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Volumn 8, Issue 18, 2006, Pages 4165-4167

Total synthesis of (R)-telomestatin

Author keywords

[No Author keywords available]

Indexed keywords

OXAZOLE DERIVATIVE; TELOMERASE; TELOMESTATIN;

EID: 33748948394     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol061793i     Document Type: Article
Times cited : (114)

References (30)
  • 11
    • 23044478330 scopus 로고    scopus 로고
    • (Taiho Pharmaceutical Co. Ltd., Sosei Co. Ltd.). WO 200248153
    • Yamada, S.; Shigeno, K.; Kitagawa, K.; Okajima, S.; Asao, T. (Taiho Pharmaceutical Co. Ltd., Sosei Co. Ltd.). WO 200248153; Chem. Abstr. 2002, 137, 47050.
    • (2002) Chem. Abstr. , vol.137 , pp. 47050
    • Yamada, S.1    Shigeno, K.2    Kitagawa, K.3    Okajima, S.4    Asao, T.5
  • 13
    • 33748931507 scopus 로고    scopus 로고
    • note
    • PyBroP = bromo-trispyrrolidino-phosphonium hexafluorophosphate.
  • 16
    • 33748925268 scopus 로고    scopus 로고
    • note
    • Several condensation reagents were investigated using the corresponding S-trityl derivative: PyBrop, 90%; HATU-HOAt, 78%; PyBop-HOBt, 69%; EDCI-HOBT, 53%.
  • 24
    • 33748926995 scopus 로고    scopus 로고
    • note
    • Chattopadhyay et al. recently reported the synthesis of its methyl ester. See ref 5e.
  • 26
    • 33748919704 scopus 로고    scopus 로고
    • note
    • In the absence of MS4A, the sulfide moiety was partially oxidized. The S-trityl derivative was decomposed under these reaction conditions.
  • 27
    • 33748924023 scopus 로고    scopus 로고
    • note
    • 3 is usually selected for an oxazoline formation. However, the elimination of thiol was observed in this system.
  • 28
    • 33748926319 scopus 로고    scopus 로고
    • note
    • In the absence of MS5A, ring opening of the oxazoline by hydrolysis was observed.
  • 30
    • 33748948805 scopus 로고    scopus 로고
    • note
    • Without addition of anisole, the reaction was not complete.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.