Obesogenic and diabetogenic impact of high organochlorine levels (HCB, p,p’-DDE, PCBs) on inhabitants in the highly polluted Eastern Slovakia

Endocrine Regulations

Volumn 48, Issue 1, 2014, Pages 17-24

  Langer, Pavel ^a   Ukropec, J ^a   Kocan, A ^b,c   Drobna, B ^b   Radikova, Z ^a   Huckova, M ^a   Imrich, R ^a   Gasperikova, D ^a   Klimes, I ^a   Trnovec, T ^b  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^b SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^c MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Body mass index; Cholesterol; Diabetes; Environmental pollution; Glucose; Human population; Insulin; Obesity; Organochlorines; Testosterone; Triglycerides

Indexed keywords

CHOLESTEROL; DICHLORODIETHYL DICHLOROETHYLENE; GLUCOSE; HEXACHLOROBENZENE; INSULIN; ORGANOCHLORINE DERIVATIVE; POLYCHLORINATED BIPHENYL; TESTOSTERONE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CHLORINATED HYDROCARBON;

ADULT; AGED; ARTICLE; BODY MASS; CHEMILUMINESCENCE IMMUNOASSAY; DIABETES MELLITUS; FEMALE; HUMAN; MALE; MASS FRAGMENTOGRAPHY; MIDDLE AGED; OBESITY; POLLUTION; SLOVAKIA; YOUNG ADULT; BLOOD; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; POLLUTANT; PREVALENCE; RISK FACTOR;

ADULT; AGED; DIABETES MELLITUS, TYPE 2; DICHLORODIPHENYL DICHLOROETHYLENE; ENVIRONMENTAL POLLUTANTS; FEMALE; HEXACHLOROBENZENE; HUMANS; HYDROCARBONS, CHLORINATED; MALE; MIDDLE AGED; OBESITY; POLYCHLORINATED BIPHENYLS; PREVALENCE; RISK FACTORS; SLOVAKIA; YOUNG ADULT;

EID: 84903550295     PISSN: 12100668     EISSN: 13360329     Source Type: Journal    
DOI: 10.4149/endo_2014_01_17     Document Type: Article

References (46)

