Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes

Journal of Medicinal Chemistry

Volumn 55, Issue 1, 2012, Pages 209-222

  Campbell, Nancy H ^a   Karim, Nurul H Abd ^b   Parkinson, Gary N ^a   Gunaratnam, Mekala ^a   Petrucci, Vanessa ^a   Todd, Alan K ^a   Vilar, Ramon ^b   Neidle, Stephen ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; COPPER; GUANINE QUADRUPLEX; N,N [4 [[1 (2 ETHYL)PIPERIDINE]OXY]SALICYLIDENE] 4 METHYLESTER 1,2 PHENYLENEDIAMINE NICKEL; N,N [4 [[1 (2 ETHYL)PIPERIDINE]OXY]SALICYLIDENE] 4,5 DIFLUORO 1,2 PHENYLENEDIAMINE COPPER; N,N [4 [[1 (2 ETHYL)PIPERIDINE]OXY]SALICYLIDENE] 4,5 DIFLUORO 1,2 PHENYLENEDIAMINE NICKEL; N,N [4 [[1 (2 ETHYL)PIPERIDINE]OXY]SALICYLIDENE] 4,5 METHYLESTER 1,2 PHENYLENEDIAMINE COPPER; NICKEL; POTASSIUM CHANNEL; SALICYLIC ACID PHENYL ESTER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRAIN MCF 7; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DNA BINDING; DNA SEQUENCE; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION; TELOMERE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COORDINATION COMPLEXES; COPPER; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; G-QUADRUPLEXES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NICKEL; PHENYLENEDIAMINES; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE; TELOMERE;

EID: 84855849686     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201140v     Document Type: Article

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