-
1
-
-
70349770695
-
Epidemiology and natural history of non-alcoholic steatohepatitis
-
Argo CK, Caldwell SH. Epidemiology and natural history of non-alcoholic steatohepatitis. Clin Liver Dis. 2009;13:511-31.
-
(2009)
Clin Liver Dis.
, vol.13
, pp. 511-531
-
-
Argo, C.K.1
Caldwell, S.H.2
-
2
-
-
77649337140
-
Nonalcoholic fatty liver disease: Pathology and pathogenesis
-
Tiniakos DG, Vos MB, Brunt EM. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol. 2010;5:145-71.
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 145-171
-
-
Tiniakos, D.G.1
Vos, M.B.2
Brunt, E.M.3
-
3
-
-
22344453700
-
Natural history of NAFLD: Remarkably benign in the absence of cirrhosis
-
DOI 10.1053/j.gastro.2005.05.041, PII S0016508505010668
-
Day CP. Natural history of NAFLD: remarkably benign in the absence of cirrhosis. Gastroenterology. 2005;129:375-8. (Pubitemid 41002070)
-
(2005)
Gastroenterology
, vol.129
, Issue.1
, pp. 375-378
-
-
Day, C.P.1
-
4
-
-
0141510580
-
The natural history of nonalcoholic fatty liver disease: A clinical histopathological study
-
DOI 10.1111/j.1572-0241.2003.07659.x
-
Harrison SA, Torgerson S, Hayashi PH. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol. 2003;98:2042-7. (Pubitemid 37185803)
-
(2003)
American Journal of Gastroenterology
, vol.98
, Issue.9
, pp. 2042-2047
-
-
Harrison, S.A.1
Torgerson, S.2
Hayashi, P.H.3
-
5
-
-
67649306197
-
Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis
-
Argo CK, Northup PG, Al-Osaimi AM, Caldwell SH. Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J Hepatol. 2009;51:371-9.
-
(2009)
J Hepatol
, vol.51
, pp. 371-379
-
-
Argo, C.K.1
Northup, P.G.2
Al-Osaimi, A.M.3
Caldwell, S.H.4
-
6
-
-
0025178612
-
The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
-
Powell EE, Cooksley WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 1990;11:74-80. (Pubitemid 20075105)
-
(1990)
Hepatology
, vol.11
, Issue.1
, pp. 74-80
-
-
Powell, E.E.1
Cooksley, W.G.E.2
Hanson, R.3
Searle, J.4
Halliday, J.W.5
Powell, L.W.6
-
7
-
-
1642355723
-
The spectrum expanded: Cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease
-
DOI 10.1016/j.jhep.2004.02.013, PII S0168827804000716
-
Caldwell SH, Crespo DM. The spectrum expanded: cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease. J Hepatol. 2004;40:578-84. (Pubitemid 38367778)
-
(2004)
Journal of Hepatology
, vol.40
, Issue.4
, pp. 578-584
-
-
Caldwell, S.H.1
Crespo, D.M.2
-
8
-
-
33645963121
-
Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
-
Sanyal AJ, Banas C, Sargeant C, Luketic VA, Sterling RK, Stravitz RT, et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology. 2006;43:682-9.
-
(2006)
Hepatology
, vol.43
, pp. 682-689
-
-
Sanyal, A.J.1
Banas, C.2
Sargeant, C.3
Luketic, V.A.4
Sterling, R.K.5
Stravitz, R.T.6
-
9
-
-
33750606061
-
Long-term follow-up of patients with NAFLD and elevated liver enzymes
-
DOI 10.1002/hep.21327
-
Ekstedt M, Franzen LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, et al. Long-term follow-up of patients with NA-FLD and elevated liver enzymes. Hepatology. 2006;44:865-73. (Pubitemid 46489550)
-
(2006)
Hepatology
, vol.44
, Issue.4
, pp. 865-873
-
-
Ekstedt, M.1
Franzen, L.E.2
Mathiesen, U.L.3
Thorelius, L.4
Holmqvist, M.5
Bodemar, G.6
Kechagias, S.7
-
10
-
-
0031947715
-
Steatohepatitis: A tale of two "hits,"?
-
Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology. 1998;114:842-5.
-
(1998)
Gastroenterology
, vol.114
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
11
-
-
0031799747
-
Hepatic steatosis: Innocent bystander or guilty party?
-
DOI 10.1002/hep.510270601
-
Day CP, James OF. Hepatic steatosis: innocent bystander or guilty party? Hepatology. 1998;27:1463-6. (Pubitemid 28264666)
-
(1998)
Hepatology
, vol.27
, Issue.6
, pp. 1463-1466
-
-
Day, C.P.1
James, O.F.W.2
-
12
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway
-
DOI 10.1002/hep.20283
-
Feldstein AE, Werneburg NW, Canbay A, Guicciardi ME, Bronk SF, Rydzewski R, et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology. 2004;40:185-94. (Pubitemid 38868937)
-
(2004)
Hepatology
, vol.40
, Issue.1
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
Guicciardi, M.E.4
Bronk, S.F.5
Rydzewski, R.6
Burgart, L.J.7
Gores, G.J.8
-
13
-
-
34250356015
-
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
-
DOI 10.1002/hep.21655
-
Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007;45:1366-74. (Pubitemid 46918320)
-
(2007)
Hepatology
, vol.45
, Issue.6
, pp. 1366-1374
-
-
Yamaguchi, K.1
Yang, L.2
McCall, S.3
Huang, J.4
Xing, X.Y.5
Pandey, S.K.6
Bhanot, S.7
Monia, B.P.8
Li, Y.-X.9
Diehl, A.M.10
-
14
-
-
0042033294
-
Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease
-
Roskams T, Yang SQ, Koteish A, Durnez A, DeVos R, Huang X, et al. Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am J Pathol. 2003;163:1301-11. (Pubitemid 37175079)
-
(2003)
American Journal of Pathology
, vol.163
, Issue.4
, pp. 1301-1311
-
-
Roskams, T.1
Yang, S.Q.2
Koteish, A.3
Durnez, A.4
DeVos, R.5
Huang, X.6
Achten, R.7
Verslype, C.8
Diehl, A.M.9
-
15
-
-
56649083495
-
Mechanisms of disease progression in nonalcoholic fatty liver disease
-
Jou J, Choi SS, Diehl AM. Mechanisms of disease progression in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28: 370-9.
-
(2008)
Semin Liver Dis.
, vol.28
, pp. 370-379
-
-
Jou, J.1
Choi, S.S.2
Diehl, A.M.3
-
16
-
-
61949153022
-
Burning hepatic fat: Therapeutic potential for liverspecific thyromimetics in the treatment of nonalcoholic fatty liver disease
-
Arrese M. Burning hepatic fat: therapeutic potential for liverspecific thyromimetics in the treatment of nonalcoholic fatty liver disease. Hepatology. 2009;49:348-51.
-
(2009)
Hepatology
, vol.49
, pp. 348-351
-
-
Arrese, M.1
-
17
-
-
33644547706
-
Nonalcoholic fatty liver disease: From steatosis to cirrhosis
-
Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43:S99-112.
-
(2006)
Hepatology
, vol.43
-
-
Farrell, G.C.1
Larter, C.Z.2
-
19
-
-
57349116780
-
Causes and metabolic consequences of fatty liver
-
Stefan N, Kantartzis K, Haring HU. Causes and metabolic consequences of fatty liver. Endocr Rev. 2008;29:939-60.
-
(2008)
Endocr Rev.
, vol.29
, pp. 939-960
-
-
Stefan, N.1
Kantartzis, K.2
Haring, H.U.3
-
20
-
-
40549135297
-
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
-
DOI 10.1172/JCI34275
-
Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest. 2008;118:829-38. (Pubitemid 351364588)
-
(2008)
Journal of Clinical Investigation
, vol.118
, Issue.3
, pp. 829-838
-
-
Postic, C.1
Girard, J.2
-
21
-
-
33846253661
-
Insulin Resistance Accelerates a Dietary Rat Model of Nonalcoholic Steatohepatitis
-
DOI 10.1053/j.gastro.2006.10.014, PII S0016508506022372
-
Ota T, Takamura T, Kurita S, Matsuzawa N, Kita Y, Uno M, et al. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Gastroenterology. 2007;132:282-93. (Pubitemid 46108737)
-
(2007)
Gastroenterology
, vol.132
, Issue.1
, pp. 282-293
-
-
Ota, T.1
Takamura, T.2
Kurita, S.3
Matsuzawa, N.4
Kita, Y.5
Uno, M.6
Akahori, H.7
Misu, H.8
Sakurai, M.9
Zen, Y.10
Nakanuma, Y.11
Kaneko, S.12
-
22
-
-
33845670353
-
Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: Role of insulin resistance and hepatic steatosis
-
DOI 10.1002/hep.21429
-
Bugianesi E, Marchesini G, Gentilcore E, Cua IH, Vanni E, Rizzetto M, et al. Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: role of insulin resistance and hepatic steatosis. Hepatology. 2006;44:1648-55. (Pubitemid 44953669)
-
(2006)
Hepatology
, vol.44
, Issue.6
, pp. 1648-1655
-
-
Bugianesi, E.1
Marchesini, G.2
Gentilcore, E.3
Cua, I.H.Y.4
Vanni, E.5
Rizzetto, M.6
George, J.7
-
23
-
-
0027947379
-
Beta-cell lipotoxicity in the pathogenesis of non-insulindependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
-
Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH. Beta-cell lipotoxicity in the pathogenesis of non-insulindependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci USA. 1994;91:10878-82.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10878-10882
-
-
Lee, Y.1
Hirose, H.2
Ohneda, M.3
Johnson, J.H.4
McGarry, J.D.5
Unger, R.H.6
-
24
-
-
54049150442
-
Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
-
Anderson N, Borlak J. Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol Rev. 2008;60: 311-57.
