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Volumn 36, Issue 1, 2014, Pages 55-71

CEACAM1 loss links inflammation to insulin resistance in obesity and non-alcoholic steatohepatitis (NASH)

Author keywords

Adipokines; CEACAM1; Insulin resistance; Metabolic syndrome; NASH

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; FATTY ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84895878340     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-013-0407-3     Document Type: Review
Times cited : (35)

References (263)
  • 1
    • 73949115305 scopus 로고    scopus 로고
    • The metabolic syndrome
    • doi:10.1016/S0140-6736(09)61794-3
    • Eckel RH, Alberti KG, Grundy SM, Zimmet PZ (2010) The metabolic syndrome. Lancet 375(9710):181-183. doi:10.1016/S0140-6736(09)61794-3
    • (2010) Lancet , vol.375 , Issue.9710 , pp. 181-183
    • Eckel, R.H.1    Alberti, K.G.2    Grundy, S.M.3    Zimmet, P.Z.4
  • 3
    • 34548639473 scopus 로고    scopus 로고
    • Obesity-induced inflammation: A metabolic dialogue in the language of inflammation
    • doi:10.1111/j.1365-2796.2007.01852.x
    • Ferrante AW Jr (2007) Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 262(4):408-414. doi:10.1111/j.1365-2796.2007.01852.x
    • (2007) J Intern Med , vol.262 , Issue.4 , pp. 408-414
    • Ferrante Jr., A.W.1
  • 4
    • 79953046341 scopus 로고    scopus 로고
    • Inflammatory mechanisms in obesity
    • doi:10.1146/annurev-immunol-031210-101322
    • Gregor MF, Hotamisligil GS (2011) Inflammatory mechanisms in obesity. Annu Rev Immunol 29:415-445. doi:10.1146/annurev-immunol-031210-101322
    • (2011) Annu Rev Immunol , vol.29 , pp. 415-445
    • Gregor, M.F.1    Hotamisligil, G.S.2
  • 5
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • doi:10.1172/JCI57132
    • Lumeng CN, Saltiel AR (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121(6):2111-2117. doi:10.1172/JCI57132
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 6
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • doi:10.1038/nm.2627
    • Osborn O, Olefsky JM (2012) The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 18(3):363-374. doi:10.1038/nm.2627
    • (2012) Nat Med , vol.18 , Issue.3 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 7
    • 84862001089 scopus 로고    scopus 로고
    • Insulin resistance in the defense against obesity
    • doi:10.1016/j.cmet.2012.03.001
    • Saltiel AR (2012) Insulin resistance in the defense against obesity. Cell Metab 15(6):798-804. doi:10.1016/j.cmet.2012.03.001
    • (2012) Cell Metab , vol.15 , Issue.6 , pp. 798-804
    • Saltiel, A.R.1
  • 8
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • doi:10.1126/science.1230721
    • Odegaard JI, Chawla A (2013) Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science 339(6116):172-177. doi:10.1126/science.1230721
    • (2013) Science , vol.339 , Issue.6116 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 11
    • 43249092409 scopus 로고    scopus 로고
    • Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
    • DOI 10.1097/MOL.0b013e3282ff5e55, PII 0004143320080600000013
    • Choi SS, Diehl AM (2008) Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Curr Opin Lipidol 19(3):295-300 (Pubitemid 351653569)
    • (2008) Current Opinion in Lipidology , vol.19 , Issue.3 , pp. 295-300
    • Choi, S.S.1    Diehl, A.M.2
  • 12
    • 0024026298 scopus 로고
    • Lilly lecture, 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA (1988) Lilly lecture, 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes Care 37(6):667-687
    • (1988) Diabetes Care , vol.37 , Issue.6 , pp. 667-687
    • DeFronzo, R.A.1
  • 13
    • 0033779714 scopus 로고    scopus 로고
    • Free fatty acids and pathogenesis of type 2 diabetes mellitus
    • Bergman RN, Ader M (2000) Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 11(9):351-356
    • (2000) Trends Endocrinol Metab , vol.11 , Issue.9 , pp. 351-356
    • Bergman, R.N.1    Ader, M.2
  • 14
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259(5091):87-91 (Pubitemid 23036092)
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 16
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • DOI 10.1038/90992
    • Berg AH, Combs TP, Du X, Brownlee M, Scherer PE (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7(8):947-953. doi:10.1038/90992 (Pubitemid 32756433)
    • (2001) Nature Medicine , vol.7 , Issue.8 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 17
    • 84866133825 scopus 로고    scopus 로고
    • Adiponectin: Mechanistic insights and clinical implications
    • doi:10.1007/s00125-012-2598-x
    • Turer AT, Scherer PE (2012) Adiponectin: mechanistic insights and clinical implications. Diabetologia 55(9):2319-2326. doi:10.1007/s00125-012- 2598-x
    • (2012) Diabetologia , vol.55 , Issue.9 , pp. 2319-2326
    • Turer, A.T.1    Scherer, P.E.2
  • 18
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91 (Pubitemid 23036092)
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 19
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factoralpha in human obesity and insulin resistance
    • doi:10.1172/JCI117936
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM (1995) Increased adipose tissue expression of tumor necrosis factoralpha in human obesity and insulin resistance. J Clin Invest 95(5):2409-2415. doi:10.1172/JCI117936
    • (1995) J Clin Invest , vol.95 , Issue.5 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 20
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271(5249):665-668 (Pubitemid 26052915)
    • (1996) Science , vol.271 , Issue.5249 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 26
    • 32144454172 scopus 로고    scopus 로고
    • Mechanisms of disease: The many roles of chemokines and chemokine receptors in inflammation
    • DOI 10.1056/NEJMra052723
    • Charo IF, Ransohoff RM (2006) The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354(6):610-621. doi:10.1056/NEJMra052723 (Pubitemid 43209108)
    • (2006) New England Journal of Medicine , vol.354 , Issue.6 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 27
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • doi:10.1146/annurev-physiol-021909-135846
    • Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219-246. doi:10.1146/annurev-physiol-021909- 135846
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 29
    • 84880974817 scopus 로고    scopus 로고
    • Adipokines mediate inflammation and insulin resistance
    • doi:10.3389/fendo.2013.00071
    • Kwon H, Pessin JE (2013) Adipokines mediate inflammation and insulin resistance. Front Endocrinol 4:71. doi:10.3389/fendo.2013.00071
    • (2013) Front Endocrinol , vol.4 , pp. 71
    • Kwon, H.1    Pessin, J.E.2
  • 31
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • doi:10.1126/science.1201475
    • Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332(6026):243-247. doi:10.1126/science.1201475
    • (2011) Science , vol.332 , Issue.6026 , pp. 243-247
    • Wu, D.1    Molofsky, A.B.2    Liang, H.E.3    Ricardo-Gonzalez, R.R.4    Jouihan, H.A.5    Bando, J.K.6    Chawla, A.7    Locksley, R.M.8
  • 33
    • 84872142459 scopus 로고    scopus 로고
    • JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
    • doi:10.1126/science.1227568
    • Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ (2013) JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339(6116):218-222. doi:10.1126/science.1227568
    • (2013) Science , vol.339 , Issue.6116 , pp. 218-222
    • Han, M.S.1    Jung, D.Y.2    Morel, C.3    Lakhani, S.A.4    Kim, J.K.5    Flavell, R.A.6    Davis, R.J.7
  • 36
    • 13844298724 scopus 로고    scopus 로고
    • Endothelial inflammation in insulin resistance
    • DOI 10.1016/S0140-6736(05)17912-4
    • Sjoholm A, Nystrom T (2005) Endothelial inflammation in insulin resistance. Lancet 365(9459):610-612. doi:10.1016/S0140-6736(05)17912-4 (Pubitemid 40247919)
    • (2005) Lancet , vol.365 , Issue.9459 , pp. 610-612
    • Sjoholm, A.1    Nystrom, T.2
  • 37
    • 12344266697 scopus 로고    scopus 로고
    • How obesity causes diabetes: Not a tall tale
    • DOI 10.1126/science.1104342
    • Lazar MA (2005) How obesity causes diabetes: not a tall tale. Science 307(5708):373-375. doi:10.1126/science.1104342 (Pubitemid 40139971)
    • (2005) Science , vol.307 , Issue.5708 , pp. 373-375
    • Lazar, M.A.1
  • 38
    • 15944408334 scopus 로고    scopus 로고
    • A burning question: Does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?
    • DOI 10.2337/diabetes.54.4.917
    • Tataranni PA, Ortega E (2005) A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes? Diabetes 54(4):917-927 (Pubitemid 40446304)
    • (2005) Diabetes , vol.54 , Issue.4 , pp. 917-927
    • Tataranni, P.A.1    Ortega, E.2
  • 39
    • 9444246403 scopus 로고    scopus 로고
    • Association between inflammation and insulin resistance in U.S. nondiabetic adults: Results from the Third National Health and Nutrition Examination Survey
    • DOI 10.2337/diacare.27.12.2960
    • Chen J, Wildman RP, Hamm LL, Muntner P, Reynolds K, Whelton PK, He J (2004) Association between inflammation and insulin resistance in U.S. nondiabetic adults: results from the Third National Health and Nutrition Examination Survey. Diabetes Care 27:2960-2965 (Pubitemid 39565066)
    • (2004) Diabetes Care , vol.27 , Issue.12 , pp. 2960-2965
    • Chen, J.1    Wildman, R.P.2    Hamm, L.L.3    Muntner, P.4    Reynolds, K.5    Whelton, P.K.6    He, J.7
  • 40
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults
    • DOI 10.1056/NEJMoa021423
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348:1625-1638 (Pubitemid 36459468)
    • (2003) New England Journal of Medicine , vol.348 , Issue.17 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 41
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF- alpha function
    • DOI 10.1038/39335
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389(6651):610-614. doi:10.1038/39335 (Pubitemid 27446179)
    • (1997) Nature , vol.389 , Issue.6651 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 42
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • DOI 10.1126/science.1061620
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE (2001) Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 293(5535):1673-1677. doi:10.1126/science.1061620 (Pubitemid 32807849)
    • (2001) Science , vol.293 , Issue.5535 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.-W.5    Karin, M.6    Shoelson, S.E.7
  • 43
    • 0034770292 scopus 로고    scopus 로고
    • Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
    • DOI 10.1038/nm1001-1138
    • Perreault M, Marette A (2001) Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7(10):1138-1143. doi:10.1038/nm1001-1138 (Pubitemid 33010023)
    • (2001) Nature Medicine , vol.7 , Issue.10 , pp. 1138-1143
    • Perreault, M.1    Marette, A.2
  • 45
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • DOI 10.1038/nm1166
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11(2):183-190. doi:10.1038/nm1166 (Pubitemid 40321354)
    • (2005) Nature Medicine , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 46
    • 0034033372 scopus 로고    scopus 로고
    • Visceral fat and insulin resistance - causative or correlative?
