Adiponectin modulates NK-cell function

European Journal of Immunology

Volumn 43, Issue 4, 2013, Pages 1024-1033

  Wilk, Sabrina ^a   Jenke, Alexander ^a   Stehr, Jenny ^a   Yang, Chin An ^a   Bauer, Sandra ^a   Göldner, Katrin ^a   Kotsch, Katja ^b   Volk, Hans Dieter ^a,c   Poller, Wolfgang ^a   Schultheiss, Heinz Peter ^a   Skurk, Carsten ^a   Scheibenbogen, Carmen ^a,c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c Berlin Brandenburg Center for Regenerative Therapies   (Germany)

Author keywords

Adiponectin; Adiponectin KO mice; Adiponectin receptors 1 or 2; Immunomodulation; NK cells

Indexed keywords

ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; CD11B ANTIGEN; CD27 ANTIGEN; CD56 ANTIGEN; CD94 ANTIGEN; GAMMA INTERFERON; NATURAL KILLER CELL RECEPTOR NKG2D; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CELL FUNCTION; CELL SUBPOPULATION; CONTROLLED STUDY; CYTOTOXICITY; DEGRANULATION; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; KNOCKOUT MOUSE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; VIRUS INFECTION;

ADIPONECTIN; ANIMALS; CELL DEGRANULATION; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LIGANDS; MICE; MICE, KNOCKOUT; RECEPTORS, ADIPONECTIN; TOLL-LIKE RECEPTORS;

EID: 84876433299     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242382     Document Type: Article

References (32)

