Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes

Biochemical Pharmacology

Volumn 65, Issue 5, 2003, Pages 807-812

  García Villafranca, Javier ^a   Guillén, Alberto ^a   Castro, José ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Acetyl CoA carboxylase; Carnitine palmitoyltransferase I; Cyclic GMP; Fatty acid metabolism; Hepatocyte; Nitric oxide

Indexed keywords

8 BROMO CYCLIC GMP; ACETYL COENZYME A CARBOXYLASE; CALCIUM ION; CARNITINE PALMITOYLTRANSFERASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP DEPENDENT PROTEIN KINASE; FATTY ACID; GUANYLATE CYCLASE; KT 5823; NITRIC OXIDE; NITRIC OXIDE DONOR;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ESTERIFICATION; FATTY ACID METABOLISM; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; HYDROLYSIS; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0037333221     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01623-4     Document Type: Article

References (36)

1. Jones B.E., Czaja M.J. Mechanisms of hepatic toxicity. III. Intracellular signaling in response to toxic liver injury. Am. J. Physiol. 275:1998;G874-G878.
2. Li J., Billiar T.R. Nitric oxide. IV. Determinants of nitric oxide protection and toxicity in liver. Am. J. Physiol. 276:1999;G1069-G1073.
3. Duval D.L., Sieg D.J., Billings R.E. Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione. Arch. Biochem. Biophys. 316:1995;699-706.
4. Nussler A.K., Geller D.A., Sweetland M.A., Di Silvio M., Billiar T.R., Madariaga J.B., Simmons R.L., Lancaster J.R. Jr. Induction of nitric oxide synthesis and its reactions in cultured human and rat hepatocytes stimulated with cytokines plus LPS. Biochem. Biophys. Res. Commun. 194:1993;826-835.
5. Lucas K.A., Pitari G.M., Kazerounian S., Ruiz-Stewart I., Park J., Schulz S., Chepenik K.P., Waldman S.A. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol. Rev. 52:2000;375-413.
6. Lohmann S.M., Vaandrager A.B., Smolenski A., Walter U., De Jonge H.R. Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem. Sci. 22:1997;307-312.
7. Stamler J.S. Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell. 78:1994;931-936.
8. Roberts C.K., Barnard R.J., Scheck S.H., Balon T.W. Exercise-stimulated glucose transport in skeletal muscle is nitric oxide dependent. Am. J. Physiol. 273:1997;E220-E225.
9. Young M.E., Radda G.K., Leighton B. Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro. Biochem. J. 322:1997;223-228.
10. Higaki Y., Hirshman M.F., Fujii N., Goodyear L.J. Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle. Diabetes. 50:2001;241-247.
11. Borgs M., Bollen M., Keppens S., Yapp S.H., Stalmans W., Vanstapel F. Modulation of basal hepatic glycogenolysis by nitric oxide. Hepatology. 23:1996;1564-1571.
12. Sprangers F., Sauerwein H.P., Romijn J.A., van Woerkom G.M., Meijer A.J. Nitric oxide inhibits glycogen synthesis in isolated rat hepatocytes. Biochem. J. 330:1998;1045-1049.
13. Monti L.D., Valsecchi G., Costa S., Sandoli E.P., Phan C.V., Pontiroli A.E., Pozza G., Piatti P.M. Effects of endothelin-1 and nitric oxide on glucokinase activity in isolated rat hepatocytes. Metabolism. 49:2000;73-80.
14. ωNitroarginine, elevates serum triglyceride and cholesterol and lowers hepatic fatty acid oxidation. J. Nutr. 126:1996;2563-2567.
15. Nomura T., Ohtsuki M., Matsui S., Sumi-Ichinose C., Nomura H., Hagino Y. Nitric oxide donor NOR3 inhibits ketogenesis from oleate in isolated rat hepatocytes by a cyclic GMP-independent mechanism. Pharmacol. Toxicol. 82:1998;40-46.
16. Depre C., Gaussin V., Ponchaut S., Fischer Y., Vanoverschelde J.-L., Hue L. Inhibition of myocardial glucose uptake by cGMP. Am. J. Physiol. 274:1998;H1443-H1449.
17. Kim K.-H. Regulation of mammalian acetyl-coenzyme A carboxylase. Ann. Rev. Nutr. 17:1997;77-99.
18. McGarry J.D., Brown N.F. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 244:1997;1-14.
19. Beynen A.C., Vaartjes W.J., Geelen M.J.H. Opposite effects of insulin and glucagon in acute hormonal control of hepatic lipogenesis. Diabetes. 28:1979;828-835.
20. Bijleveld C., Geelen M.J.H. Measurement of acetyl-CoA carboxylase activity in isolated hepatocytes. Biochim. Biophys. Acta. 918:1987;274-283.
21. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
22. Guzmán M., Castro J. Zonal heterogeneity of the effects of chronic ethanol feeding on hepatic fatty acid metabolism. Hepatology. 12:1990;1098-1105.
23. Linn T.C. Purification and crystallization of rat liver fatty acid synthetase. Arch. Biochem. Biophys. 209:1981;613-619.
24. Declercq P.E., Falck J.R., Kuwajima M., Tyminski H., Foster D.W., McGarry J.D. Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors. J. Biol. Chem. 262:1987;9812-9821.
25. Guzmán M., Geelen M.J.H. Activity of carnitine palmitoyltransferase in mitochondrial outer membranes and peroxisomes in digitonin-permeabilized hepatocytes. Biochem. J. 287:1992;487-492.
26. Guzmán M., Castro J. Zonation of fatty acid metabolism in rat liver. Biochem. J. 264:1989;107-113.
27. Zammit V.A. Carnitine acyltransferases: functional significance of subcellular distribution and membrane topology. Prog. Lipid Res. 38:1999;199-224.
28. Velasco G., Geelen M.J.H., Guzmán M. Control of hepatic fatty acid oxidation by 5′-AMP-activated protein kinase involves a malonyl-CoA-dependent and a malonyl-CoA-independent mechanism. Arch. Biochem. Biophys. 337:1997;169-175.
29. Wilcox R.A., Primrose W.U., Nahorski S.R., Challiss R.A.J. New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor. Trends Pharmacol. Sci. 19:1998;467-475.
30. Geiger J., Nolte C., Butt E., Sage S.O., Walter U. Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets. Proc. Natl. Acad. Sci. U.S.A. 89:1992;1031-1035.
31. Komalavilas P., Lincoln T.M. Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. J. Biol. Chem. 269:1994;8701-8707.
32. 3 receptor and cGMP kinase Iβ Nature. 404:2000;197-201.
33. Rooney T.A., Joseph S.K., Queen C., Thomas A.P. Cyclic GMP induces oscillatory calcium signals in rat hepatocytes. J. Biol. Chem. 271:1996;19817-19825.
34. Dufour J.-F., Turner T.J., Arias I.M. Nitric oxide blocks bile canalicular contraction by inhibiting inositol trisphosphate-dependent calcium mobilization. Gastroenterology. 108:1995;841-849.
35. Guzmán M., Velasco G., Geelen M.J.H. Do cytoskeletal components control fatty acid translocation into liver mitochondria? Trends Endocrinol. Metab. 11:2000;49-53.
36. Kerner J., Hoppel C. Fatty acid import into mitochondria. Biochim. Biophys. Acta. 1486:2000;1-17.