Drug Targeting of the c-MYC Promoter to Repress Gene Expression via a G-Quadruplex Silencer Element

Seminars in Oncology

Volumn 33, Issue 4, 2006, Pages 498-512

  Hurley, Laurence H ^a,b   Von Hoff, Daniel D ^c   Siddiqui Jain, Adam ^d   Yang, Danzhou ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^d Cylene Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; TELOMERASE REVERSE TRANSCRIPTASE; TETRAKIS(N METHYL 4 PYRIDYL)PORPHINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOGENESIS; CANCER ADJUVANT THERAPY; CANCER GROWTH; CANCER INHIBITION; CANCER MODEL; CANCER SURVIVAL; COLON CARCINOGENESIS; DNA STRAND; DOWN REGULATION; DRUG BINDING SITE; DRUG DETERMINATION; DRUG STRUCTURE; DRUG TARGETING; GENE EXPRESSION; GENE REPRESSION; GLIOBLASTOMA; MOLECULAR MODEL; MYELOID LEUKEMIA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ONCOGENE C MYC; OSTEOSARCOMA; PRIORITY JOURNAL; PROMOTER REGION; SILENCER ELEMENT; SMALL CELL CARCINOMA; STRUCTURE ANALYSIS; SURVIVAL RATE; SURVIVAL TIME; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; UTERINE CERVIX CARCINOMA;

ANIMALS; BASE SEQUENCE; GENE EXPRESSION REGULATION; GENE SILENCING; GENES, MYC; HUMANS; ISOMERISM; PORPHYRINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; SILENCER ELEMENTS, TRANSCRIPTIONAL; TRANSCRIPTION, GENETIC;

EID: 33746520122     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2006.04.012     Document Type: Article

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