Small-molecule quadruplex-targeted drug discovery

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 12, 2014, Pages 2602-2612

  Ohnmacht, Stephan A ^a   Neidle, Stephen ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cancer; Quadruplex DNA, RNA; Small molecules

Indexed keywords

ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; BERBERINE; BISQUINOLINI UM; BRACO 19; GUANINE QUADRUPLEX; N METHYL MESOPORPHYRIN IX; NAPHTHALENE DERIVATIVE; QUARFLOXIN; QUINDOLINE DERIVATIVE; TELOMESTATIN; UNCLASSIFIED DRUG; MOLECULAR LIBRARY; BISQUINOLINIUM PHEN DC3; BMSG SH 3; BMSG SH 4; MESOPORPHYRIN; NAPHTHALENE; PHENANTHROLINE;

5' UNTRANSLATED REGION; ARTICLE; BINDING AFFINITY; CANCER CELL; DNA BINDING; DNA STRUCTURE; DOWN REGULATION; GENE EXPRESSION; GENE TARGETING; GENOMIC INSTABILITY; MOLECULAR SIZE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONCOGENE; PROMOTER REGION; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; HUMAN; MOLECULAR LIBRARY; ANTINEOPLASTIC ACTIVITY; CANCER CELL LINE; DRUG STRUCTURE; HUMAN GENOME; INTRON; TELOMERE;

CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; DRUG DISCOVERY; G-QUADRUPLEXES; HUMANS; MODELS, MOLECULAR; SMALL MOLECULE LIBRARIES;

EID: 84900824121     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.029     Document Type: Review

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