-
(2008)
Pharmacol Rev.
, vol.60
, pp. 311-357
-
-
Anderson, N.1
Borlak, J.2
-
25
-
-
56649094325
-
Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
-
Malhi H, Gores GJ. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28: 360-9.
-
(2008)
Semin Liver Dis.
, vol.28
, pp. 360-369
-
-
Malhi, H.1
Gores, G.J.2
-
26
-
-
78049522194
-
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
-
Tilg H, Moschen AR. Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology. 2010;52:1836-46.
-
(2010)
Hepatology
, vol.52
, pp. 1836-1846
-
-
Tilg, H.1
Moschen, A.R.2
-
27
-
-
34250315771
-
And fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidationdriven activation of the PKC-PI3K-Akt pathway
-
Nieto N. Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidationdriven activation of the PKC-PI3K-Akt pathway. Hepatology 2007;45:1433-45.
-
(2007)
Hepatology
, vol.45
, pp. 1433-1445
-
-
Ethanol, N.N.1
-
28
-
-
35948954244
-
Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
-
Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 2008;88:125-72.
-
(2008)
Physiol Rev.
, vol.88
, pp. 125-172
-
-
Friedman, S.L.1
-
29
-
-
79951803916
-
Evolution of hepatic fibrosis research
-
Kawada N. Evolution of hepatic fibrosis research. Hepatol Res. 2011;41:199-208.
-
(2011)
Hepatol Res.
, vol.41
, pp. 199-208
-
-
Kawada, N.1
-
30
-
-
34249775833
-
Role of adipocytokines in hepatic fibrogenesis
-
DOI 10.1111/j.1440-1746.2007.04961.x
-
Ikejima K, Okumura K, Kon K, Takei Y, Sato N. Role of adipocytokines in hepatic fibrogenesis. J Gastroenterol Hepatol. 2007;22(Suppl 1):S87-92. (Pubitemid 46849004)
-
(2007)
Journal of Gastroenterology and Hepatology
, vol.22
, Issue.SUPPL. 1
-
-
Ikejima, K.1
Okumura, K.2
Kon, K.3
Takei, Y.4
Sato, N.5
-
31
-
-
43049096057
-
Adipokines and the peripheral and neural control of energy balance
-
DOI 10.1210/me.2007-0529
-
Ahima RS, Lazar MA. Adipokines and the peripheral and neural control of energy balance. Mol Endocrinol. 2008;22:1023-31. (Pubitemid 351629604)
-
(2008)
Molecular Endocrinology
, vol.22
, Issue.5
, pp. 1023-1031
-
-
Ahima, R.S.1
Lazar, M.A.2
-
33
-
-
57349199263
-
Cell signaling. Fat stress and liver resistance
-
Ogawa W, Kasuga M. Cell signaling. Fat stress and liver resistance. Science. 2008;322:1483-4.
-
(2008)
Science
, vol.322
, pp. 1483-1484
-
-
Ogawa, W.1
Kasuga, M.2
-
34
-
-
0027459878
-
Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesitylinked insulin resistance. Science. 1993;259:87-91. (Pubitemid 23036092)
-
(1993)
Science
, vol.259
, Issue.5091
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
36
-
-
0348134733
-
Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
-
DOI 10.1016/S0168-8278(03)00460-4
-
Feldstein AE, Canbay A, Guicciardi ME, Higuchi H, Bronk SF, Gores GJ. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J Hepatol. 2003;39:978-83. (Pubitemid 37523769)
-
(2003)
Journal of Hepatology
, vol.39
, Issue.6
, pp. 978-983
-
-
Feldstein, A.E.1
Canbay, A.2
Guicciardi, M.E.3
Higuchi, H.4
Bronk, S.F.5
Gores, G.J.6
-
37
-
-
33144463511
-
Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice
-
DOI 10.1136/gut.2005.071118
-
Tomita K, Tamiya G, Ando S, Ohsumi K, Chiyo T, Mizutani A, et al. Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of nonalcoholic steatohepatitis in mice. Gut. 2006;55:415-24. (Pubitemid 43268283)
-
(2006)
Gut
, vol.55
, Issue.3
, pp. 415-424
-
-
Tomita, K.1
Tamiya, G.2
Ando, S.3
Ohsumi, K.4
Chiyo, T.5
Mizutani, A.6
Kitamura, N.7
Toda, K.8
Kaneko, T.9
Horie, Y.10
Han, J.-Y.11
Kato, S.12
Shimoda, M.13
Oike, Y.14
Tomizawa, M.15
Makino, S.16
Ohkura, T.17
Saito, H.18
Kumagai, N.19
Nagata, H.20
Ishii, H.21
Hibi, T.22
more..
-
38
-
-
0037309589
-
Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease
-
DOI 10.1053/jhep.2003.50048
-
Li Z, Yang S, Lin H, Huang J, Watkins PA, Moser AB, et al. Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology. 2003;37:343-50. (Pubitemid 36152533)
-
(2003)
Hepatology
, vol.37
, Issue.2
, pp. 343-350
-
-
Li, Z.1
Yang, S.2
Lin, H.3
Huang, J.4
Watkins, P.A.5
Moser, A.B.6
DeSimone, C.7
Song, X.-Y.8
Diehl, A.M.9
-
39
-
-
38349107613
-
Adipokines and cytokines in non-alcoholic fatty liver disease
-
Jarrar MH, Baranova A, Collantes R, Ranard B, Stepanova M, Bennett C, et al. Adipokines and cytokines in non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2008;27:412-21.
-
(2008)
Aliment Pharmacol Ther
, vol.27
, pp. 412-421
-
-
Jarrar, M.H.1
Baranova, A.2
Collantes, R.3
Ranard, B.4
Stepanova, M.5
Bennett, C.6
-
40
-
-
34250632770
-
Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease
-
Manco M, Marcellini M, Giannone G, Nobili V. Correlation of serum TNF-alpha levels and histologic liver injury scores in pediatric nonalcoholic fatty liver disease. Am J Clin Pathol. 2007;127:954-60.
-
(2007)
Am J Clin Pathol
, vol.127
, pp. 954-960
-
-
Manco, M.1
Marcellini, M.2
Giannone, G.3
Nobili, V.4
-
41
-
-
0035183475
-
Gene expression of tumor necrosis factor α and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
-
DOI 10.1053/jhep.2001.29628
-
Crespo J, Cayon A, Fernandez-Gil P, Hernandez-Guerra M, Mayorga M, Dominguez-Diez A, et al. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology. 2001;34: 1158-63. (Pubitemid 33096588)
-
(2001)
Hepatology
, vol.34
, Issue.6
, pp. 1158-1163
-
-
Crespo, J.1
Cayoen, A.2
Fernendez-Gil, P.3
Hernndez-Guerra, M.4
Mayorga, M.5
Domnguez-Dez, A.6
Fernndez-Escalante, J.C.7
Pons-Romero, F.8
-
42
-
-
7044269614
-
Beneficial effects of tumor necrosis factor-α inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis
-
DOI 10.1111/j.1572-0241.2004.40220.x
-
Satapathy SK, Garg S, Chauhan R, Sakhuja P, Malhotra V, Sharma BC, et al. Beneficial effects of tumor necrosis factoralpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2004;99:1946-52. (Pubitemid 39421237)
-
(2004)
American Journal of Gastroenterology
, vol.99
, Issue.10
, pp. 1946-1952
-
-
Satapathy, S.K.1
Garg, S.2
Chauhan, R.3
Sakhuja, P.4
Malhotra, V.5
Sharma, B.C.6
Sarin, S.K.7
-
43
-
-
80055028155
-
Pentoxifylline improves nonalcoholic steatohepatitis: A randomized placebo-controlled trial
-
Zein CO, Yerian LM, Gogate P, Lopez R, Kirwan JP, Feldstein AE, et al. Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. Hepatology. 2011;54: 1610-9.