1. Akins JR, Waldrep K, Bernert JT Jr: The estimation of total serum-lipids by a completely enzymatic summation method. Clin Chim Acta 184, 219-226, 1989. http://dx.doi.org/10.1016/0009-8981(89)90054-5
2. Alexander CM, Landsman PB, Teutsch SM, Haffner SM: NCEP-Defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III Participants Age 50 Years and Older. Diabetes 52, 1210-1214, 2003. http://dx.doi.org/10.2337/diabetes.52.5.1210
3. Arrebola JP, Pumarega MG, Gasull M, Fernandez MF, Martin-Olmedo P, Molina-Molina JM, Fernandez-Rodriguez M, Porta M, Olea N: Adipose tissue concentration of persistent organic pollutants and prevalence of type 2 diabetes in Southern Spain. Environ Res 122, 31-37, 2013. http://dx.doi.org/10.1016/j.envres.2012.12.001
4. Baillie-Hamilton PF: Chemical toxins: a hypothesis to explain the global obesity epidemic. J Altern Complement Med 8, 185-192, 2002. http://dx.doi.org/10.1089/107555302317371479
5. Bloom MS, Vena JE, Olson JR, Kostyniak PJ: Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York state anglers. Int J Hyg Environ Health 212, 599-611, 2009. http://dx.doi.org/10.1016/j.ijheh.2009.04.005
6. Bodin J, Bolling AK, Samuelsen M, Becher R, Lovik M, Nygaard UC: Long-term bisphenol A exposure accelerates insulitis development in diabetes-prone NOD mice. Immunopharmacol Immunotoxicol 35, 349-358, 2013. http://dx.doi.org/10.3109/08923973.2013.772195
7. Casals-Casas C, Desvergne B: Endocrine disruptors: from endocrine to metabolic disruption. Ann Rev Physiol 73, 135-162, 2011. http://dx.doi.org/10.1146/annurev-physiol-012110-142200
8. Chovancova J, Kocan A, Jursa S: PCDDs, PCDFs and dioxin-like PCB in foods of animal origin (Slovakia). Chemosphere 61, 1305-1311, 2005. http://dx.doi.org/10.1016/j.chemosphere.2005.03.057
9. Donato F, Magoni M, Bergonzi R, Scarcella C, Indelicato A, Carasi S, Apostoli P: Exposure to polychlorinated biphenyls in residents near a chemical factory in Italy: the food chain a man source of contamination. Chemosphere 64, 1562-1572, 2006. http://dx.doi.org/10.1016/j.chemosphere.2005.11.057
10. Donato F, Zani C, Magoni M, Gelatti U, Covolo L, Orizio G, Speziani F, Indelicato A, Scarcella C, Bergonzi R, Apostoli P: Polychlorinated biphenyls and thyroid hormone serum concentrations among people living in a highly polluted area: a cross-sectional population-based study. Environ Res 108, 380-386, 2008. http://dx.doi.org/10.1016/j.envres.2008.08.003
11. Gasull M, Pumarega J, Tellez-Plaza M, Castell C, Tresserras R, Lee DH, Porta M: Blood concentrations of persistent organic pollutants and prediabetes and diabetes in the general population of Catalonia. Environ Sci Technol 46, 7799-7810, 2012. http://dx.doi.org/10.1021/es300712g
12. Gong H, Zhang X, Cheng B, Sun Y, Li C, Li T, Zheng L, Huang K: Bisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetes. PLoS One 8, e54198, 2013. http://dx.doi.org/10.1371/journal.pone.0054198
13. Hagmar L, Bjork J, Sjodin A, Bergman A, Erfurth EM: Plasma levels of persistent organohalogens and hormone levels in adult male humans. Arch Environ Health 56, 138-143, 2001. http://dx.doi.org/10.1080/00039890109604065
14. Hectors TL, Vanparys C, van der Ven K, Martens GA, Jorens PG, Van Gaal LF, Covaci A, De Coen W, Blust R: Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function. Diabetologia 54, 1273-1290, 2011. http://dx.doi.org/10.1007/s00125-011-2109-5
15. Hu FB: Globalization of diabetes: The role of diet, lifestyle, and genes. Diabetes Care 34, 1249-1257, 2011. http://dx.doi.org/10.2337/dc11-0442
16. Hunter DJ, Hankinson SE, Laden F, Colditz GA, Manson JE, Willett WC, Speizer FE, Wolff MS: Plasma organochlorine levels and the risk of breast cancer. N Eng J Med 337, 1253-1258, 1997. http://dx.doi.org/10.1056/NEJM199710303371801
