Brown adipose tissue, β3-adrenergic receptors, and obesity

Annual Review of Medicine

Volumn 48, Issue , 1997, Pages 307-316

  Lowell, B B ^a   Flier, J S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

3 adrenergic receptors; Brown adipose tissue; Leptin; Obesity; Uncoupling protein

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; BROWN ADIPOSE TISSUE; ENERGY EXPENDITURE; HOMEOSTASIS; HUMAN; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUTRITION; OBESITY; PRIORITY JOURNAL; RAT; REVIEW; SYMPATHETIC TONE;

ADIPOSE TISSUE, BROWN; ANIMALS; ENERGY METABOLISM; HUMANS; MICE; MICE, OBESE; MICE, TRANSGENIC; OBESITY; RATS; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-3;

EID: 0031040576     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.48.1.307     Document Type: Review

References (67)

1. Himms-Hagen J. 1989. Brown adipose tissue thermogenesis and obesity. Prog. Lipid Res. 28:67-115
2. Nnodim JO, Lever JD. 1988. Neural and vascular provisions of rat interscapular brown adipose tissue. Am. J. Anat. 182: 283-93
3. Leonard JL, Mellen SA, Larsen PR. 1983. Thyroxine 5′-deiodinase activity in brown adipose tissue. Endocrinology 112:1153-55
4. Silava JE, Larsen PR. 1983. Adrenergic activation of triiodotyronine production in brown adipose tissue. Nature 305:712-13
5. Néchad M. 1986. Structure and development of brown adipose tissue. In Brown Adipose Tissue, ed. P Trayhurn, DG Nicholls, pp. 1-30. London: Arnold
6. Nicholls DG, Locke RM. 1984 Thermogeneic mechanisms in brown fat. Physol. Rev. 64:1-64
7. Bukowiecki LJ, Folléa N, Lupien J, Paradis A. 1981. Metabolic relationships between lipolysis and respiration in rat brown adipocytes. J. Biol. Chem . 256:12840-48
8. Locke RM, Rial E, Scott ID, Nicholls DG. 1982. Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria. Eur. J. Biochem. 129:373-80
9. Strieleman PJ, Schalinske KL, Shrago E. 1985. Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein. J. Biol. Chem. 260: 13402-5
10. Jezek P, Orosz DE, Modriansky M, Garlid KD. 1994. Transport of anions and protons by the mitochondrial uncoupling protein and its regulation by nucleotides and fatty acids. A new look at old hypotheses. J. Biol. Chem. 269:26184-90
11. Jezek P, Hanus J, Semrad C, Garlid KD. 1996. Photoactivated azido fatty acid irreversibly inhibits anion and proton transport through the mitochondrial uncoupling protein. J. Biol. Chem. 271:6199-205
12. Bouillaud F, Ricquier D, Thibault J, Weissenbach J. 1985. Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein. Proc. Natl. Acad. Sci. USA 82:445-48
13. Jacobsson A, Stadler U, Glotzer M, Kozak L. 1985. Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping and mRNA expression. J. Biol. Chem. 260:16250-54
14. Ridley RG, Patel HV, Gerber GE, et al. 1986. Complete nucleotide sequence and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue: lack of mitochondrial targeting pre-sequence. Nucleic Acids Res. 14:4025-35
15. Kozak LP, Britton JH, Kozak UC, Wells JM. 1988. The mitochondrial uncoupling protein gene. Correlation of exon structures to transmembrane domains. J. Biol. Chem. 263:1274-77
16. Bouillaud F, Raimbault S, Ricquier D. 1988. The gene for rat uncoupling protein: complete sequence, structure of primary transcript and evolutionary relationship between exons. Biochem. Biophys. Res. Commun. 157:783-92
17. Rehnmark S, Néchad M, Herron D, et al. 1990. α- and β-adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. J. Biol. Chem. 265: 16464-71
18. Ricquier D, Bouillaud F, Toumelin P, et al. 1986. Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. J. Biol. Chem. 261:13905-10
