Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice

Journal of Biological Chemistry

Volumn 286, Issue 40, 2011, Pages 34959-34975

  Shinozaki, Shohei ^a   Choi, Cheol Soo ^b   Shimizu, Nobuyuki ^a   Yamada, Marina ^a   Kim, Minhye ^a   Zhang, Ting ^c   Dong, H Henry ^c   Kim, Young Bum ^d   Kaneki, Masao ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Gachon University College of Medicine   (South Korea)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE DISRUPTIONS; GLUCOSE-6-PHOSPHATASE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE ACTIVITIES; GLYCOGEN SYNTHASE KINASE-3; HEPATIC INSULIN RESISTANCE; IN-VIVO; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); INSULIN RECEPTOR SUBSTRATE-1; INSULIN RECEPTORS; INSULIN RESISTANCE; INSULIN SIGNALING; MAMMALIAN TARGET; NITRIC-OXIDE SYNTHASE; PHARMACOLOGICAL INHIBITORS; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE; S-NITROSYLATION; SKELETAL MUSCLE; TRANSGENE; TRANSGENICS; WILD TYPES;

AMINO ACIDS; ANTIBIOTICS; ENZYME ACTIVITY; GENES; GLUCOSE; MAMMALS; MUSCLE; NUTRITION; PHOSPHATASES; PHOSPHORYLATION; PLANTS (BOTANY); SUBSTRATES;

INSULIN;

CHOLESTEROL; FATTY ACID; GLUCOSE 6 PHOSPHATASE; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3BETA; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROTEIN KINASE B; PROTEIN P85; PROTEIN TYROSINE PHOSPHATASE 1B; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVITY; FATTY ACID BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLYCOGEN LIVER LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID LIVER LEVEL; LIVER; MOUSE; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL;

ALBUMINS; ANIMALS; FEMALE; GLUCOSE TOLERANCE TEST; HEPATOCYTES; HYPERGLYCEMIA; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE TYPE II; PHENOTYPE; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; TRIGLYCERIDES;

MAMMALIA; MUS;

EID: 80053400882     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.187666     Document Type: Article

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