-
1
-
-
79953313413
-
Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?
-
Balasubramanian, S.; Hurley, L.H.; Neidle, S. Targeting G-quadruplexes in gene promoters: A novel anticancer strategy? Nat. Rev. Drug Discov. 2011, 10, 261-275.
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 261-275
-
-
Balasubramanian, S.1
Hurley, L.H.2
Neidle, S.3
-
2
-
-
81455140677
-
The application of DNA and RNA G-quadruplexes to therapeutic medicines
-
Collie, G.W.; Parkinson, G.N. The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chem. Soc. Rev. 2011, 40, 5867-5892.
-
(2011)
Chem. Soc. Rev.
, vol.40
, pp. 5867-5892
-
-
Collie, G.W.1
Parkinson, G.N.2
-
3
-
-
84862229118
-
5′-UTR RNA G-quadruplexes: Translation regulation and targeting
-
Bugaut, A.; Balasubramanian, S. 5′-UTR RNA G-quadruplexes: Translation regulation and targeting. Nucleic Acids Res. 2012, 40, 4727-4741.
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 4727-4741
-
-
Bugaut, A.1
Balasubramanian, S.2
-
4
-
-
66549124907
-
The structures of quadruplex nucleic acids and their drug complexes
-
Neidle, S. The structures of quadruplex nucleic acids and their drug complexes. Curr. Opin. Struct. Biol. 2009, 19, 239-250.
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, pp. 239-250
-
-
Neidle, S.1
-
5
-
-
67649833785
-
G-quadruplex nucleic acids as therapeutic targets
-
Balasubramanian, S.; Neidle, S. G-quadruplex nucleic acids as therapeutic targets. Curr. Opin. Chem. Biol. 2009, 13, 345-353.
-
(2009)
Curr. Opin. Chem. Biol.
, vol.13
, pp. 345-353
-
-
Balasubramanian, S.1
Neidle, S.2
-
6
-
-
84867744921
-
DNA secondary structures: Stability and function of G-quadruplex structures
-
Bochman, M.L.; Paeschke, K.; Zakian, V.A. DNA secondary structures: Stability and function of G-quadruplex structures. Nat. Rev. Genet. 2012, 13, 770-780.
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 770-780
-
-
Bochman, M.L.1
Paeschke, K.2
Zakian, V.A.3
-
7
-
-
84882250300
-
Targeting non-B-form DNA in living cells
-
Du, Y.; Zhou, X. Targeting non-B-form DNA in living cells. Chem. Record 2013, 13, 371-384.
-
(2013)
Chem. Record
, vol.13
, pp. 371-384
-
-
Du, Y.1
Zhou, X.2
-
8
-
-
84860143903
-
G-quadruplex binding ligands: From naturally occurring to rationally designed molecules
-
Vy Thi Le, T.; Han, S.; Chae, J.; Park, H.J. G-quadruplex binding ligands: From naturally occurring to rationally designed molecules. Curr. Pharm. Des. 2012, 18, 1948-1972.
-
(2012)
Curr. Pharm. Des.
, vol.18
, pp. 1948-1972
-
-
Vy Thi Le, T.1
Han, S.2
Chae, J.3
Park, H.J.4
-
9
-
-
84880725971
-
Alternative lengthening of telomeres: Remodeling the telomere architecture
-
doi:10.3389/fonc.2013.00027
-
Conomos, D.; Pickett, H.A.; Reddel, R.R. Alternative lengthening of telomeres: Remodeling the telomere architecture. Front. Oncol. 2013, doi:10.3389/fonc.2013.00027.
-
(2013)
Front. Oncol.
-
-
Conomos, D.1
Pickett, H.A.2
Reddel, R.R.3
-
10
-
-
84873170179
-
Telomerase and the search for the end of cancer
-
Mocellin, S.; Pooley, K.A.; Nitti, D. Telomerase and the search for the end of cancer. Trends Mol. Med. 2013, 19, 125-133.
-
(2013)
Trends Mol. Med.
, vol.19
, pp. 125-133
-
-
Mocellin, S.1
Pooley, K.A.2
Nitti, D.3
-
11
-
-
84855183935
-
Pharmaceutical regulation of telomerase and its clinical potential
-
Sprouse, A.A.; Steding, C.E.; Herbert, B.S. Pharmaceutical regulation of telomerase and its clinical potential. J. Cell. Mol. Med. 2012, 16, 1-7.
-
(2012)
J. Cell. Mol. Med.
, vol.16
, pp. 1-7
-
-
Sprouse, A.A.1
Steding, C.E.2
Herbert, B.S.3
-
12
-
-
42149110183
-
High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma
-
Cairney, C.J.; Hoare, S.F.; Daidone, M.G.; Zaffaroni, N.; Keith, W.N. High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma. Br. J. Cancer 2008, 98, 1467-1474.
-
(2008)
Br. J. Cancer
, vol.98
, pp. 1467-1474
-
-
Cairney, C.J.1
Hoare, S.F.2
Daidone, M.G.3
Zaffaroni, N.4
Keith, W.N.5
-
13
-
-
79960700556
-
Altered telomeres in tumors with ATRX and DAXX mutations
-
Heaphy, C.M.; de Wilde, R.F.; Jiao, Y.; Klein, A.P.; Edil, B.H.; Shi, C.; Bettegowda, C.; Rodriguez, F.J.; Eberhart, C.G.; Hebbar, S.; et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science 2011, 333, 425.
-
(2011)
Science
, vol.333
, pp. 425
-
-
Heaphy, C.M.1
De Wilde, R.F.2
Jiao, Y.3
Klein, A.P.4
Edil, B.H.5
Shi, C.6
Bettegowda, C.7
Rodriguez, F.J.8
Eberhart, C.G.9
Hebbar, S.10
-
14
-
-
74949143829
-
The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth
-
Marian, C.O.; Cho, S.K.; McEllin, B.M.; Maher, E.A.; Hatanpaa, K.J.; Madden, C.J.; Mickey, B.E.; Wright, W.E.; Shay, J.W.; Bachoo, R.M. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clin. Cancer Res. 2010, 16, 154-163.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 154-163
-
-
Marian, C.O.1
Cho, S.K.2
McEllin, B.M.3
Maher, E.A.4
Hatanpaa, K.J.5
Madden, C.J.6
Mickey, B.E.7
Wright, W.E.8
Shay, J.W.9
Bachoo, R.M.10
-
15
-
-
84863116250
-
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer
-
Hu, J.; Hwang, S.S.; Liesa, M.; Gan, B.; Sahin, E.; Jaskelioff, M.; Ding, Z.; Ying, H.; Boutin, A.T.; Zhang, H.; et al. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 2012, 148, 651-663.