-
(2011)
Hepatology
, vol.54
, pp. 1610-1619
-
-
Zein, C.O.1
Yerian, L.M.2
Gogate, P.3
Lopez, R.4
Kirwan, J.P.5
Feldstein, A.E.6
-
44
-
-
34047155003
-
Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
-
DOI 10.2337/db06-1656
-
Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes. 2007;56:1010-3. (Pubitemid 46525079)
-
(2007)
Diabetes
, vol.56
, Issue.4
, pp. 1010-1013
-
-
Fontana, L.1
Eagon, J.C.2
Trujillo, M.E.3
Scherer, P.E.4
Klein, S.5
-
45
-
-
49649096375
-
Visceral fat: A key mediator of steatohepatitis in metabolic liver disease
-
van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, et al. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology. 2008;48:449-57.
-
(2008)
Hepatology
, vol.48
, pp. 449-457
-
-
Van Der Poorten, D.1
Milner, K.L.2
Hui, J.3
Hodge, A.4
Trenell, M.I.5
Kench, J.G.6
-
46
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
-
DOI 10.1038/nm1166
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005;11:183-90. (Pubitemid 40321354)
-
(2005)
Nature Medicine
, vol.11
, Issue.2
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
47
-
-
0033586747
-
The role of leptin in human obesity and disease: A review of current evidence
-
Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med. 1999;130:671-80. (Pubitemid 29196202)
-
(1999)
Annals of Internal Medicine
, vol.130
, Issue.8
, pp. 671-680
-
-
Mantzoros, C.S.1
-
48
-
-
0036790386
-
Role of leptin in immunology
-
discussion S68-84, 5-7
-
Lord G. Role of leptin in immunology. Nutr Rev. 2002;60: S35-8. discussion S68-84, 5-7.
-
(2002)
Nutr Rev.
, vol.60
-
-
Lord, G.1
-
50
-
-
0036022846
-
Leptin is essential for the hepatic fibrogenic response to chronic liver injury
-
DOI 10.1016/S0168-8278(02)00102-2, PII S0168827802001022
-
Leclercq IA, Farrell GC, Schriemer R, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol. 2002;37:206-13. (Pubitemid 34833082)
-
(2002)
Journal of Hepatology
, vol.37
, Issue.2
, pp. 206-213
-
-
Leclercq, I.A.1
Farrell, G.C.2
Schriemer, R.3
Robertson, G.R.4
-
51
-
-
0037335208
-
Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration
-
DOI 10.1016/S0168-8278(02)00414-2
-
Potter JJ, Rennie-Tankesley L, Mezey E. Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration. J Hepatol 2003;38:281-8. (Pubitemid 36286540)
-
(2003)
Journal of Hepatology
, vol.38
, Issue.3
, pp. 281-288
-
-
Potter, J.J.1
Rennie-Tankesley, L.2
Mezey, E.3
-
52
-
-
0036234147
-
Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat
-
Ikejima K, Takei Y, Honda H, Hirose M, Yoshikawa M, Zhang YJ, et al. Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology. 2002;122:1399-410. (Pubitemid 34465182)
-
(2002)
Gastroenterology
, vol.122
, Issue.5
, pp. 1399-1410
-
-
Ikejima, K.1
Takei, Y.2
Honda, H.3
Hirose, M.4
Yoshikawa, M.5
Zhang, Y.-J.6
Lang, T.7
Fukuda, T.8
Yamashina, S.9
Kitamura, T.10
Sato, N.11
-
53
-
-
9444223845
-
Leptin as a novel profibrogenic cytokine in hepatic stellate cells: Mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation
-
DOI 10.1096/fj.04-1847fje
-
Saxena NK, Titus MA, Ding X, Floyd J, Srinivasan S, Sitaraman SV, et al. Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB J. 2004;18:1612-4. (Pubitemid 39561650)
-
(2004)
FASEB Journal
, vol.18
, Issue.13
, pp. 1612-1614
-
-
Saxena, N.K.1
Titus, M.A.2
Ding, X.3
Floyd, J.4
Srinivasan, S.5
Sitaraman, S.V.6
Anania, F.A.7
-
54
-
-
58149380810
-
Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells
-
De Minicis S, Seki E, Oesterreicher C, Schnabl B, Schwabe RF, Brenner DA. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology. 2008;48:2016-26.
-
(2008)
Hepatology
, vol.48
, pp. 2016-2026
-
-
De Minicis, S.1
Seki, E.2
Oesterreicher, C.3
Schnabl, B.4
Schwabe, R.F.5
Brenner, D.A.6
-
55
-
-
0033943527
-
Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis
-
DOI 10.1016/S0168-8278(00)80156-7
-
Testa R, Franceschini R, Giannini E, Cataldi A, Botta F, Fasoli A, et al. Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis. J Hepatol. 2000;33:33-7. (Pubitemid 30418931)
-
(2000)
Journal of Hepatology
, vol.33
, Issue.1
, pp. 33-37
-
-
Testa, R.1
Franceschini, R.2
Giannini, E.3
Cataldi, A.4
Botta, F.5
Fasoli, A.6
Tenerelli, P.7
Rolandi, E.8
Barreca, T.9
-
56
-
-
0141958538
-
Leptin in relation to hepatocellular carcinoma in patients with liver cirrhosis
-
Wang YY, Lin SY. Leptin in relation to hepatocellular carcinoma in patients with liver cirrhosis. Horm Res. 2003;60:185-90.
-
(2003)
Horm Res.
, vol.60
, pp. 185-190
-
-
Wang, Y.Y.1
Lin, S.Y.2
-
57
-
-
9644265298
-
Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease
-
DOI 10.1016/j.jhep.2004.08.020, PII S0168827804004192
-
Angulo P, Alba LM, Petrovic LM, Adams LA, Lindor KD, Jensen MD. Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease. J Hepatol. 2004;41: 943-9. (Pubitemid 39575661)
-
(2004)
Journal of Hepatology
, vol.41
, Issue.6
, pp. 943-949
-
-
Angulo, P.1
Alba, L.M.2
Petrovic, L.M.3
Adams, L.A.4
Lindor, K.D.5
Jensen, M.D.6
-
58
-
-
0036329894
-
Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: A manifestation of lipotoxicity?
-
DOI 10.1053/jhep.2002.34738
-
Chitturi S, Farrell G, Frost L, Kriketos A, Lin R, Fung C, et al. Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology. 2002;36: 403-9. (Pubitemid 34810360)
-
(2002)
Hepatology
, vol.36
, Issue.2
, pp. 403-409
-
-
Chitturi, S.1
Farrell, G.2
Frost, L.3
Kriketos, A.4
Lin, R.5
Liddle, C.6
Samarasinghe, D.7
George, J.8
-
59
-
-
0347364706
-
Does Leptin Play a Role in the Pathogenesis of Human Nonalcoholic Steatohepatitis?
-
DOI 10.1111/j.1572-0241.2003.08767.x
-
Chalasani N, Crabb DW, Cummings OW, Kwo PY, Asghar A, Pandya PK, et al. Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis? Am J Gastroenterol. 2003;98:2771-6. (Pubitemid 38020122)
-
(2003)
American Journal of Gastroenterology
, vol.98
, Issue.12
, pp. 2771-2776
-
-
Chalasani, N.1
Crabb, D.W.2
Cummings, O.W.3
Kwo, P.Y.4
Asghar, A.5
Pandya, P.K.6
Considine, R.V.7
-
60
-
-
0029980285
-
CDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1)
-
DOI 10.1006/bbrc.1996.0587
-
Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun. 1996; 221:286-9. (Pubitemid 26136463)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.221
, Issue.2
, pp. 286-289
-
-
Maeda, K.1
Okubo, K.2
Shimomura, I.3
Funahashi, T.4
Matsuzawa, Y.5
Matsubara, K.6
-
61
-
-
33745834319
-
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
-
DOI 10.1172/JCI29126
-
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116:1784-92. (Pubitemid 44033298)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1784-1792
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
Hara, K.4
Ueki, K.5
Tobe, K.6
-
62
-
-
0041302377
-
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
-
DOI 10.1172/JCI200317797
-
Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest. 2003;112:91-100. (Pubitemid 38056380)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.1
, pp. 91-100
-
-
Xu, A.1
Wang, Y.2
Keshaw, H.3
Xu, L.Y.4
Lam, K.S.L.5
Cooper, G.J.S.6
-
63
-
-
70349678823
-
Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis
-
Asano T, Watanabe K, Kubota N, Gunji T, Omata M, Kadowaki T, et al. Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis. J Gastroenterol Hepatol. 2009;24: 1669-76.
