Downregulation of androgen receptor transcription by promoter G-quadruplex stabilization as a potential alternative treatment for castrate-resistant prostate cancer

Biochemistry

Volumn 52, Issue 8, 2013, Pages 1429-1436

  Mitchell, Tom ^a   Ramos Montoya, Antonio ^a   Di Antonio, Marco ^b   Murat, Pierre ^b   Ohnmacht, Stephan ^c   Micco, Marialuisa ^c   Jurmeister, Sarah ^a   Fryer, Lee ^a   Balasubramanian, Shankar ^a,b   Neidle, Stephen ^c   Neal, David E ^a  

^a CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTORS; DOSE-DEPENDENT; DOWN-REGULATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-QUADRUPLEX STRUCTURE; G-QUADRUPLEXES; GENE TRANSCRIPTIONS; MRNA LEVEL; PROOF OF CONCEPT; PROSTATE CANCER CELLS; PROSTATE CANCERS; REGULATORY PATHWAY; REPORTER ASSAY; SMALL MOLECULES; SUBMICROMOLAR CONCENTRATIONS; THERMAL MELTING; TRANSCRIPTIONAL REPRESSION;

CELL CULTURE; DISEASES; ENERGY TRANSFER; GENES; MELTING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ULTRAVIOLET SPECTROSCOPY;

TRANSCRIPTION;

ANDROGEN RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CASTRATION RESISTANT PROSTATE CANCER; CELL GROWTH; CIRCULAR DICHROISM; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CIRCULAR DICHROISM; DOWN-REGULATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-QUADRUPLEXES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMIDES; MALE; NAPHTHALENES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROMOTER REGIONS, GENETIC; PROSTATE; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; SPECTROPHOTOMETRY, ULTRAVIOLET; TRANSCRIPTIONAL ACTIVATION;

EID: 84874432663     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301349c     Document Type: Article

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