Liver failure and defective hepatocyte regeneration in interleukin-6- deficient mice

Science

Volumn 274, Issue 5291, 1996, Pages 1379-1383

  Cressman, Drew E ^a,c   Greenbaum, Linda E ^a   DeAngelis, Robert A ^a   Ciliberto, Gennaro ^b   Furth, Emma E ^a   Poli, Valeria ^b   Taub, Rebecca ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b IRBM   (Italy)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; INTERLEUKIN 1; INTERLEUKIN 6; ONCOPROTEIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; DNA SYNTHESIS; LIVER CELL; LIVER FAILURE; LIVER NECROSIS; LIVER PARENCHYMA; LIVER REGENERATION; LIVER RESECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

ANIMALS; CYCLIN D1; CYCLINS; DNA; DNA-BINDING PROTEINS; G1 PHASE; GENE EXPRESSION REGULATION; GENE TARGETING; GENES, IMMEDIATE-EARLY; HEPATECTOMY; INTERLEUKIN-6; LIVER; LIVER FAILURE; LIVER REGENERATION; MICE; MICE, INBRED C57BL; MITOSIS; MUTATION; NECROSIS; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTOR AP-1;

ANIMALIA;

EID: 0029846756     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5291.1379     Document Type: Article

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61. We thank J. Darnell for the STAT3 cDNA, U. Muller Eberhard and S. Maeda for the hemopexin (HPX) and serum amyloid P-component (SAP) probes, and C. Steer for the gift of the cyclin D1 cDNA and helpful discussions. We also thank C. Deutschmann, R. Diamond, D. Tewari, P. Traber, M. Lazar, and F. Rauscher for helpful discussions; S. Hwang and V. Miles for technical assistance; and J. Matthews for assistance with manuscript preparation. This work was in part supported by NIH grants DK44237, DK49210, and DK49629 (to R.T.); NIH grant K08 (to L.E.G.); the University of Pennsylvania Genetics Training Grant (to R.A.D.); and the Howard Hughes Medical Institute.