    • Frayn KN (2000) Visceral fat and insulin resistance - causative or correlative? Br J Nutr 83(Suppl 1):S71-S77
    • (2000) Br J Nutr , vol.83 , Issue.SUPPL. 1
    • Frayn, K.N.1
  • 49
    • 0034751858 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate-1: A novel target for the reversal of insulin resistance
    • DOI 10.1210/me.15.11.1864
    • Sykiotis GP, Papavassiliou AG (2001) Serine phosphorylation of insulin receptor substrate-1: a novel target for the reversal of insulin resistance. Mol Endocrinol 15:1864-1869 (Pubitemid 33022527)
    • (2001) Molecular Endocrinology , vol.15 , Issue.11 , pp. 1864-1869
    • Sykiotis, G.P.1    Papavassiliou, A.G.2
  • 50
    • 0348049842 scopus 로고    scopus 로고
    • Fatty acid-induced insulin resistance: Role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling
    • Le Marchand-Brustel Y, Gual P, Gremeaux T, Gonzalez T, Barres R, Tanti JF (2003) Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling. Biochem Soc Trans 31:1152-1156 (Pubitemid 38030928)
    • (2003) Biochemical Society Transactions , vol.31 , Issue.6 , pp. 1152-1156
    • Le M.-Brustel, Y.1    Gual, P.2    Gremeaux, T.3    Gonzalez, T.4    Barres, R.5    Tanti, J.-F.6
  • 51
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • doi:10.1016/j.cell.2010.02.034
    • Hotamisligil GS (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140(6):900-917. doi:10.1016/j.cell.2010.02.034
    • (2010) Cell , vol.140 , Issue.6 , pp. 900-917
    • Hotamisligil, G.S.1
  • 52
    • 79953005424 scopus 로고    scopus 로고
    • Inflammation and insulin resistance: An old story with new ideas
    • doi:10.4093/kdj.2010.34.3.137
    • Kim JK (2010) Inflammation and insulin resistance: an old story with new ideas. Korean Diabetes J 34(3):137-145. doi:10.4093/kdj.2010.34.3.137
    • (2010) Korean Diabetes J , vol.34 , Issue.3 , pp. 137-145
    • Kim, J.K.1
  • 53
    • 0348049842 scopus 로고    scopus 로고
    • Fatty acid-induced insulin resistance: Role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling
    • doi:10.1042
    • Le Marchand-Brustel Y, Gual P, Gremeaux T, Gonzalez T, Barres R, Tanti JF (2003) Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling. Biochem Soc Trans 31(Pt 6):1152-1156. doi:10.1042/
    • (2003) Biochem Soc Trans , vol.31 , Issue.PART 6 , pp. 1152-1156
    • Le Marchand-Brustel, Y.1    Gual, P.2    Gremeaux, T.3    Gonzalez, T.4    Barres, R.5    Tanti, J.F.6
  • 54
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • DOI 10.1038/nm1166
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11:183-190 (Pubitemid 40321354)
    • (2005) Nature Medicine , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 55
    • 0026549669 scopus 로고
    • Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
    • Lang CH, Dobrescu C, Bagby GJ (1992) Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 130(1):43-52
    • (1992) Endocrinology , vol.130 , Issue.1 , pp. 43-52
    • Lang, C.H.1    Dobrescu, C.2    Bagby, G.J.3
  • 56
    • 0036010030 scopus 로고    scopus 로고
    • Effects of TNF-alpha on glucose metabolism and lipolysis in adipose tissue and isolated fat-cell preparations
    • DOI 10.1067/mlc.2002.121552
    • Porter MH, Cutchins A, Fine JB, Bai Y, DiGirolamo M (2002) Effects of TNF-alpha on glucosemetabolism and lipolysis in adipose tissue and isolated fat-cell preparations. J Lab Clin Med 139(3):140-146 (Pubitemid 34286950)
    • (2002) Journal of Laboratory and Clinical Medicine , vol.139 , Issue.3 , pp. 140-146
    • Porter, M.H.1    Cutchins, A.2    Fine, J.B.3    Bai, Y.4    Digirolamo, M.5
  • 57
    • 0027332738 scopus 로고
    • Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
    • Feinstein R, Kanety H, Papa MZ, Lunenfeld B, Karasik A (1993) Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem 268(35):26055-26058
    • (1993) J Biol Chem , vol.268 , Issue.35 , pp. 26055-26058
    • Feinstein, R.1    Kanety, H.2    Papa, M.Z.3    Lunenfeld, B.4    Karasik, A.5
  • 58
    • 29244465117 scopus 로고    scopus 로고
    • Fat as an endocrine organ: Relationship to the metabolic syndrome
    • Hutley L, Prins JB (2005) Fat as an endocrine organ: relationship to the metabolic syndrome. Am J Med Sci 330(6):280-289 (Pubitemid 41831898)
    • (2005) American Journal of the Medical Sciences , vol.330 , Issue.6 , pp. 280-289
    • Hutley, L.1    Prins, J.B.2
  • 61
    • 34047155003 scopus 로고    scopus 로고
    • Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
    • DOI 10.2337/db06-1656
    • Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S (2007) Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes 56(4):1010-1013. doi:10.2337/db06-1656 (Pubitemid 46525079)
    • (2007) Diabetes , vol.56 , Issue.4 , pp. 1010-1013
    • Fontana, L.1    Eagon, J.C.2    Trujillo, M.E.3    Scherer, P.E.4    Klein, S.5
  • 62
    • 0037853260 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    • DOI 10.1074/jbc.M210689200
    • Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA (2003) Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem 278(16):13740-13746. doi:10.1074/jbc.M210689200 (Pubitemid 36799910)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 13740-13746
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Zimmers, T.A.4    Koniaris, L.G.5    Furlanetto, R.W.6    Mooney, R.A.7
  • 65
    • 84883294068 scopus 로고    scopus 로고
    • Interleukin-6 and obesity: The crosstalk between intestine, pancreas and liver
    • doi :10.1097/MCO.0b013e32836410e6
    • El-Kadre LJ, Tinoco AC (2013) Interleukin-6 and obesity: the crosstalk between intestine, pancreas and liver. Curr Opin Clin Nutr Metab Care 16(5):564-568. doi :10.1097/MCO.0b013e32836410e6
    • (2013) Curr Opin Clin Nutr Metab Care , vol.16 , Issue.5 , pp. 564-568
    • El-Kadre, L.J.1    Tinoco, A.C.2
  • 68
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • DOI 10.1038/372425a0
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372(6505):425-432. doi:10.1038/372425a0 (Pubitemid 24365442)
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 69
    • 0033586747 scopus 로고    scopus 로고
    • The role of leptin in human obesity and disease: A review of current evidence
    • Mantzoros CS (1999) The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 130(8):671-680
    • (1999) Ann Intern Med , vol.130 , Issue.8 , pp. 671-680
    • Mantzoros, C.S.1
  • 70
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation- induced immunosuppression
    • DOI 10.1038/29795
    • Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394(6696):897-901. doi:10.1038/29795 (Pubitemid 28410912)
    • (1998) Nature , vol.394 , Issue.6696 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 73
    • 84870172217 scopus 로고    scopus 로고
    • TNF-alpha up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism
    • doi:10.1210/en.2012-1510
    • Gan L, Guo K, Cremona ML, McGraw TE, Leibel RL, Zhang Y (2012) TNF-alpha up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism. Endocrinology 153(12):5821-5833. doi:10.1210/en.2012-1510
    • (2012) Endocrinology , vol.153 , Issue.12 , pp. 5821-5833
    • Gan, L.1    Guo, K.2    Cremona, M.L.3    McGraw, T.E.4    Leibel, R.L.5    Zhang, Y.6
  • 74
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • DOI 10.1172/JCI29126
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116(7):1784-1792. doi:10.1172/JCI29126 (Pubitemid 44033298)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.7 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 76
    • 67650169799 scopus 로고    scopus 로고
    • Adiponectin levels and risk of type 2 diabetes: A systematic review and meta-analysis
    • doi:10.1001/jama.2009.976
    • Li S, Shin HJ, Ding EL, van Dam RM (2009) Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 302(2):179-188. doi:10.1001/jama.2009.976
    • (2009) JAMA , vol.302 , Issue.2 , pp. 179-188
    • Li, S.1    Shin, H.J.2    Ding, E.L.3    Van Dam, R.M.4
  • 78
    • 0034284038 scopus 로고    scopus 로고
    • Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    • Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, Kihara S, Funahashi T, Tenner AJ, Tomiyama Y, Matsuzawa Y (2000) Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions ofmacrophages. Blood 96(5):1723-1732 (Pubitemid 30661055)
    • (2000) Blood , vol.96 , Issue.5 , pp. 1723-1732
    • Yokota, T.1    Oritani, K.2    Takahashi, I.3    Ishikawa, J.4    Matsuyama, A.5    Ouchi, N.6    Kihara, S.7    Funahashi, T.8    Tenner, A.J.9    Tomiyama, Y.10    Matsuzawa, Y.11
  • 82
    • 17844396206 scopus 로고    scopus 로고
    • Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes
    • DOI 10.1152/ajpregu.00397.2004
    • Ajuwon KM, Spurlock ME (2005) Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol 288(5):R1220-R1225. doi:10.1152/ajpregu.00397.2004 (Pubitemid 40593705)
    • (2005) American Journal of Physiology - Regulatory Integrative and Comparative Physiology , vol.288 , Issue.5
    • Ajuwon, K.M.1    Spurlock, M.E.2
  • 83
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • DOI 10.1002/hep.20920
    • Bugianesi E, McCullough AJ, Marchesini G (2005) Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42(5):987-1000. doi:10.1002/hep.20920 (Pubitemid 43112663)
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 86
    • 18144375989 scopus 로고    scopus 로고
    • Adiponectin: A key fat-derived molecule regulating inflammation
    • DOI 10.1517/14728222.9.2.245
    • Tilg H, Wolf AM (2005) Adiponectin: a key fat-derived molecule regulating inflammation. Expert Opin Ther 9(2):245-251. doi:10.1517/14728222.9.2.245 (Pubitemid 40613866)
    • (2005) Expert Opinion on Therapeutic Targets , vol.9 , Issue.2 , pp. 245-251
    • Tilg, H.1    Wolf, A.M.2
  • 87
    • 33745239304 scopus 로고    scopus 로고
    • Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver
    • Boden G (2006) Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver. Curr Diab Rep 6:177-181