-
(2012)
Cell
, vol.148
, pp. 651-663
-
-
Hu, J.1
Hwang, S.S.2
Liesa, M.3
Gan, B.4
Sahin, E.5
Jaskelioff, M.6
Ding, Z.7
Ying, H.8
Boutin, A.T.9
Zhang, H.10
-
16
-
-
84855996113
-
G-quadruplexes: From guanine gels to chemotherapeutics
-
Bryan, T.M.; Baumann, P. G-quadruplexes: From guanine gels to chemotherapeutics. Mol. Biotechnol. 2011, 49, 198-208.
-
(2011)
Mol. Biotechnol.
, vol.49
, pp. 198-208
-
-
Bryan, T.M.1
Baumann, P.2
-
17
-
-
84874039558
-
High-Resolution insight into G-overhang architecture
-
Hänsel, R.; Löhr, F.; Trantirek, L.; Dötsch, V. High-Resolution insight into G-overhang architecture. J. Am. Chem. Soc. 2013, 135, 2816-2824.
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 2816-2824
-
-
Hänsel, R.1
Löhr, F.2
Trantirek, L.3
Dötsch, V.4
-
18
-
-
47249089630
-
Polymorphism of human telomeric quadruplex structures
-
Dai, J.; Carver, M.; Yang, D. Polymorphism of human telomeric quadruplex structures. Biochimie 2008, 90, 1172-1183.
-
(2008)
Biochimie
, vol.90
, pp. 1172-1183
-
-
Dai, J.1
Carver, M.2
Yang, D.3
-
19
-
-
48749109524
-
Topology conservation and loop flexibility in quadruplex-drug recognition: Crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes
-
Parkinson, G.N.; Cuenca, F.; Neidle, S. Topology conservation and loop flexibility in quadruplex-drug recognition: Crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. J. Mol. Biol. 2008, 381, 1145-1156.
-
(2008)
J. Mol. Biol.
, vol.381
, pp. 1145-1156
-
-
Parkinson, G.N.1
Cuenca, F.2
Neidle, S.3
-
20
-
-
84871784359
-
The crystal structure of human telomeric DNA complexed with berberine: An interesting case of stacked ligand to G-tetrad ratio higher than 1:1
-
Bazzicalupi, C.; Ferraroni, M.; Bilia, A.R.; Scheggi, F.; Gratteri, P. The crystal structure of human telomeric DNA complexed with berberine: An interesting case of stacked ligand to G-tetrad ratio higher than 1:1. Nucleic Acids Res. 2013, 41, 632-638.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 632-638
-
-
Bazzicalupi, C.1
Ferraroni, M.2
Bilia, A.R.3
Scheggi, F.4
Gratteri, P.5
-
21
-
-
0030786928
-
Inhibition of human telomerase by a G-quadruplex-interactive compound
-
Sun, D.; Thompson, B.; Cathers, B.E.; Salazar, M.; Kerwin, S.M.; Trent, J.O.; Jenkins, T.C.; Neidle, S.; Hurley, L.H. Inhibition of human telomerase by a G-quadruplex-interactive compound. J. Med. Chem. 1997, 40, 2113-2116.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 2113-2116
-
-
Sun, D.1
Thompson, B.2
Cathers, B.E.3
Salazar, M.4
Kerwin, S.M.5
Trent, J.O.6
Jenkins, T.C.7
Neidle, S.8
Hurley, L.H.9
-
22
-
-
79954570122
-
Chemistry in human telomere biology: Structure, function and targeting of telomere DNA/RNA
-
Xu, Y. Chemistry in human telomere biology: Structure, function and targeting of telomere DNA/RNA. Chem. Soc. Rev. 2011, 40, 2719-2740.
-
(2011)
Chem. Soc. Rev.
, vol.40
, pp. 2719-2740
-
-
Xu, Y.1
-
23
-
-
84877812258
-
FDA-approved drugs selected using virtual screening bind specifically to G-quadruplex DNA
-
Castillo-González, D.; Pérez-Machado, G.; Guédin, A.; Mergny, J.L.; Cabrera-Pérez, M.A. FDA-approved drugs selected using virtual screening bind specifically to G-quadruplex DNA. Curr. Pharm. Des. 2013, 19, 2164-2173.
-
(2013)
Curr. Pharm. Des.
, vol.19
, pp. 2164-2173
-
-
Castillo-González, D.1
Pérez-Machado, G.2
Guédin, A.3
Mergny, J.L.4
Cabrera-Pérez, M.A.5
-
24
-
-
84873894447
-
Identification and characterization of new DNA G-quadruplex binders selected by a combination of ligand and structure-based virtual screening approaches
-
Alcaro, S.; Musetti, C.; Distinto, S.; Casatti, M.; Zagotto, G.; Artese, A.; Parrotta, L.; Moraca, F.; Costa, G.; Ortuso, F.; et al. Identification and characterization of new DNA G-quadruplex binders selected by a combination of ligand and structure-based virtual screening approaches. J. Med. Chem. 2013, 56, 843-855.
-
(2013)
J. Med. Chem.
, vol.56
, pp. 843-855
-
-
Alcaro, S.1
Musetti, C.2
Distinto, S.3
Casatti, M.4
Zagotto, G.5
Artese, A.6
Parrotta, L.7
Moraca, F.8
Costa, G.9
Ortuso, F.10
-
25
-
-
77953381213
-
Structural insights into G-quadruplexes: Towards new anticancer drugs
-
Yang, D.; Okamoto, K. Structural insights into G-quadruplexes: Towards new anticancer drugs. Future Med. Chem. 2010, 619-646.
-
(2010)
Future Med. Chem.
, pp. 619-646
-
-
Yang, D.1
Okamoto, K.2
-
26
-
-
37049004147
-
Targeting telomeres and telomerase
-
De Cian, A.; Lacroix, L.; Douarre, C.; Temime-Smaali, N.; Trentesaux, C.; Riou, J.F.; Mergny, J.L. Targeting telomeres and telomerase. Biochimie 2008, 90, 131-155.
-
(2008)
Biochimie
, vol.90
, pp. 131-155
-
-
De Cian, A.1
Lacroix, L.2
Douarre, C.3
Temime-Smaali, N.4
Trentesaux, C.5
Riou, J.F.6
Mergny, J.L.7
-
27
-
-
79954526406
-
Telomeres as targets for anticancer therapies
-
Folini, M.; Venturini, L.; Cimino-Reale, G.; Zaffaroni, N. Telomeres as targets for anticancer therapies. Expert Opin. Ther. Targets 2011, 15, 579-593.
