Effects of intracerebroventricular leptin administration on food intake, body weight gain and diencephalic nitric oxide synthase activity in the mouse

British Journal of Pharmacology

Volumn 125, Issue 4, 1998, Pages 798-802

  Calapai, Gioacchino ^a   Corica, Francesco ^a   Allegra, Alessandro ^a   Corsonello, Andrea ^a   Sautebin, Lidia ^b   De Gregorio, Tiziana ^a   Di Rosa, Massimo ^b   Costantino, Giuseppina ^a   Buemi, Michele ^a   Caputi, Achille P ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Body weight gain; Brain; Food intake; L arginine; Leptin; Nitric oxide; Obesity

Indexed keywords

ARGININE; CITRULLINE; LEPTIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIENCEPHALON; DOSE RESPONSE; ENZYME ACTIVITY; FEEDING BEHAVIOR; FOOD INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT GAIN;

ANIMALS; ARGININE; BODY WEIGHT; BRAIN; DIENCEPHALON; DRUG INTERACTIONS; EATING; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; MICE; NITRIC OXIDE SYNTHASE; OBESITY; PROTEINS; TIME FACTORS;

EID: 7844239801     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702121     Document Type: Article

References (30)

1. BRADFORD, M.M. (1976). A rapid method for quantitation of protein dye binding. Anal. Biochem., 72, 248-254.
2. BREDT, D.S., HWANG, P.M. & SNYDER, S.H. (1990). Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature, 347, 768-770.
3. CALAPAI, G. & CAPUTI, A.P. (1996). Nitric oxide and drinking behaviour. Regulatory Peptides, 66, 117-121.
4. CALAPAI, G. MAZZAGLIA, G., CILIA, M., ZINGARELLI, B., SQUADRITO, F. & CAPUTI, A.P. (1994). Mediation by nitric oxide formation in the preoptic area of endotoxin and tumor necrosis factor-induced inhibition of water intake in the rat. Br. J. Pharmacol., 111, 1328-1332.
5. CALAPAI, G., SQUADRITO, F., ALTAVILLA, D., ZINGARELLI, B., CAMPO, G.M., CILIA, M. & CAPUTI, A.P. (1992). Evidence that nitric oxide modulates drinking behaviour. Neuropharmacol., 31, 761-764.
6. COSTA, A., TRAINER, P., BESSER, M. & GROSSMAN, A. (1993). Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro. Brain Res., 605, 187-192.
7. DAWSON, T.M., BREDT, D.S., FOTUHI, M. HWANG, P.M. & SNYDER, S.H. (1991). Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. U.S.A., 88, 7797-7801.
8. DE SARRO, G., ASCIOTI, C., DONATO DI PAOLA, E., VIDAL, M.J. & DE SARRO, A. (1992). Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L-calcium channel in DBA/2 mice. Gen. Pharmacol., 23, 1205-1216.
9. ELMQUIST, J.K., AHIMA, R.S., MARATOS-FLIER, E., FLIER, J.S. & SAPER, C.B. (1997). Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology, 138, 839-842.
10. ERICKSON, J.C., HOLLOPETER, G. & PALMITER, R.D. (1996). Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science, 274, 1704-1707.
11. FLIER, J.S. (1997). Leptin expression and action: new experimental paradigms. Proc. Natl. Acad. Sci. U.S.A., 94, 4242-4245.
12. FORSTERMANN, U. & KLEINERT, H. (1995). Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn-Schmeideberg's Arch. Pharmacol., 352, 351-364.
13. FUKUTO, J.M. & CHAUDURI, G. (1995). Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition. Ann. Rev. Pharmacol. Toxicol., 35, 165-194.
14. HALEY, J.E., WILCOX, G.L. & CHAPMAN, P.F. (1992). The role of nitric oxide in hippocampal long-term potentiation. Neuron, 8, 211-216.
15. KNOWLES, R.G., PALACIOS, M., PALMER, R.M.J. & MONCADA, S. (1989). Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc. Natl. Acad. Sci. U.S.A., 86, 5159-5162.
16. LOWENSTEIN, C.J., DINERMAN, J.L. & SNYDER, S.H. (1994). Nitric oxide: a physiologic messenger. Ann. Int. Med., 120, 227-237.
17. MONTAGUE, P.R., GANCAYCO, C.D., WINN, M.J., MARCHASE, R.B. & FRIEDLANDER, M.J. (1994). Role of NO production in NMDA receptor-mediated neurotransmitter release in cerebral cortex. Science, 263, 973-977.
18. MORLEY, J.E. & FLOOD, J.F. (1991). Evidence that nitric oxide modulates food intake in mice. Life Sci., 49, 707-711.
19. PELLEYMOUNTER, M.A., CULLEN, M.J., BAKER, M.B., HECHT, R., WINTERS, D., BOONE, T. & COLLINS, F. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 269, 540-543.
20. 2+-independent nitric oxide synthase. FEBS Lett., 291, 145-149.
21. SCHWARTZ, M.W., SEELEY, R.J., CAMPFIELD, L.A., BURN, P. & BASKIN, D.G. (1996). Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest., 98, 1101-1106.
22. G-nitro-L-arginine, an inhibitor of nitric oxide synthase. Eur. J. Pharmacol., 255, 51-55.
23. G-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats. Eur. J. Pharmacol., 230, 125-128.
24. STRICKER-KRONGRAD, A., BECK, B. & BURLET, C. (1996). Nitric oxide mediates hyperphagia of obese Zucker rats: relation to specific changes in the microstructure of feeding behavior. Life Sci., 58, 9-15.
25. TRITOS, N.A. & MANTZOROS, C.S. (1997). Leptin: its role in obesity and beyond. Diabetologia, 40, 1371-1379.
26. WANG, M.Y., KOYAMA, K., SHIMABUKURO, M., NEWGARD, C.B. & UNGER, R.H. (1998). OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. Prac. Natl. Acad. Sci. U.S.A., 95, 714-718.
27. WHALE, P., MULLER, T.H. & SWANDULLA, D. (1993). Characterization of neurochemical phenotypes in cultured hypothalamic neurons with immunohistochcmistry and in situ hybridization. Brain Res., 611, 37-45.
28. YU, W.H., WALCZEWSKA, A., KARANTH, S. & MCCANN, S.M. (1997). Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH-and leptin-induced LH release from the pituitary gland. Endocrinology, 138, 5055-5058.
29. ZHANG, J. & SNYDER, S.H. (1995). Nitric oxide in the nervous system. Ann. Rev. Pharmacol. Toxicol., 35, 213-233.
30. ZHANG, Y., PROENCA, R., MAFFEI, M., BARONE, M., LEOPOLD, L. & FRIEDMAN, J.M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.