19. Bianco AC, Sheng X, Silva JE. 1988. Triiodothyronine amplifies norepinephrine stimulation of uncoupling gene transcription by a mechanism not requiring protein synthesis. J. Biol. Chem. 263:18168-75
20. Raasmaja A, Larsen PR. 1989. α1- and β-adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes. Endocrinology 125:2502-9
21. Boyer B, Kozak LP. 1991. The mitochondrial uncoupling protein gene in brown fat: correlation between DNase I hypersensitivity and expression in transgenic mice. Mol. Cell. Biol. 11:4147-56
22. Cassard-Doulcier AM, Gelly C, Fox N, et al. 1993. Tissue-specific and β-adrenergic regulation of the mitochondrial uncoupling protein gene: control by cis-acting elements in the 5′-flanking region. Mol. Endocrinol. 7:497-506
23. Kozak UC, Kopecky J, Teisinger J, et al. 1994. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol. Cell. Biol. 14:59-67
24. Cassard-Doulcier AM, Larose M, Matamala JC, et al. 1994. In vitro interactions between nuclear proteins and uncoupling protein gene promoter reveal several putative transactivating factors including Ets 1, retinoid X receptor, thyroid hormone receptor, and a CACCC box binding protein. J. Biol. Chem. 269:24335-42
25. Alvarez R, Andrés J, Yubero P, et al. 1995. A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene. J. Biol. Chem. 270: 5666-73
26. Himms-Hagen J. 1990. Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J. 4:2890-98
27. Himms-Hagen J, Cui J, Danforth E Jr, et al. 1994. Effect of CL-316,243, a thermogenic β3-agonist, on energy balance and brown and white adipose tissues in rats. Am. J. Physiol. 266:R1371-82
28. Rothwell NJ, Stock MJ. 1979. A role for brown adipose tissue in diet induced thermogenesis. Nature 281:31-35
29. Arch JRS, Kaumann AJ. 1993. β3- and atypical β-adrenoceptors. Med. Res. Rev. 13:663-729
30. Lowell BB, Susulic VS, Hamann A, et al. 1993. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366:740-42
31. Hamann A, Benecke H, Le Marchand-Brustel Y, et al. 1995. Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat. Diabetes 44:1266-73
32. Hamann A, Flier JS, Lowell BB. 1996. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes and hyperlipidemia. Endocrinology 137:21-29
33. Cassard A-M, Bouillaud F, Matei MG, et al. 1990. Human uncoupling protein gene: structure, comparison with rat gene, and assignment to the long arm of chromosome 4. J. Cell. Biochem. 43:255-64
34. Heaton JM. 1972. The distibution of brown adipose tissue in the human. J. Anat. 112: 35-39
35. Garruti G, Ricquier D. 1992. Analysis of uncoupling protein and its mRNA in adipose tissue deposits of adult humans. Int. J. Obesity 16:383-90
36. Krief S, Lönnqvist F, Raimbault S, et al. 1993. Tissue distribution of β3-adrenergic receptor mRNA in man. J. Clin. Invest. 91:344-49
37. Ricquier D, Néchad M, Mory G. 1982. Ultrastructural and biochemical characterization of human brown adipose tissue activity in phaeochromocytoma. J. Clin. Endocrinol. Metab. 54:803-7
38. Zhang Y, Proenca R, Maffel M, et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-32
39. Considine RV, Considine EL, Williams CJ, et al. 1995. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J. Clin. Invest. 95:2986-88
40. Maffei M, Fei H, Lee G-H, et al. 1995. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc. Natl. Acad. Sci. USA 92:6957-60
41. Funahashi T, Shimomura I, Hiraoka H, et al. 1995. Enhanced expression of rat obese (ob) gene in adipose tissue of ventromedial hypothalamus (VMH)-lesioned rats. Biochem. Biophys. Res. Commun. 211:469-75
42. Frederich RC, Löllmann B, Hamann A, et al. 1995. Expression of ob mRNA and its encoded protein in rodents: impact of nutrition and obesity. J. Clin. Invest. 96:1658-63
