Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 2, 2011, Pages

  Taguchi, Kumiko ^a   Kobayashi, Tsuneo ^a   Matsumoto, Takayuki ^a   Kamata, Katsuo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Akt endothelial nitric oxide synthase pathway; G protein coupled receptor kinase 2; Hyperinsulinemia; Insulin signaling; Membrane fraction; Protein kinase c

Indexed keywords

BETA ARRESTIN 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; G PROTEIN COUPLED RECEPTOR KINASE 2; INSULIN; PROTEIN KINASE B; PROTEIN KINASE C; SERINE; THREONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; INSULIN BLOOD LEVEL; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; AORTA; ARRESTINS; BLOOD GLUCOSE; BLOTTING, WESTERN; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HYPERINSULINISM; INSULIN; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIME FACTORS; VASODILATION; VASODILATOR AGENTS;

EID: 79961038726     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01189.2010     Document Type: Article

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