-
(2009)
J Gastroenterol Hepatol
, vol.24
, pp. 1669-1676
-
-
Asano, T.1
Watanabe, K.2
Kubota, N.3
Gunji, T.4
Omata, M.5
Kadowaki, T.6
-
64
-
-
34548249277
-
Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model
-
DOI 10.1016/j.jhep.2007.03.020, PII S0168827807001894
-
Kamada Y, Matsumoto H, Tamura S, Fukushima J, Kiso S, Fukui K, et al. Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model. J Hepatol. 2007;47:556-64. (Pubitemid 47331742)
-
(2007)
Journal of Hepatology
, vol.47
, Issue.4
, pp. 556-564
-
-
Kamada, Y.1
Matsumoto, H.2
Tamura, S.3
Fukushima, J.4
Kiso, S.5
Fukui, K.6
Igura, T.7
Maeda, N.8
Kihara, S.9
Funahashi, T.10
Matsuzawa, Y.11
Shimomura, I.12
Hayashi, N.13
-
65
-
-
10844220730
-
Adiponectin and its receptors in non-alcoholic steatohepatitis
-
DOI 10.1136/gut.2003.037010
-
Kaser S, Moschen A, Cayon A, Kaser A, Crespo J, Pons-Romero F, et al. Adiponectin and its receptors in non-alcoholic steatohepatitis. Gut. 2005;54:117-21. (Pubitemid 40007229)
-
(2005)
Gut
, vol.54
, Issue.1
, pp. 117-121
-
-
Kaser, S.1
Maschen, A.2
Cayon, A.3
Kaser, A.4
Crespo, J.5
Pons-Romero, F.6
Ebenbichler, C.F.7
Patsch, J.R.8
Tilg, H.9
-
66
-
-
28844440050
-
Decreased serum adiponectin: An early event in pediatric nonalcoholic fatty liver disease
-
DOI 10.1016/j.jpeds.2005.07.030, PII S0022347605007079
-
Louthan MV, Barve S, McClain CJ, Joshi-Barve S. Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease. J Pediatr. 2005;147:835-8. (Pubitemid 41774843)
-
(2005)
Journal of Pediatrics
, vol.147
, Issue.6
, pp. 835-838
-
-
Louthan, M.V.1
Barve, S.2
McClain, C.J.3
Joshi-Barve, S.4
-
67
-
-
40749092464
-
Influence of insulin resistance and adipokines in the grade of steatosis of nonalcoholic fatty liver disease
-
DOI 10.1007/s10620-007-9981-3
-
Aller R, de Luis DA, Fernandez L, Calle F, Velayos B, Olcoz JL, et al. Influence of insulin resistance and adipokines in the grade of steatosis of nonalcoholic fatty liver disease. Dig Dis Sci. 2008;53:1088-92. (Pubitemid 351379844)
-
(2008)
Digestive Diseases and Sciences
, vol.53
, Issue.4
, pp. 1088-1092
-
-
Aller, R.1
De Luis, D.A.2
Fernandez, L.3
Calle, F.4
Velayos, B.5
Olcoz, J.L.6
Izaola, O.7
Sagrado, M.G.8
Conde, R.9
Gonzalez, J.M.10
-
68
-
-
3042744737
-
Beyond insulin resistance in NASH: TNF-α or adiponectin?
-
DOI 10.1002/hep.20280
-
Hui JM, Hodge A, Farrell GC, Kench JG, Kriketos A, George J. Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology. 2004;40:46-54. (Pubitemid 38868922)
-
(2004)
Hepatology
, vol.40
, Issue.1
, pp. 46-54
-
-
Hui, J.M.1
Hodge, A.2
Farrell, G.C.3
Kench, J.G.4
Kriketos, A.5
George, J.6
-
69
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
DOI 10.1038/35053000
-
Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409:307-12. (Pubitemid 32151228)
-
(2001)
Nature
, vol.409
, Issue.6818
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
Brown, E.J.4
Banerjee, R.R.5
Wright, C.M.6
Patel, H.R.7
Ahima, R.S.8
Lazar, M.A.9
-
70
-
-
10744225368
-
Regulation of fasted blood glucose by resistin
-
DOI 10.1126/science.1092341
-
Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, et al. Regulation of fasted blood glucose by resistin. Science. 2004;303:1195-8. (Pubitemid 38233585)
-
(2004)
Science
, vol.303
, Issue.5661
, pp. 1195-1198
-
-
Banerjee, R.R.1
Rangwala, S.M.2
Shapiro, J.S.3
Rich, A.S.4
Rhoades, B.5
Qi, Y.6
Wang, J.7
Rajala, M.W.8
Pocai, A.9
Scherer, P.E.10
Steppan, C.M.11
Ahima, R.S.12
Obici, S.13
Rossetti, L.14
Lazar, M.A.15
-
71
-
-
11144236848
-
Adenovirus-mediated high expression of resistin causes dyslipidemia in mice
-
DOI 10.1210/en.2004-0985
-
Sato N, Kobayashi K, Inoguchi T, Sonoda N, Imamura M, Sekiguchi N, et al. Adenovirus-mediated high expression of resistin causes dyslipidemia in mice. Endocrinology. 2005;146: 273-9. (Pubitemid 40051749)
-
(2005)
Endocrinology
, vol.146
, Issue.1
, pp. 273-279
-
-
Sato, N.1
Kobayashi, K.2
Inoguchi, T.3
Sonoda, N.4
Imamura, M.5
Sekiguchi, N.6
Nakashima, N.7
Nawata, H.8
-
72
-
-
0035487109
-
Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator - Activated Receptor-γ Action in Humans
-
Savage DB, Sewter CP, Klenk ES, Segal DG, Vidal-Puig A, Considine RV, et al. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes. 2001;50:2199-202. (Pubitemid 33641901)
-
(2001)
Diabetes
, vol.50
, Issue.10
, pp. 2199-2202
-
-
Savage, D.B.1
Sewter, C.P.2
Klenk, E.S.3
Segal, D.G.4
Vidal-Puig, A.5
Considine, R.V.6
O'Rahilly, S.7
-
73
-
-
33644826101
-
Macrophages in human visceral adipose tissue: Increased accumulation in obesity and a source of resistin and visfatin
-
DOI 10.1007/s00125-006-0173-z
-
Curat CA, Wegner V, Sengenes C, Miranville A, Tonus C, Busse R, et al. Macrophages in human visceral adipose tissue: increased accumulation in obesity and a source of resistin and visfatin. Diabetologia. 2006;49:744-7. (Pubitemid 43357549)
-
(2006)
Diabetologia
, vol.49
, Issue.4
, pp. 744-747
-
-
Curat, C.A.1
Wegner, V.2
Sengenes, C.3
Miranville, A.4
Tonus, C.5
Busse, R.6
Bouloumie, A.7
-
74
-
-
34249887451
-
Resistin as an intrahepatic cytokine: Overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells
-
DOI 10.2353/ajpath.2006.060081
-
Bertolani C, Sancho-Bru P, Failli P, Bataller R, Aleffi S, DeFranco R, et al. Resistin as an intrahepatic cytokine: over-expression during chronic injury and induction of proinflammatory actions in hepatic stellate cells. Am J Pathol. 2006;169: 2042-53. (Pubitemid 351181964)
-
(2006)
American Journal of Pathology
, vol.169
, Issue.6
, pp. 2042-2053
-
-
Bertolani, C.1
Sancho-Bru, P.2
Failli, P.3
Bataller, R.4
Aleffi, S.5
DeFranco, R.6
Mazzinghi, B.7
Romagnani, P.8
Milani, S.9
Gines, P.10
Colmenero, J.11
Parola, M.12
Gelmini, S.13
Tarquini, R.14
Laffi, G.15
Pinzani, M.16
Marra, F.17
-
75
-
-
33644825288
-
Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance
-
DOI 10.1210/jc.2005-1056
-
Pagano C, Soardo G, Pilon C, Milocco C, Basan L, Milan G, et al. Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance. J Clin Endocrinol Metab. 2006;91:1081-6. (Pubitemid 43357784)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.3
, pp. 1081-1086
-
-
Pagano, C.1
Soardo, G.2
Pilon, C.3
Milocco, C.4
Basan, L.5
Milan, G.6
Donnini, D.7
Faggian, D.8
Mussap, M.9
Plebani, M.10
Avellini, C.11
Federspil, G.12
Sechi, L.A.13
Vettor, R.14
-
77
-
-
4444382031
-
Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis
-
DOI 10.1111/j.1572-0241.2004.30159.x
-
Chalasani N, Deeg MA, Crabb DW. Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2004;99:1497-502. (Pubitemid 39193189)
-
(2004)
