G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells

Journal of the American Chemical Society

Volumn 135, Issue 26, 2013, Pages 9640-9643

  McLuckie, Keith I E ^a   Di Antonio, Marco ^a,b   Zecchini, Heather ^a   Xian, Jian ^a,b   Caldas, Carlos ^a,b   Krippendorff, Ben Fillippo ^a   Tannahill, David ^a   Lowe, Christopher ^b   Balasubramanian, Shankar ^a,b,c  

^a CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DAMAGE RESPONSE; DNA DOUBLE STRAND BREAKS; MOLECULAR TARGETS; NONHOMOLOGOUS END JOINING; SENSITIVE GENES; SMALL MOLECULES; TARGETING LIGANDS; THERAPEUTIC AGENTS;

CELL DEATH; DNA SEQUENCES; GENES; LIGANDS; MACHINERY; MOLECULES; REPAIR;

DNA;

GUANINE QUADRUPLEX; LIGAND;

ARTICLE; CANCER CELL; CANCER THERAPY; CELL DEATH; DNA DAMAGE; DNA END JOINING REPAIR; DOUBLE STRANDED DNA BREAK; GENE MUTATION; HOMOLOGOUS RECOMBINATION; HUMAN; LETHALITY;

AMINOQUINOLINES; ANTINEOPLASTIC AGENTS; BRCA2 PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHROMONES; DNA BREAKS; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; G-QUADRUPLEXES; HUMANS; MOLECULAR STRUCTURE; MORPHOLINES; NEOPLASMS; PICOLINIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879756242     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja404868t     Document Type: Article

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