-
(2011)
Expert Opin. Ther. Targets
, vol.15
, pp. 579-593
-
-
Folini, M.1
Venturini, L.2
Cimino-Reale, G.3
Zaffaroni, N.4
-
28
-
-
70349084987
-
The G-quadruplex ligand telomestatitn impairs binding of topoisomerase III alpha to G-quadruplex forming oligonucleotides and uncaps telomeres in ALT cells
-
Temime-Smaali, N.; Guittat, L.; Sidibe, A.; Shin-ya, A.; Trentesaux, C. The G-quadruplex ligand telomestatitn impairs binding of topoisomerase III alpha to G-quadruplex forming oligonucleotides and uncaps telomeres in ALT cells. PLoS One 2009, 4, e6919.
-
(2009)
PLoS One
, vol.4
-
-
Temime-Smaali, N.1
Guittat, L.2
Sidibe, A.3
Shin-Ya, A.4
Trentesaux, C.5
-
29
-
-
36049045013
-
Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect
-
Salvati, E.; Leonetti, C.; Rizzo, A.; Scarsell, M.; Mottolese, M.; Galati, R.; Stevens, M.F.; D'Incalci, M.; Blasco, M.; Chiorino, G.; et al. Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J. Clin. Invest. 2007, 117, 3236-3247.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3236-3247
-
-
Salvati, E.1
Leonetti, C.2
Rizzo, A.3
Scarsell, M.4
Mottolese, M.5
Galati, R.6
Stevens, M.F.7
D'Incalci, M.8
Blasco, M.9
Chiorino, G.10
-
30
-
-
58149359322
-
G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors
-
Leonetti, C.; Scarsella, M.; Riggio, G.; Rizzo, A.; Salvati, E.; D'Incalci, M.; Staszewsky, L.; Frapolli, R.; Stevens, M.F.; Stoppacciaro, A.; et al. G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors. Clin. Cancer Res. 2008, 14, 7284-7291.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 7284-7291
-
-
Leonetti, C.1
Scarsella, M.2
Riggio, G.3
Rizzo, A.4
Salvati, E.5
D'Incalci, M.6
Staszewsky, L.7
Frapolli, R.8
Stevens, M.F.9
Stoppacciaro, A.10
-
31
-
-
80655136954
-
Targeting pancreatic cancer with a G-quadruplex ligand
-
Gunaratnam, M.; de la Fuente, M.; Hampel, S.M.; Todd, A.K.; Reszka, A.P.; Schätzlein, A.; Neidle, S. Targeting pancreatic cancer with a G-quadruplex ligand. Bioorg. Med. Chem. 2011, 19, 7151-7157.
-
(2011)
Bioorg. Med. Chem.
, vol.19
, pp. 7151-7157
-
-
Gunaratnam, M.1
De La Fuente, M.2
Hampel, S.M.3
Todd, A.K.4
Reszka, A.P.5
Schätzlein, A.6
Neidle, S.7
-
32
-
-
84860374939
-
Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures
-
Doria, F.; Nadai, M.; Folini, M.; di Antonio, M.; Germani, L.; Percivalle, C.; Sissi, C.; Zaffaroni, N.; Alcaro, S.; Artese, A.; et al. Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures. Org. Biomol. Chem. 2012, 10, 2798-27806.
-
(2012)
Org. Biomol. Chem.
, vol.10
, pp. 2798-27806
-
-
Doria, F.1
Nadai, M.2
Folini, M.3
Di Antonio, M.4
Germani, L.5
Percivalle, C.6
Sissi, C.7
Zaffaroni, N.8
Alcaro, S.9
Artese, A.10
-
33
-
-
84876215753
-
Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells
-
Micco, M.; Collie, G.W.; Dale, A.G.; Ohnmacht, S.A.; Pazitna, I.; Gunaratham, M.; Reszka, A.P.; Neidle, S. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J. Med. Chem. 2013, 56, 2959-2974.
-
(2013)
J. Med. Chem.
, vol.56
, pp. 2959-2974
-
-
Micco, M.1
Collie, G.W.2
Dale, A.G.3
Ohnmacht, S.A.4
Pazitna, I.5
Gunaratham, M.6
Reszka, A.P.7
Neidle, S.8
-
34
-
-
50349102258
-
G-quadruplex stabilizer 3,6-bis(1-methyl-4-vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells
-
Huang, F.C.; Chang, C.C.; Lou, P.J.; Kuo, I.C.; Chien, C.W.; Chen, C.T.; Shieh, F.Y.; Chang, T.C.; Lin, J.J. G-quadruplex stabilizer 3,6-bis(1-methyl-4- vinylpyridinium)carbazole diiodide induces accelerated senescence and inhibits tumorigenic properties in cancer cells. Mol. Cancer Res. 2008, 6, 955-964.
-
(2008)
Mol. Cancer Res.
, vol.6
, pp. 955-964
-
-
Huang, F.C.1
Chang, C.C.2
Lou, P.J.3
Kuo, I.C.4
Chien, C.W.5
Chen, C.T.6
Shieh, F.Y.7
Chang, T.C.8
Lin, J.J.9
-
35
-
-
84864447477
-
Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells
-
Muller, S.; Sanders, D.A.; di Antonio, M.; Matsis, S.; Riou, J.F.; Balasubramanian, S. Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells. Org. Biomol. Chem. 2012, 10, 6537-6546.
-
(2012)
Org. Biomol. Chem.
, vol.10
, pp. 6537-6546
-
-
Muller, S.1
Sanders, D.A.2
Di Antonio, M.3
Matsis, S.4
Riou, J.F.5
Balasubramanian, S.6
-
36
-
-
84865437096
-
Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity
-
Huang, F.C.; Chang, C.C.; Wang, J.M.; Chang, T.C.; Lin, J.J. Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity. Br. J. Pharmacol. 2012, 167, 393-406.
-
(2012)
Br. J. Pharmacol.
, vol.167
, pp. 393-406
-
-
Huang, F.C.1
Chang, C.C.2
Wang, J.M.3
Chang, T.C.4
Lin, J.J.5
-
37
-
-
38049089850
-
Quadruplex ligand recognition: Biological aspects
-
Neidle, S., Balasubramanian, S., Eds.; The Royal Society of Chemistry: London, UK, Chapter 6
-
Riou, J.F.; Gomez, D.; Morjani, H.; Trentesaux, C. Quadruplex Ligand Recognition: Biological Aspects. In Quadruplex Nucleic Acids; Neidle, S., Balasubramanian, S., Eds.; The Royal Society of Chemistry: London, UK, 2006; Chapter 6, pp. 154-180.