1. Tilg, H. and Moschen, A. R., Adipocytokines mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 2006. 6: 772-783.
2. Han, S. H., Sakuma, I., Shin, E.K. and Koh, K. K., Antiatherosclerotic and anti-insulin resistance effects of Adiponectin: basic and clinical studies. Prog. Cardiovasc. Dis 2009. 52: 126-140.
3. Okamoto, Y., Christen, T., Shimizu, K., Asano, K., Kihara, S., Mitchell, R. N. and Libby, P., Adiponectin inhibits allograft rejection in murine cardiac transplantation. Transplantation 2009. 88: 879-883.
4. Kamada, Y., Tamura, S., Kiso, S., Matsumoto H., Saji, Y., Yoshiba, Y., Fukui, K. et al., Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin. Gastroenterology 2003. 125: 1796-1807.
5. Nishihara, T., Matsuda, M., Araki, H., Oshima, K., Kihara, S., Funahashi, T. and Shimomura, I., Effect of adiponectin on murine colitis induced by dextran sulfate sodium. Gastroenterology 2006. 131: 853-861.
6. Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, Y., Kita, S., Sugiyama, T. et al., Cloning of adiponectin receptor that mediate antidiabetic metabolic effects. Nature 2004. 423: 762-769.
7. Pang, T. T. and Narendran, P., The distribution of adiponectin receptors on human peripheral blood mononuclear cells. Ann. N. Y. Acad. Sci. 2008. 1150: 143-145.
8. Wilk, S., Scheibenbogen, C., Bauer, S., Jenke, A., Rother, M., Guerreiro, M., Kudernatsch, R. et al., Adiponectin is a negative regulator of antigen-activated T cells. Eur. J. Immunol. 2011. 41: 2323-2332.
9. Robinson, K., Prins, J., Venkatesh, B., Clinical review: adiponectin biology and its role in inflammation and critical illness. Crit. Care 2011. 15:221-229.
10. Yamaguchi, N., Argueta, J. G., Masuhiro, Y., Kagishita, M., Nonaka, K., Saito, T., Hanazawa, S. et al., Adiponectin inhibits Toll-like receptor family-induced signaling. FEBS Lett. 2005. 579: 6821-6826.
11. Ohashi, K., Parker, J. L., Ouchi, N., Higuchi, A., Vita, J. A., Gokce, N., Pedersen, A. A. et al., Adiponectin promotes macrophage polarization towards an anti-inflammatory phenotype. J. Biol. Chem. 2010. 285: 6153-6160.
12. Yokota, T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi, N., Kihara, S. et al., Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000. 96: 1723-1732.
13. Yokota, T., Meka, C. S. R., Kouro, T., Medina, K. L., Igarashi, H., Takahashi, M., Oritani, K. et al., APN, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase-prostaglandin pathway in stromal cells. J. Immunol. 2003. 171: 5091-5099.
14. Trinchieri, G., Biology of natural killer cells. Adv. Immunol. 1989. 47: 187-376.
15. Zitvogel, L., Terme, M., Borg, C. and Trinchieri, G., Dentritic cell-NK cell cross-talk: regulation and physiopathology. Curr. Top Microbiol. Immunol. 2006. 298: 157-174.
16. Kim, K. Y., Kim, J. K., Han, S. H., Lim, J. S., Kim, J. I., Cho, D. H., Lee, M. S. et al., Adiponectin is a negative regulator of NK cell cytotoxicity. J. Immunol. 2006. 176: 5958-5964.
17. O'Shea, D., Cawood, T. J., O'Farrelly, C. and Lynch, L., Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PloS One 2010. 5(1); e8668.
18. Brooks, A. G., Posch, P. E., Scorzelli, C. J., Borrego, F. and Coligan, J. E., NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. J. Exp. Med. 1997. 185: 795-800.
19. Yu, J., Wei, M., Mao, H., Zhang, J., Hughes, T., Mitsui, T., Park, I. et al., CD94 defines phenotypically and functionally distinct mouse NK cell subsets. J. Immunol. 2009. 183: 4968-49724.
20. Muntasell, A., Magri, G., Pende, D., Angulo, A. and Lopez-Botet, M., Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection. Blood 2010. 115: 5170-5179.
21. Chiossone, L., Chaix, J., Fuseri, N., Roth, C., Vivier, E. and Walzer, T., Maturation of mouse NK cells is a 4-stage developmental program. Blood 2008. 113: 5488-5496.
22. Fu, B., Wang, F., Sun, R., Ling, B., Tian, Z. and Wie, H., CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells. Immunology 2011. 133: 350-359.
23. Pang, T. T. and Narendran, P. The distribution of adiponectin receptors on human peripheral blood mononuclear cells. Ann. N.Y. Acad. Sci. 2008. 1150: 143-145.
24. dim cells: role of contact with peripheral fibroblasts. J. Immunol. 2007. 179: 89-94.
25. dim NK cells upon activation. J. Immunol. 2008. 178: 4947-4955.
26. Eckelheart, E., Warsch, W., Zebedin, E., Simma, O., Stoiber, D., Kolbe, T., Rülicke, T. et al., A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development. Blood 2011. 117: 1565-1573.
27. Hayakawa, Y., Huntington, N. D., Nutt, S. L. and Smyth, M. J., Functional subsets of mouse natural killer cells. Immunol. Rev. 2006. 214: 47-55.
28. Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips J. H., Lanier, L. L. and Spies, T., Activation of NK cells and T cells by NKG2D, a receptor for stress-Inducible MICA. Science 1999. 285: 727-729.
29. Cosman, D., Müllberg, J., Sutherland, C. L., Chin, W., Armitage, R., Fanslow, W., Kubin, M. et al., ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 2001. 14: 123-133.
30. Kubin, M., Cassiano, L., Chalupny J., Chin, W., Cosman, D., Fanslow W., Müllberg, J. et al., ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur. J. Immunol. 2001. 31: 1428-1437.
31. Alter, G., Malenfant, J. M. and Altfeld, M., CD107a as a functional marker for the identification of natural killer cell activity. J. Immunol. Methods 2004. 294: 15-22.
32. Li, J., Schwimmbeck, P. L., Tschope, C., Leschka, S., Husmann, L., Rutschow, S., Reichenbach, F. et al., Collagen degradetion in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction. Cardiovasc. Res. 2002. 56: 235-247.