American Journal of Gastroenterology
, vol.99
, Issue.8
, pp. 1497-1502
-
-
Chalasani, N.1
Deeg, M.A.2
Crabb, D.W.3
-
78
-
-
20244370723
-
Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic fatty liver disease
-
DOI 10.1111/j.1572-0241.2005.41500.x
-
Yesilova Z, Yaman H, Oktenli C, Ozcan A, Uygun A, Cakir E, et al. Systemic markers of lipid peroxidation and antioxidants in patients with nonalcoholic fatty liver disease. Am J Gastroenterol. 2005;100:850-5. (Pubitemid 40592378)
-
(2005)
American Journal of Gastroenterology
, vol.100
, Issue.4
, pp. 850-855
-
-
Yesilova, Z.1
Yaman, H.2
Oktenli, C.3
Ozcan, A.4
Uygun, A.5
Cakir, E.6
Sanisoglu, S.Y.7
Erdil, A.8
Ates, Y.9
Aslan, M.10
Musabak, U.11
Erbil, M.K.12
Karaeren, N.13
Dagalp, K.14
-
79
-
-
0035991444
-
In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
-
DOI 10.1016/S0168-8278(02)00073-9, PII S0168827802000739
-
Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K, Wakasa K. In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases. J Hepatol. 2002;37:56-62. (Pubitemid 34713055)
-
(2002)
Journal of Hepatology
, vol.37
, Issue.1
, pp. 56-62
-
-
Seki, S.1
Kitada, T.2
Yamada, T.3
Sakaguchi, H.4
Nakatani, K.5
Wakasa, K.6
-
80
-
-
20044393839
-
NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells
-
DOI 10.1002/hep.20719
-
Adachi T, Togashi H, Suzuki A, Kasai S, Ito J, Sugahara K, et al. NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells. Hepatology. 2005;41: 1272-81. (Pubitemid 40770279)
-
(2005)
Hepatology
, vol.41
, Issue.6
, pp. 1272-1281
-
-
Adachi, T.1
Togashi, H.2
Suzuki, A.3
Kasai, S.4
Ito, J.5
Sugahara, K.6
Kawata, S.7
-
81
-
-
13544261760
-
Activation of the phagocyte NADPH oxidase by rac guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase
-
DOI 10.1074/jbc.M410257200
-
Mizrahi A, Molshanski-Mor S, Weinbaum C, Zheng Y, Hirshberg M, Pick E. Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase. J Biol Chem. 2005;280:3802-11. (Pubitemid 40223849)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.5
, pp. 3802-3811
-
-
Mizrahi, A.1
Molshanski-Mor, S.2
Weinbaum, C.3
Zheng, Y.4
Hirshberg, M.5
Pick, E.6
-
82
-
-
0035893937
-
The role of kupffer cell oxidant production in early ethanol-induced liver disease
-
DOI 10.1016/S0891-5849(01)00748-1, PII S0891584901007481
-
Wheeler MD, Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, et al. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med. 2001;31: 1544-9. (Pubitemid 34026339)
-
(2001)
Free Radical Biology and Medicine
, vol.31
, Issue.12
, pp. 1544-1549
-
-
Wheeler, M.D.1
Kono, H.2
Yin, M.3
Nakagami, M.4
Uesugi, T.5
Arteel, G.E.6
Gabele, E.7
Rusyn, I.8
Yamashina, S.9
Froh, M.10
Adachi, Y.11
Iimuro, Y.12
Bradford, B.U.13
Smutney, O.M.14
Connor, H.D.15
Mason, R.P.16
Goyert, S.M.17
Peters, J.M.18
Gonzalez, F.J.19
Samulski, R.J.20
Thurman, R.G.21
more..
-
83
-
-
34249791153
-
NOX in liver fibrosis
-
DOI 10.1016/j.abb.2007.04.016, PII S0003986107002056, Highlight Issue: Pro- and antiapoptotic Signalling
-
De Minicis S, Brenner DA. NOX in liver fibrosis. Arch Biochem Biophys. 2007;462:266-72. (Pubitemid 46856330)
-
(2007)
Archives of Biochemistry and Biophysics
, vol.462
, Issue.2
, pp. 266-272
-
-
De Minicis, S.1
Brenner, D.A.2
-
84
-
-
22844440003
-
Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis
-
DOI 10.1074/jbc.M414361200
-
Reinehr R, Becker S, Eberle A, Grether-Beck S, Haussinger D. Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J Biol Chem. 2005;280:27179-94. (Pubitemid 41040757)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.29
, pp. 27179-27194
-
-
Reinehr, R.1
Becker, S.2
Eberle, A.3
Grether-Beck, S.4
Haussinger, D.5
-
85
-
-
33745739887
-
NADPH oxidase in the liver: Defensive, offensive, or fibrogenic?
-
De Minicis S, Bataller R, Brenner DA. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Gastroenterology. 2006;131:272-5.
-
(2006)
Gastroenterology
, vol.131
, pp. 272-275
-
-
De Minicis, S.1
Bataller, R.2
Brenner, D.A.3
-
86
-
-
77957946240
-
Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis
-
De Minicis S, Seki E, Paik YH, Osterreicher CH, Kodama Y, Kluwe J, et al. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Hepatology. 2010;52:1420-30.
-
(2010)
Hepatology
, vol.52
, pp. 1420-1430
-
-
De Minicis, S.1
Seki, E.2
Paik, Y.H.3
Osterreicher, C.H.4
Kodama, Y.5
Kluwe, J.6
-
88
-
-
68049142588
-
Non-alcoholic fatty liver disease pathogenesis: The present and the future
-
Petta S, Muratore C, Craxi A. Non-alcoholic fatty liver disease pathogenesis: the present and the future. Dig Liver Dis. 2009;41:615-25.
-
(2009)
Dig Liver Dis.
, vol.41
, pp. 615-625
-
-
Petta, S.1
Muratore, C.2
Craxi, A.3
-
89
-
-
0035084699
-
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
-
Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology. 2001;120:1183-92. (Pubitemid 32246672)
-
(2001)
Gastroenterology
, vol.120
, Issue.5
, pp. 1183-1192
-
-
Sanyal, A.J.1
Campbell-Sargent, C.2
Mirshahi, F.3
Rizzo, W.B.4
Contos, M.J.5
Sterling, R.K.6
Luketic, V.A.7
Shiffman, M.L.8
Clore, J.N.9
-
90
-
-
18144444592
-
Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis
-
DOI 10.1053/jhep.2003.50398
-
Perez-Carreras M, Del Hoyo P, Martin MA, Rubio JC, Martin A, Castellano G, et al. Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology. 2003;38:999-1007. (Pubitemid 37221683)
-
(2003)
Hepatology
, vol.38
, Issue.4
, pp. 999-1007
-
-
Perez-Carreras, M.1
Del Hoyo, P.2
Martin, M.A.3
Rubio, J.C.4
Martin, A.5
Castellano, G.6
Colina, F.7
Arenas, J.8
Solis-Herruzo, J.A.9
-
91
-
-
33749999530
-
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
-
DOI 10.1016/j.cell.2006.09.024, PII S0092867406012281
-
St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006;127:397-408. (Pubitemid 44572377)
-
(2006)
Cell
, vol.127
, Issue.2
, pp. 397-408
-
-
St-Pierre, J.1
Drori, S.2
Uldry, M.3
Silvaggi, J.M.4
Rhee, J.5
Jager, S.6
Handschin, C.7
Zheng, K.8
Lin, J.9
Yang, W.10
Simon, D.K.11
Bachoo, R.12
Spiegelman, B.M.13
-
93
-
-
0037369729
-
Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis
-
DOI 10.1053/jhep.2003.50095
-
Chalasani N, Gorski JC, Asghar MS, Asghar A, Foresman B, Hall SD, et al. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Hepatology. 2003;37:544-50. (Pubitemid 36258775)
-
(2003)
Hepatology
, vol.37
, Issue.3
, pp. 544-550
-
-
Chalasani, N.1
Christopher Gorski, J.2
Asghar, M.S.3
Asghar, A.4
Foresman, B.5
Hall, S.D.6
Crabb, D.W.7
-
94
-
-
0842287450
-
Mitochondrial beta-oxidation
-
Bartlett K, Eaton S. Mitochondrial beta-oxidation. Eur J Biochem. 2004;271:462-9.
-
(2004)
Eur J Biochem.
