Activation of endothelial nitric-oxide synthase by tumor necrosis factor-α: A novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt

Molecular Pharmacology

Volumn 63, Issue 4, 2003, Pages 886-895

  Barsacchi, Rico ^a   Perrotta, Cristiana ^a,b   Bulotta, Stefania ^c   Moncada, Salvador ^d   Borgese, Nica ^c,e   Clementi, Emilio ^a,b,e,f  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e CNR   (Italy)

^f SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; CERAMIDE; EPIDERMAL GROWTH FACTOR; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENDOTHELIUM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELLS, CULTURED; ENZYME ACTIVATION; HELA CELLS; HUMANS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037382346     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.4.886     Document Type: Article

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