-
(2006)
Quadruplex Nucleic Acids
, pp. 154-180
-
-
Riou, J.F.1
Gomez, D.2
Morjani, H.3
Trentesaux, C.4
-
38
-
-
23344451160
-
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro
-
Zaug, A.J.; Podell, E.R.; Cech, T.R. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc. Natl. Acad. Sci. USA 2005, 102, 10864-10869.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 10864-10869
-
-
Zaug, A.J.1
Podell, E.R.2
Cech, T.R.3
-
39
-
-
12844254472
-
POT1 and TRF2 cooperate to maintain telomeric integrity
-
Yang, Q.; Zheng, Y.L.; Harris, C.C. POT1 and TRF2 cooperate to maintain telomeric integrity. Mol. Cell. Biol. 2005, 25, 1070-1080.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 1070-1080
-
-
Yang, Q.1
Zheng, Y.L.2
Harris, C.C.3
-
40
-
-
84866054725
-
Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage
-
Orlotti, N.I.; Cimino-Reale, G.; Borghini, E.; Pennati, M.; Sissi, C.; Perrone, F.; Palumbo, M.; Daidone, M.G.; Folini, M.; Zaffaroni, N. Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage. Autophagy 2012, 8, 1185-1196.
-
(2012)
Autophagy
, vol.8
, pp. 1185-1196
-
-
Orlotti, N.I.1
Cimino-Reale, G.2
Borghini, E.3
Pennati, M.4
Sissi, C.5
Perrone, F.6
Palumbo, M.7
Daidone, M.G.8
Folini, M.9
Zaffaroni, N.10
-
41
-
-
44349168303
-
Telomeres: The silence is broken
-
Azzalin, C.M.; Lingner, J. Telomeres: The silence is broken. Cell Cycle 2008, 7, 1161-1165.
-
(2008)
Cell Cycle
, vol.7
, pp. 1161-1165
-
-
Azzalin, C.M.1
Lingner, J.2
-
42
-
-
73249117060
-
CpG-island promoters drive transcription of human telomeres
-
Nergadze, S.G.; Farnung, B.O.; Wischnewski, H.; Khoriauli, L.; Vitelli, V.; Chawla, R.; Giulotto, E.; Azzalin, C.M. CpG-island promoters drive transcription of human telomeres. RNA 2009, 15, 2186-2194.
-
(2009)
RNA
, vol.15
, pp. 2186-2194
-
-
Nergadze, S.G.1
Farnung, B.O.2
Wischnewski, H.3
Khoriauli, L.4
Vitelli, V.5
Chawla, R.6
Giulotto, E.7
Azzalin, C.M.8
-
43
-
-
77957243987
-
The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
-
Redon, S.; Reichenbach, P.; Lingner, J. The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res. 2010, 38, 5797-5806.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 5797-5806
-
-
Redon, S.1
Reichenbach, P.2
Lingner, J.3
-
44
-
-
68949198783
-
TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres
-
Deng, Z.; Norseen, J.; Wiedmer, A.; Riethman, H.; Lieberman, P.M. TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol. Cell 2009, 35, 403-413.
-
(2009)
Mol. Cell
, vol.35
, pp. 403-413
-
-
Deng, Z.1
Norseen, J.2
Wiedmer, A.3
Riethman, H.4
Lieberman, P.M.5
-
45
-
-
69849104275
-
TERRA: Telomeric repeat-containing RNA
-
Luke, B.; Lingner, J. TERRA: Telomeric repeat-containing RNA. EMBO J. 2009, 28, 2503-2510.
-
(2009)
EMBO J.
, vol.28
, pp. 2503-2510
-
-
Luke, B.1
Lingner, J.2
-
46
-
-
62549122535
-
Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription
-
Ng, L.J.; Cropley, J.E.; Pickett, H.A.; Reddel, R.R.; Suter, C.M. Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription. Nucleic Acids Res. 2009, 37, 1152-1159.
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. 1152-1159
-
-
Ng, L.J.1
Cropley, J.E.2
Pickett, H.A.3
Reddel, R.R.4
Suter, C.M.5
-
47
-
-
38849111756
-
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
-
Schoeftner, S.; Blasco, M.A. Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Nat. Cell. Biol. 2008, 10, 228-236.
-
(2008)
Nat. Cell. Biol.
, vol.10
, pp. 228-236
-
-
Schoeftner, S.1
Blasco, M.A.2
-
48
-
-
84855984815
-
Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade
-
Sampl, S.; Pramhas, S.; Stern, C.; Preusser, M.; Marosi, C.; Holzmann, K. Expression of telomeres in astrocytoma WHO grade 2 to 4: TERRA level correlates with telomere length, telomerase activity, and advanced clinical grade. Transl. Oncol. 2012, 5, 56-65.
-
(2012)
Transl. Oncol.
, vol.5
, pp. 56-65
-
-
Sampl, S.1
Pramhas, S.2
Stern, C.3
Preusser, M.4
Marosi, C.5
Holzmann, K.6
-
49
-
-
84868513499
-
Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma
-
Deng, Z.; Wang, Z.; Xiang, C.; Molczan, A.; Baubet, V.; Conejo-Garcia, J.; Xu, X.; Lieberman, P.M.; Dahmane, N. Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. J. Cell Sci. 2012, 125, 4383-4394.
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4383-4394
-
-
Deng, Z.1
Wang, Z.2
Xiang, C.3
Molczan, A.4
Baubet, V.5
Conejo-Garcia, J.6
Xu, X.7
Lieberman, P.M.8
Dahmane, N.9
-
50
-
-
33646894709
-
HnRNP A1 associates with telomere ends and stimulates telomerase activity
-
Zhang, Q.S.; Manche, L.; Xu, R.M.; Krainer, A.R. hnRNP A1 associates with telomere ends and stimulates telomerase activity. RNA 2006, 12, 1116-1128.
-
(2006)
RNA
, vol.12
, pp. 1116-1128
-
-
Zhang, Q.S.1
Manche, L.2
Xu, R.M.3
Krainer, A.R.4
-
51
-
-
78649441161
-
Human telomeric RNA in G-quadruplex structure
-
Xu, Y.; Kaminaga, K.; Komiyama, M. Human telomeric RNA in G-quadruplex structure. Nucleic Acids Symp. Ser. (Oxf.) 2008, 52, 175-176.
-
(2008)
Nucleic Acids Symp. Ser. (Oxf.)
, vol.52
, pp. 175-176
-
-
Xu, Y.1
Kaminaga, K.2
Komiyama, M.3
-
52
-
-
64249119735
-
Human telomere RNA and DNA form an intermolecular G-quadruplex
-
Xu, Y.; Kimura, T.; Komiyama, M. Human telomere RNA and DNA form an intermolecular G-quadruplex. Nucleic Acids Symp. Ser. (Oxf.) 2008, 52, 169-170.