    • (2006) Curr Diab Rep , vol.6 , pp. 177-181
    • Boden, G.1
  • 88
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM (1995) Pathophysiology of insulin resistance in human disease. Physiol Rev 75:473-486
    • (1995) Physiol Rev , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 89
    • 0002031490 scopus 로고    scopus 로고
    • Insulin resistance, lipid and fatty acid concentrations in 867 healthy Europeans
    • DOI 10.1046/j.1365-2362.2000.00597.x
    • Baldeweg SE, Golay A, Natali A, Balkau B, Del Prato S, Coppack SW (2000) Insulin resistance, lipid and fatty acid concentrations in 867 healthy Europeans. European Group for the Study of Insulin Resistance (EGIR). Eur J Clin Invest 30:45-52 (Pubitemid 30071856)
    • (2000) European Journal of Clinical Investigation , vol.30 , Issue.1 , pp. 45-52
    • Baldeweg, S.E.1    Golay, A.2    Natali, A.3    Balkau, B.4    Del, P.S.5    Coppack, S.W.6
  • 90
    • 0030759095 scopus 로고    scopus 로고
    • The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: Results of the Paris Prospective study
    • DOI 10.1007/s001250050793
    • Charles MA, Eschwege E, Thibult N, Claude JR, Warnet JM, Rosselin GE, Girard J, Balkau B (1997) The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia 40:1101-1106 (Pubitemid 27381974)
    • (1997) Diabetologia , vol.40 , Issue.9 , pp. 1101-1106
    • Charles, M.A.1    Eschwege, E.2    Thibult, N.3    Claude, J.-R.4    Warnet, J.-M.5    Rosselin, G.E.6    Girard, J.7    Balkau, B.8
  • 92
    • 0018596025 scopus 로고
    • Regional differences in the control of lipolysis in human adipose tissue
    • DOI 10.1016/0026-0495(79)90131-8
    • Ostman J, Arner P, Engfeldt P, Kager L (1979) Regional differences in the control of lipolysis in human adipose tissue. Metabolism 28:1198-1205 (Pubitemid 10181708)
    • (1979) Metabolism: Clinical and Experimental , vol.28 , Issue.12 , pp. 1198-1205
    • Ostman, J.1    Arner, P.2    Engfeldt, P.3    Kager, L.4
  • 93
    • 0036217052 scopus 로고    scopus 로고
    • Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes
    • DOI 10.1210/er.23.2.201
    • Lewis GF, Carpentier A, Adeli K, Giacca A (2002) Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23(2):201-229 (Pubitemid 34299024)
    • (2002) Endocrine Reviews , vol.23 , Issue.2 , pp. 201-229
    • Lewis, G.F.1    Carpentier, A.2    Adeli, K.3    Giacca, A.4
  • 94
    • 0842263981 scopus 로고    scopus 로고
    • The biology of peroxisome proliferator-activated receptors: Relationship with lipid metabolism and insulin sensitivity
    • Ferre P (2004) The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53(Suppl 1):S43-S50
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Ferre, P.1
  • 95
    • 0031014830 scopus 로고    scopus 로고
    • Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
    • Boden G (1997) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46:3-10
    • (1997) Diabetes , vol.46 , pp. 3-10
    • Boden, G.1
  • 96
    • 0033779714 scopus 로고    scopus 로고
    • Free fatty acids and pathogenesis of type 2 diabetes mellitus
    • Bergman RN, Ader M (2000) Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol Metab 11:351-356
    • (2000) Trends Endocrinol Metab , vol.11 , pp. 351-356
    • Bergman, R.N.1    Ader, M.2
  • 97
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin K, Steil GM, Getty L, Bergman RN (1995) Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44(9):1038-1045
    • (1995) Diabetes , vol.44 , Issue.9 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 98
    • 1442352339 scopus 로고    scopus 로고
    • Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
    • DOI 10.1210/jc.2003-030723
    • Bays H, Mandarino L, DeFronzo RA (2004) Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 89:463-478, Review (Pubitemid 38269844)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.2 , pp. 463-478
    • Bays, H.1    Mandarino, L.2    DeFronzo, R.A.3
  • 100
    • 0013923479 scopus 로고
    • Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
    • Williamson JR, Kreisberg RA, Felts PW (1966) Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci U S A 56:247-254
    • (1966) Proc Natl Acad Sci U S A , vol.56 , pp. 247-254
    • Williamson, J.R.1    Kreisberg, R.A.2    Felts, P.W.3
  • 101
    • 0031031276 scopus 로고    scopus 로고
    • Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion
    • Massillon D, Barzilai N, Hawkins M, Prus-Wertheimer D, Rossetti L (1997) Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion. Diabetes 46(1):153-157 (Pubitemid 27009965)
    • (1997) Diabetes , vol.46 , Issue.1 , pp. 153-157
    • Massillon, D.1    Barzilai, N.2    Hawkins, M.3    Prus-Wertheimer, D.4    Rossetti, L.5
  • 102
    • 0030689043 scopus 로고    scopus 로고
    • Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding
    • Oakes ND, Cooney GJ, Camilleri S, Chisholm DJ, Kraegen EW (1997) Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding. Diabetes 46:1768-1774 (Pubitemid 27456409)
    • (1997) Diabetes , vol.46 , Issue.11 , pp. 1768-1774
    • Oakes, N.D.1    Cooney, G.J.2    Camilleri, S.3    Chisholm, D.J.4    Kraegen, E.W.5
  • 103
    • 0031731373 scopus 로고    scopus 로고
    • Hyperglycemia-induced inhibition of splanchnic fatty acid oxidation increases hepatic triacylglycerol secretion
    • Sidossis LS, Mittendorfer B, Walser E, Chinkes D, Wolfe RR (1998) Hyperglycemia-induced inhibition of splanchnic fatty acid oxidation increases hepatic triacylglycerol secretion. Am J Physiol 275:E798-E805
    • (1998) Am J Physiol , vol.275
    • Sidossis, L.S.1    Mittendorfer, B.2    Walser, E.3    Chinkes, D.4    Wolfe, R.R.5
  • 105
    • 0033656589 scopus 로고    scopus 로고
    • Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response
    • Mittelman SD, Van Citters GW, Kim SP, Davis DA, Dea MK, Hamilton-Wessler M, Bergman RN (2000) Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response. Diabetes 49:2116-2125
    • (2000) Diabetes , vol.49 , pp. 2116-2125
    • Mittelman, S.D.1    Van Citters, G.W.2    Kim, S.P.3    Davis, D.A.4    Dea, M.K.5    Hamilton-Wessler, M.6    Bergman, R.N.7
  • 106
    • 50549202600 scopus 로고
    • The glucose-fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Hales CN, Garland PB, Newsholm EA (1963) The glucose-fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1:785-789
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Hales, C.N.2    Garland, P.B.3    Newsholm, E.A.4
  • 107
    • 15544387164 scopus 로고    scopus 로고
    • Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: Implications for controlling dietary carbohydrates: A review
    • Lond
    • Freedland ES (2004) Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review. Nutr Metab (Lond) 1:12
    • (2004) Nutr Metab , vol.1 , pp. 12
    • Freedland, E.S.1
  • 108
    • 15544387164 scopus 로고    scopus 로고
    • Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: Implications for controlling dietary carbohydrates: A review
    • Lond doi:10.1186/1743-7075-1-12
    • Freedland ES (2004) Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review. NutrMetab (Lond) 1(1):12. doi:10.1186/1743-7075-1-12
    • (2004) NutrMetab , vol.1 , Issue.1 , pp. 12
    • Freedland, E.S.1
  • 109
    • 0042093781 scopus 로고    scopus 로고
    • Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: Reversal with weight reduction
    • DOI 10.2337/diabetes.52.8.1935
    • Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB (2003) Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction. Diabetes 52:1935-1942 (Pubitemid 36919784)
    • (2003) Diabetes , vol.52 , Issue.8 , pp. 1935-1942
    • Kim, Y.-B.1    Kotani, K.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 111
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • doi:10.1002/hep.20973
    • Farrell GC, Larter CZ (2006) Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43(2 Suppl 1):S99-S112. doi:10.1002/hep.20973
    • (2006) Hepatology , vol.43 , Issue.2 SUPPL. 1
    • Farrell, G.C.1    Larter, C.Z.2
  • 112
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • doi:10.1126/science.1204265
    • Cohen JC, Horton JD, Hobbs HH (2011) Human fatty liver disease: old questions and new insights. Science 332(6037):1519-1523. doi:10.1126/science. 1204265
    • (2011) Science , vol.332 , Issue.6037 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 113
    • 33748150370 scopus 로고    scopus 로고
    • Pathophysiology of nonalcoholic steatohepatitis
    • doi:10.1097/01.mcg.0000168645.86658.22
    • McCullough AJ (2006) Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 40(Suppl 1):S17-S29. doi:10.1097/01.mcg.0000168645.86658.22
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL. 1
    • McCullough, A.J.1
  • 114
    • 0036841764 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: What we know in the new millennium
    • PII S0002927002054862
    • Harrison SA, Kadakia S, Lang KA, Schenker S (2002) Nonalcoholic steatohepatitis: what we know in the new millennium. Am J Gastroenterol 97(11):2714-2724. doi:10.1111/j.1572-0241.2002.07069.x (Pubitemid 35265419)
    • (2002) American Journal of Gastroenterology , vol.97 , Issue.11 , pp. 2714-2724
    • Harrison, S.A.1    Kadakia, S.2    Lang, K.A.3    Schenker, S.4
  • 115
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW (1990) The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 11(1):74-80 (Pubitemid 20075105)
    • (1990) Hepatology , vol.11 , Issue.1 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.E.2    Hanson, R.3    Searle, J.4    Halliday, J.W.5    Powell, L.W.6
  • 116
    • 0043268063 scopus 로고    scopus 로고
    • Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C
    • DOI 10.1053/jhep.2003.50320
    • Hui JM, Kench JG, Chitturi S, Sud A, Farrell GC, Byth K, Hall P, Khan M, George J (2003) Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C. Hepatology 38(2):420-427. doi:10.1053/jhep.2003.50320 (Pubitemid 36919863)
