Design, synthesis, biophysical and biological studies of trisubstituted naphthalimides as G-quadruplex ligands

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 21, 2011, Pages 6419-6429

  Peduto, Antonella ^a   Pagano, Bruno ^a   Petronzi, Carmen ^a   Massa, Antonio ^a   Esposito, Veronica ^b   Virgilio, Antonella ^b   Paduano, Francesco ^c   Trapasso, Francesco ^c   Fiorito, Filomena ^b   Florio, Salvatore ^b   Giancola, Concetta ^b   Galeone, Aldo ^b   Filosa, Rosanna ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Cancer; G quadruplex; Naphthalimides; Telomerase

Indexed keywords

5,8 DIAMINO 2 (2 MORPHOLINOETHYL) 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; 5,8 DIAMINO 2 (MORPHOLINOPROPYL) 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; 5,8 DIAMINO 2 [2 (DIMETHYLAMINO)ETHYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; 5,8 DIAMINO 2 [2 (PIPERIDIN 1 YL)ETHYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; 5,8 DIAMINO 2 [2 (PYRROLIDIN 1 IL)ETHYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; 5,8 DIAMINO 2 [3 (DIMETHYLAMINO)PROPYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; 5,8 DIAMINO 2 [3 (PIPERAZIN 1 YL)ETHYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; 5,8 DIAMINO 2 [3 (PIPERIDIN 1 YL)PROPYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; 5,8 DIAMINO 2 [3 (PYRROLIDIN 1 YL)PROPYL] 1H BENZO[DE]ISOQUINOLINE 1,3(2H)DIONE; GUANINE QUADRUPLEX; N,N' [1,3 DIOXO 2 [2 (PIPERIDIN 1 YL)ETHYL] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); N,N' [1,3 DIOXO 2 [2 (PIPERIDIN1 YL)ETHYL] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS[3 (PYRROLIDIN 1 YL)PROPANAMIDE]; N,N' [1,3 DIOXO 2 [2 (PYRROLIDIN 1 YL)ETHYL] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); N,N' [1,3 DIOXO 2 [2 (PYRROLIDIN 1 YL)ETHYL] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS[3 (PYRROLIDIN 1 YL)PROPANAMIDE]; N,N' [1,3 DIOXO 2 [2 [4 [3 (PYRROLIDIN 1 YL)PROPANOYL]PIPERAZIN 1 YL]ETHYL] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS[3 (PYRROLIDIN 1 YL)PROPANAMIDE]; N,N' [1,3 DIOXO 2 [3 (PIPERIDIN 1 YL)PROPYL] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS[3 (PYRROLIDIN 1 YL)PROPANAMIDE]; N,N' [1,3 DIOXO 2 [3 (PYRROLIDIN 1 YL)PROPYL] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); N,N' [1,3 DIOXO 2 [3 (PYRROLIDIN 1 YL)PROPYL] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS[3 (PYRROLIDIN 1 YL)PROPANAMIDE]; N,N' [2 (2 MORPHOLINOETHYL) 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); N,N' [2 (2 MORPHOLINOETHYL) 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS[3 (PYRROLIDIN 1 YL)PROPANAMIDE]; N,N' [2 (3 MORPHOLINOPROPYL) 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); N,N' [2 [2 (DIMETHYLAMINO)ETHYL] 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); N,N' [2 [2 (DIMETHYLAMINO)ETHYL] 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS[3 (PYRROLIDIN 1 YL)PROPANAMIDE]; N,N' [2 [2 (DIMETHYLAMINO)PROPYL] 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); N,N' [2 [2 [4 (3 CHLOROPROPANOYL)PIPERAZIN 1 YL]ETHYL] 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); N,N' [2 [3 (DIMETHYLAMINO)PROPYL] 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS[3 (PYRROLIDIN 1 YL)PROPANAMIDE]; N,N' [2 [3 [4 (3 CHLOROPROPANOYL)PIPERAZIN 1 YL]PROPYL] 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLINE 5,8 DIYL]BIS(3 CHLOROPROPANAMIDE); NAPHTHALIMIDE DERIVATIVE; TERT BUTYL 4 [3 (5,8 DIAMINO 1,3 DIOXO 1H BENZO[DE]ISOQUINOLIN 2(3H) YL)PROPYL]PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGY; BIOPHYSICS; CANCER CELL CULTURE; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; LUNG CANCER; MELANOMA; MOUSE; NONHUMAN; STOICHIOMETRY; TREATMENT RESPONSE;

EID: 80054925309     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.062     Document Type: Article

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