Macrocyclic pyridyl polyoxazoles: Structure-activity studies of the aminoalkyl side-chain on G-quadruplex stabilization and cytotoxic activity

Molecules

Volumn 18, Issue 10, 2013, Pages 11938-11963

  Blankson, Gifty ^a   Rzuczek, Suzanne G ^a,d   Bishop, Cody ^a   Pilch, Daniel S ^b,c   Liu, Angela ^b,c   Liu, Leroy ^b,c   LaVoie, Edmond J ^a,c   Rice, Joseph E ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

G quadruplex; G quadruplex ligands; G quadruplex stabilizer; Macrocycle; Synthesis

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; GUANINE QUADRUPLEX; MACROCYCLIC COMPOUND; OXAZOLE DERIVATIVE; PYRIDINE DERIVATIVE;

CELL SURVIVAL; CHEMISTRY; CYCLIZATION; DRUG EFFECTS; DRUG SCREENING; HUMAN; IC50; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; ARTICLE; DRUG EFFECT; IC 50;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIZATION; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; G-QUADRUPLEXES; HUMANS; INHIBITORY CONCENTRATION 50; MACROCYCLIC COMPOUNDS; OXAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886609413     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules181011938     Document Type: Article

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