The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 20, 2013, Pages 6162-6170

  Mpima, Sheila ^a   Ohnmacht, Stephan A ^a   Barletta, Maria ^a   Husby, Jarmila ^a   Pett, Luke C ^a   Gunaratnam, Mekala ^a   Hilton, Stephen T ^a   Neidle, Stephen ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

G quadruplex; Molecular dynamics; Naphthalene diimide; Pancreatic cancer

Indexed keywords

ANTINEOPLASTIC AGENT; GUANINE QUADRUPLEX; NAPHTHALENE DERIVATIVE; NAPHTHALENE DIIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IC 50; ISOMERISM; KIDNEY CARCINOMA; LUNG CARCINOMA; MOLECULAR DYNAMICS; MOLECULAR MODEL; PANCREAS CARCINOMA; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TELOMERE HOMEOSTASIS;

G-QUADRUPLEX; MOLECULAR DYNAMICS; NAPHTHALENE DIIMIDE; PANCREATIC CANCER;

CELL GROWTH PROCESSES; CELL LINE, TUMOR; G-QUADRUPLEXES; HUMANS; IMIDES; ISOMERISM; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; NAPHTHALENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884998781     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.027     Document Type: Article

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