The Adipocyte as an Endocrine Cell

Endocrinology and Metabolism Clinics of North America

Volumn 37, Issue 3, 2008, Pages 753-768

  Halberg, Nils ^a,b   Wernstedt Asterholm, Ingrid ^a   Scherer, Philipp E ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; CATHEPSIN K; FUMAGILLOL CHLOROACETYLCARBAMATE; MATRIX METALLOPROTEINASE; OSTEONECTIN;

ADIPOCYTE; ANGIOGENESIS; CELL FUNCTION; ENDOCRINE CELL; EXTRACELLULAR MATRIX; HORMONE RELEASE; HUMAN; IMMUNOREGULATION; INFLAMMATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVIEW; SIGNAL TRANSDUCTION;

ADIPOCYTES; ADIPOKINES; HUMANS; MATRIX METALLOPROTEINASES; NEOVASCULARIZATION, PHYSIOLOGIC; PPAR GAMMA;

EID: 50449100949     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecl.2008.07.002     Document Type: Review

References (74)

1. Ahima R.S. Adipose tissue as an endocrine organ. Obesity (Silver Spring) 14 Suppl 5 (2006) 242S-249S
2. Nawrocki A.R., and Scherer P.E. Keynote review: the adipocyte as a drug discovery target. Drug Discov Today 10 (2005) 1219-1230
3. Scherer P.E. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes 55 (2006) 1537-1545
4. Trayhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 184 (2005) 285-293
5. Alvarez-Llamas G., Szalowska E., de Vries M.P., et al. Characterization of the human visceral adipose tissue secretome. Mol Cell Proteomics 6 (2007) 589-600
6. Chen X., Cushman S.W., Pannell L.K., et al. Quantitative proteomic analysis of the secretory proteins from rat adipose cells using a 2D liquid chromatography-MS/MS approach. J Proteome Res 4 (2005) 570-577
7. Klimcakova E., Moro C., Mazzucotelli A., et al. Profiling of adipokines secreted from human subcutaneous adipose tissue in response to PPAR agonists. Biochem Biophys Res Commun 358 (2007) 897-902
8. Kratchmarova I., Kalume D.E., Blagoev B., et al. A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics 1 (2002) 213-222
9. Scherer P.E., Bickel P.E., Kotler M., et al. Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Nat Biotechnol 16 (1998) 581-586
10. Tsuruga H., Kumagai H., Kojima T., et al. Identification of novel membrane and secreted proteins upregulated during adipocyte differentiation. Biochem Biophys Res Commun 272 (2000) 293-297
11. Wang P., Mariman E., Keijer J., et al. Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines. Cell Mol Life Sci 61 (2004) 2405-2417
12. Zhang Y., Proenca R., Maffei M., et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
13. Antras J., Hilliou F., Redziniak G., et al. Decreased biosynthesis of actin and cellular fibronectin during adipose conversion of 3T3-F442A cells. Reorganization of the cytoarchitecture and extracellular matrix fibronectin. Biol Cell 66 (1989) 247-254
14. Spiegelman B.M., and Ginty C.A. Fibronectin modulation of cell shape and lipogenic gene expression in 3t3-adipocytes. Cell 35 (1983) 657-666
15. Taleb S., Cancello R., Clement K., et al. Cathepsin S promotes human preadipocyte differentiation: possible involvement of fibronectin degradation. Endocrinology 147 (2006) 4950-4959
16. Xiao Y., Junfeng H., Tianhong L., et al. Cathepsin K in adipocyte differentiation and its potential role in the pathogenesis of obesity. J Clin Endocrinol Metab 91 (2006) 4520-4527
17. Brekken R.A., and Sage E.H. SPARC, a matricellular protein: at the crossroads of cell-matrix communication. Matrix Biol 19 (2001) 816-827
18. Bradshaw A.D., Graves D.C., Motamed K., et al. SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc Natl Acad Sci U S A 100 (2003) 6045-6050
19. Tartare-Deckert S., Chavey C., Monthouel M.N., et al. The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. J Biol Chem 276 (2001) 22231-22237
20. Chavey C., Mari B., Monthouel M.N., et al. Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J Biol Chem 278 (2003) 11888-11896
21. Bouloumie A., Sengenes C., Portolan G., et al. Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation. Diabetes 50 (2001) 2080-2086
22. Croissandeau G., Chretien M., and Mbikay M. Involvement of matrix metalloproteinases in the adipose conversion of 3T3-L1 preadipocytes. Biochem J 364 (2002) 739-746
23. Lijnen H.R., Demeulemeester D., Van Hoef B., et al. Deficiency of tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) impairs nutritionally induced obesity in mice. Thromb Haemost 89 (2003) 249-255
24. Alexander C.M., Selvarajan S., Mudgett J., et al. Stromelysin-1 regulates adipogenesis during mammary gland involution. J Cell Biol 152 (2001) 693-703
25. Kralisch S., Bluher M., Tonjes A., et al. Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans. Eur J Endocrinol 156 (2007) 257-261
26. Unger R.H. Lipotoxic diseases. Annu Rev Med 53 (2002) 319-336
27. Kim J.Y., van de Wall E., Laplante M., et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 117 (2007) 2621-2637
28. Tataranni P.A., and Ortega E. A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?. Diabetes 54 (2005) 917-927
29. Kim J.K., Kim Y.J., Fillmore J.J., et al. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108 (2001) 437-446
30. Visser M., Bouter L.M., McQuillan G.M., et al. Elevated C-reactive protein levels in overweight and obese adults. JAMA 282 (1999) 2131-2135
31. Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 (2003) 1796-1808
32. Xu H., Barnes G.T., Yang Q., et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112 (2003) 1821-1830
33. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259 (1993) 87-91
34. Pickup J.C., and Crook M.A. Is type II diabetes mellitus a disease of the innate immune system?. Diabetologia 41 (1998) 1241-1248
