메뉴 건너뛰기




Volumn 18, Issue 10, 2013, Pages 12368-12395

G-quadruplex structures in the human genome as novel therapeutic targets

Author keywords

G quadruplex; Oncogene; Small molecules; Telomeres

Indexed keywords

ANTINEOPLASTIC AGENT; GUANINE QUADRUPLEX;

EID: 84886626805     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules181012368     Document Type: Review
Times cited : (133)

References (108)
  • 1
    • 79953313413 scopus 로고    scopus 로고
    • Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?
    • Balasubramanian, S.; Hurley, L.H.; Neidle, S. Targeting G-quadruplexes in gene promoters: A novel anticancer strategy? Nat. Rev. Drug Discov. 2011, 10, 261-275.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 261-275
    • Balasubramanian, S.1    Hurley, L.H.2    Neidle, S.3
  • 2
    • 81455140677 scopus 로고    scopus 로고
    • The application of DNA and RNA G-quadruplexes to therapeutic medicines
    • Collie, G.W.; Parkinson, G.N. The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chem. Soc. Rev. 2011, 40, 5867-5892.
    • (2011) Chem. Soc. Rev. , vol.40 , pp. 5867-5892
    • Collie, G.W.1    Parkinson, G.N.2
  • 3
    • 84862229118 scopus 로고    scopus 로고
    • 5′-UTR RNA G-quadruplexes: Translation regulation and targeting
    • Bugaut, A.; Balasubramanian, S. 5′-UTR RNA G-quadruplexes: Translation regulation and targeting. Nucleic Acids Res. 2012, 40, 4727-4741.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 4727-4741
    • Bugaut, A.1    Balasubramanian, S.2
  • 4
    • 66549124907 scopus 로고    scopus 로고
    • The structures of quadruplex nucleic acids and their drug complexes
    • Neidle, S. The structures of quadruplex nucleic acids and their drug complexes. Curr. Opin. Struct. Biol. 2009, 19, 239-250.
    • (2009) Curr. Opin. Struct. Biol. , vol.19 , pp. 239-250
    • Neidle, S.1
  • 5
    • 67649833785 scopus 로고    scopus 로고
    • G-quadruplex nucleic acids as therapeutic targets
    • Balasubramanian, S.; Neidle, S. G-quadruplex nucleic acids as therapeutic targets. Curr. Opin. Chem. Biol. 2009, 13, 345-353.
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , pp. 345-353
    • Balasubramanian, S.1    Neidle, S.2
  • 6
    • 84867744921 scopus 로고    scopus 로고
    • DNA secondary structures: Stability and function of G-quadruplex structures
    • Bochman, M.L.; Paeschke, K.; Zakian, V.A. DNA secondary structures: Stability and function of G-quadruplex structures. Nat. Rev. Genet. 2012, 13, 770-780.
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 770-780
    • Bochman, M.L.1    Paeschke, K.2    Zakian, V.A.3
  • 7
    • 84882250300 scopus 로고    scopus 로고
    • Targeting non-B-form DNA in living cells
    • Du, Y.; Zhou, X. Targeting non-B-form DNA in living cells. Chem. Record 2013, 13, 371-384.
    • (2013) Chem. Record , vol.13 , pp. 371-384
    • Du, Y.1    Zhou, X.2
  • 8
    • 84860143903 scopus 로고    scopus 로고
    • G-quadruplex binding ligands: From naturally occurring to rationally designed molecules
    • Vy Thi Le, T.; Han, S.; Chae, J.; Park, H.J. G-quadruplex binding ligands: From naturally occurring to rationally designed molecules. Curr. Pharm. Des. 2012, 18, 1948-1972.
    • (2012) Curr. Pharm. Des. , vol.18 , pp. 1948-1972
    • Vy Thi Le, T.1    Han, S.2    Chae, J.3    Park, H.J.4
  • 9
    • 84880725971 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres: Remodeling the telomere architecture
    • doi:10.3389/fonc.2013.00027
    • Conomos, D.; Pickett, H.A.; Reddel, R.R. Alternative lengthening of telomeres: Remodeling the telomere architecture. Front. Oncol. 2013, doi:10.3389/fonc.2013.00027.
    • (2013) Front. Oncol.
    • Conomos, D.1    Pickett, H.A.2    Reddel, R.R.3
  • 10
    • 84873170179 scopus 로고    scopus 로고
    • Telomerase and the search for the end of cancer
    • Mocellin, S.; Pooley, K.A.; Nitti, D. Telomerase and the search for the end of cancer. Trends Mol. Med. 2013, 19, 125-133.
    • (2013) Trends Mol. Med. , vol.19 , pp. 125-133
    • Mocellin, S.1    Pooley, K.A.2    Nitti, D.3
  • 11
    • 84855183935 scopus 로고    scopus 로고
    • Pharmaceutical regulation of telomerase and its clinical potential
    • Sprouse, A.A.; Steding, C.E.; Herbert, B.S. Pharmaceutical regulation of telomerase and its clinical potential. J. Cell. Mol. Med. 2012, 16, 1-7.