    • (2003) Hepatology , vol.38 , Issue.2 , pp. 420-427
    • Hui, J.M.1    Kench, J.G.2    Chitturi, S.3    Sud, A.4    Farrell, G.C.5    Byth, K.6    Hall, P.7    Khan, M.8    George, J.9
  • 117
    • 29244444549 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and the metabolic syndrome
    • Neuschwander-Tetri BA (2005) Nonalcoholic steatohepatitis and the metabolic syndrome. Am J Med Sci 330(6):326-335
    • (2005) Am J Med Sci , vol.330 , Issue.6 , pp. 326-335
    • Neuschwander-Tetri, B.A.1
  • 118
    • 33746383056 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Pathologic features and differential diagnosis
    • Brunt EM (2005) Nonalcoholic steatohepatitis: pathologic features and differential diagnosis. Semin Diagn Pathol 22:330-338
    • (2005) Semin Diagn Pathol , vol.22 , pp. 330-338
    • Brunt, E.M.1
  • 120
    • 39149104311 scopus 로고    scopus 로고
    • Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis
    • doi:10.1016/j.molmed.2007.12.003
    • Marra F, Gastaldelli A, Svegliati Baroni G, Tell G, Tiribelli C (2008) Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis. Trends Mol Med 14(2):72-81. doi:10.1016/j.molmed.2007.12.003
    • (2008) Trends Mol Med , vol.14 , Issue.2 , pp. 72-81
    • Marra, F.1    Gastaldelli, A.2    Svegliati Baroni, G.3    Tell, G.4    Tiribelli, C.5
  • 121
    • 84864081494 scopus 로고    scopus 로고
    • Features, diagnosis, and treatment of nonalcoholic fatty liver disease
    • doi:10.1016/j.cgh.2012.03.011
    • Torres DM, Williams CD, Harrison SA (2012) Features, diagnosis, and treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 10(8):837-858. doi:10.1016/j.cgh.2012.03.011
    • (2012) Clin Gastroenterol Hepatol , vol.10 , Issue.8 , pp. 837-858
    • Torres, D.M.1    Williams, C.D.2    Harrison, S.A.3
  • 122
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF (1998) Steatohepatitis: a tale of two "hits"? Gastroenterology 114:842-845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 123
    • 0036780582 scopus 로고    scopus 로고
    • Pathogenesis of steatohepatitis
    • Day CP (2002) Pathogenesis of steatohepatitis. Best Pract Res Clin Gastroenterol 16(5):663-678
    • (2002) Best Pract Res Clin Gastroenterol , vol.16 , Issue.5 , pp. 663-678
    • Day, C.P.1
  • 125
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • DOI 10.1053/j.gastro.2005.04.014, PII S0016508505006943
    • Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, Angulo P (2005) The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 129:113-121 (Pubitemid 41002048)
    • (2005) Gastroenterology , vol.129 , Issue.1 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St., S.J.3    Sanderson, S.O.4    Lindor, K.D.5    Feldstein, A.6    Angulo, P.7
  • 127
    • 0037785066 scopus 로고    scopus 로고
    • NASH-hepatic metabolism and not simply the metabolic syndrome
    • doi:10.1053/jhep.2003.50325
    • Green RM (2003) NASH-hepatic metabolism and not simply the metabolic syndrome. Hepatology 38(1):14-17. doi:10.1053/jhep.2003.50325
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 14-17
    • Green, R.M.1
  • 128
    • 66349125337 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • doi:10.1194/jlr.R800089-JLR200
    • Erickson SK (2009) Nonalcoholic fatty liver disease. J Lipid Res 50(Suppl):S412-S416. doi:10.1194/jlr.R800089-JLR200
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Erickson, S.K.1
  • 129
    • 0037124084 scopus 로고    scopus 로고
    • Complexity in the secretory pathway: The assembly and secretion of apolipoprotein B-containing lipoproteins
    • DOI 10.1074/jbc.R100068200
    • Fisher EA, Ginsberg HN (2002) Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins. J Biol Chem 277(20):17377-17380 (Pubitemid 34967535)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.20 , pp. 17377-17380
    • Fisher, E.A.1    Ginsberg, H.N.2
  • 130
    • 45549104962 scopus 로고    scopus 로고
    • The Double Life of Irs
    • DOI 10.1016/j.cmet.2008.06.010, PII S1550413108001812
    • Haeusler RA, Accili D (2008) The double life of Irs. Cell Metab 8(1):7-9. doi:10.1016/j.cmet.2008.06.010 (Pubitemid 351859234)
    • (2008) Cell Metabolism , vol.8 , Issue.1 , pp. 7-9
    • Haeusler, R.A.1    Accili, D.2
  • 131
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus Total Insulin Resistance: A Pathogenic Paradox
    • DOI 10.1016/j.cmet.2007.12.009, PII S1550413107003828
    • Brown MS, Goldstein JL (2008) Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 7(2):95-96. doi:10.1016/j.cmet.2007.12.009 (Pubitemid 351168559)
    • (2008) Cell Metabolism , vol.7 , Issue.2 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 132
    • 78649393986 scopus 로고    scopus 로고
    • Pediatric nonalcoholic fatty liver disease: Overview with emphasis on histology
    • Takahashi Y, Fukusato T (2010) Pediatric nonalcoholic fatty liver disease: overview with emphasis on histology. World J Gastroenterol 16(42):5280-5285
    • (2010) World J Gastroenterol , vol.16 , Issue.42 , pp. 5280-5285
    • Takahashi, Y.1    Fukusato, T.2
  • 133
    • 84865126374 scopus 로고    scopus 로고
    • Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: A multicenter large retrospective study
    • doi:10.1007/s00535-012-0533-z
    • Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T (2012) Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. J Gastroenterol 47(5):586-595. doi:10.1007/s00535-012-0533-z
    • (2012) J Gastroenterol , vol.47 , Issue.5 , pp. 586-595
    • Eguchi, Y.1    Hyogo, H.2    Ono, M.3    Mizuta, T.4    Ono, N.5    Fujimoto, K.6    Chayama, K.7    Saibara, T.8
  • 134
    • 0033539272 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis
    • doi:10.1016/S0140-6736(05)76068-2
    • Knobler H, Schattner A (1999) Non-alcoholic steatohepatitis. Lancet 354(9186):1298-1299. doi:10.1016/S0140-6736(05)76068-2
    • (1999) Lancet , vol.354 , Issue.9186 , pp. 1298-1299
    • Knobler, H.1    Schattner, A.2
  • 135
    • 10044271037 scopus 로고    scopus 로고
    • SREBP transcription factors: Master regulators of lipid homeostasis
    • DOI 10.1016/j.biochi.2004.09.018, PII S0300908404001658, Recent Advances in Lipid Metabolism and Related Disorders
    • Eberle D, Hegarty B, Bossard P, Ferre P, Foufelle F (2004) SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86(11):839-848 (Pubitemid 39602764)
    • (2004) Biochimie , vol.86 , Issue.11 , pp. 839-848
    • Eberle, D.1    Hegarty, B.2    Bossard, P.3    Ferre, P.4    Foufelle, F.5
  • 136
    • 33846821856 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predisposing factors and the role of nutrition
    • DOI 10.1016/j.jnutbio.2006.12.006, PII S0955286306002737
    • Cave M, Deaciuc I, Mendez C, Song Z, Joshi-Barve S, Barve S, McClain C (2007) Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. J Nutr Biochem 18(3):184-195. doi:10.1016/j.jnutbio.2006.12.006 (Pubitemid 46216810)
    • (2007) Journal of Nutritional Biochemistry , vol.18 , Issue.3 , pp. 184-195
    • Cave, M.1    Deaciuc, I.2    Mendez, C.3    Song, Z.4    Joshi-Barve, S.5    Barve, S.6    McClain, C.7
  • 137
    • 0037785066 scopus 로고    scopus 로고
    • NASH-hepatic metabolism and not simply the metabolic syndrome
    • Green RM (2003) NASH-hepatic metabolism and not simply the metabolic syndrome. Hepatology 38(1):14-17
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 14-17
    • Green, R.M.1
  • 138
    • 35448963836 scopus 로고    scopus 로고
    • Nonalcoholic Fatty Liver Disease as a Complication of Insulin Resistance
    • DOI 10.1016/j.mcna.2007.06.001, PII S0025712507000740, Metabolic Syndrome
    • Abdelmalek MF, Diehl AM (2007) Nonalcoholic fatty liver disease as a complication of insulin resistance. Med Clin North Am 91:1125-1149, ix (Pubitemid 47625434)
    • (2007) Medical Clinics of North America , vol.91 , Issue.6 , pp. 1125-1149
    • Abdelmalek, M.F.1    Diehl, A.M.2
  • 139
    • 34247844680 scopus 로고    scopus 로고
    • Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: Implications for the pathogenesis of human nonalcoholic steatohepatitis
    • DOI 10.2353/ajpath.2007.060441
    • Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Ikura Y, Ueda M, Arakawa T, Hato F, Kawada N (2007) Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. Am J Pathol 170:967-980 (Pubitemid 47339365)
    • (2007) American Journal of Pathology , vol.170 , Issue.3 , pp. 967-980
    • Otogawa, K.1    Kinoshita, K.2    Fujii, H.3    Sakabe, M.4    Shiga, R.5    Nakatani, K.6    Ikeda, K.7    Nakajima, Y.8    Ikura, Y.9    Ueda, M.10    Arakawa, T.11    Hato, F.12    Kawada, N.13
  • 140
    • 0036022846 scopus 로고    scopus 로고
    • Leptin is essential for the hepatic fibrogenic response to chronic liver injury
    • DOI 10.1016/S0168-8278(02)00102-2, PII S0168827802001022
    • Leclercq IA, Farrell GC, Schriemer R, Robertson GR (2002) Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 37(2):206-213 (Pubitemid 34833082)
    • (2002) Journal of Hepatology , vol.37 , Issue.2 , pp. 206-213
    • Leclercq, I.A.1    Farrell, G.C.2    Schriemer, R.3    Robertson, G.R.4
  • 141
    • 14844340146 scopus 로고    scopus 로고
    • Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue
    • DOI 10.1128/MCB.25.6.2498-2510.2005
    • Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H (2005) Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol 25(6):2498-2510. doi:10.1128/MCB.25.6.2498-2510.2005 (Pubitemid 40354642)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.6 , pp. 2498-2510
    • Kurlawalla-Martinez, C.1    Stiles, B.2    Wang, Y.3    Devaskar, S.U.4    Kahn, B.B.5    Wu, H.6
  • 142
    • 33947264902 scopus 로고    scopus 로고
    • Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis
    • DOI 10.1016/j.metabol.2006.11.004, PII S002604950600429X
