Effect of exercise on coronary endothelial function in patients with coronary artery disease

New England Journal of Medicine

Volumn 342, Issue 7, 2000, Pages 454-460

  Hambrecht, Rainer ^a   Wolf, Anamaria ^a   Gielen, Stephan ^a   Linke, Axel ^a   Hofer, Jürgen ^a   Erbs, Sandra ^a   Schoene, Nina ^a   Schuler, Gerhard ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE;

ADULT; ARTERY DIAMETER; ARTERY ENDOTHELIUM; ARTICLE; BLOOD FLOW VELOCITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; DOSE RESPONSE; HEART PROTECTION; HUMAN; KINESIOTHERAPY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ACETYLCHOLINE; BLOOD FLOW VELOCITY; CORONARY DISEASE; CORONARY VESSELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; EXERCISE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; VASODILATION; VASODILATOR AGENTS;

EID: 0034677448     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200002173420702     Document Type: Article

References (26)

1. Furchgott RF, Zawadzki JV, Jothiananda D. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-6.
2. Zeiher AM, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans: effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J Clin Invest 1993;92:652-62.
3. Mancini GBJ, Henry GC, Macaya C, et al. Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease: the TREND (Trial on Reversing ENdothelial Dysfunction) Study. Circulation 1996;94:258-65. [Erratum, Circulation 1996;94:1490.]
4. Solzbach U, Hornig B, Jeserich M, Just H. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation 1997;96:1513-9.
5. Treasure CB, Klein JL, Weintraub WS, et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 1995;332:481-7.
6. Andrews TC, Raby K, Barry J, et al. Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease. Circulation 1997; 95:324-8.
7. Ehsani AA, Heath GW, Hagberg JM, Sobel BE, Holloszy JO. Effects of 12 months of intense exercise training on ischemic ST-segment depression in patients with coronary artery disease. Circulation 1981;64:1116-24.
8. Schuler G, Hambrecht R, Schlierf G, et al. Myocardial perfusion and regression of coronary artery disease in patients on a regime of intensive physical exercise and low fat diet. J Am Coll Cardiol 1992;19:34-42.
9. Schuler G, Hambrecht R, Schlierf G, et al. Regular physical exercise and low-fat diet: effects on progression of coronary artery disease. Circulation 1992;86:1-11.
10. Ferguson RJ, Petitclerc R, Choquette G, et al. Effect of physical training on treadmill exercise capacity, collateral circulation and progression of coronary artery disease. Am J Cardiol 1974;34:764-9.
11. Niebauer J, Hambrecht R, Marburger C, et al. Impact of intensive physical exercise and low-fat diet on collateral vessel formation in stable angina pectoris and angiographically confirmed coronary artery disease. Am J Cardiol 1995;76:771-5.
12. Hambrecht R, Fiehn E, Weigl C, et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998;98:2709-15.
13. Wilson RF, Laughlin DE, Ackell PH, et al. Transluminal, subselective measurement of coronary artery blood flow velocity and vasodilator reserve in man. Circulation 1985;72:82-92.
14. Haskell WL, Alderman EL, Fair JM, et al. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease: the Stanford Coronary Risk Intervention Project (SCRIP). Circulation 1994;89:975-90.
15. Cohen MV, Yipintsoi T, Scheuer J. Coronary collateral stimulation by exercise in dogs with stenotic coronary arteries. J Appl Physiol 1982;52: 664-71.
16. Scheel KW, Ingram LA, Wilson JL. Effects of exercise on the coronary and collateral vasculature of beagles with and without coronary occlusion. Circ Res 1981;48:523-30.
17. Ernst E. Influence of regular physical activity on blood rheology. Eur Heart J 1987;8:Suppl G:59-62.
18. Reinhart WH, Dziekan G, Goebbels U, Myers J, Dubach P. Influence of exercise training on blood viscosity in patients with coronary artery disease and impaired left ventricular function. Am Heart J 1998;135:379-82.
19. Gould KL, Martucci JP, Goldberg DI, et al. Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease: a potential noninvasive marker of healing coronary endothelium. Circulation 1994;89:1530-8
20. Woodman CR, Muller JM, Laughlin MH, Price EM. Induction of nitric oxide synthase mRNA in coronary resistance arteries isolated from exercise-trained pigs. Am J Physiol 1997;273:H2575-H2579.
21. Inoue N, Ramasamy S, Fukai T, Nerem RM, Harrison DG. Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells. Circ Res 1996;79:32-7.
22. Rieder MJ, Carmona R, Krieger JE, Pritchard KA Jr, Greene AS. Suppression of angiotensin-converting enzyme expression and activity by shear stress. Circ Res 1997;80:312-9.
23. Haskell WL, Sims C, Myll J, Bortz WM, St Goar FG, Alderman EL. Coronary artery size and dilating capacity in ultradistance runners. Circulation 1993;87:1076-82.
24. White FC, Bloor CM, McKirnan MD, Carroll SM. Exercise training in swine promotes growth of arteriolar bed and capillary angiogenesis in heart. J Appl Physiol 1998;85:1160-8.
25. Laughlin MH, McAllister RM. Exercise training-induced coronary vascular adaptation. J Appl Physiol 1992;73:2209-25.
26. Muller JM, Myers PR, Laughlin MH. Vasodilator responses of coronary resistance arteries of exercise-trained pigs. Circulation 1994;89:2308-14.