    • (2012) J. Cell. Mol. Med. , vol.16 , pp. 1-7
    • Sprouse, A.A.1    Steding, C.E.2    Herbert, B.S.3
  • 12
    • 42149110183 scopus 로고    scopus 로고
    • High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma
    • Cairney, C.J.; Hoare, S.F.; Daidone, M.G.; Zaffaroni, N.; Keith, W.N. High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma. Br. J. Cancer 2008, 98, 1467-1474.
    • (2008) Br. J. Cancer , vol.98 , pp. 1467-1474
    • Cairney, C.J.1    Hoare, S.F.2    Daidone, M.G.3    Zaffaroni, N.4    Keith, W.N.5
  • 16
    • 84855996113 scopus 로고    scopus 로고
    • G-quadruplexes: From guanine gels to chemotherapeutics
    • Bryan, T.M.; Baumann, P. G-quadruplexes: From guanine gels to chemotherapeutics. Mol. Biotechnol. 2011, 49, 198-208.
    • (2011) Mol. Biotechnol. , vol.49 , pp. 198-208
    • Bryan, T.M.1    Baumann, P.2
  • 17
    • 84874039558 scopus 로고    scopus 로고
    • High-Resolution insight into G-overhang architecture
    • Hänsel, R.; Löhr, F.; Trantirek, L.; Dötsch, V. High-Resolution insight into G-overhang architecture. J. Am. Chem. Soc. 2013, 135, 2816-2824.
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 2816-2824
    • Hänsel, R.1    Löhr, F.2    Trantirek, L.3    Dötsch, V.4
  • 18
    • 47249089630 scopus 로고    scopus 로고
    • Polymorphism of human telomeric quadruplex structures
    • Dai, J.; Carver, M.; Yang, D. Polymorphism of human telomeric quadruplex structures. Biochimie 2008, 90, 1172-1183.
    • (2008) Biochimie , vol.90 , pp. 1172-1183
    • Dai, J.1    Carver, M.2    Yang, D.3
  • 19
    • 48749109524 scopus 로고    scopus 로고
    • Topology conservation and loop flexibility in quadruplex-drug recognition: Crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
    • Parkinson, G.N.; Cuenca, F.; Neidle, S. Topology conservation and loop flexibility in quadruplex-drug recognition: Crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. J. Mol. Biol. 2008, 381, 1145-1156.
    • (2008) J. Mol. Biol. , vol.381 , pp. 1145-1156
    • Parkinson, G.N.1    Cuenca, F.2    Neidle, S.3
  • 20
    • 84871784359 scopus 로고    scopus 로고
    • The crystal structure of human telomeric DNA complexed with berberine: An interesting case of stacked ligand to G-tetrad ratio higher than 1:1
    • Bazzicalupi, C.; Ferraroni, M.; Bilia, A.R.; Scheggi, F.; Gratteri, P. The crystal structure of human telomeric DNA complexed with berberine: An interesting case of stacked ligand to G-tetrad ratio higher than 1:1. Nucleic Acids Res. 2013, 41, 632-638.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 632-638
    • Bazzicalupi, C.1    Ferraroni, M.2    Bilia, A.R.3    Scheggi, F.4    Gratteri, P.5
  • 22
    • 79954570122 scopus 로고    scopus 로고
    • Chemistry in human telomere biology: Structure, function and targeting of telomere DNA/RNA
    • Xu, Y. Chemistry in human telomere biology: Structure, function and targeting of telomere DNA/RNA. Chem. Soc. Rev. 2011, 40, 2719-2740.
    • (2011) Chem. Soc. Rev. , vol.40 , pp. 2719-2740
    • Xu, Y.1
  • 24
    • 84873894447 scopus 로고    scopus 로고
    • Identification and characterization of new DNA G-quadruplex binders selected by a combination of ligand and structure-based virtual screening approaches
    • Alcaro, S.; Musetti, C.; Distinto, S.; Casatti, M.; Zagotto, G.; Artese, A.; Parrotta, L.; Moraca, F.; Costa, G.; Ortuso, F.; et al. Identification and characterization of new DNA G-quadruplex binders selected by a combination of ligand and structure-based virtual screening approaches. J. Med. Chem. 2013, 56, 843-855.
    • (2013) J. Med. Chem. , vol.56 , pp. 843-855
    • Alcaro, S.1    Musetti, C.2    Distinto, S.3    Casatti, M.4    Zagotto, G.5    Artese, A.6    Parrotta, L.7    Moraca, F.8    Costa, G.9    Ortuso, F.10
  • 25
    • 77953381213 scopus 로고    scopus 로고
    • Structural insights into G-quadruplexes: Towards new anticancer drugs
    • Yang, D.; Okamoto, K. Structural insights into G-quadruplexes: Towards new anticancer drugs. Future Med. Chem. 2010, 619-646.