    • Nakayama H, Otabe S, Ueno T, Hirota N, Yuan X, Fukutani T, Hashinaga T, Wada N, Yamada K (2007) Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis. Metabolism 56:470-475 (Pubitemid 46427843)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.4 , pp. 470-475
    • Nakayama, H.1    Otabe, S.2    Ueno, T.3    Hirota, N.4    Yuan, X.5    Fukutani, T.6    Hashinaga, T.7    Wada, N.8    Yamada, K.9
  • 145
    • 0346689994 scopus 로고    scopus 로고
    • The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
    • DOI 10.1016/j.jhep.2003.09.020
    • Rinella ME, Green RM (2004) The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 40:47-51 (Pubitemid 38064712)
    • (2004) Journal of Hepatology , vol.40 , Issue.1 , pp. 47-51
    • Rinella, M.E.1    Green, R.M.2
  • 146
    • 0742306111 scopus 로고    scopus 로고
    • CYP2E1: From ASH to NASH
    • Lieber CS (2004) CYP2E1: from ASH to NASH. Hepatol Res 28:1-11
    • (2004) Hepatol Res , vol.28 , pp. 1-11
    • Lieber, C.S.1
  • 148
    • 18244375243 scopus 로고    scopus 로고
    • Fructose-induced fatty liver disease: Hepatic effects of blood pressure and plasma triglyceride reduction
    • DOI 10.1161/01.HYP.0000164570.20420.67
    • Ackerman Z, Oron-Herman M, Grozovski M, Rosenthal T, Pappo O, Link G, Sela BA (2005) Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction. Hypertension 45(5):1012-1018. doi:10.1161/01.HYP.0000164570.20420.67 (Pubitemid 40628952)
    • (2005) Hypertension , vol.45 , Issue.5 , pp. 1012-1018
    • Ackerman, Z.1    Oron-Herman, M.2    Grozovski, M.3    Rosenthal, T.4    Pappo, O.5    Link, G.6    Sela, B.-A.7
  • 149
    • 84874618646 scopus 로고    scopus 로고
    • Fructose as a key player in the development of fatty liver disease
    • doi:10.3748/wjg.v19.i8.1166
    • Basaranoglu M, Basaranoglu G, Sabuncu T, Senturk H (2013) Fructose as a key player in the development of fatty liver disease. World J Gastroenterol 19(8):1166-1172. doi:10.3748/wjg.v19.i8.1166
    • (2013) World J Gastroenterol , vol.19 , Issue.8 , pp. 1166-1172
    • Basaranoglu, M.1    Basaranoglu, G.2    Sabuncu, T.3    Senturk, H.4
  • 151
    • 80053910309 scopus 로고    scopus 로고
    • JNKs, insulin resistance and inflammation: A possible link between NAFLD and coronary artery disease
    • doi:10.3748/wjg.v17.i33.3785
    • Tarantino G, Caputi A (2011) JNKs, insulin resistance and inflammation: a possible link between NAFLD and coronary artery disease. World J Gastroenterol 17(33):3785-3794. doi:10.3748/wjg.v17.i33.3785
    • (2011) World J Gastroenterol , vol.17 , Issue.33 , pp. 3785-3794
    • Tarantino, G.1    Caputi, A.2
  • 154
    • 22544480378 scopus 로고    scopus 로고
    • "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis
    • DOI 10.1016/j.cmet.2005.04.002, PII S1550413105001105
    • Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF (2005) "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 1(5):309-322. doi:10.1016/j.cmet.2005.04.002 (Pubitemid 43977168)
    • (2005) Cell Metabolism , vol.1 , Issue.5 , pp. 309-322
    • Chakravarthy, M.V.1    Pan, Z.2    Zhu, Y.3    Tordjman, K.4    Schneider, J.G.5    Coleman, T.6    Turk, J.7    Semenkovich, C.F.8
  • 158
    • 27744458510 scopus 로고    scopus 로고
    • NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • DOI 10.1053/j.gastro.2005.09.004, PII S0016508505017889
    • Dela Pena A, Leclercq I, Field J, George J, Jones B, Farrell G (2005) NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 129:1663-1674 (Pubitemid 41597405)
    • (2005) Gastroenterology , vol.129 , Issue.5 , pp. 1663-1674
    • Dela Pena, A.1    Leclercq, I.2    Field, J.3    George, J.4    Jones, B.5    Farrell, G.6
  • 159
    • 30044431801 scopus 로고    scopus 로고
    • From fat to inflammation
    • Day CP (2006) From fat to inflammation. Gastroenterology 130:207-210
    • (2006) Gastroenterology , vol.130 , pp. 207-210
    • Day, C.P.1
  • 161
    • 57049146350 scopus 로고    scopus 로고
    • ER stress and lipogenesis: A slippery slope toward hepatic steatosis
    • doi:10.1016/j.devcel.2008.11.013
    • Basseri S, Austin RC (2008) ER stress and lipogenesis: a slippery slope toward hepatic steatosis. Dev Cell 15(6):795-796. doi:10.1016/j.devcel.2008.11. 013
    • (2008) Dev Cell , vol.15 , Issue.6 , pp. 795-796
    • Basseri, S.1    Austin, R.C.2
  • 163
    • 40749083206 scopus 로고    scopus 로고
    • Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury
    • doi:10.1111/j.1440-1746.2007.05276.x
    • Ji C (2008) Dissection of endoplasmic reticulum stress signaling in alcoholic and non-alcoholic liver injury. J Gastroenterol Hepatol 23(Suppl 1):S16-S24. doi:10.1111/j.1440-1746.2007.05276.x
    • (2008) J Gastroenterol Hepatol , vol.23 , Issue.SUPPL. 1
    • Ji, C.1
  • 166
    • 58249093873 scopus 로고    scopus 로고
    • Induction of hepatitis by JNK-mediated expression of TNF-alpha
    • doi:10.1016/j.cell.2008.11.017
    • Das M, Sabio G, Jiang F, Rincon M, Flavell RA, Davis RJ (2009) Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136(2):249-260. doi:10.1016/j.cell.2008.11.017
    • (2009) Cell , vol.136 , Issue.2 , pp. 249-260
    • Das, M.1    Sabio, G.2    Jiang, F.3    Rincon, M.4    Flavell, R.A.5    Davis, R.J.6
  • 167
    • 35748931783 scopus 로고    scopus 로고
    • The roles of innate immune cells in liver injury and regeneration
    • Dong Z, Wei H, Sun R, Tian Z (2007) The roles of innate immune cells in liver injury and regeneration. Cell Mol Immunol 4(4):241-252
    • (2007) Cell Mol Immunol , vol.4 , Issue.4 , pp. 241-252
    • Dong, Z.1    Wei, H.2    Sun, R.3    Tian, Z.4
  • 168
    • 0036083787 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines
    • doi:10.1152/ajpgi.00384.2001
    • Diehl AM (2002) Nonalcoholic steatosis and steatohepatitis IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines. Am J Physiol Gastrointest Liver Physiol 282(1):G1-G5. doi:10.1152/ajpgi.00384.2001
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282 , Issue.1
    • Diehl, A.M.1
  • 169
    • 84883788474 scopus 로고    scopus 로고
    • Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo
    • doi:10.1186/1755-1536-5-S1-S27
    • Tacke F (2012) Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo. Fibrogenesis Tissue Repair 5 Suppl 1:S27. doi:10.1186/1755-1536-5-S1-S27
    • (2012) Fibrogenesis Tissue Repair , vol.5 , Issue.SUPPL. 1
    • Tacke, F.1
  • 172
    • 84860243402 scopus 로고    scopus 로고
    • Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice
    • Lond doi:10.1042/CS20110366
    • Maina V, Sutti S, Locatelli I, Vidali M, Mombello C, Bozzola C, Albano E (2012) Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice. Clin Sci (Lond) 122(11):545-553. doi:10.1042/CS20110366
    • (2012) Clin Sci , vol.122 , Issue.11 , pp. 545-553
    • Maina, V.1    Sutti, S.2    Locatelli, I.3    Vidali, M.4    Mombello, C.5    Bozzola, C.6    Albano, E.7
  • 173
    • 65249147213 scopus 로고    scopus 로고
    • Obesity and the microbiota
    • doi:10.1053/j.gastro.2009.03.030
    • Tilg H, Moschen AR, Kaser A (2009) Obesity and the microbiota. Gastroenterology 136(5):1476-1483. doi:10.1053/j.gastro.2009.03.030
    • (2009) Gastroenterology , vol.136 , Issue.5 , pp. 1476-1483
    • Tilg, H.1    Moschen, A.R.2    Kaser, A.3
  • 174
    • 34249792393 scopus 로고    scopus 로고
    • Role of mitochondria in non-alcoholic fatty liver disease
    • doi:10.1111/j.1440-1746.2006.04640.x
    • Pessayre D (2007) Role of mitochondria in non-alcoholic fatty liver disease. JGastroenterolHepatol 22(Suppl 1):S20-S27. doi:10.1111/j.1440-1746. 2006.04640.x
    • (2007) JGastroenterolHepatol , vol.22 , Issue.SUPPL. 1
    • Pessayre, D.1
  • 175
    • 33751193496 scopus 로고    scopus 로고
    • Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease
    • DOI 10.1016/j.molmed.2006.10.001, PII S147149140600222X
    • Videla LA, Rodrigo R, Araya J, Poniachik J (2006) Insulin resistance and oxidative stress interdependency in non-alcoholic fatty liver disease. Trends Mol Med 12(12):555-558. doi:10.1016/j.molmed.2006.10.001 (Pubitemid 44780196)
    • (2006) Trends in Molecular Medicine , vol.12 , Issue.12 , pp. 555-558
    • Videla, L.A.1    Rodrigo, R.2    Araya, J.3    Poniachik, J.4
  • 176
    • 84863098121 scopus 로고    scopus 로고
    • Inflammation and fibrogenesis in steatohepatitis
    • doi:10.1007/s00535-012-0527-x
    • Fujii H, Kawada N (2012) Inflammation and fibrogenesis in steatohepatitis. J Gastroenterol 47(3):215-225. doi:10.1007/s00535-012-0527-x
    • (2012) J Gastroenterol , vol.47 , Issue.3 , pp. 215-225
    • Fujii, H.1    Kawada, N.2
  • 177
    • 21044437187 scopus 로고    scopus 로고
    • Immune response towards lipid peroxidation products as a predictor of progression of non-alcoholic fatty liver disease to advanced fibrosis
    • DOI 10.1136/gut.2004.057968
    • Albano E, Mottaran E, Vidali M, Reale E, Saksena S, Occhino G, Burt AD, Day CP (2005) Immune response towards lipid peroxidation products as a predictor of progression of non-alcoholic fatty liver disease to advanced fibrosis. Gut 54(7):987-993. doi:10.1136/gut.2004.057968 (Pubitemid 40873914)
    • (2005) Gut , vol.54 , Issue.7 , pp. 987-993
    • Albano, E.1    Mottaran, E.2    Vidali, M.3    Reale, E.4    Saksena, S.5    Occhino, G.6    Burt, A.D.7    Day, C.P.8
  • 178
    • 84860564377 scopus 로고    scopus 로고
    • Natural killer cell recognition and killing of activated hepatic stellate cells
    • doi:10.1136/gutjnl-2011-301968
    • Claria J (2012) Natural killer cell recognition and killing of activated hepatic stellate cells. Gut 61(6):792-793. doi:10.1136/gutjnl-2011-301968
    • (2012) Gut , vol.61 , Issue.6 , pp. 792-793
    • Claria, J.1
  • 179
    • 10744219822 scopus 로고    scopus 로고
    • Mirimostim (macrophage colony-stimulating factor; M-CSF) improves chemotherapy-induced impaired natural killer cell activity, The1 Th2 balance and granulocyte function
    • DOI 10.1111/j.1349-7006.2003.tb01524.x
