Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: Insights into G-quadruplex-interactive small molecule drug design

Journal of the American Chemical Society

Volumn 133, Issue 44, 2011, Pages 17673-17680

  Dai, Jixun ^c   Carver, Megan ^c   Hurley, Laurence H ^a,b,c   Yang, Danzhou ^a,b,c  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING POCKETS; DRUG BINDING; ELECTRONIC INTERACTIONS; FLANKING SEQUENCE; G-QUADRUPLEX STRUCTURE; G-QUADRUPLEXES; GENE PROMOTER; NUCLEASE HYPERSENSITIVITY; PROMOTER ELEMENTS; RATIONAL DESIGN; SMALL-MOLECULE DRUGS; SOLUTION STRUCTURES; STRUCTURE-BASED; TRANSCRIPTIONAL SILENCING; TRANSCRIPTIONALLY ACTIVE; UNIMOLECULAR;

COMPLEXATION; GENES; USER INTERFACES;

DNA SEQUENCES;

CRYPTOLEPINE DERIVATIVE; GUANINE QUADRUPLEX; MYC PROTEIN; QUINDOLINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DNA BINDING; DNA DRUG COMPLEX; DNA FLANKING REGION; DNA STRUCTURE; DRUG DESIGN; DRUG DNA BINDING; DRUG DNA INTERACTION; GENE SILENCING; PROMOTER REGION;

ALKALOIDS; CRYSTALLOGRAPHY, X-RAY; DNA; DRUG DESIGN; G-QUADRUPLEXES; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; QUINOLINES; SOLUTIONS;

EID: 80455123924     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja205646q     Document Type: Article

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