    • (2010) Future Med. Chem. , pp. 619-646
    • Yang, D.1    Okamoto, K.2
  • 28
    • 70349084987 scopus 로고    scopus 로고
    • The G-quadruplex ligand telomestatitn impairs binding of topoisomerase III alpha to G-quadruplex forming oligonucleotides and uncaps telomeres in ALT cells
    • Temime-Smaali, N.; Guittat, L.; Sidibe, A.; Shin-ya, A.; Trentesaux, C. The G-quadruplex ligand telomestatitn impairs binding of topoisomerase III alpha to G-quadruplex forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One 2009, 4, e6919.
    • (2009) PLoS One , vol.4
    • Temime-Smaali, N.1    Guittat, L.2    Sidibe, A.3    Shin-Ya, A.4    Trentesaux, C.5
  • 33
    • 84876215753 scopus 로고    scopus 로고
    • Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells
    • Micco, M.; Collie, G.W.; Dale, A.G.; Ohnmacht, S.A.; Pazitna, I.; Gunaratham, M.; Reszka, A.P.; Neidle, S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J. Med. Chem. 2013, 56, 2959-2974.
    • (2013) J. Med. Chem. , vol.56 , pp. 2959-2974
    • Micco, M.1    Collie, G.W.2    Dale, A.G.3    Ohnmacht, S.A.4    Pazitna, I.5    Gunaratham, M.6    Reszka, A.P.7    Neidle, S.8
  • 34
    • 50349102258 scopus 로고    scopus 로고
    • G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells
    • Huang, F.C.; Chang, C.C.; Lou, P.J.; Kuo, I.C.; Chien, C.W.; Chen, C.T.; Shieh, F.Y.; Chang, T.C.; Lin, J.J. G-quadruplex stabilizer 3,6-bis(1-methyl-4- vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells. Mol. Cancer Res. 2008, 6, 955-964.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 955-964
    • Huang, F.C.1    Chang, C.C.2    Lou, P.J.3    Kuo, I.C.4    Chien, C.W.5    Chen, C.T.6    Shieh, F.Y.7    Chang, T.C.8    Lin, J.J.9
  • 35
    • 84864447477 scopus 로고    scopus 로고
    • Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
    • Muller, S.; Sanders, D.A.; di Antonio, M.; Matsis, S.; Riou, J.F.; Balasubramanian, S. Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org. Biomol. Chem. 2012, 10, 6537-6546.
    • (2012) Org. Biomol. Chem. , vol.10 , pp. 6537-6546
    • Muller, S.1    Sanders, D.A.2    Di Antonio, M.3    Matsis, S.4    Riou, J.F.5    Balasubramanian, S.6
  • 36
    • 84865437096 scopus 로고    scopus 로고
    • Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity
    • Huang, F.C.; Chang, C.C.; Wang, J.M.; Chang, T.C.; Lin, J.J. Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity. Br. J. Pharmacol. 2012, 167, 393-406.
    • (2012) Br. J. Pharmacol. , vol.167 , pp. 393-406
    • Huang, F.C.1    Chang, C.C.2    Wang, J.M.3    Chang, T.C.4    Lin, J.J.5
  • 37
    • 38049089850 scopus 로고    scopus 로고
    • Quadruplex ligand recognition: Biological aspects
    • Neidle, S., Balasubramanian, S., Eds.; The Royal Society of Chemistry: London, UK, Chapter 6
    • Riou, J.F.; Gomez, D.; Morjani, H.; Trentesaux, C. Quadruplex Ligand Recognition: Biological Aspects. In Quadruplex Nucleic Acids; Neidle, S., Balasubramanian, S., Eds.; The Royal Society of Chemistry: London, UK, 2006; Chapter 6, pp. 154-180.
    • (2006) Quadruplex Nucleic Acids , pp. 154-180
    • Riou, J.F.1    Gomez, D.2    Morjani, H.3    Trentesaux, C.4
  • 38
    • 23344451160 scopus 로고    scopus 로고
    • Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
    • Zaug, A.J.; Podell, E.R.; Cech, T.R. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc. Natl. Acad. Sci. USA 2005, 102, 10864-10869.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 10864-10869
    • Zaug, A.J.1    Podell, E.R.2    Cech, T.R.3
  • 39
    • 12844254472 scopus 로고    scopus 로고
    • POT1 and TRF2 cooperate to maintain telomeric integrity
    • Yang, Q.; Zheng, Y.L.; Harris, C.C. POT1 and TRF2 cooperate to maintain telomeric integrity. Mol. Cell. Biol. 2005, 25, 1070-1080.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 1070-1080
    • Yang, Q.1    Zheng, Y.L.2    Harris, C.C.3
  • 41
    • 44349168303 scopus 로고    scopus 로고
    • Telomeres: The silence is broken
    • Azzalin, C.M.; Lingner, J. Telomeres: The silence is broken. Cell Cycle 2008, 7, 1161-1165.
