Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands

Journal of the American Chemical Society

Volumn 134, Issue 5, 2012, Pages 2723-2731

  Collie, Gavin W ^a   Promontorio, Rossella ^a   Hampel, Sonja M ^a   Micco, Marialuisa ^a   Neidle, Stephen ^a   Parkinson, Gary N ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR ACTIVITIES; BIOLOGICAL DATA; BOND CONTACT; CANCER CELL GROWTH; CANCER CELL LINES; CANCER CELLS; FUNCTIONALIZED; G-QUADRUPLEX STRUCTURE; G-QUADRUPLEXES; HUMAN TELOMERE; HUMAN TELOMERIC DNA; IN-VIVO; LIGAND MOBILITY; NAPHTHALENE DIIMIDE; PHOSPHATE GROUP; POSITIVELY CHARGED; SIDE-CHAINS; SMALL MOLECULES; STRUCTURAL BASIS; STRUCTURAL DATA; STRUCTURE-BASED; TELOMERASE; TELOMERASE ACTIVITY; TELOMERE MAINTENANCE; TELOMERES; THERMAL STABILIZATION;

CELL CULTURE; CHROMOSOMES; DNA; NAPHTHALENE; RNA;

LIGANDS;

GUANINE QUADRUPLEX; NAPHTHALENE DERIVATIVE; NAPHTHALENE DIIMIDE; PHOSPHATE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL; CANCER GROWTH; CRYSTAL STRUCTURE; DNA STRUCTURE; ENZYME ACTIVITY; HYDROGEN BOND; PROTEIN INTERACTION; PROTEIN LOCALIZATION; THERMOSTABILITY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; G-QUADRUPLEXES; HUMANS; HYDROGEN BONDING; IMIDES; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERE;

EID: 84856708526     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2102423     Document Type: Article

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