, vol.271
, pp. 462-469
-
-
Bartlett, K.1
Eaton, S.2
-
95
-
-
0029829455
-
Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
-
Weltman MD, Farrell GC, Liddle C. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology. 1996;111:1645-53. (Pubitemid 26404230)
-
(1996)
Gastroenterology
, vol.111
, Issue.6
, pp. 1645-1653
-
-
Weltman, M.D.1
Farrell, G.C.2
Liddle, C.3
-
96
-
-
0031962151
-
Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis
-
DOI 10.1002/hep.510270121
-
Weltman MD, Farrell GC, Hall P, Ingelman-Sundberg M, Liddle C. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology. 1998;27:128-33. (Pubitemid 28041545)
-
(1998)
Hepatology
, vol.27
, Issue.1
, pp. 128-133
-
-
Weltman, M.D.1
Farrell, G.C.2
Hall, P.3
Ingelman-Sundberg, M.4
Liddle, C.5
-
97
-
-
69549138691
-
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease
-
Kathirvel E, Morgan K, French SW, Morgan TR. Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 2009;21:973-83.
-
(2009)
Eur J Gastroenterol Hepatol
, vol.21
, pp. 973-983
-
-
Kathirvel, E.1
Morgan, K.2
French, S.W.3
Morgan, T.R.4
-
98
-
-
79954514102
-
Apoptosis in nonalcoholic fatty liver disease: Diagnostic and therapeutic implications
-
Alkhouri N, Carter-Kent C, Feldstein AE. Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications. Expert Rev Gastroenterol Hepatol. 2011;5:201-12.
-
(2011)
Expert Rev Gastroenterol Hepatol
, vol.5
, pp. 201-212
-
-
Alkhouri, N.1
Carter-Kent, C.2
Feldstein, A.E.3
-
99
-
-
34848861130
-
Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis
-
DOI 10.1074/jbc.M704391200
-
Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ. Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem. 2007;282: 27141-54. (Pubitemid 47501972)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.37
, pp. 27141-27154
-
-
Barreyro, F.J.1
Kobayashi, S.2
Bronk, S.F.3
Werneburg, N.W.4
Malhi, H.5
Gores, G.J.6
-
100
-
-
0142151769
-
Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
-
DOI 10.1053/jhep.2003.50472
-
Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF, et al. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology. 2003;38:1188-98. (Pubitemid 37314827)
-
(2003)
Hepatology
, vol.38
, Issue.5
, pp. 1188-1198
-
-
Canbay, A.1
Feldstein, A.E.2
Higuchi, H.3
Werneburg, N.4
Grambihler, A.5
Bronk, S.F.6
Gores, G.J.7
-
101
-
-
77649132053
-
Mechanisms and clinical implications of hepatocyte lipoapoptosis
-
Cazanave SC, Gores GJ. Mechanisms and clinical implications of hepatocyte lipoapoptosis. Clin Lipidol. 2010;5:71-85.
-
(2010)
Clin Lipidol
, vol.5
, pp. 71-85
-
-
Cazanave, S.C.1
Gores, G.J.2
-
102
-
-
72949123737
-
Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis
-
Witek RP, Stone WC, Karaca FG, Syn WK, Pereira TA, Agboola KM, et al. Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. Hepatology. 2009;50:1421-30.
-
(2009)
Hepatology
, vol.50
, pp. 1421-1430
-
-
Witek, R.P.1
Stone, W.C.2
Karaca, F.G.3
Syn, W.K.4
Pereira, T.A.5
Agboola, K.M.6
-
103
-
-
33745904468
-
In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
-
DOI 10.1002/hep.21223
-
Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology. 2006;44:27-33. (Pubitemid 44049136)
-
(2006)
Hepatology
, vol.44
, Issue.1
, pp. 27-33
-
-
Wieckowska, A.1
Zein, N.N.2
Yerian, L.M.3
Lopez, A.R.4
McCullough, A.J.5
Feldstein, A.E.6
-
104
-
-
53849114643
-
A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH)
-
Younossi ZM, Jarrar M, Nugent C, Randhawa M, Afendy M, Stepanova M, et al. A novel diagnostic biomarker panel for obesity-related nonalcoholic steatohepatitis (NASH). Obes Surg. 2008;18:1430-7.
-
(2008)
Obes Surg
, vol.18
, pp. 1430-1437
-
-
Younossi, Z.M.1
Jarrar, M.2
Nugent, C.3
Randhawa, M.4
Afendy, M.5
Stepanova, M.6
-
105
-
-
78449286054
-
A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients
-
Anty R, Iannelli A, Patouraux S, Bonnafous S, Lavallard VJ, Senni-Buratti M, et al. A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients. Aliment Pharmacol Ther. 2010;32:1315-22.
-
(2010)
Aliment Pharmacol Ther
, vol.32
, pp. 1315-1322
-
-
Anty, R.1
Iannelli, A.2
Patouraux, S.3
Bonnafous, S.4
Lavallard, V.J.5
Senni-Buratti, M.6
-
106
-
-
75449091150
-
Noninvasive assessment of liver disease severity with liver fat score and CK-18 in NAFLD: Prognostic value of liver fat equation goes beyond hepatic fat estimation
-
Musso G, Gambino R, Durazzo M, Cassader M. Noninvasive assessment of liver disease severity with liver fat score and CK-18 in NAFLD: prognostic value of liver fat equation goes beyond hepatic fat estimation. Hepatology. 2010;51:715-7.
-
(2010)
Hepatology
, vol.51
, pp. 715-717
-
-
Musso, G.1
Gambino, R.2
Durazzo, M.3
Cassader, M.4
-
107
-
-
24144432258
-
Liver fibrogenesis: A new role for the renin-angiotensin system
-
DOI 10.1089/ars.2005.7.1346
-
Bataller R, Sancho-Bru P, Gines P, Brenner DA. Liver fibrogenesis: a new role for the renin-angiotensin system. Antioxid Redox Signal. 2005;7:1346-55. (Pubitemid 41232532)
-
(2005)
Antioxidants and Redox Signaling
, vol.7
, Issue.9-10
, pp. 1346-1355
-
-
Bataller, R.1
Sancho-Bru, P.2
Gines, P.3
Brenner, D.A.4
-
108
-
-
0037772442
-
Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II
-
DOI 10.1016/S0016-5085(03)00695-4
-
Bataller R, Sancho-Bru P, Gines P, Lora JM, Al-Garawi A, Sole M, et al. Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology. 2003;125:117-25. (Pubitemid 36799113)
-
(2003)
Gastroenterology
, vol.125
, Issue.1
, pp. 117-125
-
-
Bataller, R.1
Sancho-Bru, P.2
Gines, P.3
Lora, J.M.4
Al-Garawi, A.5
Sole, M.6
Colmenero, J.7
Nicolas, J.M.8
Jimenez, W.9
Weich, N.10
Gutierrez-Ramos, J.-C.11
Arroyo, V.12
Rodes, J.13
-
109
-
-
0034120267
-
Angiotensin II induces contraction and proliferation of human hepatic stellate cells
-
Bataller R, Gines P, Nicolas JM, Gorbig MN, Garcia-Ramallo E, Gasull X, et al. Angiotensin II induces contraction and proliferation of human hepatic stellate cells. Gastroenterology. 2000;118:1149-56. (Pubitemid 30346992)
-
(2000)
Gastroenterology
, vol.118
, Issue.6
, pp. 1149-1156
-
-
Bataller, R.1
Gines, P.2
Nicolas, J.M.3
Gorbig M.Nieves4
GarciaRamallo, E.5
Gasull, X.6
Bosch, J.7
Arroyo, V.8
Rodes, J.9
-
110
-
-
0347986777
-
NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis
-
DOI 10.1172/JCI200318212
-
Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, et al. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003;112:1383-94. (Pubitemid 38057692)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.9
, pp. 1383-1394
-
-
Bataller, R.1
Schwabe, R.F.2
Choi, Y.H.3
Yang, L.4
Paik, Y.H.5
Lindquist, J.6
Qian, T.7
Schoonhoven, R.8
Hagedorn, C.H.9
Lemasters, J.J.10
Brenner, D.A.11
-
111
-
-
54549098072
-
Cytokines and renin-angiotensin system signaling in hepatic fibrosis
-
ix
-
Moreno M, Bataller R. Cytokines and renin-angiotensin system signaling in hepatic fibrosis. Clin Liver Dis. 2008;12:825-52, ix.
-
(2008)
Clin Liver Dis.