    • Hidaka T, Akada S, Teranishi A, Morikawa H, Sato S, Yoshida Y, Yajima A, Yaegashi N, Okamura K, Saito S (2003) Mirimostim (macrophage colony-stimulating factor; M-CSF) improves chemotherapy-induced impaired natural killer cell activity, Th1/Th2 balance, and granulocyte function. Cancer Sci 94(9):814-820 (Pubitemid 37258781)
    • (2003) Cancer Science , vol.94 , Issue.9 , pp. 814-820
    • Hidaka, T.1    Akada, S.2    Teranishi, A.3    Morikawa, H.4    Sato, S.5    Yoshida, Y.6    Yajima, A.7    Yaegashi, N.8    Okamura, K.9    Saito, S.10
  • 180
    • 37149015739 scopus 로고    scopus 로고
    • Natural killer T-cell characterization through gene expression profiling: An account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses
    • DOI 10.1111/j.1365-2567.2007.02701.x
    • Niemeyer M, Darmoise A, Mollenkopf HJ, Hahnke K, Hurwitz R, Besra GS, Schaible UE, Kaufmann SH (2008) Natural killer T-cell characterization through gene expression profiling: an account of versatility bridging T helper type 1 (Th1), Th2 and Th17 immune responses. Immunology 123(1):45-56. doi:10.1111/j.1365-2567.2007.02701.x (Pubitemid 350255998)
    • (2008) Immunology , vol.123 , Issue.1 , pp. 45-56
    • Niemeyer, M.1    Darmoise, A.2    Mollenkopf, H.-J.3    Hahnke, K.4    Hurwitz, R.5    Besra, G.S.6    Schaible, U.E.7    Kaufmann, S.H.E.8
  • 181
    • 49649094683 scopus 로고    scopus 로고
    • Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis
    • doi:10.1002/hep.22399
    • Maher JJ, Leon P, Ryan JC (2008) Beyond insulin resistance: innate immunity in nonalcoholic steatohepatitis. Hepatology 48(2):670-678. doi:10.1002/hep.22399
    • (2008) Hepatology , vol.48 , Issue.2 , pp. 670-678
    • Maher, J.J.1    Leon, P.2    Ryan, J.C.3
  • 182
    • 40049104519 scopus 로고    scopus 로고
    • Natural killer T cells and non-alcoholic fatty liver disease: Fat chews on the immune system
    • DOI 10.3748/wjg.14.487
    • Kremer M, Hines IN (2008) Natural killer T cells and non-alcoholic fatty liver disease: fat chews on the immune system. World J Gastroenterol 14(3):487-488 (Pubitemid 351320862)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.3 , pp. 487-488
    • Kremer, M.1    Hines, I.N.2
  • 183
    • 34548674932 scopus 로고    scopus 로고
    • Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease
    • Xu CF, Yu CH, Li YM, Xu L, Du J, Shen Z (2007) Association of the frequency of peripheral natural killer T cells with nonalcoholic fatty liver disease. World J Gastroenterol 13(33):4504-4508 (Pubitemid 47412416)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.33 , pp. 4504-4508
    • Xu, C.-F.1    Yu, C.-H.2    Li, Y.-M.3    Xu, L.4    Du, J.5    Shen, Z.6
  • 184
    • 25844437136 scopus 로고    scopus 로고
    • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
    • DOI 10.1002/hep.20826
    • Li Z, Soloski MJ, Diehl AM (2005) Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology 42:880-885 (Pubitemid 41401126)
    • (2005) Hepatology , vol.42 , Issue.4 , pp. 880-885
    • Li, Z.1    Soloski, M.J.2    Diehl, A.M.3
  • 185
    • 33646016323 scopus 로고    scopus 로고
    • Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping
    • Elinav E, Pappo O, Sklair-Levy M, Margalit M, Shibolet O, Gomori M, Alper R, Thalenfeld B, Engelhardt D, Rabbani E, Ilan Y (2006) Adoptive transfer of regulatory NKT lymphocytes ameliorates non-alcoholic steatohepatitis and glucose intolerance in ob/ob mice and is associated with intrahepatic CD8 trapping. J Pathol 209:121-128
    • (2006) J Pathol , vol.209 , pp. 121-128
    • Elinav, E.1    Pappo, O.2    Sklair-Levy, M.3    Margalit, M.4    Shibolet, O.5    Gomori, M.6    Alper, R.7    Thalenfeld, B.8    Engelhardt, D.9    Rabbani, E.10    Ilan, Y.11
  • 186
    • 67649669912 scopus 로고    scopus 로고
    • Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease
    • doi:10.1097/MEG.0b013e32831bc3d6
    • Tajiri K, Shimizu Y, Tsuneyama K, Sugiyama T (2009) Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol 21(6):673-680. doi:10.1097/MEG.0b013e32831bc3d6
    • (2009) Eur J Gastroenterol Hepatol , vol.21 , Issue.6 , pp. 673-680
    • Tajiri, K.1    Shimizu, Y.2    Tsuneyama, K.3    Sugiyama, T.4
  • 189
    • 33748111665 scopus 로고    scopus 로고
    • Nonalcoholic Fatty Liver Disease: Cytokine-Adipokine Interplay and Regulation of Insulin Resistance
    • DOI 10.1053/j.gastro.2006.05.054, PII S0016508506012078
    • Tilg H, Hotamisligil GS (2006) Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 131:934-945 (Pubitemid 44307061)
    • (2006) Gastroenterology , vol.131 , Issue.3 , pp. 934-945
    • Tilg, H.1    Hotamisligil, G.S.2
  • 190
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoholic steatohepatitis
    • doi:10.1056/NEJM200011163432007
    • Tilg H, Diehl AM (2000) Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 343(20):1467-1476. doi:10.1056/NEJM200011163432007
    • (2000) N Engl J Med , vol.343 , Issue.20 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 191
    • 0037309589 scopus 로고    scopus 로고
    • Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
    • DOI 10.1053/jhep.2003.50048
    • Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, Desimone C, Song XY, Diehl AM (2003) Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37:343-350 (Pubitemid 36152533)
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 343-350
    • Li, Z.1    Yang, S.2    Lin, H.3    Huang, J.4    Watkins, P.A.5    Moser, A.B.6    DeSimone, C.7    Song, X.-Y.8    Diehl, A.M.9
  • 192
    • 3042744737 scopus 로고    scopus 로고
    • Beyond insulin resistance in NASH: TNF-alpha or adiponectin?
    • DOI 10.1002/hep.20280
    • Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J (2004) Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 40(1):46-54. doi:10.1002/hep.20280 (Pubitemid 38868922)
    • (2004) Hepatology , vol.40 , Issue.1 , pp. 46-54
    • Hui, J.M.1    Hodge, A.2    Farrell, G.C.3    Kench, J.G.4    Kriketos, A.5    George, J.6
  • 194
    • 34250632770 scopus 로고    scopus 로고
    • Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease
    • Manco M, Marcellini M, Giannone G, Nobili V (2007) Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease. Am J Clin Pathol 127:954-960
    • (2007) Am J Clin Pathol , vol.127 , pp. 954-960
    • Manco, M.1    Marcellini, M.2    Giannone, G.3    Nobili, V.4
  • 195
    • 68149182338 scopus 로고    scopus 로고
    • Diagnostic value of a group of biochemical markers of liver fibrosis in patients with nonalcoholic steatohepatitis
    • doi:10.1111/j.1751-2980.2009.00386.x
    • Lesmana CR, Hasan I, Budihusodo U, Gani RA, Krisnuhoni E, Akbar N, Lesmana LA (2009) Diagnostic value of a group of biochemical markers of liver fibrosis in patients with nonalcoholic steatohepatitis. J Dig Dis 10(3):201-206. doi:10.1111/j.1751-2980.2009.00386.x
    • (2009) J Dig Dis , vol.10 , Issue.3 , pp. 201-206
    • Lesmana, C.R.1    Hasan, I.2    Budihusodo, U.3    Gani, R.A.4    Krisnuhoni, E.5    Akbar, N.6    Lesmana, L.A.7
  • 197
    • 44949233003 scopus 로고    scopus 로고
    • Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis
    • DOI 10.1111/j.1572-0241.2007.01774.x
    • Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE (2008) Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis. Am J Gastroenterol 103(6):1372-1379. doi:10.1111/j.1572-0241. 2007.01774.x (Pubitemid 351813900)
    • (2008) American Journal of Gastroenterology , vol.103 , Issue.6 , pp. 1372-1379
    • Wieckowska, A.1    Papouchado, B.G.2    Li, Z.3    Lopez, R.4    Zein, N.N.5    Feldstein, A.E.6
  • 198
    • 27644530112 scopus 로고    scopus 로고
    • B cells: No longer bystanders in liver fibrosis
    • DOI 10.1172/JCI26845
    • Bhogal RK, Bona CA (2005) B cells: no longer bystanders in liver fibrosis. J Clin Invest 115(11):2962-2965. doi:10.1172/JCI26845 (Pubitemid 41567558)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.11 , pp. 2962-2965
    • Bhogal, R.K.1    Bona, C.A.2
  • 200
    • 0029846756 scopus 로고    scopus 로고
    • Liver failure and defective hepatocyte regeneration in interleukin-6- deficient mice
    • DOI 10.1126/science.274.5291.1379
    • Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, Taub R (1996) Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274(5291):1379-1383 (Pubitemid 26391463)
    • (1996) Science , vol.274 , Issue.5291 , pp. 1379-1383
    • Cressman, D.E.1    Greenbaum, L.E.2    DeAngelis, R.A.3    Ciliberto, G.4    Furth, E.E.5    Poli, V.6    Taub, R.7
  • 201
    • 12744259191 scopus 로고    scopus 로고
    • IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver
    • El-Assal O, Hong F, Kim WH, Radaeva S, Gao B (2004) IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver. Cell Mol Immunol 1(3):205-211
    • (2004) Cell Mol Immunol , vol.1 , Issue.3 , pp. 205-211
    • El-Assal, O.1    Hong, F.2    Kim, W.H.3    Radaeva, S.4    Gao, B.5
  • 202
    • 77955150888 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice
    • doi:10.1038/labinvest.2010.75
    • Yamaguchi K, Itoh Y, Yokomizo C, Nishimura T, Niimi T, Fujii H, Okanoue T, Yoshikawa T (2010) Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. Lab Invest 90(8):1169-1178. doi:10.1038/labinvest.2010.75
    • (2010) Lab Invest , vol.90 , Issue.8 , pp. 1169-1178
    • Yamaguchi, K.1    Itoh, Y.2    Yokomizo, C.3    Nishimura, T.4    Niimi, T.5    Fujii, H.6    Okanoue, T.7    Yoshikawa, T.8
  • 203
    • 12344332455 scopus 로고    scopus 로고
    • Cytokines and the pathogenesis of non-alcoholic steatohepatitis
    • DOI 10.1136/gut.2003.024935
    • Diehl AM, Li ZP, Lin HZ, Yang SQ (2005) Cytokines and the pathogenesis of non-alcoholic steatohepatitis. Gut 54(2):303-306. doi:10.1136/gut.2003.024935 (Pubitemid 40139250)
    • (2005) Gut , vol.54 , Issue.2 , pp. 303-306
    • Diehl, A.M.1    Li, Z.P.2    Lin, H.Z.3    Yang, S.Q.4
  • 204
    • 0036329894 scopus 로고    scopus 로고
    • Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity?
