On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

Journal of Experimental and Clinical Cancer Research

Volumn 32, Issue 1, 2013, Pages

  Iachettini, Sara ^a   Stevens, Malcolm F G ^b   Frigerio, Mark ^c   Hummersone, Marc G ^c   Hutchinson, Ian ^c   Garner, Thomas P ^b   Searle, Mark S ^b   Wilson, David W ^d   Munde, Manoj ^d   Nanjunda, Rupesh ^d   D'Angelo, Carmen ^a   Zizza, Pasquale ^a   Rizzo, Angela ^a   Cingolani, Chiara ^a   De Cicco, Federica ^a   Porru, Manuela ^a   D'Incalci, Maurizio ^e   Leonetti, Carlo ^a   Biroccio, Annamaria ^a   Salvati, Erica ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c Pharminox Ltd   (United Kingdom)

^d GEORGIA STATE UNIVERSITY   (United States)

^e MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Anti cancer therapy; G quadruplex; Telomere targeting agents

Indexed keywords

ACETIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; BETA 2 ADRENERGIC RECEPTOR; GUANINE QUADRUPLEX; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; PENTACYCLIC ACRIDINIUM SALT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CARDIOTOXICITY; CARDIOVASCULAR EFFECT; CELL POPULATION; CELL PROLIFERATION; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GENE TARGETING; GUINEA PIG MODEL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LIGAND BINDING; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; TELOMERE; THERMOSTABILITY;

ACRIDINES; ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; G-QUADRUPLEXES; GUINEA PIGS; HUMANS; LIGANDS; TELOMERASE; TELOMERE;

EID: 84884239677     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-32-68     Document Type: Article

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