-
(2008)
Nucleic Acids Symp. Ser. (Oxf.)
, vol.52
, pp. 169-170
-
-
Xu, Y.1
Kimura, T.2
Komiyama, M.3
-
53
-
-
67749143935
-
Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution
-
Martadinata, H.; Phan, A.T. Structure of propeller-type parallel-stranded RNA G-quadruplexes, formed by human telomeric RNA sequences in K+ solution. J. Am. Chem. Soc. 2009, 131, 2570-2578.
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 2570-2578
-
-
Martadinata, H.1
Phan, A.T.2
-
54
-
-
77957032993
-
Telomeric repeat-containing RNA structure in living cells
-
Xu, Y.; Suzuki, Y.; Ito, K.; Komiyama, M. Telomeric repeat-containing RNA structure in living cells. Proc. Natl. Acad. Sci. USA 2010, 107, 14579-14584.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14579-14584
-
-
Xu, Y.1
Suzuki, Y.2
Ito, K.3
Komiyama, M.4
-
55
-
-
72149088424
-
Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes
-
Collie, G.; Reszka, A.P.; Haider, S.M.; Gabelica, V.; Parkinson, G.N.; Neidle, S. Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chem. Commun. 2009, 48, 7482-7484.
-
(2009)
Chem. Commun.
, vol.48
, pp. 7482-7484
-
-
Collie, G.1
Reszka, A.P.2
Haider, S.M.3
Gabelica, V.4
Parkinson, G.N.5
Neidle, S.6
-
56
-
-
79952269800
-
Structural basis of telomeric RNA quadruplex-acridine ligand recognition
-
Collie, G.W.; Sparapani, S.; Parkinson, G.N.; Neidle, S. Structural basis of telomeric RNA quadruplex-acridine ligand recognition. J. Am. Chem. Soc. 2011, 133, 2721-2728.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 2721-2728
-
-
Collie, G.W.1
Sparapani, S.2
Parkinson, G.N.3
Neidle, S.4
-
57
-
-
84865974713
-
G4 motifs in human genes
-
Maizels, N. G4 motifs in human genes. Ann. N. Y. Acad. Sci. 2012, 1267, 53-60.
-
(2012)
Ann. N.Y. Acad. Sci.
, vol.1267
, pp. 53-60
-
-
Maizels, N.1
-
58
-
-
84878589341
-
MYC oncogene in myeloid neoplasias
-
Delgado, M.D.; Albajar, M.; Gomez-Casares, M.T.; Batlle, A.; León, J. MYC oncogene in myeloid neoplasias. Clin. Transl. Oncol. 2013, 15, 87-94.
-
(2013)
Clin. Transl. Oncol.
, vol.15
, pp. 87-94
-
-
Delgado, M.D.1
Albajar, M.2
Gomez-Casares, M.T.3
Batlle, A.4
León, J.5
-
60
-
-
0037015078
-
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription
-
Siddiqui-Jain, A.; Grand, C.L.; Bearss, D.J.; Hurley, L.H. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl. Acad. Sci. USA 2002, 99, 11593-11598.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11593-11598
-
-
Siddiqui-Jain, A.1
Grand, C.L.2
Bearss, D.J.3
Hurley, L.H.4
-
61
-
-
79952763614
-
Targeting MYC expression through G-Quadruplexes
-
Brooks, T.A.; Hurley, L.H. Targeting MYC expression through G-Quadruplexes. Genes Cancer 2010, 1, 641-649.
-
(2010)
Genes Cancer
, vol.1
, pp. 641-649
-
-
Brooks, T.A.1
Hurley, L.H.2
-
62
-
-
34147100699
-
Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives
-
Ou, T.M.; Lu, Y.J.; Zhang, C.; Huang, Z.S.; Wang, X.D.; Tan, J.H.; Chen, Y.; Ma, D.L.; Wong, K.Y.; Tang, J.C.; et al. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives. J. Med. Chem. 2007, 50, 1465-1474.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 1465-1474
-
-
Ou, T.M.1
Lu, Y.J.2
Zhang, C.3
Huang, Z.S.4
Wang, X.D.5
Tan, J.H.6
Chen, Y.7
Ma, D.L.8
Wong, K.Y.9
Tang, J.C.10
-
63
-
-
81755172447
-
Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex
-
Brown, R.V.; Danford, F.L.; Gokhale, V.; Hurley, L.H.; Brooks, T.A. Demonstration that drug-targeted down-regulation of MYC in non-Hodgkins lymphoma is directly mediated through the promoter G-quadruplex. J. Biol. Chem. 2011, 286, 41018-41027.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 41018-41027
-
-
Brown, R.V.1
Danford, F.L.2
Gokhale, V.3
Hurley, L.H.4
Brooks, T.A.5
-
64
-
-
68249156463
-
Formation of a unique end-to-end stacked pair of G-quadruplex in the TERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands
-
Palumbo, L.; Ebbinghaus, S.W.; Hurley, L.H. Formation of a unique end-to-end stacked pair of G-quadruplex in the TERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands. J. Am. Chem. Soc. 2009, 131, 10878-10891.
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 10878-10891
-
-
Palumbo, L.1
Ebbinghaus, S.W.2
Hurley, L.H.3
-
65
-
-
84873312526
-
Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells
-
Taka, T.; Huang, L.; Wongnoppavich, A.; Tam-Chang, S.W.; Lee, T.R.; Tuntiwechapikul, W. Telomere shortening and cell senescence induced by perylene derivatives in A549 human lung cancer cells. Bioorg. Med. Chem. 2013, 21, 883-890.
-
(2013)
Bioorg. Med. Chem.
, vol.21
, pp. 883-890
-
-
Taka, T.1
Huang, L.2
Wongnoppavich, A.3
Tam-Chang, S.W.4
Lee, T.R.5
Tuntiwechapikul, W.6
-
67
-
-
23044485047
-
Putative DNA quadruplex formation within the human c-kit oncogene
-
Rankin, S.; Reszka, A.P.; Huppert, J.; Zloh, M.; Parkinson, G.N.; Todd, A.K.; Ladame, S.; Balasubramanian, S.; Neidle, S. Putative DNA quadruplex formation within the human c-kit oncogene. J. Am. Chem. Soc. 2005, 127, 10584-10589.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 10584-10589
-
-
Rankin, S.1
Reszka, A.P.2
Huppert, J.3
Zloh, M.4
Parkinson, G.N.5
Todd, A.K.6
Ladame, S.7
Balasubramanian, S.8
Neidle, S.9
-
68
-
-
33746908213
-
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene
-
Fernando, H.; Reszka, A.P.; Huppert, J.; Ladame, S.; Rankin, S.; Venkitaraman, A.R.; Neidle, S.; Balasubramanian, S. A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry 2006, 45, 7854-7860.
