Abnormal biopterin metabolism is a major cause of impaired endothelium- dependent relaxation through nitric oxide/O2- imbalance in insulin- resistant rat aorta

Diabetes

Volumn 48, Issue 12, 1999, Pages 2437-2445

  Shinozaki, Kazuya ^a   Kashiwagi, Atsunori ^a   Nishio, Yoshihiko ^a   Okamura, Tomio ^a   Yoshida, Yuichi ^b   Masada, Masahiro ^b   Toda, Noboru ^a   Kikkawa, Ryuichi ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPTERIN; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0033512422     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.12.2437     Document Type: Article

References (43)

1. Pyörälä K: Relationship of glucose tolerance and plasma insulin to the incidence of coronary heart disease: relationship to the incidence of coronary heart disease: results from two population studies in Finland. Diabetes Care 2:131-141, 1979
2. Ducimentiere P, Eschwege E, Papoz L, Richard JL, Claude JR, Rosselin G: Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease in a middle-aged population. Diabetologia 19:205-210, 1980
3. Welborn TA, Wearne K: Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentration. Diabetes Care 2:154-160, 1979
4. Zavaroni I, Bonora E, Pagliara M, Dall'Aglio E, Luchetti L, Buonanno G, Bonati PA, Bergonzani M, Gundi L, Passeri M, Reaven GM: Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 320:702-706, 1989
5. Stout RW: Insulin and atheroma: 20-yr perspective. Diabetes Care 13:631-654, 1990
6. Jarrett RJ: In defence of insulin: a critique of syndrome X. Lancet 340:469-471, 1992
7. Capron L, Jarnet J: Effects of injury and insulin on lipid synthesis from glucose by the rat thoracic aorta. Arterioscler Thromb 11:91-96, 1991
8. Shinozaki K, Suzuki M, Ikebuchi M, Takaki H, Hara Y, Tsushima M, Harano Y: Insulin resistance associated with compensatory hyperinsulinemia as an independent risk factor for vasospastic angina. Circulation 92:1749-1757, 1995
9. Shinozaki K, Suzuki M, Ikebuchi M, Hara Y, Harano Y: Demonstration of insulin resistance in coronary artery disease documented with angiography. Diabetes Care 19:1-7, 1996
10. Laakso M, Sarlund H, Salonen R, Suhonen M, Pyörälä K, Salonen JT, Karhapää P: Asymptomatic atherosclerosis and insulin resistance. Arterioscler Thromb 11:1068-1076, 1991
11. Baron AD, Brechtel-Hook G, Johnson A, Hardin D: Skeletal muscle blood flow: a possible link between insulin resistance and blood pressure. Hypertension 21:129-135, 1993
12. Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G, Baron AD: Obesity/insulin resistance is associated with endothelial dysfunction: implication for the syndrome for insulin resistance. J Clin Invest 97:2601-2610, 1996
13. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA: Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 97:22-28, 1996
14. Kontos HA, Kontos MC: Role of products of univalent reduction of oxygen in hypertensive vascular injury. In Hypertension: Pathophysiology, Diagnosis, and Management. Laragh JH, Brenner BM, Eds. New York, Raven Press, 1995, p. 685-696
15. Wever RMF, Lüscher TF, Cosentino F, Rabelink TJ: Atherosclerosis and the two faces of endothelial nitric oxide synthase. Circulation 97:108-112, 1998
16. Kwon NS, Nathan CF, Stuehr DJ: Reduced biopterin as cofactor in the generation of nitrogen oxides by murine macrophages. J Biol Chem 264:20446-20501, 1989
17. Baek KJ, Thiel BA, Lucas S, Stuehr DJ: Macrophage nitric oxide synthase subunit: purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. J Biol Chem 268:21120-21129, 1993
18. Berka V, Chen PF, Tsai AL: Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthase. J Biol Chem 271:33293-33000, 1986
19. Pieper GM: Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin. J Cardiavasc Pharmacol 29:8-15, 1997
20. Stroes E, Kastelin J, Cosentino F, Erkelens W, Wever R, Koomans H, Lüscher TF, Rabelink T: Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest 99:41-46, 1997