    • (2008) Cell Cycle , vol.7 , pp. 1161-1165
    • Azzalin, C.M.1    Lingner, J.2
  • 43
    • 77957243987 scopus 로고    scopus 로고
    • The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
    • Redon, S.; Reichenbach, P.; Lingner, J. The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res. 2010, 38, 5797-5806.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 5797-5806
    • Redon, S.1    Reichenbach, P.2    Lingner, J.3
  • 44
    • 68949198783 scopus 로고    scopus 로고
    • TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres
    • Deng, Z.; Norseen, J.; Wiedmer, A.; Riethman, H.; Lieberman, P.M. TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol. Cell 2009, 35, 403-413.
    • (2009) Mol. Cell , vol.35 , pp. 403-413
    • Deng, Z.1    Norseen, J.2    Wiedmer, A.3    Riethman, H.4    Lieberman, P.M.5
  • 45
    • 69849104275 scopus 로고    scopus 로고
    • TERRA: Telomeric repeat-containing RNA
    • Luke, B.; Lingner, J. TERRA: Telomeric repeat-containing RNA. EMBO J. 2009, 28, 2503-2510.
    • (2009) EMBO J. , vol.28 , pp. 2503-2510
    • Luke, B.1    Lingner, J.2
  • 46
    • 62549122535 scopus 로고    scopus 로고
    • Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription
    • Ng, L.J.; Cropley, J.E.; Pickett, H.A.; Reddel, R.R.; Suter, C.M. Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Res. 2009, 37, 1152-1159.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1152-1159
    • Ng, L.J.1    Cropley, J.E.2    Pickett, H.A.3    Reddel, R.R.4    Suter, C.M.5
  • 47
    • 38849111756 scopus 로고    scopus 로고
    • Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
    • Schoeftner, S.; Blasco, M.A. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat. Cell. Biol. 2008, 10, 228-236.
    • (2008) Nat. Cell. Biol. , vol.10 , pp. 228-236
    • Schoeftner, S.1    Blasco, M.A.2
  • 48
    • 84855984815 scopus 로고    scopus 로고
    • Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade
    • Sampl, S.; Pramhas, S.; Stern, C.; Preusser, M.; Marosi, C.; Holzmann, K. Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade. Transl. Oncol. 2012, 5, 56-65.
    • (2012) Transl. Oncol. , vol.5 , pp. 56-65
    • Sampl, S.1    Pramhas, S.2    Stern, C.3    Preusser, M.4    Marosi, C.5    Holzmann, K.6
  • 49
    • 84868513499 scopus 로고    scopus 로고
    • Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma
    • Deng, Z.; Wang, Z.; Xiang, C.; Molczan, A.; Baubet, V.; Conejo-Garcia, J.; Xu, X.; Lieberman, P.M.; Dahmane, N. Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. J. Cell Sci. 2012, 125, 4383-4394.
    • (2012) J. Cell Sci. , vol.125 , pp. 4383-4394
    • Deng, Z.1    Wang, Z.2    Xiang, C.3    Molczan, A.4    Baubet, V.5    Conejo-Garcia, J.6    Xu, X.7    Lieberman, P.M.8    Dahmane, N.9
  • 50
    • 33646894709 scopus 로고    scopus 로고
    • HnRNP A1 associates with telomere ends and stimulates telomerase activity
    • Zhang, Q.S.; Manche, L.; Xu, R.M.; Krainer, A.R. hnRNP A1 associates with telomere ends and stimulates telomerase activity. RNA 2006, 12, 1116-1128.
    • (2006) RNA , vol.12 , pp. 1116-1128
    • Zhang, Q.S.1    Manche, L.2    Xu, R.M.3    Krainer, A.R.4
  • 52
    • 64249119735 scopus 로고    scopus 로고
    • Human telomere RNA and DNA form an intermolecular G-quadruplex
    • Xu, Y.; Kimura, T.; Komiyama, M. Human telomere RNA and DNA form an intermolecular G-quadruplex. Nucleic Acids Symp. Ser. (Oxf.) 2008, 52, 169-170.