-
(2006)
Biochemistry
, vol.45
, pp. 7854-7860
-
-
Fernando, H.1
Reszka, A.P.2
Huppert, J.3
Ladame, S.4
Rankin, S.5
Venkitaraman, A.R.6
Neidle, S.7
Balasubramanian, S.8
-
69
-
-
35848942604
-
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression
-
Bejugam, M.; Sewitz, S.; Shirude, P.S.; Rodriguez, R.; Shahid, R.; Balasubramanian, S. Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: Small molecule regulation of c-kit oncogene expression. J. Am. Chem. Soc. 2007, 129, 12926-12927.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 12926-12927
-
-
Bejugam, M.1
Sewitz, S.2
Shirude, P.S.3
Rodriguez, R.4
Shahid, R.5
Balasubramanian, S.6
-
70
-
-
46149112367
-
G-quadruplex recognition by bis-indole carboxamides
-
Dash, J.; Shirude, P.S.; Balasubramanian, S. G-quadruplex recognition by bis-indole carboxamides. Chem. Commun. (Camb.) 2008, 26, 3055-3057.
-
(2008)
Chem. Commun. (Camb.)
, vol.26
, pp. 3055-3057
-
-
Dash, J.1
Shirude, P.S.2
Balasubramanian, S.3
-
71
-
-
79952253500
-
G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells
-
McLuckie, K.I.; Waller, Z.A.; Sanders, D.A.; Alves, D.; Rodriguez, R.; Dash, J.; McKenzie, G.J.; Venkitaraman, A.R.; Balasubramanian, S. G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells. J. Am. Chem. Soc. 2011, 133, 2658-2663.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 2658-2663
-
-
McLuckie, K.I.1
Waller, Z.A.2
Sanders, D.A.3
Alves, D.4
Rodriguez, R.5
Dash, J.6
McKenzie, G.J.7
Venkitaraman, A.R.8
Balasubramanian, S.9
-
72
-
-
67549100961
-
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule
-
Gunaratnam, M.; Swank, S.; Haider, S.M.; Galesa, K.; Reszka, A.P.; Beltran, M.; Cuenca, F.; Fletcher, J.A.; Neidle, S. Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. J. Med. Chem. 2009, 52, 3774-3783.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 3774-3783
-
-
Gunaratnam, M.1
Swank, S.2
Haider, S.M.3
Galesa, K.4
Reszka, A.P.5
Beltran, M.6
Cuenca, F.7
Fletcher, J.A.8
Neidle, S.9
-
73
-
-
69849097341
-
A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression
-
Waller, Z.A.; Sewitz, S.A.; Hsu, S.D.; Balasubramanian, S. A small molecule that disrupts G-quadruplex DNA structure and enhances gene expression. J. Am. Chem. Soc. 2009, 131, 12628-12633.
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 12628-12633
-
-
Waller, Z.A.1
Sewitz, S.A.2
Hsu, S.D.3
Balasubramanian, S.4
-
74
-
-
84875192416
-
Structure and physiology of the RET receptor tyrosine kinase
-
Ibáñez, C.F. Structure and physiology of the RET receptor tyrosine kinase. Cold Spring Harb. Perspect. Biol. 2013, 5, a009134.
-
(2013)
Cold Spring Harb. Perspect. Biol.
, vol.5
-
-
Ibáñez, C.F.1
-
75
-
-
34548183518
-
Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene
-
Guo, K.; Pourpak, A.; Beetz-Rogers, K.; Gokhale, V.; Sun, D.; Hurley, L.H. Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene. J. Am. Chem. Soc. 2007, 129, 10220-10228.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 10220-10228
-
-
Guo, K.1
Pourpak, A.2
Beetz-Rogers, K.3
Gokhale, V.4
Sun, D.5
Hurley, L.H.6
-
76
-
-
80055092362
-
Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
-
Tong, X.; Lan, W.; Zhang, X.; Wu, H.; Liu, M.; Cao, C. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence. Nucleic Acids Res. 2011, 39, 6753-6763.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 6753-6763
-
-
Tong, X.1
Lan, W.2
Zhang, X.3
Wu, H.4
Liu, M.5
Cao, C.6
-
77
-
-
84855590085
-
Targeting the RAS pathway in melanoma
-
Ji, Z.; Flaherty, K.T.; Tsao, H. Targeting the RAS pathway in melanoma. Trends Mol. Med. 2012, 18, 27-35.
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 27-35
-
-
Ji, Z.1
Flaherty, K.T.2
Tsao, H.3
-
78
-
-
33744472232
-
G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription
-
Cogoi, S.; Xodo, L.E. G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription. Nucleic Acids Res. 2006, 34, 2536-2549.
-
(2006)
Nucleic Acids Res.
, vol.34
, pp. 2536-2549
-
-
Cogoi, S.1
Xodo, L.E.2
-
79
-
-
60549101098
-
Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells
-
Cogoi, S.; Paramasivam, M.; Filichev, V.; Géci, I.; Pedersen, E.B.; Xodo, L.E. Identification of a new G-quadruplex motif in the KRAS promoter and design of pyrene-modified G4-decoys with antiproliferative activity in pancreatic cancer cells. J. Med. Chem. 2009, 52, 564-568.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 564-568
-
-
Cogoi, S.1
Paramasivam, M.2
Filichev, V.3
Géci, I.4
Pedersen, E.B.5
Xodo, L.E.6
-
80
-
-
84884950457
-
Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains
-
doi:10.1002/cmdc.201300288
-
Lavrado, J.; Borralho, P.M.; Ohnmacht, S.A.; Castro, R.E.; Rodrigues, C.M.; Moreira, R.; Santos, D.J.; Neidle, S.; Paulo, A. Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains. Chem Med Chem 2013, doi:10.1002/cmdc.201300288.
-
(2013)
Chem Med Chem
-
-
Lavrado, J.1
Borralho, P.M.2
Ohnmacht, S.A.3
Castro, R.E.4
Rodrigues, C.M.5
Moreira, R.6
Santos, D.J.7
Neidle, S.8
Paulo, A.9
-
81
-
-
80052532707
-
G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy
-
Membrino, A.; Cogoi, S.; Pedersen, E.B.; Xodo, L.E. G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy. PLoS One 2011, 6, e24421.
-
(2011)
PLoS One
, vol.6
-
-
Membrino, A.1
Cogoi, S.2
Pedersen, E.B.3
Xodo, L.E.4
-
82
-
-
84869093332
-
Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy
-
Tomek, M.; Akiyama, T.; Dass, C.R. Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy. J. Pharm. Pharmacol. 2012, 64, 1695-1702.