17. James KA, Marshall JA, Hokanson JE, Meliker JR, Zerbe GO, Byers TE: A case-cohort study examining lifetime exposure to inorganic arsenic in drinking water and diabetes mellitus. Environ Res 123, 33-38, 2013. http://dx.doi.org/10.1016/j.envres.2013.02.005
18. Jursa S, Chovancova J, Petrik J, Loksa J: Dioxin-like and non-dioxin-like PCBs in human serum in Slovak population. Chemosphere 64, 686-691, 2006. http://dx.doi.org/10.1016/j.chemosphere.2005.10.048
19. Kim NH, Mason CC, Nelson RG, Afton SE, Essader AS, Medlin JE, Levine KE, Hoppin JA, Lin C, Knowler WC, Sandler DP: Arsenic Exposure and Incidence of Type 2 Diabetes in Southwestern American Indians. Am J Epidemiol 2013 Mar 15. http://dx.doi.org/10.1093/aje/kws329
20. Kocan A, Petrik J, Drobna B, Chovancova J: Levels of PCBs and some organochlorinated pesticides in the human population of selected areas of the Slovak Republic. I. Blood. Chemosphere 29, 2315-2325, 1994. http://dx.doi.org/10.1016/0045-6535(94)90400-6
21. Kocan A, Petrik J, Jursa S, Chovancova J, Drobna B: Environmental contamination with polychlorinated biphenyls in the area of their former manufacture in Slovakia. Chemosphere 43, 595-600, 2001. http://dx.doi.org/10.1016/S0045-6535(00)00411-2
22. Langer P, Kocan A, Tajtakova M, Petrik J, Chovancova J, Drobna B, Jursa S, Pavuk M, Koska J, Trnovec T, Sebokova E, Klimes I: Effects of polychlorinated biphenyls and organchlorinated pesticides on the thyroid after long-term exposure to heavy environmental pollution. J Occup Environ Med 45, 526-531, 2003. http://dx.doi.org/10.1097/01.jom.0000058346.05741.b0
23. Langer P, Kocan A, Drobna B, Susienkova K, Radikova Z, Huckova M, Imrich R, Gasperikova D, Klimes I: Blood testosterone in middle aged males heavily exposed to endocrine disruptors is decreasing more with HCB and p,p‘-DDE related to BMI and blood lipids, but not with Σ15PCBs. Endocrine Regul 46, 51-59, 2012. http://dx.doi.org/10.4149/endo_2012_02_51
24. Lee DH, Lee IK, Song K, Steffes M, Toscano W, Baker BA, Jacobs DR Jr: Strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care 9, 1638-1644, 2006. http://dx.doi.org/10.2337/dc06-0543
25. Lee DH, Steffes MW, Sjodin A, Jones RS, Needham LL, Jacobs DR Jr: Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes. PLoS One 6, e15977, 2011. http://dx.doi.org/10.1371/journal.pone.0015977
26. Lee DH, Lind L, Jacobs DR Jr, Salihovic S, van Bavel B, Lind PM: Associations of persistent organic pollutants with abdominal obesity in the elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Environ Int 40, 170-178, 2012. http://dx.doi.org/10.1016/j.envint.2011.07.010
27. Lopez-Espinosa MJ, Vizcaino E, Murcia M, Llop S, Espada M, Seco V, Marco A, Rebagliato M, Grimalt JO, Ballester F: Association between thyroid hormone levels and 4,4‘-DDE concentrations in pregnant women (Valencia, Spain). Environ Res 109,479-485, 2009. http://dx.doi.org/10.1016/j.envres.2009.02.003
28. Meeker JD, Altshul L, Hauser R: Serum PCB, p,p‘-DDE and HCB predict thyroid hormone levels in men. Environ Res 104, 296-304, 2007. http://dx.doi.org/10.1016/j.envres.2006.11.007
29. Montgomery MP, Kamel F, Saldana TM, Alavanja MC, Sandler DP: Incident diabetes and pesticide exposure among licensed pesticide applicators: Agricultural Health Study 1993 – 2003. Am J Epidemiol 167, 1235-1246, 2008. http://dx.doi.org/10.1093/aje/kwn028
30. Neel BA, Sargis RM: The paradox of progress: environmental disruption of metabolism and the diabetes epidemic. Diabetes 60, 1838-1848, 2011. http://dx.doi.org/10.2337/db11-0153
31. Pavuk M, Cerhan JR, Lynch CF, Schecter A, Petrik J, Chovancova J, Kocan A: Environmental exposure to PCBs and cancer incidence in eastern Slovakia. Chemosphere 54, 1509-1520, 2004. http://dx.doi.org/10.1016/j.chemosphere.2003.10.038