, vol.12
, pp. 825-852
-
-
Moreno, M.1
Bataller, R.2
-
112
-
-
0038071747
-
Angiotensin II stimulates the nuclear translocation of Smad2 and induces PAI-1 mRNA in rat hepatic stellate cells
-
DOI 10.1016/S1386-6346(02)00306-6, PII S1386634602003066
-
Kamada Y, Tamura S, Kiso S, Fukui K, Doi Y, Ito N, et al. Angiotensin II stimulates the nuclear translocation of Smad2 and induces PAI-1 mRNA in rat hepatic stellate cells. Hepatol Res. 2003;25:296-305. (Pubitemid 36546356)
-
(2003)
Hepatology Research
, vol.25
, Issue.3
, pp. 296-305
-
-
Kamada, Y.1
Tamura, S.2
Kiso, S.3
Fukui, K.4
Doi, Y.5
Ito, N.6
Terui, Y.7
Saito, T.8
Watanabe, H.9
Togashi, H.10
Kawata, S.11
Matsuzawa, Y.12
-
113
-
-
18844457924
-
Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expression
-
DOI 10.1007/s10620-005-2669-7
-
Kanno K, Tazuma S, Nishioka T, Hyogo H, Chayama K. Angiotensin II participates in hepatic inflammation and fibrosis through MCP-1 expression. Dig Dis Sci. 2005;50:942-8. (Pubitemid 40684916)
-
(2005)
Digestive Diseases and Sciences
, vol.50
, Issue.5
, pp. 942-948
-
-
Kanno, K.1
Tazuma, S.2
Nishioka, T.3
Hyogo, H.4
Chayama, K.5
-
114
-
-
21844457440
-
Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice
-
DOI 10.1016/j.jhep.2005.02.034, PII S0168827805002710
-
Yang L, Bataller R, Dulyx J, Coffman TM, Gines P, Rippe RA, et al. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005;43: 317-23. (Pubitemid 40956886)
-
(2005)
Journal of Hepatology
, vol.43
, Issue.2
, pp. 317-323
-
-
Yang, L.1
Bataller, R.2
Dulyx, J.3
Coffman, T.M.4
Gines, P.5
Rippe, R.A.6
Brenner, D.A.7
-
115
-
-
65649112801
-
Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis
-
Georgescu EF, Ionescu R, Niculescu M, Mogoanta L, Vancica L. Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis. World J Gastroenterol. 2009;15:942-54.
-
(2009)
World J Gastroenterol
, vol.15
, pp. 942-954
-
-
Georgescu, E.F.1
Ionescu, R.2
Niculescu, M.3
Mogoanta, L.4
Vancica, L.5
-
116
-
-
0001513966
-
Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
-
DOI 10.1073/pnas.94.6.2557
-
Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA. 1997;94:2557-62. (Pubitemid 27136914)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.6
, pp. 2557-2562
-
-
Yang, S.Q.1
Lin, H.Z.2
Lane, M.D.3
Clemens, M.4
Diehl, A.M.5
-
117
-
-
35948958955
-
TLR4 enhances TGF-β signaling and hepatic fibrosis
-
DOI 10.1038/nm1663, PII NM1663
-
Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med. 2007;13:1324-32. (Pubitemid 350073596)
-
(2007)
Nature Medicine
, vol.13
, Issue.11
, pp. 1324-1332
-
-
Seki, E.1
De Minicis, S.2
Osterreicher, C.H.3
Kluwe, J.4
Osawa, Y.5
Brenner, D.A.6
Schwabe, R.F.7
-
118
-
-
24044432235
-
Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells
-
DOI 10.1152/ajpgi.00537.2004
-
Brun P, Castagliuolo I, Pinzani M, Palu G, Martines D. Exposure to bacterial cell wall products triggers an inflammatory phenotype in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2005;289:G571-8. (Pubitemid 41216395)
-
(2005)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.289
, Issue.3
-
-
Brun, P.1
Castagliuolo, I.2
Pinzani, M.3
Palu, G.4
Martines, D.5
-
119
-
-
47149105036
-
Toll-like receptors and adaptor molecules in liver disease: Update
-
DOI 10.1002/hep.22306
-
Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology. 2008;48:322-35. (Pubitemid 351975556)
-
(2008)
Hepatology
, vol.48
, Issue.1
, pp. 322-335
-
-
Seki, E.1
Brenner, D.A.2
-
120
-
-
70349421143
-
Review article: Nuclear receptors and liver disease-current understanding and new therapeutic implications
-
Elfaki DA, Bjornsson E, Lindor KD. Review article: nuclear receptors and liver disease-current understanding and new therapeutic implications. Aliment Pharmacol Ther. 2009;30:816-25.
-
(2009)
Aliment Pharmacol Ther
, vol.30
, pp. 816-825
-
-
Elfaki, D.A.1
Bjornsson, E.2
Lindor, K.D.3
-
121
-
-
79953173235
-
Nuclear receptors as new perspective for the management of liver diseases
-
Trauner M, Halilbasic E. Nuclear receptors as new perspective for the management of liver diseases. Gastroenterology. 2011;140:1120-5.
-
(2011)
Gastroenterology
, vol.140
, pp. 1120-1125
-
-
Trauner, M.1
Halilbasic, E.2
-
122
-
-
33748794808
-
A model of insulin resistance and nonalcoholic steatohepatitis in rats: Role of peroxisome proliferator-activated receptor-α and n-3 polyunsaturated fatty acid treatment on liver injury
-
DOI 10.2353/ajpath.2006.050953
-
Svegliati-Baroni G, Candelaresi C, Saccomanno S, Ferretti G, Bachetti T, Marzioni M, et al. A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury. Am J Pathol. 2006;169:846-60. (Pubitemid 44411952)
-
(2006)
American Journal of Pathology
, vol.169
, Issue.3
, pp. 846-860
-
-
Svegliati-Baroni, G.1
Candelaresi, C.2
Saccomanno, S.3
Ferretti, G.4
Bachetti, T.5
Marzioni, M.6
De Minicis, S.7
Nobili, L.8
Salzano, R.9
Omenetti, A.10
Pacetti, D.11
Sigmund, S.12
Benedetti, A.13
Casini, A.14
-
123
-
-
63449137594
-
Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia
-
Zhu FS, Liu S, Chen XM, Huang ZG, Zhang DW. Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. World J Gastroenterol. 2008;14:6395-400.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 6395-6400
-
-
Zhu, F.S.1
Liu, S.2
Chen, X.M.3
Huang, Z.G.4
Zhang, D.W.5
-
124
-
-
70349902776
-
Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: A randomized controlled trial employing proton magnetic resonance spectroscopy
-
Cussons AJ, Watts GF, Mori TA, Stuckey BG. Omega-3 fatty acid supplementation decreases liver fat content in polycystic ovary syndrome: a randomized controlled trial employing proton magnetic resonance spectroscopy. J Clin Endocrinol Metab. 2009;94:3842-8.
-
(2009)
J Clin Endocrinol Metab.
, vol.94
, pp. 3842-3848
-
-
Cussons, A.J.1
Watts, G.F.2
Mori, T.A.3
Stuckey, B.G.4
-
125
-
-
36049034344
-
Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
-
DOI 10.1016/j.it.2007.09.003, PII S147149060700244X
-
Straus DS, Glass CK. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol. 2007;28:551-8. (Pubitemid 350101420)
-
(2007)
Trends in Immunology
, vol.28
, Issue.12
, pp. 551-558
-
-
Straus, D.S.1
Glass, C.K.2
-
126
-
-
0036082703
-
Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
-
Galli A, Crabb DW, Ceni E, Salzano R, Mello T, Svegliati-Baroni G, et al. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology. 2002;122:1924-40. (Pubitemid 34651436)
-
(2002)
Gastroenterology
, vol.122
, Issue.7
, pp. 1924-1940
-
-
Galli, A.1
Crabb, D.W.2
Ceni, E.3
Salzano, R.4
Mello, T.5
SvegliatiBaroni, G.6
Ridolfi, F.7
Trozzi, L.8
Surrenti, C.9
Casini, A.10
-
127
-
-
0033855572
-
Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells
-
Marra F, Efsen E, Romanelli RG, Caligiuri A, Pastacaldi S, Batignani G, et al. Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology. 2000;119: 466-78. (Pubitemid 30621997)
-
(2000)
Gastroenterology
, vol.119
, Issue.2
, pp. 466-478
-
-
Marra, F.1
Efsen, E.2
Romanelli, R.G.3
Caligiuri, A.4
Pastacaldi, S.5
Batignani, G.6
Bonacchi, A.7
Caporale, R.8
Laffi, G.9
Pinzani, M.10
Gentilini, P.11
-
128
-
-
78649596998
-
Therapeutic trials in nonalcoholic steatohepatitis: Insulin sensitizers and related methodological issues
-
Ratziu V, Caldwell S, Neuschwander-Tetri BA. Therapeutic trials in nonalcoholic steatohepatitis: insulin sensitizers and related methodological issues. Hepatology. 2010;52:2206-15.
-
(2010)
Hepatology
, vol.52
, pp. 2206-2215
-
-
Ratziu, V.1
Caldwell, S.2
Neuschwander-Tetri, B.A.3
-
129
-
-
0035800772
-
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
-
Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem. 2001;276:28857-65.