35. Lin Y., Rajala M.W., Berger J.P., et al. Hyperglycemia-induced production of acute phase reactants in adipose tissue. J Biol Chem 276 (2001) 42077-42083
36. Ajuwon K.M., Jacobi S.K., Kuske J.L., et al. Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-gamma in primary pig adipocytes. Am J Physiol Regul Integr Comp Physiol 286 (2004) R547-R553
37. Berg A.H., Lin Y., Lisanti M.P., et al. Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity. Am J Physiol Endocrinol Metab 287 (2004) E1178-E1188
38. Pajvani U.B., Trujillo M.E., Combs T.P., et al. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med 11 (2005) 797-803
39. Tsuchida A., Yamauchi T., Takekawa S., et al. Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 54 (2005) 3358-3370
40. Moller D.E., and Berger J.P. Role of PPARs in the regulation of obesity-related insulin sensitivity and inflammation. Int J Obes Relat Metab Disord 27 Suppl 3 (2003) S17-S21
41. do Nascimento C.O., Hunter L., and Trayhurn P. Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgamma. Biochem Biophys Res Commun 313 (2004) 702-708
42. Alleva D.G., Johnson E.B., Lio F.M., et al. Regulation of murine macrophage proinflammatory and anti-inflammatory cytokines by ligands for peroxisome proliferator-activated receptor-gamma: counter-regulatory activity by IFN-gamma. J Leukoc Biol 71 (2002) 677-685
43. Ramakers J.D., Verstege M.I., Thuijls G., et al. The PPARgamma agonist rosiglitazone impairs colonic inflammation in mice with experimental colitis. J Clin Immunol 27 (2007) 275-283
44. Tahan V., Eren F., Avsar E., et al. Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis. Dig Dis Sci 52 12 (2007) 3465-3472
45. Russell J.A. Management of sepsis. N Engl J Med 355 (2006) 1699-1713
46. Toussirot E., Streit G., and Wendling D. The contribution of adipose tissue and adipokines to inflammation in joint diseases. Curr Med Chem 14 (2007) 1095-1100
47. Chen T.H., Chen L., Hsieh M.S., et al. Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta 1762 (2006) 711-718
48. Neels J.G., Thinnes T., and Loskutoff D.J. Angiogenesis in an in vivo model of adipose tissue development. FASEB J 18 (2004) 983-985
49. Nishimura S., Manabe I., Nagasaki M., et al. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 56 (2007) 1517-1526
50. Cho C.H., Koh Y.J., Han J., et al. Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res 100 (2007) e47-e57
51. Brakenhielm E., Cao R., Gao B., et al. Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res 94 (2004) 1579-1588
52. Kolonin M.G., Saha P.K., Chan L., et al. Reversal of obesity by targeted ablation of adipose tissue. Nat Med 10 (2004) 625-632
53. Rupnick M.A., Panigrahy D., Zhang C.Y., et al. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A 99 (2002) 10730-10735
54. Cao Y. Angiogenesis modulates adipogenesis and obesity. J Clin Invest 117 (2007) 2362-2368
55. Hosogai N., Fukuhara A., Oshima K., et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56 (2007) 901-911
56. Rausch M.E., Weisberg S., Vardhana P., et al. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 32 3 (2008) 451-463
57. Ye J., Gao Z., Yin J., et al. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293 (2007) E1118-E1128
58. Silha J.V., Krsek M., Sucharda P., et al. Angiogenic factors are elevated in overweight and obese individuals. Int J Obes (Lond) 29 (2005) 1308-1314
59. Mantovani A., Sica A., and Locati M. New vistas on macrophage differentiation and activation. Eur J Immunol 37 (2007) 14-16
60. Lumeng C.N., Bodzin J.L., and Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117 (2007) 175-184
61. Lolmede K., Durand de Saint Front V., Galitzky J., et al. Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord 27 (2003) 1187-1195
62. Bergers G., Brekken R., McMahon G., et al. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol 2 (2000) 737-744
63. Kim Y.M., An J.J., Jin Y.J., et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol 38 (2007) 455-465
64. Combs T.P., Wagner J.A., Berger J., et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology 143 (2002) 998-1007
65. Watson R.T., Kanzaki M., and Pessin J.E. Regulated membrane trafficking of the insulin-responsive glucose transporter 4 in adipocytes. Endocr Rev 25 (2004) 177-204
66. Qiang L., Wang H., and Farmer S.R. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Mol Cell Biol 27 (2007) 4698-4707
67. Wang Z.V., Schraw T.D., Kim J.Y., et al. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol Cell Biol 27 (2007) 3716-3731
68. Grujic D., Susulic V.S., Harper M.E., et al. Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J Biol Chem 272 (1997) 17686-17693
69. Roh C., Roduit R., Thorens B., et al. Lipoprotein lipase and leptin are accumulated in different secretory compartments in rat adipocytes. J Biol Chem 276 (2001) 35990-35994
70. Scherer P.E., Lisanti M.P., Baldini G., et al. Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J Cell Biol 127 (1994) 1233-1243
71. Flieger O., Engling A., Bucala R., et al. Regulated secretion of macrophage migration inhibitory factor is mediated by a non-classical pathway involving an ABC transporter. FEBS Lett 551 (2003) 78-86
72. Anderson R.G. Caveolae: where incoming and outgoing messengers meet. Proc Natl Acad Sci U S A 90 (1993) 10909-10913
73. Okamoto T., Schlegel A., Scherer P.E., et al. Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem 273 (1998) 5419-5422
74. Shaul P.W., and Anderson R.G. Role of plasmalemmal caveolae in signal transduction. Am J Physiol 275 (1998) L843-L851