    • DOI 10.1053/jhep.2002.34738
    • Chitturi S, Farrell G, Frost L, Kriketos A, Lin R, Fung C, Liddle C, Samarasinghe D, George J (2002) Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology 36(2):403-409. doi:10.1053/jhep.2002.34738 (Pubitemid 34810360)
    • (2002) Hepatology , vol.36 , Issue.2 , pp. 403-409
    • Chitturi, S.1    Farrell, G.2    Frost, L.3    Kriketos, A.4    Lin, R.5    Liddle, C.6    Samarasinghe, D.7    George, J.8
  • 206
    • 0037335208 scopus 로고    scopus 로고
    • Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration
    • DOI 10.1016/S0168-8278(02)00414-2
    • Potter JJ, Rennie-Tankesley L, Mezey E (2003) Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration. J Hepatol 38(3):281-288 (Pubitemid 36286540)
    • (2003) Journal of Hepatology , vol.38 , Issue.3 , pp. 281-288
    • Potter, J.J.1    Rennie-Tankesley, L.2    Mezey, E.3
  • 207
    • 9644265298 scopus 로고    scopus 로고
    • Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease
    • DOI 10.1016/j.jhep.2004.08.020, PII S0168827804004192
    • Angulo P, Alba LM, Petrovic LM, Adams LA, Lindor KD, Jensen MD (2004) Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease. J Hepatol 41(6):943-949. doi:10.1016/j.jhep.2004.08.020 (Pubitemid 39575661)
    • (2004) Journal of Hepatology , vol.41 , Issue.6 , pp. 943-949
    • Angulo, P.1    Alba, L.M.2    Petrovic, L.M.3    Adams, L.A.4    Lindor, K.D.5    Jensen, M.D.6
  • 210
    • 33644636469 scopus 로고    scopus 로고
    • Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis
    • doi:10.1111/j.1572-0241.2005.00297.x
    • Musso G, Gambino R, Biroli G, Carello M, Faga E, Pacini G, De Michieli F, Cassader M, Durazzo M, Rizzetto M, Pagano G (2005) Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis. Am J Gastroenterol 100(11):2438-2446. doi:10.1111/j.1572-0241.2005.00297.x
    • (2005) Am J Gastroenterol , vol.100 , Issue.11 , pp. 2438-2446
    • Musso, G.1    Gambino, R.2    Biroli, G.3    Carello, M.4    Faga, E.5    Pacini, G.6    De Michieli, F.7    Cassader, M.8    Durazzo, M.9    Rizzetto, M.10    Pagano, G.11
  • 214
    • 0035023128 scopus 로고    scopus 로고
    • Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
    • Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280(5):E745-E751
    • (2001) Am J Physiol Endocrinol Metab , vol.280 , Issue.5
    • Kern, P.A.1    Ranganathan, S.2    Li, C.3    Wood, L.4    Ranganathan, G.5
  • 215
    • 84870452496 scopus 로고    scopus 로고
    • Adiponectin: Key player in the adipose tissue-liver crosstalk
    • Moschen AR, Wieser V, Tilg H (2012) Adiponectin: key player in the adipose tissue-liver crosstalk. Curr Med Chem 19(32):5467-5473
    • (2012) Curr Med Chem , vol.19 , Issue.32 , pp. 5467-5473
    • Moschen, A.R.1    Wieser, V.2    Tilg, H.3
  • 216
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • DOI 10.1172/JCI200317797
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ (2003) The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112(1):91-100. doi:10.1172/JCI17797 (Pubitemid 38056380)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.1 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.L.5    Cooper, G.J.S.6
  • 218
    • 0030777241 scopus 로고    scopus 로고
    • CEA adhesion molecules: Multifunctional proteins with signal-regulatory properties
    • Öbrink B (1997) CEA adhesion molecules: multifunctional proteins with signal-regulatory properties. Curr Opin Cell Biol 9(5):616-626
    • (1997) Curr Opin Cell Biol , vol.9 , Issue.5 , pp. 616-626
    • Öbrink, B.1
  • 219
    • 0027458375 scopus 로고
    • pp120/Ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms
    • Najjar SM, Accili D, Philippe N, Jernberg J, Margolis R, Taylor SI (1993) pp 120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms. J Biol Chem 268:1201-1206 (Pubitemid 23019761)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.2 , pp. 1201-1206
    • Najjar, S.M.1    Accili, D.2    Philippe, N.3    Jernberg, J.4    Margolis, R.5    Taylor, S.I.6
  • 220
    • 33749020847 scopus 로고    scopus 로고
    • Role of CEACAM1 as a regulator of T cells
    • DOI 10.1196/annals.1326.004, Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms, and Microbial Pathways
    • Nagaishi T, Iijima H, Nakajima A, Chen D, Blumberg RS (2006) Role of CEACAM1 as a regulator of T cells. Ann N Y Acad Sci 1072:155-175. doi:10.1196/annals.1326.004 (Pubitemid 44448450)
    • (2006) Annals of the New York Academy of Sciences , vol.1072 , pp. 155-175
    • Nagaishi, T.1    Iijima, H.2    Nakajima, A.3    Chen, D.4    Blumberg, R.S.5
  • 221
    • 33745684548 scopus 로고    scopus 로고
    • CEACAM1: Contact-dependent control of immunity
    • Gray-Owen SD, Blumberg RS (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol 6:433-446
    • (2006) Nat Rev Immunol , vol.6 , pp. 433-446
    • Gray-Owen, S.D.1    Blumberg, R.S.2
  • 222
    • 0036792506 scopus 로고    scopus 로고
    • Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions
    • doi:10.1172/JCI15643
    • Markel G, Wolf D, Hanna J, Gazit R, Goldman-Wohl D, Lavy Y, Yagel S, Mandelboim O (2002) Pivotal role of CEACAM1 protein in the inhibition of activated decidual lymphocyte functions. J Clin Invest 110(7):943-953. doi:10.1172/JCI15643
    • (2002) J Clin Invest , vol.110 , Issue.7 , pp. 943-953
    • Markel, G.1    Wolf, D.2    Hanna, J.3    Gazit, R.4    Goldman-Wohl, D.5    Lavy, Y.6    Yagel, S.7    Mandelboim, O.8
  • 223
    • 1542514774 scopus 로고    scopus 로고
    • The cell-cell adhesion molecule carcinoembryonic antigen-related cellular adhesion molecule 1 inhibits IL-2 production and proliferation in human T cells by association with Src homology protein-1 and down-regulates IL-2 receptor
    • Chen CJ, Shively JE (2004) The cell-cell adhesion molecule carcinoembryonic antigen-related cellular adhesion molecule 1 inhibits IL-2 production and proliferation in human T cells by association with Src homology protein-1 and down-regulates IL-2 receptor. J Immunol 172:3544-3552
    • (2004) J Immunol , vol.172 , pp. 3544-3552
    • Chen, C.J.1    Shively, J.E.2
  • 224
    • 0031772640 scopus 로고    scopus 로고
    • Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: Structure, expression and involvement in T cell activation
    • DOI 10.1002/(SICI)1521-4141(199811)28:11<3664::AID
    • Kammerer R, Hahn S, Singer BB, Luo JS, von Kleist S (1998) Biliary glycoprotein (CD66a), a cell adhesion molecule of the immunoglobulin superfamily, on human lymphocytes: structure, expression and involvement in T cell activation. Eur J Immunol 28(11):3664-3674. doi:10.1002/(SICI)1521- 4141(199811)28:11〈3664::AID-IMMU3664〉3.0.CO;2-D (Pubitemid 28510777)
    • (1998) European Journal of Immunology , vol.28 , Issue.11 , pp. 3664-3674
    • Kammerer, R.1    Hahn, S.2    Singer, B.B.3    Luo, J.S.4    Von Kleist, S.5
  • 229
    • 0036219193 scopus 로고    scopus 로고
    • Negative regulation of immunoreceptor signaling
    • DOI 10.1146/annurev.immunol.20.081501.130710
    • Veillette A, Latour S, Davidson D (2002) Negative regulation of immunoreceptor signaling. Annu Rev Immunol 20:669-707. doi:10.1146/annurev. immunol.20.081501.130710 (Pubitemid 34293437)
    • (2002) Annual Review of Immunology , vol.20 , pp. 669-707
    • Veillette, A.1    Latour, S.2    Davidson, D.3
  • 230
    • 1842631103 scopus 로고    scopus 로고
    • Jurkat T cells and development of the T-cell receptor signalling paradigm
    • Abraham RT, Weiss A (2004) Jurkat T cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol 4(4):301-308. doi:10.1038/nri1330 (Pubitemid 38478665)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.4 , pp. 301-308
    • Abraham, R.T.1    Weiss, A.2
  • 231
    • 0028364813 scopus 로고
    • B lymphocyte and macrophage expression of carcinoembryonic antigen-related adhesion molecules that serve as receptors for murine coronavirus
    • DOI 10.1002/eji.1830240622
    • Coutelier JP, Godfraind C, Dveksler GS, Wysocka M, Cardellichio CB, Noel H, Holmes KV (1994) B lymphocyte and macrophage expression of carcinoembryonic antigen-related adhesion molecules that serve as receptors formurine coronavirus. Eur J Immunol 24(6):1383-1390. doi:10.1002/eji.1830240622 (Pubitemid 24169523)
    • (1994) European Journal of Immunology , vol.24 , Issue.6 , pp. 1383-1390
    • Coutelier, J.-P.1    Godfraind, C.2    Dveksler, G.S.3    Wysocka, M.4    Cardellichio, C.B.5    Noel, H.6    Holmes, K.V.7
  • 234
    • 69449100854 scopus 로고    scopus 로고
    • Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependentmanner
