Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains

ChemMedChem

Volumn 8, Issue 10, 2013, Pages 1648-1661

  Lavrado, João ^a   Borralho, Pedro M ^a   Ohnmacht, Stephan A ^b   Castro, Rui E ^a   Rodrigues, Cecília M P ^a   Moreira, Rui ^a   Dos Santos, Daniel J V A ^a,c   Neidle, Stephen ^b   Paulo, Alexandra ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Alkaloids; Cancer; Cryptolepine; G quadruplexes; Indoloquinolines

Indexed keywords

2 (DIETHYLAMINO)ETHYL 11 (2 (DIETHYLAMINO)ETHOXY) 10 (2 (DIETHYLAMINO)ETHYL) 10H INDOLO[3,2 B]QUINOLINE 7 CARBOXYLATE; 2 (DIETHYLAMINO)ETHYL 5,10 BIS(2 (DIETHYLAMINO)ETHYL) 11 OXO 10,11 DIHYDRO 5H INDOLO [3,2 B]QUINOLINE 7 CARBOXYLATE; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; DOUBLE STRANDED DNA; FLUOROURACIL; GUANINE QUADRUPLEX; HEAT SHOCK PROTEIN 90; INDOLOQUINOLINE DERIVATIVE; K RAS PROTEIN; PROPYLAMINE; UNCLASSIFIED DRUG; 2-(DIETHYLAMINO)ETHYL 11-(2-(DIETHYLAMINO)ETHOXY)-10-(2-(DIETHYLAMINO)ETHYL)-10H-INDOLO(3,2-B)QUINOLINE-7-CARBOXYLATE; 2-(DIETHYLAMINO)ETHYL 5,10-BIS(2-(DIETHYLAMINO)ETHYL)-11-OXO-10,11-DIHYDRO-5H-INDOLO(3,2-B)QUINOLINE-7-CARBOXYLATE; INDOLE; INDOLE DERIVATIVE; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN BINDING; QUINOLINE DERIVATIVE; QUINOLONE DERIVATIVE; RAS PROTEIN;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFECT; DRUG SYNTHESIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; LIGAND BINDING; LIVER CELL; MELTING POINT; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THERMOSTABILITY; ANIMAL; BINDING SITE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DOWN REGULATION; DRUG EFFECTS; HCT116 CELL LINE; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; G-QUADRUPLEXES; HCT116 CELLS; HEPATOCYTES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INDOLES; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; QUINOLINES; QUINOLONES; RAS PROTEINS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884950457     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300288     Document Type: Article

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