1
Brzozowski, A.M.2
Derewanda, Z.S.3
Dodson, E.4
Dodson, G.5
Tolley, S.6
Turkenburg, J.P.7
Christiansen, L.8
Huge-Jensen, B.9
Norskov, L.10
Thim, L.11
Menge, U.12
-
29
-
-
0026432669
-
Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum
-
Schrag JD, Li Y, Wu S, Cygler M. Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum. Nature 1991; 351: 761-764.
-
(1991)
Nature
, vol.351
, pp. 761-764
-
-
Schrag, J.D.1
Li, Y.2
Wu, S.3
Cygler, M.4
-
30
-
-
0026802491
-
The catalytic site residues and interfacial binding of human pancreatic lipase
-
Lowe ME. The catalytic site residues and interfacial binding of human pancreatic lipase. J Biol Chem 1992; 267: 17069-17073.
-
(1992)
J Biol Chem
, vol.267
, pp. 17069-17073
-
-
Lowe, M.E.1
-
31
-
-
0026687923
-
Structure of pancreatic lipase-procolipase complex
-
Van Tilebeurgh H, Egloff MP, Martinez C, Rugani N, Verger R, Cambillau C. Structure of pancreatic lipase-procolipase complex. Nature 1992; 359: 159-162.
-
(1992)
Nature
, vol.359
, pp. 159-162
-
-
Van Tilebeurgh, H.1
Egloff, M.P.2
Martinez, C.3
Rugani, N.4
Verger, R.5
Cambillau, C.6
-
32
-
-
0027200087
-
Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography
-
Van Tilebeurgh H, Egloff MP, Martinez C, Rugani N, Verger R, Cambillau C. Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. Nature 1993; 362: 814-820.
-
(1993)
Nature
, vol.362
, pp. 814-820
-
-
Van Tilebeurgh, H.1
Egloff, M.P.2
Martinez, C.3
Rugani, N.4
Verger, R.5
Cambillau, C.6
-
34
-
-
0028103894
-
Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers
-
Zhi J, Melia AT, Guerciolini R, Chung J, Kinberg J, Hauptman JB, Patel IH. Retrospective population-based analysis of the dose-response (fecal fat excretion) relationship of orlistat in normal and obese volunteers. Clin Pharmacol Ther 1994; 56: 82-85.
-
(1994)
Clin Pharmacol Ther
, vol.56
, pp. 82-85
-
-
Zhi, J.1
Melia, A.T.2
Guerciolini, R.3
Chung, J.4
Kinberg, J.5
Hauptman, J.B.6
Patel, I.H.7
-
35
-
-
0028866609
-
Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers
-
Zhi J, Melia AT, Eggers H, Joly R, Patel IH. Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers. J Clin Pharmacol 1995; 35: 1103-1108.
-
(1995)
J Clin Pharmacol
, vol.35
, pp. 1103-1108
-
-
Zhi, J.1
Melia, A.T.2
Eggers, H.3
Joly, R.4
Patel, I.H.5
-
36
-
-
0029085293
-
The influence of reduced dietary fat absorption induced by orlistat on the pharmacokinetics of digoxin in healthy volunteers
-
Melia AT, Zhi J, Koss-Twardy SG, Min BH, Smith BL, Freundlich NL, Arora S, Passe SM. The influence of reduced dietary fat absorption induced by orlistat on the pharmacokinetics of digoxin in healthy volunteers. J Clin Pharmacol 1995; 35: 840-843.
-
(1995)
J Clin Pharmacol
, vol.35
, pp. 840-843
-
-
Melia, A.T.1
Zhi, J.2
Koss-Twardy, S.G.3
Min, B.H.4
Smith, B.L.5
Freundlich, N.L.6
Arora, S.7
Passe, S.M.8
-
37
-
-
0029741559
-
The effect of orlistat on the pharmacokinetics of phenytoin in healthy volunteers
-
Melia AT, Mulligan TE, Zhi J. The effect of orlistat on the pharmacokinetics of phenytoin in healthy volunteers. J Clin Pharmacol 1996; 36(7): 654-658.
-
(1996)
J Clin Pharmacol
, vol.36
, Issue.7
, pp. 654-658
-
-
Melia, A.T.1
Mulligan, T.E.2
Zhi, J.3
-
38
-
-
0029762746
-
The effect of orlistat on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers
-
Zhi J, Melia AT, Guerciolini R, Koss-Twardy SG, Passe SM, Rakhit A, Sadowski JA. The effect of orlistat on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. J. Clin Pharmacol 1996; 36(7): 659-666.
-
(1996)
J. Clin Pharmacol
, vol.36
, Issue.7
, pp. 659-666
-
-
Zhi, J.1
Melia, A.T.2
Guerciolini, R.3
Koss-Twardy, S.G.4
Passe, S.M.5
Rakhit, A.6
Sadowski, J.A.7
-
39
-
-
0029059581
-
The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers
-
Zhi J, Melia AT, Koss-Twardy SG, Min B, Guerciolini R, Freundlich NL, Milla G, Patel IH. The influence of orlistat on the pharmacokinetics and pharmacodynamics of glyburide in healthy volunteers. J Clin Pharmacol 1995; 35(5): 521-525.
-
(1995)
J Clin Pharmacol
, vol.35
, Issue.5
, pp. 521-525
-
-
Zhi, J.1
Melia, A.T.2
Koss-Twardy, S.G.3
Min, B.4
Guerciolini, R.5
Freundlich, N.L.6
Milla, G.7
Patel, I.H.8
-
40
-
-
0029740253
-
Effect of the lipase inhibitor orlistat on the pharmacokinetics of four different antihypertensive drugs in healthy volunteers
-
Weber C, Tam YK, Schmidtke-Schrezenmeier, Jonkman JHG, van Brummelen P. Effect of the lipase inhibitor orlistat on the pharmacokinetics of four different antihypertensive drugs in healthy volunteers. Eur J Clin Pharmacol 1996; 51: 87-90.
-
(1996)
Eur J Clin Pharmacol
, vol.51
, pp. 87-90
-
-
Weber, C.1
Tam, Y.K.2
Schmidtke-Schrezenmeier3
Jonkman, J.H.G.4
Van Brummelen, P.5
-
41
-
-
0029960012
-
Lack of effect of orlistat on the bioavailability of a single dose of nifedipine extended-release tablets (Procardia XL) in healthy volunteers
-
Melia AT, Mulligan TE, Zhi J. Lack of effect of orlistat on the bioavailability of a single dose of nifedipine extended-release tablets (Procardia XL) in healthy volunteers. J Clin Pharmacol 1996; 36: 352-355.
-
(1996)
J Clin Pharmacol
, vol.36
, pp. 352-355
-
-
Melia, A.T.1
Mulligan, T.E.2
Zhi, J.3
|