    • (2008) Nucleic Acids Symp. Ser. (Oxf.) , vol.52 , pp. 169-170
    • Xu, Y.1    Kimura, T.2    Komiyama, M.3
  • 53
    • 67749143935 scopus 로고    scopus 로고
    • Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution
    • Martadinata, H.; Phan, A.T. Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution. J. Am. Chem. Soc. 2009, 131, 2570-2578.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 2570-2578
    • Martadinata, H.1    Phan, A.T.2
  • 54
    • 77957032993 scopus 로고    scopus 로고
    • Telomeric repeat-containing RNA structure in living cells
    • Xu, Y.; Suzuki, Y.; Ito, K.; Komiyama, M. Telomeric repeat-containing RNA structure in living cells. Proc. Natl. Acad. Sci. USA 2010, 107, 14579-14584.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 14579-14584
    • Xu, Y.1    Suzuki, Y.2    Ito, K.3    Komiyama, M.4
  • 56
    • 79952269800 scopus 로고    scopus 로고
    • Structural basis of telomeric RNA quadruplex-acridine ligand recognition
    • Collie, G.W.; Sparapani, S.; Parkinson, G.N.; Neidle, S. Structural basis of telomeric RNA quadruplex-acridine ligand recognition. J. Am. Chem. Soc. 2011, 133, 2721-2728.
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 2721-2728
    • Collie, G.W.1    Sparapani, S.2    Parkinson, G.N.3    Neidle, S.4
  • 57
    • 84865974713 scopus 로고    scopus 로고
    • G4 motifs in human genes
    • Maizels, N. G4 motifs in human genes. Ann. N. Y. Acad. Sci. 2012, 1267, 53-60.
    • (2012) Ann. N.Y. Acad. Sci. , vol.1267 , pp. 53-60
    • Maizels, N.1
  • 60
    • 0037015078 scopus 로고    scopus 로고
    • Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
    • Siddiqui-Jain, A.; Grand, C.L.; Bearss, D.J.; Hurley, L.H. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl. Acad. Sci. USA 2002, 99, 11593-11598.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11593-11598
    • Siddiqui-Jain, A.1    Grand, C.L.2    Bearss, D.J.3    Hurley, L.H.4
  • 61
    • 79952763614 scopus 로고    scopus 로고
    • Targeting MYC expression through G-Quadruplexes
    • Brooks, T.A.; Hurley, L.H. Targeting MYC expression through G-Quadruplexes. Genes Cancer 2010, 1, 641-649.
    • (2010) Genes Cancer , vol.1 , pp. 641-649
    • Brooks, T.A.1    Hurley, L.H.2
  • 63
    • 81755172447 scopus 로고    scopus 로고
    • Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex
    • Brown, R.V.; Danford, F.L.; Gokhale, V.; Hurley, L.H.; Brooks, T.A. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J. Biol. Chem. 2011, 286, 41018-41027.
    • (2011) J. Biol. Chem. , vol.286 , pp. 41018-41027
    • Brown, R.V.1    Danford, F.L.2    Gokhale, V.3    Hurley, L.H.4    Brooks, T.A.5
  • 64
    • 68249156463 scopus 로고    scopus 로고
    • Formation of a unique end-to-end stacked pair of G-quadruplex in the TERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands
    • Palumbo, L.; Ebbinghaus, S.W.; Hurley, L.H. Formation of a unique end-to-end stacked pair of G-quadruplex in the TERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands. J. Am. Chem. Soc. 2009, 131, 10878-10891.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 10878-10891
    • Palumbo, L.1    Ebbinghaus, S.W.2    Hurley, L.H.3
  • 65
    • 84873312526 scopus 로고    scopus 로고
    • Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells
    • Taka, T.; Huang, L.; Wongnoppavich, A.; Tam-Chang, S.W.; Lee, T.R.; Tuntiwechapikul, W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells. Bioorg. Med. Chem. 2013, 21, 883-890.
    • (2013) Bioorg. Med. Chem. , vol.21 , pp. 883-890
    • Taka, T.1    Huang, L.2    Wongnoppavich, A.3    Tam-Chang, S.W.4    Lee, T.R.5    Tuntiwechapikul, W.6
  • 69
    • 35848942604 scopus 로고    scopus 로고
    • Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression
    • Bejugam, M.; Sewitz, S.; Shirude, P.S.; Rodriguez, R.; Shahid, R.; Balasubramanian, S. Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression. J. Am. Chem. Soc. 2007, 129, 12926-12927.
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 12926-12927
    • Bejugam, M.1    Sewitz, S.2    Shirude, P.S.3    Rodriguez, R.4    Shahid, R.5    Balasubramanian, S.6
  • 73
    • 69849097341 scopus 로고    scopus 로고
    • A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression
    • Waller, Z.A.; Sewitz, S.A.; Hsu, S.D.; Balasubramanian, S. A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression. J. Am. Chem. Soc. 2009, 131, 12628-12633.
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 12628-12633
    • Waller, Z.A.1    Sewitz, S.A.2    Hsu, S.D.3    Balasubramanian, S.4
  • 74
    • 84875192416 scopus 로고    scopus 로고
    • Structure and physiology of the RET receptor tyrosine kinase
    • Ibáñez, C.F. Structure and physiology of the RET receptor tyrosine kinase. Cold Spring Harb. Perspect. Biol. 2013, 5, a009134.