21. Hamon CG, Culter P, Blair JA: Tetrahydrobiopterin metabolism in the streptozotocin induced diabetic state in rats. Clin Chim Acta 181:249-254, 1989
22. Reaven GM: Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension: parallels between human disease and rodent models. Diabetes Care 14:195-202, 1991
23. Harano Y, Ohgaku S, Kosugi K, Yasuda H, Nakano T, Kobayashi M, Hidaka H, Izumi K, Kashiwagi A, Shigeta Y: Clinical significance of altered insulin sensitivity in diabetes mellitus assessed by glucose, insulin, and somatostatin infusion. J Clin Endocrinol Metab 52:982-987, 1981
24. G-nitro-L-arginine in isolated dog and monkey cerebral arteries. Stroke 24:1584-1589, 1993
25. Rees D, Ben-Ishay D, Moncada S: Nitric oxide and the regulation of blood pressure in the hypertension-prone and hypertension-resistant sabra rat. Hypertension 28:367-371, 1996
26. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
27. Kawai N, Bloch DB, Filippov G, Rabkina D, Suen HC, Losty PD, Janssens SP, Zapol WM, de la Monte S, Bloch KD: Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Am J Physiol 268:L589-L595, 1995
28. Kita Y, Hirasawa Y, Maeda K, Nishio M, Yoshida K: Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. Eur J Pharmacol 257:123-130, 1994
29. Rajagopalan S, Kurz S, Münzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG: Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: contribution to alterations of vascular tone. J Clin Invest 97:1916-1923, 1996
30. Li Y, Zhu H, Kuppusamy P, Roubaud V, Zweier JL, Trush MA: Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J Biol Chem 273:2005-2023, 1998
31. Kuthan H, Ullrich V: A quantitative test for superoxide radicals produced in biological systems. Biochem J 203:551-558, 1982
32. Masada M, Akino M, Sueoka T, Katoh S: Dyspropterin, an intermediate formed from dihydroneopterin triphosphate in the biosynthetic pathway of tetrahydrobiopterin. Biochim Biophys Acta 840:235-244, 1985
33. Masada M, Matsumoto J, Akino M: Biosynthetic pathways of pteridines and their association with phenotypic expression in vitro in normal and neoplastic pigment cells from goldfish. Pigment Cell Res 3:61-70, 1990
34. Kafman S: Metabolism of the phenylalanine hydroxylation cofactor. J Biol Chem 242:3934-3943, 1967
35. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254, 1997
36. Abe H, Yamada N, Kamata K, Kuwaki T, Shimada M, Osuga J, Shionoiri F, Yahagi N, Kadowaki T, Tamemoto H, Ishibashi S, Yazaki Y, Makuuchi M: Hypertension, hypertriglyceridemia and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest 101:1784-1788, 1998
37. Sakamoto S, Minami K, Niwa Y, Ohnaka M, Nakaya Y, Mizuno A, Kuwajima M, Shima K: Effects of exercise training and food restriction on endothelium-dependent relaxation in the Otsuka-Long-Evans Tokushima fatty rat, a model of spontaneous NIDDM. Diabetes 47:82-86, 1998
38. Pou S, Pou WS, Bredt DS, Snyder SH, Rosen GM: Generation of superoxide by purified brain nitric oxide synthase. J Biol Chem 267:24173-24176, 1992
39. Viveros OH, Lee CL, Abou-Donia MM, Nixon JC, Nichol CA: Biopterin cofactor biosynthesis: independent regulation of GTP cyclohydrolase in adrenal medulla and cortex. Science 213:349-350, 1981
40. Abou-Donia MM, Duch DS, Nichol CA, Viveros OH: Hormonal regulation of guanosine triphosphate cyclohydrolase activity and biopterin levels in the rat adrenal cortex. Endocrinology 112:2088-2094, 1983
41. Zembowicz A, Tang J, Wu KK: Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine. J Biol Chem 270:17006-17010, 1995
42. Klatt P, Schmid M, Leopold E, Schmidt K, Werner ER, Mayer B: The pteridine binding site of brain nitric oxide synthase. J Biol Chem 269:13861-13866, 1994
43. Shen R, Alam A, Zhang Y: Inhibition of GTP cyclohydrolase I by pterins. Biochim Biophys Acta 965:9-15, 1988