43. Oqawa Y, Masuzaki H, Isse N, et al. 1995. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker faty (fa/fa) rats. J. Clin. Invest. 96:1647-52
44. Halaas JL, Gajiwala KS, Maffei M, et al. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-16
45. Pelleymounter MA, Cullen MJ, Baker MB, et al. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-43
46. Campfield LA, Smith FJ, Guisez Y, et al. 1995. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-49
47. Collins S, Kuhn CM, Petro AE, et al. 1996. Role of leptin in fat regulation. Nature 380: 677
48. Tartaglia LA, Dembski M, Weng X, et al. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-71
49. Chen H, Charlat O, Tartaglia LA, et al. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-95
50. Lee GH, Proenca R, Montez JM, et al. 1996. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-35
51. Frederich RC, Hamann A, Anderson S, et al. 1995. Leptin levels reflect lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Med. 1:1311-14
52. Granneman JG, Lahners KN, Chaudhry A. 1991. Molecular cloning and expression of the rate β3-adrenergic receptor. Mol. Pharmacol. 40:895-99
53. Muzzin P, Revelli JP, Kuhne F, et al. 1991. An adipose tissue specific beta-adrenergic receptor. J. Biol. Chem. 266:24053-58
54. Nahmias C, Blin N, Elalouf JM, et al. 1991. Molecular characterization of the mouse β3-adrenergic receptor: relationship with the atypical receptor of adipocytes. EMBO J. 10:3721-27
55. Granneman JG, Lahners KN. 1994. Analysis of human and rodent β3-adrenergic receptor messenger ribonucleic acids. Endocrinology 135:1025-31
56. Collins S, Daniel KW, Rohlfs EM, et al. 1994. Impaired expression and functional activity of the beta-3 and beta-1 adrenergic receptors in adipose tissue of congentially obese C57BL/6J ob/ob mice. Mol. Endocrin. 8:518-27
57. Walston J, Silver K, Bogardus C, et al. 1995. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3-adrenergic-receptor gene. N. Engl. J. Med. 333:343-47
58. Widén E, Lehto M, Kanninen T, et al. 1995. Association of a polymorphism in the ß3-adrenergic receptor gene with features of the insulin resistance syndrome in Finns. N. Engl. J. Med. 333:348-51
59. Clément K, Vaisse C, Manning BStJ, et al. 1995. Genetic variation in the β3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N. Engl. J. Med. 333:352-54
60. Cawthorne MA, Sennitt MV, Arch JRS, Smith SA. 1992. BRL 35135, a potent and selective atypical beta adrenoceptor agonist. Am. J. Clin. Nutr. 55:252-57S
61. Holloway BR, Howe R, Rao BS, Stribling D. 1992. ICI D7114: a novel selective adrenoceptor agonist of brown fat and thermogenesis. Am. J. Clin. Nutr. 55:262-64S
62. Bloom JD, Dutia MD, Johnson BD, et al. 1992. CL 316,243, a potent beta adrenergic agonist virtually specific for beta-3 receptors. A promising antidiabeteic and antiobesity agent. J. Med. Chem. 35: 3081-84
63. Pietri-Rouxel F, Strosberg AD. 1995. Pharmacological characteristics and species-related variations of beta-3 adrenergic receptors. Fundam. Clin. Pharmacol. 9:211-18
64. Himms-Hagen J, Danforth E Jr. 1996. The potential role of β3-adrenoceptor agonists in the treatment of obesity and diabetes. Curr. Opin. Endocrin. Diabetes 3:59-65
65. Susulic VS, Frederich RC, Lawitts J, et al. 1995. Targeted disruption of the beta-3 adrenergic receptor gene. J. Biol. Chem. 270: 29483-92
66. Mantzoros CS, Qu D, Frederich RC, et al. 1996. Activation of β3-adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 45:909-14
67. Ito M, Grujic D, Susulic VS, et al. 1996. Generation of mice expressing human but not murine β3-adrenergic receptors. In 10th Int. Congr. Endocrinol. (Abstr.)