    • (2013) Cold Spring Harb. Perspect. Biol. , vol.5
    • Ibáñez, C.F.1
  • 75
    • 34548183518 scopus 로고    scopus 로고
    • Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene
    • Guo, K.; Pourpak, A.; Beetz-Rogers, K.; Gokhale, V.; Sun, D.; Hurley, L.H. Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene. J. Am. Chem. Soc. 2007, 129, 10220-10228.
    • (2007) J. Am. Chem. Soc. , vol.129 , pp. 10220-10228
    • Guo, K.1    Pourpak, A.2    Beetz-Rogers, K.3    Gokhale, V.4    Sun, D.5    Hurley, L.H.6
  • 76
    • 80055092362 scopus 로고    scopus 로고
    • Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
    • Tong, X.; Lan, W.; Zhang, X.; Wu, H.; Liu, M.; Cao, C. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence. Nucleic Acids Res. 2011, 39, 6753-6763.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 6753-6763
    • Tong, X.1    Lan, W.2    Zhang, X.3    Wu, H.4    Liu, M.5    Cao, C.6
  • 77
    • 84855590085 scopus 로고    scopus 로고
    • Targeting the RAS pathway in melanoma
    • Ji, Z.; Flaherty, K.T.; Tsao, H. Targeting the RAS pathway in melanoma. Trends Mol. Med. 2012, 18, 27-35.
    • (2012) Trends Mol. Med. , vol.18 , pp. 27-35
    • Ji, Z.1    Flaherty, K.T.2    Tsao, H.3
  • 78
    • 33744472232 scopus 로고    scopus 로고
    • G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription
    • Cogoi, S.; Xodo, L.E. G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription. Nucleic Acids Res. 2006, 34, 2536-2549.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 2536-2549
    • Cogoi, S.1    Xodo, L.E.2
  • 79
    • 60549101098 scopus 로고    scopus 로고
    • Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells
    • Cogoi, S.; Paramasivam, M.; Filichev, V.; Géci, I.; Pedersen, E.B.; Xodo, L.E. Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells. J. Med. Chem. 2009, 52, 564-568.
    • (2009) J. Med. Chem. , vol.52 , pp. 564-568
    • Cogoi, S.1    Paramasivam, M.2    Filichev, V.3    Géci, I.4    Pedersen, E.B.5    Xodo, L.E.6
  • 80
    • 84884950457 scopus 로고    scopus 로고
    • Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains
    • doi:10.1002/cmdc.201300288
    • Lavrado, J.; Borralho, P.M.; Ohnmacht, S.A.; Castro, R.E.; Rodrigues, C.M.; Moreira, R.; Santos, D.J.; Neidle, S.; Paulo, A. Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains. Chem Med Chem 2013, doi:10.1002/cmdc.201300288.
    • (2013) Chem Med Chem
    • Lavrado, J.1    Borralho, P.M.2    Ohnmacht, S.A.3    Castro, R.E.4    Rodrigues, C.M.5    Moreira, R.6    Santos, D.J.7    Neidle, S.8    Paulo, A.9
  • 81
    • 80052532707 scopus 로고    scopus 로고
    • G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy
    • Membrino, A.; Cogoi, S.; Pedersen, E.B.; Xodo, L.E. G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy. PLoS One 2011, 6, e24421.
    • (2011) PLoS One , vol.6
    • Membrino, A.1    Cogoi, S.2    Pedersen, E.B.3    Xodo, L.E.4
  • 82
    • 84869093332 scopus 로고    scopus 로고
    • Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy
    • Tomek, M.; Akiyama, T.; Dass, C.R. Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy. J. Pharm. Pharmacol. 2012, 64, 1695-1702.
    • (2012) J. Pharm. Pharmacol. , vol.64 , pp. 1695-1702
    • Tomek, M.1    Akiyama, T.2    Dass, C.R.3
  • 84
    • 33646462913 scopus 로고    scopus 로고
    • Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter
    • Dexheimer, T.S.; Sun, D.; Hurley, L.H. Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. J. Am. Chem. Soc. 2006, 128, 5404-5415.
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 5404-5415
    • Dexheimer, T.S.1    Sun, D.2    Hurley, L.H.3
  • 85
    • 77953211752 scopus 로고    scopus 로고
    • Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives
    • Wang, X.D.; Ou, T.M.; Lu, Y.J.; Li, Z.; Xu, Z.; Xi, C.; Tan, J.H.; Huang, S.L.; An, L.K.; Li, D.; et al. Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives. J. Med. Chem. 2010, 53, 4390-4398.
    • (2010) J. Med. Chem. , vol.53 , pp. 4390-4398
    • Wang, X.D.1    Ou, T.M.2    Lu, Y.J.3    Li, Z.4    Xu, Z.5    Xi, C.6    Tan, J.H.7    Huang, S.L.8    An, L.K.9    Li, D.10
  • 86
    • 84861845402 scopus 로고    scopus 로고
    • The updated biology of hypoxia-inducible factor
    • Greer, S.N.; Metcalf, J.L.; Wang, Y.; Ohh, M. The updated biology of hypoxia-inducible factor. EMBO J. 2012, 31, 2448-2460.