    • doi:10.1189/jlb.0109037
    • Lobo EO, Zhang Z, Shively JE (2009) Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependentmanner. J Leukoc Biol 86(2):205-218. doi:10.1189/jlb.0109037
    • (2009) J Leukoc Biol , vol.86 , Issue.2 , pp. 205-218
    • Lobo, E.O.1    Zhang, Z.2    Shively, J.E.3
  • 235
    • 0035337109 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation
    • Kammerer R, Stober D, Singer BB, Obrink B, Reimann J (2001) Carcinoembryonic antigen-related cell adhesion molecule 1 on murine dendritic cells is a potent regulator of T cell stimulation. J Immunol 166(11):6537-6544 (Pubitemid 32467192)
    • (2001) Journal of Immunology , vol.166 , Issue.11 , pp. 6537-6544
    • Kammerer, R.1    Stober, D.2    Singer, B.B.3    Obrink, B.4    Reimann, J.5
  • 236
    • 84861204618 scopus 로고    scopus 로고
    • CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex
    • doi:10.1371/journal.ppat.1002597
    • Lu R, Pan H, Shively JE (2012) CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog 8(4):e1002597. doi:10.1371/journal.ppat. 1002597
    • (2012) PLoS Pathog , vol.8 , Issue.4
    • Lu, R.1    Pan, H.2    Shively, J.E.3
  • 237
    • 0036009113 scopus 로고    scopus 로고
    • + T lymphocytes
    • DOI 10.1038/ni769
    • Boulton IC, Gray-Owen SD (2002) Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes. Nat Immunol 3(3):229-236. doi:10.1038/ni769 (Pubitemid 34213424)
    • (2002) Nature Immunology , vol.3 , Issue.3 , pp. 229-236
    • Boulton, I.C.1    Gray-Owen, S.D.2
  • 238
    • 77958482933 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor
    • doi:10.1016/j.immuni.2010.10.009
    • Pan H, Shively JE (2010) Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor. Immunity 33(4):620-631. doi:10.1016/j. immuni.2010.10.009
    • (2010) Immunity , vol.33 , Issue.4 , pp. 620-631
    • Pan, H.1    Shively, J.E.2
  • 239
    • 0028095286 scopus 로고
    • Insulin receptor internalization: Molecular mechanisms and physiopathological implications
    • Carpentier JL (1994) Insulin receptor internalization: molecular mechanisms and physiopathological implications. Diabetologia 37(Suppl 2):S117-S124
    • (1994) Diabetologia , vol.37 , Issue.SUPPL. 2
    • Carpentier, J.L.1
  • 240
    • 0036675186 scopus 로고    scopus 로고
    • Regulation of insulin action by CEACAM1
    • Najjar SM (2002) Regulation of insulin action by CEACAM1. Trends Endocrinol Metab 13:240-245
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 240-245
    • Najjar, S.M.1
  • 241
    • 0029149497 scopus 로고
    • Insulin-stimulated phosphorylation of recombinant pp 120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase
    • Najjar SM, Philippe N, Suzuki Y, Ignacio GA, Formisano P, Accili D, Taylor SI (1995) Insulin-stimulated phosphorylation of recombinant pp 120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry 34:9341-9349
    • (1995) Biochemistry , vol.34 , pp. 9341-9349
    • Najjar, S.M.1    Philippe, N.2    Suzuki, Y.3    Ignacio, G.A.4    Formisano, P.5    Accili, D.6    Taylor, S.I.7
  • 242
    • 0030667408 scopus 로고    scopus 로고
    • Differential effect of pp 120 on insulin endocytosis by two variant insulin receptor isoforms
    • Li Calzi S, Choice CV, Najjar SM (1997) Differential effect of pp 120 on insulin endocytosis by two variant insulin receptor isoforms. Am J Physiol 273:E801-E808
    • (1997) Am J Physiol , vol.273
    • Li Calzi, S.1    Choice, C.V.2    Najjar, S.M.3
  • 243
    • 0028822686 scopus 로고
    • Receptor-mediated internalization of insulin. Potential role of pp 120/HA4, a substrate of the insulin receptor kinase
    • Formisano P, Najjar SM, Gross CN, Philippe N, Oriente F, Kern-Buell CL, Accili D, Gorden P (1995) Receptor-mediated internalization of insulin. Potential role of pp 120/HA4, a substrate of the insulin receptor kinase. J Biol Chem 270(41):24073-24077
    • (1995) J Biol Chem , vol.270 , Issue.41 , pp. 24073-24077
    • Formisano, P.1    Najjar, S.M.2    Gross, C.N.3    Philippe, N.4    Oriente, F.5    Kern-Buell, C.L.6    Accili, D.7    Gorden, P.8
  • 246
    • 0025343708 scopus 로고
    • Effects of prolonged pulsatile hyperinsulinemia in humans. Enhancement of insulin sensitivity
    • Ward GM, Walters JM, Aitken PM, Best JD, Alford FP (1990) Effects of prolonged pulsatile hyperinsulinemia in humans. Enhancement of insulin sensitivity. Diabetes Care 39(4):501-507 (Pubitemid 20111435)
    • (1990) Diabetes , vol.39 , Issue.4 , pp. 501-507
    • Ward, G.M.1    Walters, J.M.2    Aitken, P.M.3    Best, J.D.4    Alford, F.P.5
  • 249
    • 57249094022 scopus 로고    scopus 로고
    • Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice
    • doi:10.1053/j.gastro.2008.08.007
    • Lee SJ, Heinrich G, Fedorova L, Al-Share QY, Ledford KJ, Fernstrom MA, McInerney MF, Erickson SK, Gatto-Weis C, Najjar SM (2008) Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. Gastroenterology 135(6):2084-2095. doi:10.1053/j.gastro.2008.08.007
    • (2008) Gastroenterology , vol.135 , Issue.6 , pp. 2084-2095
    • Lee, S.J.1    Heinrich, G.2    Fedorova, L.3    Al-Share, Q.Y.4    Ledford, K.J.5    Fernstrom, M.A.6    McInerney, M.F.7    Erickson, S.K.8    Gatto-Weis, C.9    Najjar, S.M.10
  • 253
    • 0029964729 scopus 로고    scopus 로고
    • Contributions of de novo synthesis of fatty acids to total VLDL- triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man
    • Aarsland A, Chinkes D, Wolfe RR (1996) Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest 98:2008-2017 (Pubitemid 26376288)
    • (1996) Journal of Clinical Investigation , vol.98 , Issue.9 , pp. 2008-2017
    • Aarsland, A.1    Chinkes, D.2    Wolfe, R.R.3
  • 254
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach JC, Batts KP, Lindor KD (1999) Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 30:1356-1362
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3    Lindor, K.D.4
  • 255
    • 70349972775 scopus 로고    scopus 로고
    • Apoptosis and cytokines in non-alcoholic steatohepatitis
    • doi:10.1016/j.cld.2009.07.003
    • Syn WK, Choi SS, Diehl AM (2009) Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis 13(4):565-580. doi:10.1016/j.cld.2009.07.003
    • (2009) Clin Liver Dis , vol.13 , Issue.4 , pp. 565-580
    • Syn, W.K.1    Choi, S.S.2    Diehl, A.M.3
  • 257
    • 55449100538 scopus 로고    scopus 로고
    • Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance
    • doi:10.1161/ATVBAHA.108.169722
    • Kim F, Pham M, Maloney E, Rizzo NO, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW (2008) Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance. Arterioscler Thromb Vasc Biol 28:1982-1988. doi:10.1161/ATVBAHA.108.169722
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1982-1988
    • Kim, F.1    Pham, M.2    Maloney, E.3    Rizzo, N.O.4    Morton, G.J.5    Wisse, B.E.6    Kirk, E.A.7    Chait, A.8    Schwartz, M.W.9
  • 260
    • 0036788277 scopus 로고    scopus 로고
    • Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
    • Canbay A, Higuchi H, Bronk SF, Taniai M, Sebo TJ, Gores GJ (2002) Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Gastroenterology 123(4):1323-1330
    • (2002) Gastroenterology , vol.123 , Issue.4 , pp. 1323-1330
    • Canbay, A.1    Higuchi, H.2    Bronk, S.F.3    Taniai, M.4    Sebo, T.J.5    Gores, G.J.6
  • 261
    • 77949311823 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A review and update
    • doi:10.1007/s10620-009-1081-0
    • Lewis JR, Mohanty SR (2010) Nonalcoholic fatty liver disease: a review and update. Dig Dis Sci 55(3):560-578. doi:10.1007/s10620-009-1081-0
    • (2010) Dig Dis Sci , vol.55 , Issue.3 , pp. 560-578
    • Lewis, J.R.1    Mohanty, S.R.2
  • 262
    • 41849123475 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: Implications for treatment
    • DOI 10.1111/j.1572-0241.2007.01709.x
    • Carter-Kent C, Zein NN, Feldstein AE (2008) Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment. Am J Gastroenterol 103:1036-1042 (Pubitemid 351501089)
    • (2008) American Journal of Gastroenterology , vol.103 , Issue.4 , pp. 1036-1042
    • Carter-Kent, C.1    Zein, N.N.2    Feldstein, A.E.3
  • 263
    • 79955755233 scopus 로고    scopus 로고
    • The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes
    • doi:10.1186/1746-1596-6-40
    • Lee W (2011) The CEACAM1 expression is decreased in the liver of severely obese patients with or without diabetes. Diagn Pathol 6:40. doi:10.1186/1746-1596-6-40
    • (2011) Diagn Pathol , vol.6 , pp. 40
    • Lee, W.1


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