-
(2001)
J Biol Chem.
, vol.276
, pp. 28857-28865
-
-
Ananthanarayanan, M.1
Balasubramanian, N.2
Makishima, M.3
Mangelsdorf, D.J.4
Suchy, F.J.5
-
130
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
DOI 10.1074/jbc.M109326200
-
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive and rostane receptor. J Biol Chem. 2002;277:2908-15. (Pubitemid 34953324)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.4
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
Kliewer, S.8
Willson, T.M.9
Edwards, P.A.10
-
131
-
-
0037101810
-
6α-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
-
DOI 10.1021/jm025529g
-
Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, et al. 6alpha-ethyl-chenodeoxycholic acid (6-EC-DCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem. 2002;45:3569-72. (Pubitemid 34856095)
-
(2002)
Journal of Medicinal Chemistry
, vol.45
, Issue.17
, pp. 3569-3572
-
-
Pellicciari, R.1
Fiorucci, S.2
Camaioni, E.3
Clerici, C.4
Costantino, G.5
Maloney, P.R.6
Morelli, A.7
Parks, D.J.8
Willson, T.M.9
-
132
-
-
0037315190
-
Bile acids induce the expression of the human peroxisome proliferator-activated receptor α gene via activation of the farnesoid X receptor
-
DOI 10.1210/me.2002-0120
-
Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Mol Endocrinol. 2003;17:259-72. (Pubitemid 36183149)
-
(2003)
Molecular Endocrinology
, vol.17
, Issue.2
, pp. 259-272
-
-
Torra, I.P.1
Claudel, T.2
Duval, C.3
Kosykh, V.4
Fruchart, J.-C.5
Staels, B.6
-
133
-
-
33645509321
-
Farnesoid X receptor is essential for normal glucose homeostasis
-
Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006;116:1102-9.
-
(2006)
J Clin Invest.
, vol.116
, pp. 1102-1109
-
-
Ma, K.1
Saha, P.K.2
Chan, L.3
Moore, D.D.4
-
134
-
-
33645821043
-
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
-
Huang W, Ma K, Zhang J, Qatanani M, Cuvillier J, Liu J, et al. Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science. 2006;312:233-6.
-
(2006)
Science
, vol.312
, pp. 233-236
-
-
Huang, W.1
Ma, K.2
Zhang, J.3
Qatanani, M.4
Cuvillier, J.5
Liu, J.6
-
135
-
-
54749112350
-
Modulation of the endocannabinoid system in cardiovascular disease: Therapeutic potential and limitations
-
Pacher P, Mukhopadhyay P, Mohanraj R, Godlewski G, Batkai S, Kunos G. Modulation of the endocannabinoid system in cardiovascular disease: therapeutic potential and limitations. Hypertension. 2008;52:601-7.
-
(2008)
Hypertension
, vol.52
, pp. 601-607
-
-
Pacher, P.1
Mukhopadhyay, P.2
Mohanraj, R.3
Godlewski, G.4
Batkai, S.5
Kunos, G.6
-
136
-
-
33745003240
-
CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
-
DOI 10.1038/nm1421, PII N1421
-
Teixeira-Clerc F, Julien B, Grenard P, Tran Van Nhieu J, Deveaux V, Li L, et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med. 2006;12:671-6. (Pubitemid 43865236)
-
(2006)
Nature Medicine
, vol.12
, Issue.6
, pp. 671-676
-
-
Teixeira-Clerc, F.1
Julien, B.2
Grenard, P.3
Van Nhieu, J.T.4
Deveaux, V.5
Li, L.6
Serriere-Lanneau, V.7
Ledent, C.8
Mallat, A.9
Lotersztajn, S.10
-
137
-
-
15744388722
-
Antifibrogenic role of the cannabinoid receptor CB2 in the liver
-
DOI 10.1053/j.gastro.2004.12.050
-
Julien B, Grenard P, Teixeira-Clerc F, Van Nhieu JT, Li L, Karsak M, et al. Antifibrogenic role of the cannabinoid receptor CB2 in the liver. Gastroenterology. 2005;128:742-55. (Pubitemid 40585376)
-
(2005)
Gastroenterology
, vol.128
, Issue.3
, pp. 742-755
-
-
Julien, B.1
Grenard, P.2
Teixeira-Clerc, F.3
Van Nhieu, J.T.4
Li, L.5
Karsak, M.6
Zimmer, A.7
Mallat, A.8
Lotersztajn, S.9
-
138
-
-
42449136138
-
1 blockade with rimonabant on cardiometabolic risk factors: Two year results from the RIO-Europe Study
-
DOI 10.1093/eurheartj/ehn076
-
Van Gaal LF, Scheen AJ, Rissanen AM, Rossner S, Hanotin C, Ziegler O. Long-term effect of CB1 blockade with rimonabant on cardiometabolic risk factors: two year results from the RIO-Europe Study. Eur Heart J. 2008;29:1761-71. (Pubitemid 352019811)
-
(2008)
European Heart Journal
, vol.29
, Issue.14
, pp. 1761-1771
-
-
Van Gaal, L.F.1
Scheen, A.J.2
Rissanen, A.M.3
Rossner, S.4
Hanotin, C.5
Ziegler, O.6
-
139
-
-
65649122618
-
Cannabinoid receptor antagonists: Pharmacological opportunities, clinical experience, and translational prognosis
-
Janero DR, Makriyannis A. Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. Expert Opin Emerg Drugs. 2009;14:43-65.
-
(2009)
Expert Opin Emerg Drugs.
, vol.14
, pp. 43-65
-
-
Janero, D.R.1
Makriyannis, A.2
-
140
-
-
79954507610
-
Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease
-
Daly AK, Ballestri S, Carulli L, Loria P, Day CP. Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease. Expert Rev Gastroenterol Hepatol. 2011;5:253-63.
-
(2011)
Expert Rev Gastroenterol Hepatol
, vol.5
, pp. 253-263
-
-
Daly, A.K.1
Ballestri, S.2
Carulli, L.3
Loria, P.4
Day, C.P.5
-
141
-
-
56749096610
-
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
-
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet. 2008;40:1461-5.
-
(2008)
Nat Genet
, vol.40
, pp. 1461-1465
-
-
Romeo, S.1
Kozlitina, J.2
Xing, C.3
Pertsemlidis, A.4
Cox, D.5
Pennacchio, L.A.6
-
142
-
-
79960729651
-
Mouse patatinlike phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis
-
Qiao A, Liang J, Ke Y, Li C, Cui Y, Shen L, et al. Mouse patatinlike phospholipase domain-containing 3 influences systemic lipid and glucose homeostasis. Hepatology. 2011;54:509-21.
-
(2011)
Hepatology
, vol.54
, pp. 509-521
-
-
Qiao, A.1
Liang, J.2
Ke, Y.3
Li, C.4
Cui, Y.5
Shen, L.6
-
143
-
-
77950607738
-
Homozygosity for the patatin-like phospholipase-3/adiponutrin I148 M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
-
Valenti L, Al-Serri A, Daly AK, Galmozzi E, Rametta R, Dongiovanni P, et al. Homozygosity for the patatin-like phospholipase-3/adiponutrin I148 M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease. Hepatology. 2010;51:1209-17.
-
(2010)
Hepatology
, vol.51
, pp. 1209-1217
-
-
Valenti, L.1
Al-Serri, A.2
Daly, A.K.3
Galmozzi, E.4
Rametta, R.5
Dongiovanni, P.6
-
144
-
-
78650336759
-
Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease
-
Hotta K, Yoneda M, Hyogo H, Ochi H, Mizusawa S, Ueno T, et al. Association of the rs738409 polymorphism in PNPLA3 with liver damage and the development of nonalcoholic fatty liver disease. BMC Med Genet. 2010;11:172.
-
(2010)
BMC Med Genet
, vol.11
, pp. 172
-
-
Hotta, K.1
Yoneda, M.2
Hyogo, H.3
Ochi, H.4
Mizusawa, S.5
Ueno, T.6
-
145
-
-
78049457761
-
Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease
-
Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S, et al. Genome-wide association study identifies variants associated with histologic features of nonalcoholic fatty liver disease. Gastroenterology. 2010;139:1567-76.
-
(2010)
Gastroenterology
, vol.139
, pp. 1567-1576
-
-
Chalasani, N.1
Guo, X.2
Loomba, R.3
Goodarzi, M.O.4
Haritunians, T.5
Kwon, S.6
-
146
-
-
79953745343
-
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
-
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, et al. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 2011;7:e1001324.
-
(2011)
PLoS Genet
, vol.7
-
-
Speliotes, E.K.1
Yerges-Armstrong, L.M.2
Wu, J.3
Hernaez, R.4
Kim, L.J.5
Palmer, C.D.6
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