32. Persky V, Turyk M, Anderson HA, Hanrahan LP, Falk C, Steenport DN, Chatterton R Jr, Freels S: Great Lakes Consortium: The effects of PCB exposure and fish consumption on endogenous hormones. Environ Health Perspect 109, 1275-1283, 2001. http://dx.doi.org/10.1289/ehp.011091275
33. Petrik J, Drobna B, Pavuk M, Jursa S, Wimmerova S, Chovancova J: Serum PCBs and orgaonochlorine pesticides in Slovakia: age, gender and residence as determinants of organchlorine concentrations. Chemosphere 65, 410-418, 2006. http://dx.doi.org/10.1016/j.chemosphere.2006.02.002
34. Rylander L, Rignell-Hydbom A, Hagmar L: A cross-sectional study of the association between persistent organochlorine pollutants and diabetes. Environ Health 4, 28, 2005. http://dx.doi.org/10.1186/1476-069X-4-28
35. Sala M, Sunyer J, Herrero C, To-Figueras J, Grimalt J: Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population. Occup Environ Med 58, 172-177, 2001. http://dx.doi.org/10.1136/oem.58.3.172
36. Sallmen M, Sandler DP, Hoppin JA, Blair A, Baird DD: Reduced fertility among overweight and obese men. Epidemiology 17, 520-523, 2006. http://dx.doi.org/10.1097/01.ede.0000229953.76862.e5
37. Stellman SD, Djordjevic MV, Britton JA, Muscat JE, Citron ML, Kemeny M, Busch E, Gong L: Breast cancer risk in relation to adipose concentrations of organochlorine pesticides and polychlorinated biphenyls in Long Island, New York. Cancer Epidemiol Biomarkers Prev 9, 1241-1249, 2000.
38. Tanaka T, Morita A, Kato M, Hirai T, Mizoue T, Terauchi Y, Watanabe S, Noda M: SCOP Study Group: Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP). Endocr J 58, 589-596, 2011. http://dx.doi.org/10.1507/endocrj.K10E-361
39. Tsai EC, Matsumoto AM, Fujimoto WY, Boyko EJ: Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat. Diabetes Care 27, 861-868, 2004. http://dx.doi.org/10.2337/diacare.27.4.861
40. Turyk ME, Anderson HA, Freels S, Chatterton R Jr, Needham LL, Patterson DG Jr, Steenport DN, Knobeloch L, Imm P, Persky VW: Great Lakes Consortium: Associations of organochlorines with endogenous hormones in male Great Lakes fish consumers and nonconsumers. Environ Res 102, 299-307, 2006. http://dx.doi.org/10.1016/j.envres.2006.01.009
41. Turyk ME, Anderson HA, Persky VW: Relationships of thyroid hormones with polychlorinated biphenyls, dioxins, furans, and DDE in adults. Environ Health Perspect 115, 1194-1203, 2007. http://dx.doi.org/10.1289/ehp.10179
42. Turyk ME, Persky VW, Imm P, Knobeloch L, Chatterton R, Anderson HA: Hormone disruption by PBDEs in adult male sport fish consumers. Environ Health Perspect 116, 1635-1641, 2008. http://dx.doi.org/10.1289/ehp.11707
43. Uemura H, Arisawa K, Hiyoshi M, Kitayama A, Takami H, Sawachika F, Dakeshita S, Nii K, Satoh H, Sumiyoshi Y, Morinaga K, Kodama K, Suzuki T, Nagai M, Suzuki T: Prevalence of metabolic syndrome associated with body burden levels of dioxin and related compounds among Japan‘s general population. Environ Health Perspect 117, 568-573, 2009.
44. Ukropec J, Radikova Z, Huckova M, Koska J, Kocan A, Sebokova E, Drobna B, Trnovec T, Susienkova K, Labudova V, Gasperikova D, Langer P, Klimes I: High prevalence of prediabetes and diabetes in a population exposed to high levels of an organochlorine cocktail. Diabetologia 53, 899-906, 2010. http://dx.doi.org/10.1007/s00125-010-1683-2
45. Valvi D, Mendez MA, Martinez D, Grimalt JO, Torrent M, Sunyer J, Vrijheid M: Prenatal concentrations of PCBs, DDE, DDT and overweight in children: a prospective birth cohort study. Environ Health Perspect 120, 451-457, 2012. http://dx.doi.org/10.1289/ehp.1103862
46. Zeliger HI: Lipophilic chemical exposure as a cause of type 2 diabetes (T2D). Rev Environ Health 28, 9-20, 2013. http://dx.doi.org/10.1515/reveh-2012-0031