    • (2012) EMBO J. , vol.31 , pp. 2448-2460
    • Greer, S.N.1    Metcalf, J.L.2    Wang, Y.3    Ohh, M.4
  • 87
    • 28944442742 scopus 로고    scopus 로고
    • Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter
    • De Armond, R.; Wood, S.; Sun, D.; Hurley, L.H.; Ebbinghaus, S.W. Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter. Biochemistry 2005, 44, 16341-1650.
    • (2005) Biochemistry , vol.44 , pp. 16341-21650
    • De Armond, R.1    Wood, S.2    Sun, D.3    Hurley, L.H.4    Ebbinghaus, S.W.5
  • 89
    • 77955809107 scopus 로고    scopus 로고
    • Making sense of G-quadruplex and i-motif functions in oncogene promoters
    • Brooks, T.A.; Kendrick, S.; Hurley, L. Making sense of G-quadruplex and i-motif functions in oncogene promoters. FEBS J. 2010, 277, 3459-3469.
    • (2010) FEBS J. , vol.277 , pp. 3459-3469
    • Brooks, T.A.1    Kendrick, S.2    Hurley, L.3
  • 91
    • 77956042544 scopus 로고    scopus 로고
    • SRC: A century of science brought to the clinic
    • Aleshin, A.; Finn, R.S. SRC: A century of science brought to the clinic. Neoplasia 2010, 12, 599-607.
    • (2010) Neoplasia , vol.12 , pp. 599-607
    • Aleshin, A.1    Finn, R.S.2
  • 92
    • 84883372353 scopus 로고    scopus 로고
    • Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
    • Murat, P.; Gormally, M.V.; Sanders, D.; Antonio, M.D.; Balasubramanian, S. Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand. Chem. Commun. (Camb.) 2013, 49, 8453-8455.
    • (2013) Chem. Commun. (Camb.) , vol.49 , pp. 8453-8455
    • Murat, P.1    Gormally, M.V.2    Sanders, D.3    Antonio, M.D.4    Balasubramanian, S.5
  • 93
    • 77957058196 scopus 로고    scopus 로고
    • 5′-UTR G-quadruplex structures acting as translational repressors
    • Beaudoin, J.D.; Perreault, J.P. 5′-UTR G-quadruplex structures acting as translational repressors. Nucleic Acids Res. 2010, 38, 7022-7036.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 7022-7036
    • Beaudoin, J.D.1    Perreault, J.P.2
  • 94
    • 0028556501 scopus 로고
    • A guanosine quadruplex and two stable hairpins flank a major cleavage site in insulin-like growth factor II mRNA
    • Christiansen, J.; Kofod, M.; Nielsen, F.C. A guanosine quadruplex and two stable hairpins flank a major cleavage site in insulin-like growth factor II mRNA. Nucleic Acids Res. 1994, 22, 5709-5716.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5709-5716
    • Christiansen, J.1    Kofod, M.2    Nielsen, F.C.3
  • 95
    • 33947310727 scopus 로고    scopus 로고
    • An RNA G-quadruplex in the 5′-UTR of the NRAS proto-oncogene modulates translation
    • Kumari, S.; Bugaut, A.; Huppert, J.L.; Balasubramanian, S. An RNA G-quadruplex in the 5′-UTR of the NRAS proto-oncogene modulates translation. Nat. Chem. Biol. 2007, 3, 218-221.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 218-221
    • Kumari, S.1    Bugaut, A.2    Huppert, J.L.3    Balasubramanian, S.4
  • 96
    • 45749139174 scopus 로고    scopus 로고
    • Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif
    • Arora, A.; Dutkiewicz, M.; Scaria, V.; Hariharan, M.; Maiti, S.; Kurreck, J. Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. RNA 2008, 14, 1290-1296.
    • (2008) RNA , vol.14 , pp. 1290-1296
    • Arora, A.1    Dutkiewicz, M.2    Scaria, V.3    Hariharan, M.4    Maiti, S.5    Kurreck, J.6
  • 98
    • 1242342930 scopus 로고    scopus 로고
    • Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by TERT RNA alternative splicing
    • Gomez, D.; Lemarteleur, T.; Lacroix, L.; Mailliet, P.; Mergny, J.-L.; Riou, J.-F. Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by TERT RNA alternative splicing. Nucleic Acids Res. 2004, 32, 371-379.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 371-379
    • Gomez, D.1    Lemarteleur, T.2    Lacroix, L.3    Mailliet, P.4    Mergny, J.-L.5    Riou, J.-F.6
  • 99
    • 84878830016 scopus 로고    scopus 로고
    • Exploring mRNA 3′-UTR G-quadruplexes: Evidence of roles in both alternative polyadenylation and mRNA shortening
    • Beaudoin, J.D.; Perreault, J.P. Exploring mRNA 3′-UTR G-quadruplexes: Evidence of roles in both alternative polyadenylation and mRNA shortening. Nucleic Acids Res. 2013, 41, 5898-5911.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 5898-5911
    • Beaudoin, J.D.1    Perreault, J.P.2
  • 100
    • 23844438712 scopus 로고    scopus 로고
    • Not so crystal clear: The structure of the human telomere G-quadruplex in solution differs from that present in a crystal
    • Li, J.; Correia, J.J.; Wang, L.; Trent, J.O.; Chairesi, J.B. Not so crystal clear: The structure of the human telomere G-quadruplex in solution differs from that present in a crystal. Nucleic Acids Res. 2005, 33, 4649-4659.