-
(2012)
J. Pharm. Pharmacol.
, vol.64
, pp. 1695-1702
-
-
Tomek, M.1
Akiyama, T.2
Dass, C.R.3
-
83
-
-
84871202790
-
Targeting the Bcl-2 family for cancer therapy
-
Thomas, S.; Quinn, B.A.; Das, S.K.; Dash, R.; Emdad, L.; Dasgupta, S.; Wang, X.Y.; Dent, P.; Reed, J.C.; Pellecchia, M.; et al. Targeting the Bcl-2 family for cancer therapy. Expert Opin. Ther. Targets 2013, 17, 61-75.
-
(2013)
Expert Opin. Ther. Targets
, vol.17
, pp. 61-75
-
-
Thomas, S.1
Quinn, B.A.2
Das, S.K.3
Dash, R.4
Emdad, L.5
Dasgupta, S.6
Wang, X.Y.7
Dent, P.8
Reed, J.C.9
Pellecchia, M.10
-
84
-
-
33646462913
-
Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter
-
Dexheimer, T.S.; Sun, D.; Hurley, L.H. Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. J. Am. Chem. Soc. 2006, 128, 5404-5415.
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 5404-5415
-
-
Dexheimer, T.S.1
Sun, D.2
Hurley, L.H.3
-
85
-
-
77953211752
-
Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives
-
Wang, X.D.; Ou, T.M.; Lu, Y.J.; Li, Z.; Xu, Z.; Xi, C.; Tan, J.H.; Huang, S.L.; An, L.K.; Li, D.; et al. Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives. J. Med. Chem. 2010, 53, 4390-4398.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4390-4398
-
-
Wang, X.D.1
Ou, T.M.2
Lu, Y.J.3
Li, Z.4
Xu, Z.5
Xi, C.6
Tan, J.H.7
Huang, S.L.8
An, L.K.9
Li, D.10
-
86
-
-
84861845402
-
The updated biology of hypoxia-inducible factor
-
Greer, S.N.; Metcalf, J.L.; Wang, Y.; Ohh, M. The updated biology of hypoxia-inducible factor. EMBO J. 2012, 31, 2448-2460.
-
(2012)
EMBO J.
, vol.31
, pp. 2448-2460
-
-
Greer, S.N.1
Metcalf, J.L.2
Wang, Y.3
Ohh, M.4
-
87
-
-
28944442742
-
Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter
-
De Armond, R.; Wood, S.; Sun, D.; Hurley, L.H.; Ebbinghaus, S.W. Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter. Biochemistry 2005, 44, 16341-1650.
-
(2005)
Biochemistry
, vol.44
, pp. 16341-21650
-
-
De Armond, R.1
Wood, S.2
Sun, D.3
Hurley, L.H.4
Ebbinghaus, S.W.5
-
88
-
-
84865527719
-
A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines
-
Lombardo, C.M.; Welsh, S.J.; Strauss, S.J.; Dale, A.G.; Todd, A.K.; Nanjunda, R.; Wilson, D.W.; Neidle, S. A novel series of G-quadruplex ligands with selectivity for HIF-expressing osteosarcoma and renal cancer cell lines. Bioorg. Med. Chem. Lett. 2012, 22, 5984-5988.
-
(2012)
Bioorg. Med. Chem. Lett.
, vol.22
, pp. 5984-5988
-
-
Lombardo, C.M.1
Welsh, S.J.2
Strauss, S.J.3
Dale, A.G.4
Todd, A.K.5
Nanjunda, R.6
Wilson, D.W.7
Neidle, S.8
-
89
-
-
77955809107
-
Making sense of G-quadruplex and i-motif functions in oncogene promoters
-
Brooks, T.A.; Kendrick, S.; Hurley, L. Making sense of G-quadruplex and i-motif functions in oncogene promoters. FEBS J. 2010, 277, 3459-3469.
-
(2010)
FEBS J.
, vol.277
, pp. 3459-3469
-
-
Brooks, T.A.1
Kendrick, S.2
Hurley, L.3
-
90
-
-
84857163904
-
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
-
Rodriguez, R.; Miller, K.M.; Forment, J.V.; Bradshaw, C.R.; Nikan, M.; Britton, S.; Oelschlaegel, T.; Xhemalce, B.; Balasubramanian S.; Jackson S.P. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat. Chem. Biol. 2012, 8, 301-310.
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 301-310
-
-
Rodriguez, R.1
Miller, K.M.2
Forment, J.V.3
Bradshaw, C.R.4
Nikan, M.5
Britton, S.6
Oelschlaegel, T.7
Xhemalce, B.8
Balasubramanian, S.9
Jackson, S.P.10
-
91
-
-
77956042544
-
SRC: A century of science brought to the clinic
-
Aleshin, A.; Finn, R.S. SRC: A century of science brought to the clinic. Neoplasia 2010, 12, 599-607.
-
(2010)
Neoplasia
, vol.12
, pp. 599-607
-
-
Aleshin, A.1
Finn, R.S.2
-
92
-
-
84883372353
-
Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand
-
Murat, P.; Gormally, M.V.; Sanders, D.; Antonio, M.D.; Balasubramanian, S. Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand. Chem. Commun. (Camb.) 2013, 49, 8453-8455.
-
(2013)
Chem. Commun. (Camb.)
, vol.49
, pp. 8453-8455
-
-
Murat, P.1
Gormally, M.V.2
Sanders, D.3
Antonio, M.D.4
Balasubramanian, S.5
-
93
-
-
77957058196
-
5′-UTR G-quadruplex structures acting as translational repressors
-
Beaudoin, J.D.; Perreault, J.P. 5′-UTR G-quadruplex structures acting as translational repressors. Nucleic Acids Res. 2010, 38, 7022-7036.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 7022-7036
-
-
Beaudoin, J.D.1
Perreault, J.P.2
-
94
-
-
0028556501
-
A guanosine quadruplex and two stable hairpins flank a major cleavage site in insulin-like growth factor II mRNA
-
Christiansen, J.; Kofod, M.; Nielsen, F.C. A guanosine quadruplex and two stable hairpins flank a major cleavage site in insulin-like growth factor II mRNA. Nucleic Acids Res. 1994, 22, 5709-5716.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 5709-5716
-
-
Christiansen, J.1
Kofod, M.2
Nielsen, F.C.3
-
95
-
-
33947310727
-
An RNA G-quadruplex in the 5′-UTR of the NRAS proto-oncogene modulates translation
-
Kumari, S.; Bugaut, A.; Huppert, J.L.; Balasubramanian, S. An RNA G-quadruplex in the 5′-UTR of the NRAS proto-oncogene modulates translation. Nat. Chem. Biol. 2007, 3, 218-221.