    • (2005) Nucleic Acids Res. , vol.33 , pp. 4649-4659
    • Li, J.1    Correia, J.J.2    Wang, L.3    Trent, J.O.4    Chairesi, J.B.5
  • 101
    • 79960700336 scopus 로고    scopus 로고
    • The evolving world of protein-G-quadruplex recognition: A medicinal chemist's perspective
    • Sissi, C.; Gatto, B.; Palumbo, M. The evolving world of protein-G-quadruplex recognition: A medicinal chemist's perspective. Biochimie 2010, 93, 1219-1230.
    • (2010) Biochimie , vol.93 , pp. 1219-1230
    • Sissi, C.1    Gatto, B.2    Palumbo, M.3
  • 102
    • 0035900649 scopus 로고    scopus 로고
    • Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
    • Darnell, J.C.; Jensen, K.B.; Jin, P.; Brown, V.; Warren, S.T.; Darnell, R.B. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 2001, 107, 489-499.
    • (2001) Cell , vol.107 , pp. 489-499
    • Darnell, J.C.1    Jensen, K.B.2    Jin, P.3    Brown, V.4    Warren, S.T.5    Darnell, R.B.6
  • 103
    • 77955791569 scopus 로고    scopus 로고
    • G-quadruplex nucleic acids and human disease
    • Wu, Y.; Brosh, R.M., Jr. G-quadruplex nucleic acids and human disease. FEBS J. 2010, 277, 3470-3488.
    • (2010) FEBS J. , vol.277 , pp. 3470-3488
    • Wu, Y.1    Brosh Jr., R.M.2
  • 104
    • 27144451010 scopus 로고    scopus 로고
    • Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
    • Paeschke, K.; Simonsson, T.; Postberg, J.; Rhodes, D.; Lipps, H.J. Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo. Nat. Struct. Mol. Biol. 2005, 12, 847-854.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 847-854
    • Paeschke, K.1    Simonsson, T.2    Postberg, J.3    Rhodes, D.4    Lipps, H.J.5
  • 105
    • 68549136741 scopus 로고    scopus 로고
    • G-quadruplex structures: In vivo evidence and function
    • Lipps, H.J.; Rhodes, D. G-quadruplex structures: In vivo evidence and function. Trends Cell Biol. 2009, 19, 414-422.
    • (2009) Trends Cell Biol. , vol.19 , pp. 414-422
    • Lipps, H.J.1    Rhodes, D.2
  • 106
    • 3042785608 scopus 로고    scopus 로고
    • Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
    • Duquette, M.L.; Handa, P.; Vincent, J.A.; Taylor, A.F.; Maizels, N. Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes Dev. 2004, 18, 1618-1629.
    • (2004) Genes Dev. , vol.18 , pp. 1618-1629
    • Duquette, M.L.1    Handa, P.2    Vincent, J.A.3    Taylor, A.F.4    Maizels, N.5
  • 107
    • 84875464903 scopus 로고    scopus 로고
    • Quantitative visualization of DNA G-quadruplex structures in human cells
    • Biffi, G.; Tannahill, D.; McCafferty, J.; Balasubramanian, S. Quantitative visualization of DNA G-quadruplex structures in human cells. Nat. Chem. 2013, 5, 182-186.
    • (2013) Nat. Chem. , vol.5 , pp. 182-186
    • Biffi, G.1    Tannahill, D.2    McCafferty, J.3    Balasubramanian, S.4
  • 108
    • 84877768759 scopus 로고    scopus 로고
    • G-quadruplex structures are stable and detectable in human genomic DNA
    • doi:10.1038/ncomms2792
    • Lam, E.Y.; Beraldi, D.; Tannahill, D.; Balasubramanian, S. G-quadruplex structures are stable and detectable in human genomic DNA. Nat. Commun. 2013, 4, 1796, doi:10.1038/ncomms2792.
    • (2013) Nat. Commun. , vol.4 , pp. 1796
    • Lam, E.Y.1    Beraldi, D.2    Tannahill, D.3    Balasubramanian, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.