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 218-221
-
-
Kumari, S.1
Bugaut, A.2
Huppert, J.L.3
Balasubramanian, S.4
-
96
-
-
45749139174
-
Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif
-
Arora, A.; Dutkiewicz, M.; Scaria, V.; Hariharan, M.; Maiti, S.; Kurreck, J. Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. RNA 2008, 14, 1290-1296.
-
(2008)
RNA
, vol.14
, pp. 1290-1296
-
-
Arora, A.1
Dutkiewicz, M.2
Scaria, V.3
Hariharan, M.4
Maiti, S.5
Kurreck, J.6
-
97
-
-
77957082956
-
A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells
-
Gomez, D.; Guédin, A.; Mergny, J.L.; Salles, B.; Riou, J.F.; Teulade-Fichou, M.P.; Calsou, P. A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res. 2010, 38, 7187-7198.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 7187-7198
-
-
Gomez, D.1
Guédin, A.2
Mergny, J.L.3
Salles, B.4
Riou, J.F.5
Teulade-Fichou, M.P.6
Calsou, P.7
-
98
-
-
1242342930
-
Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by TERT RNA alternative splicing
-
Gomez, D.; Lemarteleur, T.; Lacroix, L.; Mailliet, P.; Mergny, J.-L.; Riou, J.-F. Telomerase downregulation induced by the G-quadruplex ligand 12459 in A549 cells is mediated by TERT RNA alternative splicing. Nucleic Acids Res. 2004, 32, 371-379.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 371-379
-
-
Gomez, D.1
Lemarteleur, T.2
Lacroix, L.3
Mailliet, P.4
Mergny, J.-L.5
Riou, J.-F.6
-
99
-
-
84878830016
-
Exploring mRNA 3′-UTR G-quadruplexes: Evidence of roles in both alternative polyadenylation and mRNA shortening
-
Beaudoin, J.D.; Perreault, J.P. Exploring mRNA 3′-UTR G-quadruplexes: Evidence of roles in both alternative polyadenylation and mRNA shortening. Nucleic Acids Res. 2013, 41, 5898-5911.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 5898-5911
-
-
Beaudoin, J.D.1
Perreault, J.P.2
-
100
-
-
23844438712
-
Not so crystal clear: The structure of the human telomere G-quadruplex in solution differs from that present in a crystal
-
Li, J.; Correia, J.J.; Wang, L.; Trent, J.O.; Chairesi, J.B. Not so crystal clear: The structure of the human telomere G-quadruplex in solution differs from that present in a crystal. Nucleic Acids Res. 2005, 33, 4649-4659.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 4649-4659
-
-
Li, J.1
Correia, J.J.2
Wang, L.3
Trent, J.O.4
Chairesi, J.B.5
-
101
-
-
79960700336
-
The evolving world of protein-G-quadruplex recognition: A medicinal chemist's perspective
-
Sissi, C.; Gatto, B.; Palumbo, M. The evolving world of protein-G-quadruplex recognition: A medicinal chemist's perspective. Biochimie 2010, 93, 1219-1230.
-
(2010)
Biochimie
, vol.93
, pp. 1219-1230
-
-
Sissi, C.1
Gatto, B.2
Palumbo, M.3
-
102
-
-
0035900649
-
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
-
Darnell, J.C.; Jensen, K.B.; Jin, P.; Brown, V.; Warren, S.T.; Darnell, R.B. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 2001, 107, 489-499.
-
(2001)
Cell
, vol.107
, pp. 489-499
-
-
Darnell, J.C.1
Jensen, K.B.2
Jin, P.3
Brown, V.4
Warren, S.T.5
Darnell, R.B.6
-
103
-
-
77955791569
-
G-quadruplex nucleic acids and human disease
-
Wu, Y.; Brosh, R.M., Jr. G-quadruplex nucleic acids and human disease. FEBS J. 2010, 277, 3470-3488.
-
(2010)
FEBS J.
, vol.277
, pp. 3470-3488
-
-
Wu, Y.1
Brosh Jr., R.M.2
-
104
-
-
27144451010
-
Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo
-
Paeschke, K.; Simonsson, T.; Postberg, J.; Rhodes, D.; Lipps, H.J. Telomere end-binding proteins control the formation of G-quadruplex DNA structures in vivo. Nat. Struct. Mol. Biol. 2005, 12, 847-854.
-
(2005)
Nat. Struct. Mol. Biol.
, vol.12
, pp. 847-854
-
-
Paeschke, K.1
Simonsson, T.2
Postberg, J.3
Rhodes, D.4
Lipps, H.J.5
-
105
-
-
68549136741
-
G-quadruplex structures: In vivo evidence and function
-
Lipps, H.J.; Rhodes, D. G-quadruplex structures: In vivo evidence and function. Trends Cell Biol. 2009, 19, 414-422.
-
(2009)
Trends Cell Biol.
, vol.19
, pp. 414-422
-
-
Lipps, H.J.1
Rhodes, D.2
-
106
-
-
3042785608
-
Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA
-
Duquette, M.L.; Handa, P.; Vincent, J.A.; Taylor, A.F.; Maizels, N. Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNA. Genes Dev. 2004, 18, 1618-1629.
-
(2004)
Genes Dev.
, vol.18
, pp. 1618-1629
-
-
Duquette, M.L.1
Handa, P.2
Vincent, J.A.3
Taylor, A.F.4
Maizels, N.5
-
107
-
-
84875464903
-
Quantitative visualization of DNA G-quadruplex structures in human cells
-
Biffi, G.; Tannahill, D.; McCafferty, J.; Balasubramanian, S. Quantitative visualization of DNA G-quadruplex structures in human cells. Nat. Chem. 2013, 5, 182-186.
-
(2013)
Nat. Chem.
, vol.5
, pp. 182-186
-
-
Biffi, G.1
Tannahill, D.2
McCafferty, J.3
Balasubramanian, S.4
-
108
-
-
84877768759
-
G-quadruplex structures are stable and detectable in human genomic DNA
-
doi:10.1038/ncomms2792
-
Lam, E.Y.; Beraldi, D.; Tannahill, D.; Balasubramanian, S. G-quadruplex structures are stable and detectable in human genomic DNA. Nat. Commun. 2013, 4, 1796, doi:10.1038/ncomms2792.
-
(2013)
Nat. Commun.
, vol.4
, pp. 1796
-
-
Lam, E.Y.1
Beraldi, D.2
Tannahill, D.3
Balasubramanian, S.4
|